In our new paper, we uncover how Burkholderia switches from antibacterial T6SS-1 to eukaryotic-targeting T6SS-5. Surprisingly, actively turning off T6SS-1 assembly prevents mitochondrial damage and apoptosis.
Congrats @christy-chc.bsky.social and the team!
link.springer.com/article/10.1...
link.springer.com
Regulation of Type VI Secretion Systems of Burkholderia during transition to intracellular lifestyle - EMBO Reports
Pathogenic bacteria tightly regulate gene expression in response to environmental cues. In Burkholderia species, the Type VI Secretion Systems (T6SS) mediate interbacterial competition and host cell i...
