Functional RNA structures are typically far more dynamic than most proteins solved by cryo-electron microscopy (cryo-EM). Flexible junctions and weak tertiary contacts produce broad conformational ens...

Functional RNA structures are typically far more dynamic than most proteins solved by cryo-electron microscopy (cryo-EM). Flexible junctions and weak tertiary contacts produce broad conformational ens...

This Gradio app lets you join the OpenADMET CYP Inhibition Blind Challenge. Upload a CSV or Parquet file with your regression or classification predictions, or a ZIP archive of PDB structures for t...

Customized keybindings and scripts for Coot 1.x. Contribute to olibclarke/coot1-trimmings development by creating an account on GitHub.

This study explores the use of graphene reservoirs formed over perforated supporting films as a method to precisely control ice thickness during cryo-EM sample preparation.

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Downes et al. use in situ cryo-electron tomography and super-resolution fluorescence microscopy to define ER exit site architecture in unperturbed human cells. They visualize ribosome-exclusion zones ...

AP3 generates clathrin-free carriers on endosomes by organizing via ARF1 dimers into elongated membrane-deforming arrays.

ArnA contamination was independently observed during the purification of a soluble, low-yield protein complex, leading to an unintended 3.23 Å resolution cryo-EM structure. This work broadens recent f...

imageimagetRNAs harbour a complex set of modifications which are important for their function. Here, single particle cryo-EM, biophysics, and computational analyses of the effects of pseudouridine inc...