Sign in

Roberto Covino

@rocovino.bsky.social
453 followers 220 following 25 posts

Professor of Computational Life Science at Goethe University Frankfurt. Computer simulations of biomolecular systems, statistical modeling, and machine learning.

PostsRepliesMedia
Reposted by Roberto Covino
Inga Hänelt @ihaenelt.bsky.social · 19/12/2025
Take advantage of this fantastic opportunity to become part of the SCALE community! Several professorships and group leader positions are available at Goethe University and FIAS. We are looking for professors in the fields of molecular microbiology, cellular biochemistry, and molecular biochemistry.
11916
Reposted by Roberto Covino
Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 06/12/2025
TT in Experimental Biophysics The Danish Institute for Advanced Study and the Dept of Physics, Chemistry and Pharmacy at the University of Southern Denmark is hiring a tenure track Assistant Professor in Biophysics or a related discipline fa-eosd-saasfaprod1.fa.ocs.oraclecloud.com/hcmUI/Candid...
fa-eosd-saasfaprod1.fa.ocs.oraclecloud.com
DIAS Fellow in Experimental Biophysics
The Danish Institute for Advanced Study (DIAS) and the Department of Physics, Chemistry and Pharmacy (FKF) at the University of Southern Denmark (SDU) seek an excellent candidate to fill a tenure trac...
01011
Roberto Covino @rocovino.bsky.social · 05/12/2025
The Frankfurt Institute for Advanced Studies (FIAS) and the newly funded Cluster of Excellence SCALE are seeking several Independent Research Group Leaders to drive theoretical and computational research in molecular and cellular life science. fias.institute/de/das-fias/...
fias.institute
Independent Research Group Leaders (f/m/d) SCALE / FIAS
01110
Roberto Covino @rocovino.bsky.social · 25/08/2025
Crystal packing affects protein dynamics - super interesting!
020
Roberto Covino @rocovino.bsky.social · 21/08/2025
Amazing work!!
160
Reposted by Roberto Covino
scruss @scruss.bsky.social · 26/07/2025
On this day in 1184, this happened: Erfurt latrine disaster — en.wikipedia.org/wiki/Erfurt_...
en.wikipedia.org
Erfurt latrine disaster - Wikipedia
086
Reposted by Roberto Covino
Rocío Mercado Oropeza @rociomer.bsky.social · 07/07/2025
Are you passionate about AI for molecular engineering? Just two weeks left to apply to the 2 PhD positions currently open in our team at Chalmers! 🎓 For details: ailab.bio/join-us
066
Roberto Covino @rocovino.bsky.social · 10/06/2025
If you are interested in glycans e how they modulate the function of other biomolecules this is the CECAM meeting to be! Look at the lineup of speakers! And the location is also not too bad :P Registrations are open until 30/06/25 at www.cecam.org/workshop-det...
020
Reposted by Roberto Covino
James Saenz @jamessaenz.bsky.social · 08/06/2025
0192
Reposted by Roberto Covino
Goethe-Universität Frankfurt @goetheuni.bsky.social · 22/05/2025
🚀 Zwei neue #Exzellenzcluster für die #GoetheUni! Mit @scale-cluster-ffm.bsky.social & @cpi-exstra.bsky.social wird Frankfurt ab 2026 zum Hotspot für Zell- & Gesundheitsforschung. Nächster Schritt: Exzellenzverbund @rheinmainunis.bsky.social mit @unimainz.bsky.social & @tuda.bsky.social.
5247
Reposted by Roberto Covino
PSB_Grenoble @psb-grenoble.bsky.social · 09/05/2025
🧬PSB Symposium on " #MachineLearning in Cellular #StructuralBiology ", EPN Campus Grenoble, France, 26-27 June 2025🧬 📢Reminder - Call for abstracts (posters & short talks) Submission & registration deadline 25 May: www.psb-grenoble.eu/psbsymposium... @esrf.fr @embl.org @illneutrons.bsky.social
174
Reposted by Roberto Covino
PSB_Grenoble @psb-grenoble.bsky.social · 21/05/2025
Last days! 📆
021
Reposted by Roberto Covino
PSB_Grenoble @psb-grenoble.bsky.social · 09/05/2025
Check out the speakers! @rommieamaro.bsky.social @jessicaandreani.bsky.social @gauravbhardwaj.bsky.social @bonomimax.bsky.social @rocovino.bsky.social @arneelof.bsky.social Sergei Grudinin @magistratolab.bsky.social Christine Orengo @joanampereira.bsky.social Maya Topf, Sameer Velankar, Basile Wicky
095
Reposted by Roberto Covino
Levental Lab @leventallab.bsky.social · 07/05/2025
Been thinking about biomembranes? Wondering what next decade of research will be? Wonder no more: there's an awesome conference coming up in Copenhagen in July!! From simulations to cells and everything in between. 5 days left to submit abstract - APPLY! www.biophysics.org/blog/beyond-...
biophysics.org
Beyond Simple Models: The Consequences of Membrane Complexity in Living Systems - Copenhagen, Denmark 2025
Dear Colleagues, We are excited to announce the Biophysical Society Thematic Meeting on Beyond Simple Models: The Consequences of Membrane Complexity in Living Systems.  This meeting will be held in ...
02713
Reposted by Roberto Covino
Magnus Petersen @omorfiamorphism.bsky.social · 27/04/2025
Presenting our work on minimum energy path generation between two states for physical systems at the FPI Workshop at @ICLR tomorrow! Scaling up to solvated BPTI and observing the same conformational changes as long reference MD with six orders fewer force field evals! Drop by!
1102
Reposted by Roberto Covino
Simon Olsson @smnlssn.bsky.social · 03/04/2025
We are recruiting a colleague to our division at Chalmers in Data-Driven Life Science (broadly defined), a competitive starting package is offered and you get to be part of a support, yet young and ambitious research environment. Apply here: www.chalmers.se/en/about-cha...
chalmers.se
Vacancies
1106
Reposted by Roberto Covino
cryoEM papers @cryoempapers.bsky.social · 29/03/2025
Counting particles could give wrong probabilities in Cryo-Electron Microscopy www.biorxiv.org/content/10.1101/2025.03.27.644168v1 #cryoEM
0114
Reposted by Roberto Covino
Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 29/03/2025
Run BioEmu in Colab - just click "Runtime → Run all"! Our notebook uses ColabFold to generate MSAs, BioEmu to predict trajectories, and Foldseek to cluster conformations. Thanks @jjimenezluna.bsky.social for the help! 🌐 colab.research.google.com/github/sokry... 📄 www.biorxiv.org/content/10.1...
colab.research.google.com
Google Colab
110141
Reposted by Roberto Covino
Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 17/03/2025
⏰ Two weeks left to register for our Benzon Symposium on Protein structure prediction and design 🧶🧬🖥️ Meeting will take place in Copenhagen 🇩🇰 on Sept. 1–4, 2025, and will feature an amazing list of speakers 👨‍🔬👩‍🔬👩‍💻👨‍💻 Submit your application via: benzon-foundation.dk/benzon-sympo...
03217
Roberto Covino @rocovino.bsky.social · 17/03/2025
On my way to #APS California!
020
Reposted by Roberto Covino
Ben Coates @bencoates1.bsky.social · 05/03/2025
CDU’s debt brake turns out to be a lot like my diet: spend many months telling everyone you meet that it’s tough but totally essential and completely inviolable, before just junking the whole thing whenever you feel like it
0102
Reposted by Roberto Covino
Hennig-Lab @hennig-lab.bsky.social · 04/03/2025
Please RT: If you are interested in doing your PhD at the ILL, Grenoble in collaboration with the Hennig-Lab at University of Bayreuth, Germany, look here: esrf.gestmax.eu/1874/1/phd-s...
esrf.gestmax.eu
ESRF - PhD student at ILL: Structural biology of an RNA helicase by NMR, SANS and segmental labelling
Consultez toutes les offres d'emploi ESRF et postulez en ligne a nos annonces emploi sur le site recrutement ESRF
136
Reposted by Roberto Covino
Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 01/03/2025
Registration is now open for our Benzon Symposium on "Protein structure prediction and design" Meeting will take place in Copenhagen 🇩🇰 on Sept. 1–4, 2025, and will feature an amazing list of speakers Get your application in before March 31st via: benzon-foundation.dk/benzon-sympo...
Flyer for the conference. Confirmed invited speakers include:
Gabriel J. Rocklin
Birte Höcker
Amy E. Keating
Tanja Kortemme
Bruno Correia
Sarel J. Fleishman
Ashutosh Chilkoti
Minkyung Baek
Noelia Ferruz
James S. Fraser
Alan M. Moses
Susan Marqusee
Ben Lehner
Mohammed AlQuraishi
Dek Woolfson
Gustav Oberdorfer
Hannah K. Wayment-Steele
Ora Schueler-Furman
Jennifer Listgarten
Alexander Rives
Massimiliano Bonomi
Debora S. Marks
Gaurav Bhardwaj
13213
Reposted by Roberto Covino
Ben Coates @bencoates1.bsky.social · 01/03/2025
Zelensky’s timeline right now is a thing of beauty
1357
Reposted by Roberto Covino
Frank Noe @franknoe.bsky.social · 23/02/2025
Geht’s raus und geht’s wählen! ⚽️🗳️
0184
Reposted by Roberto Covino
Frank Noe @franknoe.bsky.social · 19/02/2025
The BioEmu-1 model and inference code are now public under MIT license!!! Please go ahead, play with it and let us know if there are issues. github.com/microsoft/bi...
github.com
GitHub - microsoft/bioemu: Inference code for scalable emulation of protein equilibrium ensembles with generative deep learning
Inference code for scalable emulation of protein equilibrium ensembles with generative deep learning - microsoft/bioemu
210339
Reposted by Roberto Covino
paulschanda.bsky.social @paulschanda.bsky.social · 17/02/2025
📢 New preprint, lead by Alex Bronstein, @sankethvedula.bsky.social and colleagues: Guiding AlphaFold with experimental data. This approach generates conformational ensembles guided by NMR, X-ray (or whatever) data. I am thrilled to tackle lots of exciting problems with it! arxiv.org/abs/2502.09372
arxiv.org
Inverse problems with experiment-guided AlphaFold
Proteins exist as a dynamic ensemble of multiple conformations, and these motions are often crucial for their functions. However, current structure prediction methods predominantly yield a single conf...
15016
Reposted by Roberto Covino
Andrew White 🐦‍⬛ @andrew.diffuse.one · 14/02/2025
Molecular dynamics requires a lot of expert knowledge to set-up and analyze simulations. We set out to automate it with LLM agents: MDCrow!
1246
Reposted by Roberto Covino
Erik Lindahl @eriklindahl.bsky.social · 14/02/2025
If you are interested in postdoctoral research on ligand-gated ion channels and the synapse, or simulation/AI methods for structural biology - drop me a line if you'll be around at Biophysical Society in LA! #bps2025 #bps #biophysics
13820
Reposted by Roberto Covino
Luciano A. Masullo @lumasullo.bsky.social · 10/02/2025
ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🧬🎨🍬 The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy www.biorxiv.org/content/10.1...
15313101
Reposted by Roberto Covino
André Nadler @nadlerlab.bsky.social · 31/01/2025
It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density, which usually isn’t attainable. Lipid-CLEM brought to you by @mathilda95.bsky.social changes that. www.biorxiv.org/content/10.1...
1223778
Reposted by Roberto Covino
Ishier Raote @ishier.bsky.social · 29/01/2025
Ooh nice preprint! Studying membrane nanodomains needs nanoscale lipid localization - current methods fall short. 'Lipid-CLEM', correlative light & EM with click chemistry to map lipids. In endosomes, it shows sphingomyelin’s differential partitioning beautifully. www.biorxiv.org/content/10.1...
biorxiv.org
Visualizing sub-organellar lipid distribution using correlative light and electron microscopy
Lipids and proteins compartmentalize biological membranes into nanoscale domains which are crucial for signaling, intracellular trafficking and many other cellular processes. Studying nanodomain funct...
13712
Roberto Covino @rocovino.bsky.social · 29/01/2025
A unique opportunity for the European research system (which we will, of course, not pick up)
020
Reposted by Roberto Covino
HPC Guru @hpcguru.bsky.social · 27/01/2025
👇Effective use of #AI tools for software development still requires deep domain knowledge and technical expertise Rather than replacing fundamental skills, #AI serves as a powerful accelerator for experienced developers who understand both the problem space and the capabilities of their tools
193
Reposted by Roberto Covino
Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 26/01/2025
Ten simple rules for developing good reading habits during graduate school and beyond To me, the most important are: Read often, read broadly (incl. older papers and outside your field), and learn to read some papers in detail and others more superficially (and quickly)
Ten simple rules for developing good reading habits during graduate school and beyond by Marcos Méndez
1: Develop the habit of reading on a daily basis
2: Read thoroughly to build a sound background understanding of your topic
3: Do not ignore the pillars of your discipline; read the classics
4: If you have to get familiar with a new topic, consider reading in chronological order
5: Avoid narrow-mindedness by reading beyond your discipline
6: Create a list of relevant journals
7: Not all interesting stuff will appear in articles; read books
8: Use a reference manager to keep track of your literature
9: Keep a long-term review for your own use as a way to remember what you read
10: Build your own library to make yourself independent and inspire others
512842
Roberto Covino @rocovino.bsky.social · 24/01/2025
Check out our new paper! Protein assembly in membranes is crucial yet elusive. Why steer when you can just observe? We introduce a bias-free simulation method that captures the full picture of transmembrane dimerization—free energies, mechanisms, and rates! pubs.acs.org/doi/10.1021/...
pubs.acs.org
Free Energy, Rates, and Mechanism of Transmembrane Dimerization in Lipid Bilayers from Dynamically Unbiased Molecular Dynamics Simulations
The assembly of proteins in membranes plays a key role in many crucial cellular pathways. Despite their importance, characterizing transmembrane assembly remains challenging for experiments and simula...
16517
Reposted by Roberto Covino
Carl Zimmer @carlzimmer.com · 23/01/2025
Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring www.science.org/content/arti...
science.org
Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring
Researchers facing
16317131
Reposted by Roberto Covino
Tim Coulson @timcoulson.bsky.social · 17/01/2025
Fed up with being asked about cryptozoological sightings I wrote about the impossibility of #Yeti, #Bigfoot and #Nessie the-european.eu/story-41724/.... Will I now be asked to comment on #alien sightings? Included is a photo of a #Yeti I took 😂. As a top scientist, @sykhalid.bsky.social, thoughts?
the-european.eu
Sorry folks: Bigfoot, Nessie, and the Yeti don’t exist – The European Magazine
141
Reposted by Roberto Covino
Gabriel Peyré @gabrielpeyre.bsky.social · 15/01/2025
Slides for a general introduction to the use of Optimal Transport methods in learning, with an emphasis on diffusion models, flow matching, training 2 layers neural networks and deep transformers. speakerdeck.com/gpeyre/optim...
312427
Roberto Covino @rocovino.bsky.social · 12/01/2025
I was wondering the same, I get 20 a day of these silly emails and my spam filter doesn’t get better at blocking them
050
Roberto Covino @rocovino.bsky.social · 12/01/2025
0204
Reposted by Roberto Covino
Jim Hurley @jimhurley.bsky.social · 09/01/2025
PhDs in biochemistry, structural biology, pharmacology, or similar, located in the US and with strong publication track records and a high motivation to solve Parkinson's, please send CV directly to me at jimhurley@berkeley.edu. Repost appreciated.
07056
Reposted by Roberto Covino
Magnus Petersen @omorfiamorphism.bsky.social · 15/12/2024
Check out my poster on 'Trajectory Level Langevin Dynamics' aka 'Simulations of simulations', using differentiable MD forcefields, at the 'ML and the Physical Sciences' Workshop @NeurIPS! Link: openreview.net/pdf?id=daEra...
0253
Reposted by Roberto Covino
pilarcossio.bsky.social @pilarcossio.bsky.social · 13/12/2024
#NeurIPS2024 check out our work: Cryo-EM images are intrinsically low dimensional at the MLSB workshop with Luke Evans, Octavian-Vlad Murad @larsdingeldein.bsky.social @rocovino.bsky.social & Marina Meila www.mlsb.io/papers_2024/...
mlsb.io
0206
Reposted by Roberto Covino
Simon Olsson @smnlssn.bsky.social · 08/12/2024
Impressive work by @franknoe.bsky.social and team! A pragmatic tour-de-force combining experimental and predicted protein structures, MD simulations and experimental stability data to sample conformational ensembles of proteins. Think AlphaFold, but capturing multiple free energy minima.
1398
Reposted by Roberto Covino
Frank Noe @franknoe.bsky.social · 06/12/2024
Super excited to preprint our work on developing a Biomolecular Emulator (BioEmu): Scalable emulation of protein equilibrium ensembles with generative deep learning from @msftresearch.bsky.social ch AI for Science. www.biorxiv.org/content/10.1...
21441147
Reposted by Roberto Covino
Martin Vögele @martinvoegele.bsky.social · 06/12/2024
Another deep-learning approach to sample conformational ensembles of proteins: BioEmu, out of Microsoft Research. www.biorxiv.org/content/10.1...
biorxiv.org
Scalable emulation of protein equilibrium ensembles with generative deep learning
Following the sequence and structure revolutions, predicting the dynamical mechanisms of proteins that implement biological function remains an outstanding scientific challenge. Several experimental t...
33612
Reposted by Roberto Covino
Bird account @dialecticbio.bsky.social · 04/12/2024
Gotta love the tone of disappointment about myoglobin not having an elegant structure. Kendrew et al. (1958) www.nature.com/articles/181...
Fig 2. Photographs of a model of the myoglobin molecule. Polypeptide chains are white; the grey disk is the hsem group. The three spheres show positions at which heavy atoms were attached to the molecule (black: Hg of p-chloro-mercuri-benzene-sulphonate; dark grey: Hg of mercury diammine; light grey: Au of auri-chloride). The marks on the scale are 1 A. apartPerhaps the most remarkable features of the molecule are its complexity and its lack of symmetry. The arrangement seems to be almost totally lacking in the kind of regularities which one instinctively anticipates, and it is more complicated than has been predicated by any theory of protein structure. Though the detailed principles of construction do not yet emerge, we may hope that they will do so at a later stage of the analysis. We are at present engaged in extending the resolution to 3 A., which should show us something of the secondary structure; we anticipate that still further extensions will later be possible eventually, perhaps, to the point of revealing even the primary structure.
2647
Reposted by Roberto Covino
COSMO Lab @labcosmo.bsky.social · 03/12/2024
Hello! I'm posting this both here and on the X-rated site, let's see where it gets more re-posts 😇. We are looking for a research software engineer to help us develop (even) better code for #compchem #atomicscale #machinelearning. Check out the specs and apply! www.epfl.ch/labs/cosmo/i...
epfl.ch
Jobs
-
35953