Podcast Episode · Entrepreneurial Thought Leaders (ETL) · October 23, 2019 · 44m

Conversations, turns, rounds, tools, agents and more!

Welcome back to the tidy design principles substack.

YouTube video by NASA

A step-by-step guide to making de novo binders.

Give Claude persistent instructions with CLAUDE.md files, and let Claude accumulate learnings automatically with auto memory.

YouTube video by NDC Conferences

YouTube video by Ask Erin, Dear Beth

Deep Learning with Python is written for anyone who wishes to explore deep learning from scratch. This new edition adds comprehensive coverage of generative AI and modern deep learning frameworks. It ...

An in vivo base editing approach targeting the PRNP gene led to a 52% increase in the lifespan of mouse models inoculated with the most common sporadic and genetic types of human pathogenic prion isol...

Single-cell measurement of the Huntington’s disease-causing CAG repeat reveals that somatic expansion of this repeat drives pathological changes in neurons, providing insights into disease progression...

Whole-genome duplication (WGD) is widespread across eukaryotes and can promote adaptive evolution^1-4. However, given the instability of newly formed polyploid genomes^5-7, understanding how WGDs arise in a population, persist, and underpin adaptations remains a challenge. Here, …

Genetic interactions can reveal gene function and identify cancer-relevant synthetic lethals, but systematic mapping in human cells is constrained by inefficient reagents, vast combinatorial search sp...

YouTube video by Ask Erin, Dear Beth

gReLU advances deep-learning-based modeling and analysis of DNA sequences with comprehensive toolsets and versatile applications.

Podcast Episode · TGen Talks · 09/30/2025 · 26m

Telomeres are essential for genome integrity, but the accurate, high-resolution mapping of their three-dimensional (3D) chromatin interactions, a process thought to mediate gene regulation and telomer...

Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.

YouTube video by Ask Erin, Dear Beth

What if scientists unlocked the most hidden, hardest-to-read regions of our DNA?

The transition from benign to malignant growth is a pivotal yet poorly understood step in cancer progression that marks the shift from a pathologically inert condition to a clinically lethal disease. ...

Why automated virtual screening and docking remains hard and why expertise remains essential

YouTube video by CultRepo (formerly Honeypot)

The genome-wide landscape of Cas-induced double-strand breaks and end structures is profiled at nucleotide resolution.

Abstract. Comparative oncology has made great strides in identifying patterns of cancer prevalence and risk across the tree of life. Such studies have ofte

PDGFRA is commonly altered in pediatric HGG. Mayr et al. report that the PDGFRA/KIT inhibitor avapritinib demonstrates on-target activity, brain penetrance, and survival benefit in pre-clinical H3K27M...

Wala et al. identify recurrent focal BRD4 deletions in tumors harboring larger amplifications, suggesting that these deletions may serve to limit toxic BRD4 overexpression. A CRISPR-Cas9 cell line mod...

To buffer the brain against menaces in the blood, a dynamic, multi-tiered system of protection is built into the brain’s blood vessels.