Our main research interest is understanding the molecular mechanisms behind extrachromosomal DNA (ecDNA) behaviors in cancers

How circular extrachromosomal DNA is inherited during cell division is a puzzle. Key sequences enabling this DNA to journey with chromosomes have been identified. How circular extrachromosomal DNA is inherited during cell division is a puzzle. Key sequences enabling this DNA to journey with chromosomes have been identified.

Summary:. Extrachromosomal DNA (ecDNA) has been suggested as a key factor of tumor heterogeneity at the genomic and transcriptional levels, via unequal segregation and ecDNA hub formation, respectivel...

Victoria’s Secret Global Fund for Women’s Cancers Career Development Award 2025: Advancing Research in Breast and Gynecologic Cancers / Breast Cancer

Abstract. Extrachromosomal DNA (ecDNA), a major focal oncogene amplification mode found across cancer, has recently regained attention as an emerging cancer hallmark, with a pervasive presence across ...