Ob Industrielle KI, Quantentechnologien oder resiliente Energiesysteme – beim Technologiepreis „The Spark" zählt, wer Deep-Tech-Innovationen unter realen Bedingungen zum Laufen bringt. Unterstützen Si...

Activation of the MAPK/ERK signaling pathway is known to influence glioma biology. Here the authors report that MAPK/ERK signaling activation drives interferon responses in glioma cells, enhancing ant...

Longitudinal transcriptomic, chromatin and genomic analyses of the two types of IDH-mutant glioma reveal in detail how disease progression is influenced by interdependent genetic, epigenetic and micro...

Organoids provide a useful model to capture the heterogeneity of brain tumours. Here, the authors assess current methodologies for generating organoids from various types of brain tumour and discuss h...

In this Review, Golebiewska and colleagues summarize the main features of the immunosuppressive microenvironment in glioblastoma (GBM) and discuss how different therapeutic approaches reshape GBM immu...

High-grade gliomas are lethal brain cancers that are powerfully regulated by glutamatergic neurons through activity-dependent paracrine factors and functional neuron-to-glioma synapses. Here, we repor...

Background: Precision medicine has transformed cancer treatment by tailoring therapies to specific molecular aberrations. Integrating high-resolution multi-omics with high-throughput functional profil...

Nature Reviews Cancer, Published online: 04 July 2025; doi:10.1038/s41568-025-00851-6In this Tools of the Trade article, Yahaya A. Yabo describes the development of neuropathology spatial transcriptomic analysis (NePSTA), an artificial intelligence (AI)-based tool to identify and map unique spatial patterns within tissues.

In this Tools of the Trade article, Yahaya A. Yabo describes the development of neuropathology spatial transcriptomic analysis (NePSTA), an artificial intelligence (AI)-based tool to identify and map ...

Glioblastoma (GB) is one of the most lethal human cancers, marked by profound intratumoral heterogeneity and near-universal treatment resistance. Cellular plasticity, the capacity of cancer cells to t...

Integrated single-cell transcriptomic and genetic characterization of 121 adult glioblastomas identifies heterogeneity at cell type, cell state and baseline expression program levels associated with s...

Spatial omics technologies offer insights into the organization of cellular and molecular components and their interactions within the tumor ecosystem. Overcoming the key challenges to integrating the...

Functional, tumour-promoting GABAergic neuron-to-glioma synapses in diffuse midline gliomas are identified.

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Ritter et al. present a spatial transcriptomics and deep learning-based approach named NePSTA (neuropathology spatial transcriptomic analysis) and leverage it to improve neuropathological diagnostics ...

Ritter et al. present a spatial transcriptomics and deep learning-based approach named NePSTA (neuropathology spatial transcriptomic analysis) and leverage it to improve neuropathological diagnostics ...

Ritter et al. present a spatial transcriptomics and deep learning-based approach named NePSTA (neuropathology spatial transcriptomic analysis) and leverage it to improve neuropathological diagnostics ...

Nature - Brain-wide neuronal circuit connectome of human glioblastoma

A study using glioblastoma mouse models, serial magnetic resonance imaging and single-cell profiling details changes in the identity and balance of cellular states from initiation of tumorigenesis to ...