Dicer has long been viewed as the RNAse III enzyme that generates small regulatory RNAs to drive RNA interference (RNAi) machinery and posttranscriptional gene silencing. However, a growing body of ev...

Longitudinal transcriptomic, chromatin and genomic analyses of the two types of IDH-mutant glioma reveal in detail how disease progression is influenced by interdependent genetic, epigenetic and micro...

Nature - This Review revisits tumour initiation and promotion in light of clonal diversity and the presence of cancer driver mutations in normal tissues, aiming to understand mechanisms that enable...

Chromosomal chaos rewires immune defense into tumor-promoting inflammation.

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The most common destination for eventual Nobel laureates in physics, chemistry and medicine since 2000 is the United States, Nature has found.

Nature Structural & Molecular Biology - Chromatin hubs, which are formed during cell differentiation, are characterized by simultaneous interactions between multiple regulatory elements and...

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Job Title: Associate or Senior Editor Nature Genetics and Nature Communication Organisation: Nature Portfolio Location: New York/Philadelphia, Shanghai/Beijing, Madrid or Milan Application Deadline: A...

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Brandon Emanuel León, Defne Bayik; An in-depth survey of immunosuppressive myeloid cell heterogeneity in GBM, Neuro-Oncology, , noaf080, https://doi.org/10

Precise spatiotemporal regulation of gene expression is critical for the development and functioning of complex, multicellular organisms. Enhancers play a fundamental role in the regulation of gene ex...

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Using single-cell DNA sequencing we show that most healthy women harbour rare populations of aneuploid epithelial cells with copy number alteration events in their breast tissue that expand and accumu...

Chromothripsis is an extreme form of chromosome instability that causes the acquisition of multiple genomic aberrations. Simovic-Lorenz and Ernst discuss mechanistic models of chromothripsis and outli...

(A.) Treatment regime diagram. Cells were treated in 4 groups. Treatment additions are represented as colored circles. Combination treatment additions were administered 24 hours after the first treatm...