iiinova — where your digital self keeps evolving

Reposted by Róża Przanowska

Waggoner Lab @labwaggoner.bsky.social · 05/02/2026

In triple-negative breast cancer, sensory neurons activate cancer-associated fibroblasts to secrete collagen, thus stimulating a dense extracellular matrix that drives immune exclusion @cellcellpress.bsky.social www.cell.com/cell/fulltex...

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Róża Przanowska @rprzanowska.bsky.social · 31/01/2026

What happens when two postdocs connected through an amazing #NCI #F99K00 grant program, really like working together? You get a paper we are truly proud of - now live on bioRxiv! #BreastCancerResearch #CancerBiology #TranslationalResearch #NCI #IL6 #Tocilizumab #Docetaxel #Organoids #UVA #UVABME

biorxiv.org

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Janusz M. Bujnicki @jmbujnicki.bsky.social · 25/10/2025

Exciting news for the RNA research community! The Human RNome Project has been launched: a global effort to map all human RNAs and their chemical modifications. Proud to support it and contribute to the article in Genome Biology doi.org/10.1186/s130... #RNA #bioinformatics #RNAstructure #modomics

genomebiology.biomedcentral.com

Unlocking the regulatory code of RNA: launching the Human RNome Project - Genome Biology

The human RNome, the complete set of RNA molecules in human cells, arises through complex processing and includes diverse molecular species. While research traditionally focuses on four canonical nucl...

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Róża Przanowska @rprzanowska.bsky.social · 25/07/2025

Excited to share one of the first papers to link #lncRNA #structure to its function in #cancer! We mapped the structure of a tumor-suppressive DRAIC lncRNA and identified a 36-nucleotide hairpin as necessary and sufficient for its #anti-oncogenic function. www.sciencedirect.com/science/arti...

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Róża Przanowska @rprzanowska.bsky.social · 25/07/2025

It’s interesting how an offside project can bring so much value. Working on ORCs gave me new experiences, deeper insights into #DNAreplication, and some of the most fun I have had giving talks. #Orc #LOTR Read more in @elife.bsky.social Version of Record: elifesciences.org/articles/102...

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Reposted by Róża Przanowska

Ryan Flynn @raflynn5.bsky.social · 23/04/2025

Excited to share Benson’s and Maria’s work in collab w/Kostas Tzelepis: we found the nucleolar protein NPM1 is a marker of AML and can be targeted therapeutically connecting ‘cell surface RNA biology’ to cancer biology @natbiotech.nature.com www.nature.com/articles/s41...

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Reposted by Róża Przanowska

Paweł Krawczyk @pakraw.bsky.social · 17/04/2025

🎉 Incredibly proud to share my first-author paper in @nature.com! Heartfelt thanks to my mentor @andrzejdziembowski.bsky.social and the brilliant team at DziembowskiLab at @iimcb.bsky.social. More details in the 🧵below ⬇️

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iimcb.bsky.social @iimcb.bsky.social · 16/04/2025

🌐Our @nature.com paper is out! Researchers from IIMCB and other Polish institutions show how TENT5A boosts mRNA vaccine efficacy by stabilizing therapeutic mRNAs and enhancing antigen production. A step toward better therapies for cancer and beyond! 🧬 👉Read the story: bit.ly/3XYvQkI #Nature #mRNA

bit.ly

IIMCB

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Liz Neeley @lizneeley.bsky.social · 08/04/2025

Urgently reposting! University leadership need to actively check the SEVIS database every day (studyinthestates.dhs.gov/sevis-help-hub). Ask your chair to commit to it. Yesterday, UW discovered 9 visa cancellations & only found out b/c they ran a status check. www.seattletimes.com/seattle-news...

seattletimes.com

UW students’ visas revoked without notice by Trump administration

The University of Washington plans to provide the affected students access to legal services that are paid for by their student fees.

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Reposted by Róża Przanowska

Ryan Flynn @raflynn5.bsky.social · 26/03/2025

A nearly 9 year effort to design and implement new CLIP-based technologies to define multimeric protein assemblies on RNA. Enables ‘watching’ of RNP assemblies inside living cells Special congrats to Luca Ducoli, Brian Zarnegar, and Paul Khavari @nature.com www.nature.com/articles/s41...

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Róża Przanowska @rprzanowska.bsky.social · 11/03/2025

Have you wondered what the @elife.bsky.social peer-review process looks like? Feel free to see our responses to the reviewer comments on our manuscript "DNA replication in primary hepatocytes without the six-subunit #ORC". I enjoyed the process and highly recommend it!

elifesciences.org

DNA replication in primary hepatocytes without the six-subunit ORC

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Reposted by Róża Przanowska

Kathleen Bachynski @bachynski.bsky.social · 18/02/2025

One of the many, many “pauses” and cancellations devastating our next generation of researchers. “The NIH Intramural Program has paused the recruitment of IRTAs, CRTAs, and Visiting Fellows in all training programs pending guidance from Health and Human Services. Check back daily for updates.”

training.nih.gov

Postbac Program

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Róża Przanowska @rprzanowska.bsky.social · 30/01/2025

This is an exciting piece of research that brings us closer to an informed choice of therapy for individual patients. I am grateful to my PI and all collaborators for letting me learn how to start a translational project and how far it can reach. Thanks to UVA Engineering for highlighting our work!

engineering.virginia.edu

UVA Researchers Fast-Track Cancer Care with Patient-Specific Tumor Models | University of Virginia School of Engineering and Applied Science

What if doctors could predict a breast cancer patient’s response to treatment in just two weeks?

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Reposted by Róża Przanowska

Ming Tommy Tang @tommytang.bsky.social · 12/01/2025

#Rstats trick: use case_when(). I use it almost every week. No more nested if else gist.github.com/crazyhottom...

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Róża Przanowska @rprzanowska.bsky.social · 10/01/2025

New university housing for graduate students #snowday #snowweek #work-life-integration

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Róża Przanowska @rprzanowska.bsky.social · 01/01/2025

Happy to close 2024 with my last first-author publication from PhD thesis: "DNA replication in primary hepatocytes without the six-subunit #ORC" in @elife.bsky.social. This study challenges existing paradigms in #DNAreplication. 🧵(1/4) elifesciences.org/reviewed-pre...

elifesciences.org

DNA replication in primary hepatocytes without the six-subunit ORC

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Róża Przanowska @rprzanowska.bsky.social · 01/01/2025

Feeling so hopeful for 2025 after an amazing close to 2024! Grateful for a wonderful family vacation to recharge and thrilled to have two first-author papers published as a late birthday surprise on the very last day of the year. Wishing everyone a happy and fulfilling new year!

Family picture of mom, dad, and three children at Driftwood Beach, GA.

Patient-derived response estimates from zero-passage organoids of luminal breast cancer
Róża K. Przanowska, Najwa Labban, Piotr Przanowski, Russell B. Hawes, Kristen A. Atkins, Shayna L. Showalter & Kevin A. Janes
Breast Cancer Research volume 26, Article number: 192 (2024)

DNA replication in primary hepatocytes without the six-subunit ORC
Róża K Przanowska, Yuechuan Chen, Takayuki-Okano Uchida, Etsuko Shibata, Xiaoxiao Hao, Isaac Segura Rueda, Kate Jensen, Piotr Przanowski, Anthony Trimboli, Yoshiyuki Shibata, Gustavo Leone, Anindya Dutta
Dept. of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, United States, Dept. of Genetics, University of Alabama in Birmingham, Birmingham, United States, Cancer Center, University of Wisconsin in Milwaukee, Milwaukee, United States
eLife, Reviewed Preprint v1, December 31, 2024

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Claus Wilke @clauswilke.com · 17/12/2024

Bioart, courtesy of the NIH. All images are in the public domain and available for download as high-quality SVGs. bioart.niaid.nih.gov

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Róża Przanowska @rprzanowska.bsky.social · 26/12/2024

Another beautiful example of #lncRNA #structure-function study from Dutta lab at UAB. Grateful to add a small puzzle piece to this work. Congratulations Xiaoxiao and all involved!

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Reposted by Róża Przanowska

bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 24/12/2024

A 36-base hairpin within lncRNA DRAIC, which is modulated by alternative splicing, interacts with the IKKα coiled-coil domain and inhibits NF-kB and tumor cell phenotypes www.biorxiv.org/content/10.1101/202…

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Reposted by Róża Przanowska

Richard Sever @richardsever.bsky.social · 21/12/2024

Many academics point to bioRxiv as “the one thing improving science publishing”. If so, the one thing you all can do is persuade colleagues to submit and make this a norm. 1/2

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Reposted by Róża Przanowska

Rohit Thakur @rohit-thakur.bsky.social · 06/12/2024

Our recent preprint about using a custom chromatin capture assay, to identify potential target genes for cancer risk variants. For several variants, the target gene for cis regulation was ~ +/- 1Mb away, and we experimentally confirmed this for multiple targets. www.medrxiv.org/content/10.1...

medrxiv.org

Mapping chromatin interactions at melanoma susceptibility loci and cell-type specific dataset integration uncovers distant gene targets of cis-regulation

Genome-wide association studies (GWAS) of melanoma risk have identified 68 independent signals at 54 loci. For most loci, specific functional variants and their respective target genes remain to be es...

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Reposted by Róża Przanowska

John Prensner @johnprensner.bsky.social · 13/12/2024

We often hear that nutrition needs are dynamic over your life, that some things are more important as kids (calcium), that there are super foods. If you are like me, these concepts can seem a bit vague. This new @pnas.org paper is a great resource. 🧵 🧪 #PEDSky #MEDSky www.pnas.org/doi/full/10....

pnas.org

Nutrient-dense foods and diverse diets are important for ensuring adequate nutrition across the life course | PNAS

The world faces a global challenge of how to meet the nutritional needs of a diverse global population through diets. This paper defines the relati...

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Reposted by Róża Przanowska

Alejandro Montenegro @aemonten.bsky.social · 12/12/2024

"We report that numerous “miRNAs” previously reported in EMT and cancer contexts are not incorporated into RISC and are not capable of endogenously silencing target genes, despite the fact that hundreds of publications in the cancer field describe their roles" www.biorxiv.org/content/10.1...

biorxiv.org

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Reposted by Róża Przanowska

Timothy Bredy @twbredy.bsky.social · 12/12/2024

Following @daylab.bsky.social’s nice paper on eRNA regulating Fos, and then our paper showing eRNA mediated regulation of NR4A2, here’s yet another eRNA controlling NPAS4. LncRNAs for the win in the brain! www.science.org/doi/10.1126/...

science.org

A long noncoding eRNA forms R-loops to shape emotional experience–induced behavioral adaptation

Emotional experiences often evoke neural plasticity that supports adaptive changes in behavior, including maladaptive plasticity associated with mood and substance use disorders. These adaptations are...

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Reposted by Róża Przanowska

theNiessingLabs @theniessinglabs.bsky.social · 12/12/2024

Hello Bluesky 🤠 Our very first post is about our recent paper in Nucleic Acids Research: so-called PUN motifs are repetitive elements enabling proteins to catalyze #RNA folding and RNA-dependent #condensate formation ( #LLPS). 15% of human proteins contain 3 or more PUN motifs. See bit.ly/4fZ3f54.

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Reposted by Róża Przanowska

Mike Feigin 🥯 @mikefeigin.bsky.social · 11/12/2024

Are you a senior PhD student or postdoc? Do you have a cool science story to tell? Do you want to visit Buffalo when the weather is perfect? Then apply for the Emerging Leaders Seminar Series at Roswell Park! DM or email me with questions. (RT please!) www.roswellpark.org/education/pr...

roswellpark.org

Emerging Leaders in Cancer Research Seminar Series

The Roswell Park Emerging Leaders in Cancer Research Seminar Series features lectures by outstanding junior scientists from around the country on a diverse range of cancer-focused topics. This include...

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Róża Przanowska @rprzanowska.bsky.social · 10/12/2024

If you ever wondered why #SystemsBiology, this movie is for you! Prepared by Sarah Groves from Janes lab at UVA BME and SASCO Center. youtu.be/rmuj1cyIn44?... WHAT is systems biology? WHY do we need systems approaches in cancer? HOW do systems approaches get used in the clinic today?

youtu.be

This is how we solve the problem of cancer

YouTube video by Sarah Groves

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Reposted by Róża Przanowska

Ben Garcia @garcialabms.bsky.social · 02/12/2024

An update on our Dept faculty search. We had 165 applications and after reviewing, we discussed the top 30. 12 were selected for Zoom interviews, and then we discussed and selected 5 for in person interviews which start soon. For those still interviewing, Zoom questions are attached. Good luck!

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Reposted by Róża Przanowska

Joe Yesselman @josephyesselman.bsky.social · 25/11/2024

🧬 Excited to share our new preprint! DMS chemical mapping, a key technique for studying RNA structure. Everyone assumes low DMS reactivity = Watson-Crick , high = non-WC. However, analyzing 7,500 RNA structures containing known 3D structures reveals it's not that simple. doi.org/10.1101/2024...

biorxiv.org

A quantitative framework for structural interpretation of DMS reactivity

Dimethyl sulfate (DMS) chemical mapping is widely used for probing RNA structure, with low reactivity interpreted as Watson-Crick (WC) base pairs and high reactivity as unpaired nucleotides. Despite i...

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Anita Corbett @acorbe2.bsky.social · 19/11/2024

Check it out! The RNA Society 2025 Meeting Site is now live! Registration will open in January RNASociety Note the fabulous artwork by former EmoryBCDB student Dr. Carly Lancaster- make your plans now to join us in San Diego May 27-June 1, 2025

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Josh Mendell @mendell-lab.bsky.social · 22/11/2024

I’m thrilled to share a collaborative story from @Mendell_lab and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu. We showed that in addition to their canonical decoding function, tRNAs play a key role in regulating mRNA stability during translation! www.science.org/doi/10.1126/...

science.org

Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes

The CCR4-NOT complex is a major regulator of eukaryotic messenger RNA (mRNA) stability. Slow decoding during translation promotes association of CCR4-NOT with ribosomes, accelerating mRNA degradation....

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Itai Yanai @itaiyanai.bsky.social · 24/11/2024

How to write a grant? 1. The application is for the reviewer, not you, the applicant. 2. Communicate in stories. 3. Make your story cohesive—leave no puzzling gaps. 4. Make your story resonate to keep the reviewer reading. 5. Accept chance and noise in peer-review. www.pnas.org/doi/epub/10....

https://www.pnas.org/doi/epub/10.1073/pnas.2315735121

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Johanna Joyce @johannajoyce.bsky.social · 25/11/2024

Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️ So how can we ever achieve #gender #equality? We discuss various strategies in this #Cell Commentary #WomeninSTEM www.cell.com/cell/fulltex... 🧵 1/

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Róża Przanowska @rprzanowska.bsky.social · 22/11/2024

Take a look at this amazing work of @camthevirusguy.bsky.social from Janes lab at UVA BME. This is what I call the scientific advance! Congratulations 🎉👏 www.science.org/doi/10.1126/...

science.org

Three modes of viral adaption by the heart

Transcriptomes of virally infected hearts are distinguished by signatures of NF-κB and p38-MK2 signaling.

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Angelika Andrzejewska-Romanowska @aandrzejewskaa.bsky.social · 20/11/2024

Hi! 👋 I'm new here 👋 I recently defended my PhD and I'm loved in #RNA structures in vivo 🫶 Very excited to share my two articles at NAR (results of my PhD)! 1📎 academic.oup.com/nar/article/... 2📎 academic.oup.com/nar/article/... The first #RNAstructure of Ty1 and Ty3 LTR #retrotransposon genomes!

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Róża Przanowska @rprzanowska.bsky.social · 19/11/2024

All packed and ready for the Cold Spring Harbor Laboratory Scientific #Writing Retreat! Excited to dive into grants and beyond starting tomorrow. It's my first time visiting @cshlaboratory.bsky.social and @cshlbanbury.bsky.social—any recommendations for must-see spots or hidden gems?

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Razvan Borza @rborza.bsky.social · 17/11/2024

⚠️THREAD OF ALL SCIENCE-RELATED STARTER PACKS! ⚠️ 🔄Share to help people finding its topic/field - STRUCTURAL BIOLOGY Structural Biology 1: bsky.app/starter-pack... Structural Biology 2: bsky.app/starter-pack... Crystallography: bsky.app/starter-pack... Synchrotron&CryoEM: bsky.app/starter-pack...

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Igor Ulitsky @igorulitsky.bsky.social · 13/11/2024

Let's make a thread of RNA-related conferences in 2025 🧵 (add missing!)

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Matthew Taliaferro @jmtali.bsky.social · 13/11/2024

Excited to share our latest work! In it, we develop a new method for studying RNA localization via proximity labeling: OINC-seq! In contrast to other proximity-based methods, labels deposited on RNAs are read directly by sequencing without the need for biotinylation. biorxiv.org/cgi/content/...

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Soragni:Lab @alice.soragnilab.com · 11/11/2024

We have a very basic starter pack!! If you work on 3D biology and organoids broadly defined and want to be included, leave a comment below go.bsky.app/QeDg2YD

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Gracjan Michlewski @gmichlew.bsky.social · 11/11/2024

🔬🧫 🧬 Are you looking for an opportunity to set up your own laboratory focused on RNA or cell biology in an inspiring environment surrounded by like-minded researchers? The IIMCB in Warsaw is offering an excellent opportunity www.rnasociety.org/junior-group... www.iimcb.gov.pl/en/ #CellBiology #RNA

rnasociety.org

Junior Group Leader Professor position

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