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Stephen Floor

@snf.bsky.social
2.4K followers 375 following 436 posts

Dad, partner, scientist, music lover. I am passionate about developing RNA technologies to impact human health.

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Stephen Floor @snf.bsky.social · 06/12/2025
It’s an inversion of liberty to deny citizenship to people who have overcome so much, it’s a betrayal of the American experiment
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Stephen Floor @snf.bsky.social · 09/11/2025
ok I have a mystery. What is the food ingredient “inland sea water powder”?
Ingredient list with “inland sea water powder” highlighted
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Stephen Floor @snf.bsky.social · 26/08/2025
I am once again reminded that the loudest person in the room is not necessarily the smartest or most qualified
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Stephen Floor @snf.bsky.social · 25/08/2025
Reader, we would not like a dictator in the “land of the free and home of the brave”
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Eugene Valkov @eugenevalkov.bsky.social · 13/08/2025
Delighted to present our second paper of the year. This one explores the molecular mechanism of TTP, a key post-transcriptional regulator of AU-rich mRNAs. Work led and coordinated by @filippekovic.bsky.social, in collaboration with Perry Blackshear. www.nature.com/articles/s41...
nature.com
Multivalent interactions with CCR4–NOT and PABPC1 determine mRNA repression efficiency by tristetraprolin - Nature Communications
Deadenylation leads to mRNA decay, with PABPC1 protecting the poly(A) tail, while tristetraprolin and CCR4–NOT promote deadenylation. Here, the authors describe how these three proteins interact to re...
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Stephen Floor @snf.bsky.social · 31/07/2025
I remember when OS updates were like "we will protect your computer from viruses and make it faster" and now they lead with
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Vikram Agarwal @vagar.bsky.social · 25/07/2025
Paper 2 -- Translational co-regulation detected in mammalian cells www.nature.com/articles/s41... A deeper explanation of the human story, scientific conclusions, and Github/Zenodo links to use the pre-trained models: www.linkedin.com/feed/update/...
nature.com
Translation efficiency covariation identifies conserved coordination patterns across cell types - Nature Biotechnology
Matched ribosome profiling and RNA sequencing data quantify translation efficiency patterns across 140 human and mouse cell lines.
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Vikram Agarwal @vagar.bsky.social · 25/07/2025
Very excited that our most significant work, a collaboration w/ Dr. Can Cenik at UT Austin on translational gene regulation, was finally published in Nature Biotechnology in a dual set of studies: Paper 1 -- an AI model trained to predict translation rates from mRNA sequences: rdcu.be/exN1l
url.de.m.mimecastprotect.com
Predicting the translation efficiency of messenger RNA in mammalian cells
Nature Biotechnology - A deep convolutional neural network model predicts the influence of the full-length mRNA sequence on translation efficiency.
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Stephen Floor @snf.bsky.social · 25/07/2025
Another example of spurious effects when you try to interpret RNA biology from DNA introduced into cells without confirming exactly what RNA processing is happening. Important and common confounder - great paper!
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Mike Feigin 🥯 @mikefeigin.bsky.social · 23/07/2025
“With these considerations, we expect to fund through the 4th percentile.” There it is, in black and white, the destruction of cancer research in the US.
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Stephen Floor @snf.bsky.social · 12/07/2025
apropos of nothing, a strong rec for “The Tyranny of Merit”, in which Sandel notes a putative meritocracy “fosters a sense of entitlement among the successful while humiliating those who do not succeed, ultimately undermining the common good and social solidarity” bookshop.org/p/books/the-...
bookshop.org
The Tyranny of Merit: Can We Find the Common Good?
Can We Find the Common Good?
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Stephen Floor @snf.bsky.social · 12/07/2025
this is an example of the so-called meritocracy that’s threatened by introspection on who gets into college and why
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Stephen Floor @snf.bsky.social · 07/07/2025
great review on the myriad ways that genetic variation in mRNA untranslated regions can cause disease!
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Stephen Floor @snf.bsky.social · 04/07/2025
This July 4 I celebrate my country born by separation from a tyrannical king, with the principles that all people are created equal and that the government represents the will of the People, not a monarch. The unalienable rights of Life, Liberty, and the pursuit of Happiness. Let freedom ring!
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Stephen Floor @snf.bsky.social · 24/06/2025
absolutely love this new tour of the cosmos using the Skyviewer app built using new images off the Vera Rubin telescope - gorgeous and great explanations skyviewer.app/tours
skyviewer.app
Astronomical Tours | Skyviewer
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Stephen Floor @snf.bsky.social · 18/06/2025
whenever I need some sunshine I turn to cientotres 103.1 FM out of San José, Costa Rica radios-de-costa-rica.com/1031-fm
radios-de-costa-rica.com
103.1 FM Cientotres en vivo, Costa Rica
103.1 FM es una emisora de radio de Costa Rica que emite en San José. Escucha gratis música dinámica para jóvenes del género rock y pop.
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Carl Zimmer @carlzimmer.com · 16/06/2025
A federal judge on Monday declared the Trump administration’s move to cut hundreds of grants issued by the National Institutes of Health illegal, accusing the government of discrimination against minorities and L.G.B.T.Q. individuals. nyti.ms/4jSIjOG
nyti.ms
Trump’s Cuts to N.I.H. Grants Are Illegal, Federal Judge Rules
The judge accused the Trump administration of discriminating against minorities and L.G.B.T.Q. people and ordered the government to restore much of the funding.
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jamelle @jamellebouie.net · 15/06/2025
the story today is of a profoundly low energy military parade being met with millions of americans in nationwide protests denouncing the dictatorial pretensions of the president
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Stephen Floor @snf.bsky.social · 15/06/2025
Traveling for a soccer tournament and there’s a rally of maybe 500 people here in South Lake Tahoe today, too. Solidarity. No kings, no tyrants 🇺🇸
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Stephen Floor @snf.bsky.social · 14/06/2025
Racism and xenophobia is already turning the US into a backwater to avoid
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Stephen Floor @snf.bsky.social · 12/06/2025
people will literally die because of this
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Stephen Floor @snf.bsky.social · 10/06/2025
"all the best" 💩🤡
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 09/06/2025
I urge others to similarly support our patriots at NIH who use their training and talents to improve human health and position the US as the world’s leader in biomedical discovery, innovation and technology development 🙏
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Stephen Floor @snf.bsky.social · 05/06/2025
fully agree - the real question is: will Trump let the DOGEs out?
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Jeff Leek @jtleek.bsky.social · 04/06/2025
These are not just grants. This is thousands of people who devoted their lives and careers - taking pay cuts, working long hours, living with uncertainty - all for the chance to try to make people's lives a bit better for you and your loved ones. This breaks my heart.
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Stephen Floor @snf.bsky.social · 02/06/2025
local yay area man discusses choices, when to go (dumb), how to be sprinkled with game, and gouda + broccoli
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Stephen Floor @snf.bsky.social · 30/05/2025
if the US wants to be competitive on the world stage, investing in education, science, and technology is the way. one doesn’t simply discriminate your way to the top
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Stephen Floor @snf.bsky.social · 29/05/2025
prelim phase 1/2 trial results of the Moderna H5N1 vaccine program included no (none) dose-limiting toxicity and 97.8% (NINETY SEVEN POINT EIGHT PERCENT) of participants reaching protective antibody levels. defunding this program makes America sicker endpts.com/trump-axes-m...
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Ariel Wittenberg @arielwittenberg.bsky.social · 27/05/2025
Thinking of this @propublica.org reporting today about stillbirths of unvaccinated parents during the Delta wave, before CDC had explicitly recommended COVID vaccines for pregnant people and the damage the virus did to the placentas. www.propublica.org/article/covi...
propublica.org
“God, No, Not Another Case.” COVID-Related Stillbirths Didn’t Have to Happen.
A lack of testing data and government guidance led many to avoid the COVID-19 vaccine during pregnancy, unwittingly increasing their chances of a stillbirth.
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Stephen Floor @snf.bsky.social · 27/05/2025
today’s anti-vaccination, pro-disease decision by RFK in the Orwellian name of “making America healthy again” will lead to more moms dying and more unhealthy babies why anyone would choose to not protect moms and babies as best we can is beyond my comprehension
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Stephen Floor @snf.bsky.social · 23/05/2025
reminiscing over simpler times when controversy involved whether figures belong inline or at the end of paper drafts
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Derek Lowe @dereklowe.bsky.social · 23/05/2025
This is exactly it. I’ve said the same thing in nearly the same words myself. The memory of this man and his very name should be a curse for future generations.
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Stephen Floor @snf.bsky.social · 21/05/2025
Eikon lays off ~15% of staff citing "external forces. For example, government funding cuts have constrained the budgets of academic institutions, necessitating that we pause development of our advanced instruments ... The market for these instruments has clearly evaporated."
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Stephen Floor @snf.bsky.social · 20/05/2025
must read thread on the Makary & Prasad NEJM screed (and corresponding FDA policy position) that will increase illness and death by limiting access to effective vaccines. this is the first action I’ve seen since Prasad’s joining CBER and it’s a bad portent
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Stephen Floor @snf.bsky.social · 15/05/2025
fire season should be fun this year, and by fun I mean really dangerous for people
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Stephen Floor @snf.bsky.social · 15/05/2025
metamodernism in fabric c/o Avavav & Adidas. mood fitting
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Charles Jennings @chasjennings.bsky.social · 15/05/2025
The GOP campaign against RNA medicines is a modern-day witch-hunt, driven by a combination of political pandering, scientific ignorance and vindictiveness toward medical research. The potential of RNA medicine is enormous, and if we don’t develop it here in the US, other countries will.
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Stephen Floor @snf.bsky.social · 14/05/2025
ok hear me out: what if we transmitted covid back to bats and they can keep it
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Needhi Bhalla 💅🏽 @needhibhalla.bsky.social · 13/05/2025
"Women are PIs on 58% of the canceled grants, although they are PIs on only 34% of all active NSF grants. Similarly, Blacks are PIs on 17% of the terminated grants, although they make only 4% of the total pool. Hispanic PIs and those with disabilities were twice as likely to lose a grant."
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Trevor A. Branch @trevorabranch.bsky.social · 13/05/2025
Racist and sexist roots in the cancellation of NSF grants under Trump: Grants with female PIs canceled 2x more than men Grants with Black PIs canceled 4x over White PIs Grants with Hispanic PIs canceled 2x over White PIs Grants with PIs with disabilities canceled 2x more than without
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Stephen Floor @snf.bsky.social · 14/05/2025
outrageous, harmful, contrary to the interest of the USA. boggles my mind on a daily basis that our Congress doesn’t stand up against this kind of regressive action
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Stephen Floor @snf.bsky.social · 10/05/2025
it’s a Faze-O kinda Friday 🍻 open.spotify.com/track/1SMve8...
open.spotify.com
Riding High
Faze-O · Riding High · Song · 1977
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Sri Kosuri @srikosuri.bsky.social · 09/05/2025
Lux Capital & @wolfejosh.bsky.social are launching the Lux Science Helpline - a $100M commitment to support American scientists whose research is threatened by funding cuts, bureaucratic hurdles, and career roadblocks - that expands our Lux Labs program. www.luxcapital.com/news/our-hel...
luxcapital.com
Our Helpline for American Scientists
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Stephen Floor @snf.bsky.social · 09/05/2025
bolded in a biotech SEQ 10-Q filing: "Changes in funding or disruptions at the FDA, the SEC and other government agencies, caused by reductions in staffing government shut downs could .. prevent new products and services from being developed or commercialized .. could negatively impact our business"
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Stephen Floor @snf.bsky.social · 07/05/2025
cant wait for the tariff bonus to my paychecks so I can pay all these tariff surcharges
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Stephen Floor @snf.bsky.social · 07/05/2025
if you like soccer at all (or if you just like amazing things) take some time out of your life and watch the full Barca vs Inter champions league semifinal from today (or at least highlights). both legs were amazing but this was one of the best soccer games I’ve ever seen. hats off to everyone
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Stephen Floor @snf.bsky.social · 07/05/2025
now that’s a funding cliff 📉💩
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Stephen Floor @snf.bsky.social · 06/05/2025
extreme whiplash from being so excited about science after the COVID vaccines saved millions of lives, likely including my own as an immunocompromised person and of my elderly family members, to the installation of anti-science, anti-vaccine, pro-dark-ages-suffering people in the FDA and government
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Stephen Floor @snf.bsky.social · 06/05/2025
take a deep breath with McCoy Tyner, Joe Henderson, Ron Carter, and Elvin Jones on this gem 💎 open.spotify.com/track/4qRJ7Z...
open.spotify.com
Search For Peace
McCoy Tyner · The Real McCoy (Remastered / Rudy Van Gelder Edition) · Song · 1967
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Stephen Floor @snf.bsky.social · 06/05/2025
outstanding reporting and among other things it’s remarkable that the director of the NIH would take such an adversarial stance with a leading journal named Science. accidental literalism
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