iiinova — where your digital self keeps evolving

Reposted by Razvan Borza

Razvan Borza @rborza.bsky.social · 14/09/2026

Here's a render of the densely interconnected chromatin structure, resolved by cryo-ET, from Kreysing et al. This reminds me how much remains unresolved about chromatin. That's why I'm excited to see what's new at CSHL Epigenetics and Chromatin tomorrow😁 #cshlepich26 @cshlmeetings.bsky.social

Structure from https://doi.org/10.1038/s41467-026-75087-5
Image rendered in Blender 5.2 using Molecular Nodes.

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Razvan Borza @rborza.bsky.social · 14/09/2026

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Razvan Borza @rborza.bsky.social · 21/08/2026

New animation of Zinc Finger transcription factors binding DNA. My favorite TF family. 👀 Excited to share more at the #EMBLTranscript Conference next week! - Rendered in Blender with #MolecularNodes

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Razvan Borza @rborza.bsky.social · 08/09/2026

🤯 This is how much space an IDR can occupy. Often hard to picture until you see it. 🤔 Did you expect this? This is my favorite complex, Zincore. Using Cryo-EM, I could only resolve the folded core. Here, I modeled the IDRs with AlphaFold3 and visualized it in Blender using MolecularNodes.

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Razvan Borza @rborza.bsky.social · 08/09/2026

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Razvan Borza @rborza.bsky.social · 21/08/2026

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Reposted by Razvan Borza

Razvan Borza @rborza.bsky.social · 09/07/2025

🚀 My first Cryo-EM structures are OUT on the PDB! 🎉Super excited about this milestone as PhD, it’s been a journey, and I’m grateful to finally have these as my first Cryo-EM structures! 🙌 🔁Thank you for sharing!❤️ Read @daaninthelab.bsky.social et. al.: www.science.org/doi/10.1126/... ⬇️ 2nd video

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Razvan Borza @rborza.bsky.social · 08/07/2025

📢 Ready for this? A new way to think about Gene Regulation! 🚨A new coregulator complex, Zincore, acts as a "MOLECULAR GRIP", stabilizing TFs at DNA binding sites across the genome!🧬 💪Proud to be part of this work led by @daaninthelab.bsky.social Read more: science.org/doi/10.1126/science.adv2861

3D render of a Zincore complex locking ZFP91 onto DNA, promoting gene activation.
Made in Blender with Molecular Nodes.

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Reposted by Razvan Borza

Danielle Bianchi @daaninthelab.bsky.social · 04/07/2025

In today’s publication in Science we introduce Zincore: a novel protein of QRICH1 and SEPHS1 and functions as a transcriptional coregulator dedicated to zinc finger transcription factors. Here’s how we found it: 🧵 www.science.org/doi/10.1126/... 1/11

science.org

Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression

Zinc finger proteins (ZNFs) are the largest family of transcription factors, yet how they activate gene expression remains unclear. In this study, we identified Zincore, a protein complex consisting o...

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Reposted by Razvan Borza

Razvan Borza @rborza.bsky.social · 28/09/2025

I think there is still much to learn about SRBD1, not only in mitosis but also regarding other potential functions. Its similarity to Spt6/SUPT6H continues to intrigue me 🤔

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Razvan Borza @rborza.bsky.social · 29/09/2025

⚠️Don't forget! You have FREE alternatives! 🔖Reminder that @niaidnews.bsky.social offers 2000+ scientific and biomedical high-quality icons for free use! Check their full catalog: bioart.niaid.nih.gov 📢And if that’s not enough, you also have SciDraw and Bioicons! Comment if you want the websites.

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Razvan Borza @rborza.bsky.social · 28/09/2025

I think there is still much to learn about SRBD1, not only in mitosis but also regarding other potential functions. Its similarity to Spt6/SUPT6H continues to intrigue me 🤔

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Reposted by Razvan Borza

Razvan Borza @rborza.bsky.social · 23/01/2025

📢 Excited to announce that our Opinion paper on GPI-anchored proteins is now Published! 🎉 👀 If you're working in this field, be sure to check out our paper — we've highlighted some truly outstanding questions on the topic! ⚠️ www.cell.com/trends/cell-...

A metallic arm holding a protein, simulating a GPI-anchored protein attached to the surface of a membrane.

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Reposted by Razvan Borza

Lidia Atencia Taboada @latencia.bsky.social · 15/07/2025

🚨 New strategy against colorectal cancer! Dual GSK-3 & BCL-XL inhibition kills APC-mutant cells in organoid models, tipping the balance towards healthy cells—a promising way to halt early tumor growth 💪🧪 ➡️Read more: www.nature.com/articles/s41...

nature.com

GSK-3 and BCL-XL inhibition mitigates the competitive advantage of APC-mutant colorectal cancer cells - Oncogenesis

Oncogenesis - GSK-3 and BCL-XL inhibition mitigates the competitive advantage of APC-mutant colorectal cancer cells

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Razvan Borza @rborza.bsky.social · 15/07/2025

👀 Just updated my Google Scholar and... can’t believe one of my papers reached 100 citations! 🚀 💪🏼 It might not seem like much, but as a PhD student, it feels like a big achievement. ❤️ To all fellow PhDs, keep going, stay strong, and celebrate every milestone!🔁 Read it: www.jbc.org/article/S002...

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Razvan Borza @rborza.bsky.social · 16/04/2025

🚨New Article Out!! 📢 In our latest work, we propose a Three-Point Lock binding mode for ATX inhibitors 🔒 🚀 This approach may represent the final piece in the puzzle of known binding mode types — and could have therapeutic relevance ♥️ Thanks for your support Read more here: doi.org/10.1016/j.bm...

Type VI inhibitor targeting both the catalytic site and the tunnel of Autotaxin (ATX). PDB ID: 9FXW

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Razvan Borza @rborza.bsky.social · 09/07/2025

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Razvan Borza @rborza.bsky.social · 08/07/2025

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Reposted by Razvan Borza

Razvan Borza @rborza.bsky.social · 28/10/2024

🚀 Excited about our pre-print: AlphaBridge: A User-Friendly Tool for Interpreting Protein Predictions Whether you're an expert or just new to the field of Protein Prediction, AlphaBridge is the way to go! 🔁Try it and share your thoughts! 📜 Article: www.biorxiv.org/content/10.1...

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Reposted by Razvan Borza

Razvan Borza @rborza.bsky.social · 03/12/2024

📢 Make your work FASTER and EASIER! Use AlphaBridge to analyze your AlphaFold results and receive a clear, easy-to-understand output—even for non-experts. ➡️ Let AlphaBridge help you accelerate your workflow! ❤️ Share and try it here: alpha-bridge.eu 👀Read more: www.biorxiv.org/content/10.1...

On the left is the structural output from the AlphaFold 3 server colored by pLDDT, which requires structural knowledge for interpretation. On the right is the AlphaBridge ring output, where the results are pre-analyzed and visually presented, making them easier to understand.

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Reposted by Razvan Borza

Razvan Borza @rborza.bsky.social · 05/11/2024

AlphaFold can predict protein, DNA, or RNA complexes.. BUT is it easy to determine the reliable interactions?🤔 ➡️ AlphaBridge will identify the most confident interactions, making your analysis easier! 🌐Try it here: alpha-bridge.eu 👀Read more: www.biorxiv.org/content/10.1...

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Razvan Borza @rborza.bsky.social · 16/04/2025

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Razvan Borza @rborza.bsky.social · 17/11/2024

⚠️THREAD OF ALL SCIENCE-RELATED STARTER PACKS! ⚠️ 🔄Share to help people finding its topic/field - STRUCTURAL BIOLOGY Structural Biology 1: bsky.app/starter-pack... Structural Biology 2: bsky.app/starter-pack... Crystallography: bsky.app/starter-pack... Synchrotron&CryoEM: bsky.app/starter-pack...

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Reposted by Razvan Borza

Razvan Borza @rborza.bsky.social · 16/11/2024

I created this Starter Pack for PhDs and Postdocs in Structural Biology to help connect with colleagues who share similar interests and concerns in the field. Feel free to recommend people or yourself! I'll be adding people 💪🏼😁 bsky.app/starter-pack...

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Razvan Borza @rborza.bsky.social · 23/01/2025

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Reposted by Razvan Borza

Daniel Álvarez Salmoral @alvarezsalmoral.bsky.social · 19/12/2024

🎄✨ Early Holiday Update from AlphaBridge! ✨🎄 Exciting new features: 🔬 Confidence Filters: Identify more/less confident interfaces. 🔬 Scoring System: New scores for overall structure & individual interfaces. Try it here!! alpha-bridge.eu 🎁 📄 Preprint: www.biorxiv.org/content/10.1...

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Reposted by Razvan Borza

Tassos Perrakis @tassosperrakis.bsky.social · 03/12/2024

Surely you have been using AlphaFold3 for your research project? If so, have you considered #AlphaBridge to analyze the output for macromolecule complexes prediction? Web server: alpha-bridge.eu Preprint: www.biorxiv.org/content/10.1... New features coming soon!

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Razvan Borza @rborza.bsky.social · 03/12/2024

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Razvan Borza @rborza.bsky.social · 25/11/2024

📢 Bluesky is emerging as the New Platform for Academia, but what's missing? 📊 Altmetric integration to track attention for articles 🔄 Share and ♥️ Like if you agree! 🙏 @altmetric.com please tell us it’s going to happen!

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Reposted by Razvan Borza

Brady Johnston @bradyajohnston.bsky.social · 25/11/2024

Just got some nice positional averaging inside of #MolecularNodes. Smooth out trajectories across frames when visualising, add subframes, also takes into account periodic boundary crossing so you don't have zooming lipids #b3d #GeometryNodes #GlycoTime #SciArt

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Razvan Borza @rborza.bsky.social · 23/11/2024

🚨 If you haven’t seen it yet… 📢 The NIH BioArt Source provides a library of FREE professionally designed illustrations and icons, available for anyone to use. They can be Downloaded in High Definition. Check it out at bioart.niaid.nih.gov

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Reposted by Razvan Borza

Razvan Borza @rborza.bsky.social · 23/11/2024

I’ve already seen plenty of images here on Bluesky using #MolecularNodes, so now it’s time to share my first one! 🤔 Which one do you prefer: with or without surface? ⚠️ Follow @bradyajohnston.bsky.social to stay updated on MolecularNodes!

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Razvan Borza @rborza.bsky.social · 23/11/2024

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Reposted by Razvan Borza

Razvan Borza @rborza.bsky.social · 16/11/2024

🚨 I want to gather all artists working in Biology, Cell Biology, or Molecular Biology illustration If you know any artists who create this kind of work, let me know so I can add them here. Drop a comment to join! 💬 go.bsky.app/KWAeJxp

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Reposted by Razvan Borza

Netherlands Cancer Institute @nkinl.bsky.social · 19/11/2024

Follow our NKI community go.bsky.app/5EK1wtK

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Razvan Borza @rborza.bsky.social · 17/11/2024

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Reposted by Razvan Borza

Daniel Álvarez Salmoral @alvarezsalmoral.bsky.social · 17/11/2024

I haven’t come across this starter pack yet, so I made one! 👉 Check out the "Protein Prediction & Design" Starter Pack and join the conversation. Think someone should be included? Tag them below! 👇 🧬🧶 go.bsky.app/C1oNcnj

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Reposted by Razvan Borza

Daniel Álvarez Salmoral @alvarezsalmoral.bsky.social · 15/11/2024

🚀 Excited to share my first preprint on bioRxiv www.biorxiv.org/content/10.1... AlphaBridge simplifies protein structure predictions for experts and novices by combining complex analysis with visual representations and interactive tools in one user-friendly platform.

biorxiv.org

AlphaBridge: tools for the analysis of predicted macromolecular complexes

Artificial intelligence (AI)-powered protein structure prediction methods have revolutionised how life scientists explore macromolecular function. Using AI to predict the structure of macromolecular c...

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Razvan Borza @rborza.bsky.social · 16/11/2024

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Razvan Borza @rborza.bsky.social · 16/11/2024

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Razvan Borza @rborza.bsky.social · 16/11/2024

Working on a figure for my seminar today made me realize just how many design styles you can create with ChimeraX! 🤔Is everyone familiar with the full range of styles in ChimeraX? ⚠️ By the way, the toughest choice (and always will be) is picking the right colors!

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Razvan Borza @rborza.bsky.social · 05/11/2024

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Razvan Borza @rborza.bsky.social · 29/10/2024

🚨 Great FREE alternatives to BioRender are Now Available!! 📢 NIH offers a collection of public figures and icons for everyone bioart.niaid.nih.gov 📢 SciDraw is a free repository of anything that might be useful for scientific presentations scidraw.io ❤️🔄 FREE Science!! RIP BioRender!

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Razvan Borza @rborza.bsky.social · 28/10/2024

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