The facial skeleton is essential for eating, breathing, kissing, speech and personal identity. Our spatiotemporally resolved cell atlas of human embryonic craniofacial development will facilitate a de...

The Cantù Lab at LiU is focused on one important goal: to discover the mechanisms of genome regulation that drive cell differentiation and specialization during embryonic development.

Jha et al. show that the transmembrane protein CD44 restricts EGFR mobility to maintain an EGFR–PI3K–Rac gradient during bleb-based cell migration.

During regeneration, tissues must translate transient cellular variability into stable spatial organization. Tissue architecture generates a density-dependent window of heterogeneity in the mechanosen...

Tissue phase transitions are key to morphogenesis. Now adhesion-driven rigidification is identified as key to epithelial organization but only if uncoupled from density-driven jamming.

Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.

Come to this beautiful Swedish inland scenario to learn the most advanced technologies to study transcriptional regulation.

Come to this beautiful Swedish inland scenario to learn the most advanced technologies to study transcriptional regulation.

In development, cells navigate highly complex gene-regulatory landscapes to make fate choices. Steinschaden et al. synthesize concepts of multilineage priming, microheterogeneity, and collective multi...

The dental pulp is a highly vascularized and innervated connective tissue located at the central part of the tooth and composed of a diverse array of cell types, including fibroblasts, multipotent mes...

Vinculin buffers force via dynamic domain unfolding/refolding under physiological load and lacks a stable head-tail lock.

In these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different.

Using mouse pancreatic cancer models, Tsanov et al. show that reactivation of SMAD4 at metastatic sites promotes tumor growth in the lung through RUNX1 but restrains metastatic growth through KLF4 in the liver, influenced by organ-specific epigenetic states.

Learn more about open scholarship positions in bioengineering at IFM.

Summary: The transcriptional regulators SOX2 and NR2F1 drive the development of the visual thalamus. Mutations in these genes cause visual impairment in humans.

Learn more about open scholarship positions in bioengineering at IFM.

This work presents a “tooth-on-chip” device that mimics dental pulp tissue. By co-culturing key cell types, it recreates vascular networks, stem cell niches, the odontoblast/dentine interface, and tr...

Here the authors show that reducing enhancer-promoter distance at the Pitx1 locus increases proportion of Pitx1 forelimb expressing cells, worsening skeletal defects in Liebenberg syndrome. They also ...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

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Inflammatory monocytes in the brain meninges promote stress-induced fear behaviour, and the pathways involved can be modulated using psychedelic compounds.