Key Points. A four–residue IPRR insertion enhances kindlin-3 membrane recruitment and promotes β2 integrin activationFERMT3 alternative splicing dynamicall

Jha et al. show that the transmembrane protein CD44 restricts EGFR mobility to maintain an EGFR–PI3K–Rac gradient during bleb-based cell migration.

Vocal fold cancer tumours lose some of their malignant traits when mechanically stimulated by physiological stretch or vibrations, mimicking the opening and closing of vocal folds and phonation.

Iu et al. uncover a Ca2+ signaling pathway promoting cell migration by facilitating actin assembly in protrusions. Ca2+ influx through TRPV4 channel activates RhoA in lamellipodia via CaMKII and TEM4,...

We study cell migration in health and disease

The rapid, transient, and unpredictable nature of interactions between circulating cells and the endothelium challenges the investigation of these events under flow conditions. Here, we developed an i...

Cancer cells utilize filopodia to explore, adhere to, and invade their surrounding microenvironment, yet the protein networks that organize these protrusions remain incompletely defined. To uncover th...

A groundbreaking study reveals how physical confinement triggers ferroptosis. It finds the nucleus acts as a mechanosensor, orchestrating Drp1 and cPLA2 that leads to mitochondrial dysfunction and ult...

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Integrin-based adhesion complexes serve as primary sites for actomyosin force transmission to the extracellular matrix, providing traction that drives cell mechanical responses including adhesion, mig...

PhD Project - (BBSRC NWD) A novel redox mechanosignalling nexus in the synapse that is misregulated in neurodegeneration at University of Liverpool, listed on FindAPhD.com

Vinculin buffers force via dynamic domain unfolding/refolding under physiological load and lacks a stable head-tail lock.

Vinculin buffers force via dynamic domain unfolding/refolding under physiological load and lacks a stable head-tail lock.

PhD Project - MRC DiMeN Doctoral Training Partnership: The intersection of mechanical signalling and the hypoxic response as a targetable signalling nexus in pancreatic cancer at University of Liverpo...