iiinova — where your digital self keeps evolving

Reposted by Anna Nordin

Claudio Cantù @claudiocantu81.bsky.social · 01/10/2026

CUT&ID does Genomics+Proteomics in one shot via the fusion protein Lazarus Out @narjournal.bsky.social Unstoppable @annanordin.bsky.social is thinker+executor Get in touch if you wish to try it—plasmid soon @addgene.bsky.social 🙏 @liu.se @scilifelab.se @kawresearch.bsky.social @cancerfonden

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Anna Nordin @annanordin.bsky.social · 16/06/2026

Very excited to present some of my PhD work from the @claudiocantu81.bsky.social Cantù lab tomorrow!

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Reposted by Anna Nordin

Claudio Cantù @claudiocantu81.bsky.social · 12/06/2026

Hepatoblastoma is a nasty childhood liver cancer driven by mutant β-catenin How tumor cells get different and more or less aggressive? We found this out w Peng & Thomas from the Princess Maxima Center for Pediatric Oncology & @annanordin.bsky.social @liu.se @pnas.org www.pnas.org/doi/10.1073/...

pnas.org

Differential Wnt/β-catenin signaling via TCF7L2/LEF1 binding specificity shapes cellular and tumor phenotypes | PNAS

The mechanisms by which Wnt/β-catenin signaling regulates gene expression in a tissue- and context-specific manner remain poorly understood, limiti...

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Anna Nordin @annanordin.bsky.social · 13/12/2025

2 years of work packed into 2 little figures. When it finally worked, it 𝘸𝘰𝘳𝘬𝘦𝘥, beyond my wildest dreams. Try it out!

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Reposted by Anna Nordin

Claudio Cantù @claudiocantu81.bsky.social · 12/05/2025

We had previously shown that TBX3 and #WNT cooperate in limb #DevBio We now have a shocking finding, just published in @pnas.org TBX3 physically engages with β-catenin to drive metastasis genes in #ColorectalCancer (CRC) www.pnas.org/doi/epub/10....

pnas.org

The developmental factor TBX3 engages with the Wnt/β-catenin transcriptional complex in colorectal cancer to regulate metastasis genes

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Reposted by Anna Nordin

Development @dev-journal.bsky.social · 29/03/2025

Construction of an atlas of transcription factor binding during mouse development identifies popular regulatory regions Read this Techniques & Resources Article by @annanordin.bsky.social @gianlucazamba.bsky.social @claudiocantu81.bsky.social & co.: doi.org/10.1242/dev....

Figure 1 TFBomics of the E11.5 mouse embryo. (A) Schematic overview of the experimental design, detailing the tissues dissected from E11.5 JAX/Swiss mice and the targets profiled in each tissue using C&R LoV-U. (B) Left: Clustering of data according to Spearman's correlation. Black boxes highlight higher correlation or clustering according to the profiled factor, whereas red boxes highlight this between factors within the same tissue. IgG negative controls are highlighted in a gray box. Right: Overall data patterns shown by PCA. PC1 (58.7% of variance) separated some samples by the target factor (ellipses shaded by factor color code), while PC2 (9.7% of variance) typically separates the liver (marked with stars) from other tissues.

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Reposted by Anna Nordin

Claudio Cantù @claudiocantu81.bsky.social · 18/03/2025

Our first release in the attempt to build the Transcription Factor Binding (TFB)-OMICS during #DevBio is now out in Development @dev-journal.bsky.social doi.org/10.1242/dev.... 👉We hope many will use our data, and some will want to help mapping their beloved gene regulators in their favorite tissue

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