Arabidopsis coordinates Fe acquisition with its root microbiota by releasing distinct coumarin chemotypes in response to environmental pH. These root-exuded specialized metabolites interact with root-...

PIN-FORMED (PIN) auxin transporters are essential for plant development, relying on asymmetric localization at the plasma membrane. While the centr...

The immune signal SA triggers metabolic changes to activate SnRK1 while inhibiting TOR. These central metabolic kinases antagonistically phosphorylate the key immune regulator NPR1, thereby coupling cellular metabolic state to systemic acquired resistance.

The RING type ubiquitin ligase (E3), XBAT35.2, positively regulates FLS2-mediated plant immunity against bacterial pathogens by modifying the ESCRT-I subunits VPS28-2 and VPS37-1 with distinct ubiqui...

The gradual assembly and oligomerization of cell surface receptors are critical for regulating immune activation and turnover. Yet, how dynamic, spatiotemporally regulated assembly enables rapid and s...

In early results from our new life sciences research lab, Claude agents found an enzyme system whose function is still unknown.

Genetically encoded biosensors are central to plant cell biology, but low reporter signal can limit their use. Here, we developed modular intronised fluorophores to improve reporter output in transien...

The sequential assembly of over 50 proteins during clathrin-mediated endocytosis (CME) is well documented in yeast. However, the mechanisms governing this ordered recruitment remain poorly understood....

Stable developmental programs normally resist reprogramming, yet pathogens can override these constraints to induce profound tissue and cellular remodeling. How microbial pathogens access conserved de...

Cells undergo membrane remodeling in response to the environment to perform specific functions. Now, a cytometry-based method with immune cell biomarker analysis captures variations in plasma membrane...

The PLANT CYSTEINE OXIDASE (PCO) N-degron pathway contributes to oxygen sensing in plants. Here the authors identify HYPOXIA TRANSDUCER1 (HYT1) as a substrate of PCO and show it forms a coherent feed-...

Radulovic et al. show that phosphatidylinositol 3-phosphate (PI3P), produced by the phosphatidylinositol 3-kinase PIK3C3, is formed on ER domains after lysosome damage. ER domain PI3P helps to recruit...

Identification of new regulators of Arabidopsis IRT1 endocytosis and metal transport using TurboID. TurboID proximity labeling of the Arabidopsis IRT1 root metal transporter identified new IRT1-inter....

Cell elongation is a fundamental process allowing plants to change size and shape, a process governed by several growth promoting hormones. While hormones such as brassinosteroids (BRs) and phytosulfo...

Pathogens target and degrade the extracellular matrix surrounding plant cells. A central question is how cell wall-derived damage-associated molecular patterns (DAMPs) are recognized and integrated to...

By tethering a protein of interest to anti-CRISPR, protein degradation is transformed into amplified and programmable transcriptional outputs via Cas-based transcription factors, with sensitivity to p...

Biomolecular condensates formed through phase separation have emerged as a central principle of cellular organization, enabling the dynamic regulation of gene expression, signaling, metabolism, and st...

Here, Schwarze et al. reveal how plant cells match protein quality control to changing rates of protein production through a functional link between TOR kinase signalling and NOT4 E3 ubiquitin ligases

Abstract. Iron (Fe) is a fundamental micronutrient for plant and animal physiology. Consequently, Fe limitation in agricultural systems not only compromise

Cell polarity is an ancient organizing principle across kingdoms. As in animal epithelial cells, plant cells asymmetrically distribute proteins to establish functionally distinct membrane domains. In ...

Clathrin adaptors link cargo to the clathrin coat. The clathrin adaptor Ent5 is also required for the maturation of clathrin coats at the trans-Golgi network or endosome, suggesting that it plays a ke...

Thylakoid membranes are indispensable for oxygenic photosynthesis, yet the mechanisms that protect these membranes from photooxidative damage remai...

Cryo-EM captures FAT10 activation and transfer from UBA6 to E2 UBE2Z, revealing FAT10 monopolises UBA6. Efficient transfer requires E2 engagement of both FAT10 UBL domains, particularly UBL2, and co-o...

Group Lead Wheat Research & Pre-Breeding (m/f/d)

The model plant Arabidopsis thaliana has been a workhorse of plant biology since the 1950s, when the Columbia-0 (Col-0) accession was widely adopted by the research community as a reference genotype. ...

This study reports a bivalent factor, ULTRAPETALA1, that can counteract as well as promote PRC2 activity at hundreds of developmental genes in Arabidopsis thaliana. The pro-PRC2 activity of ULTRAPETAL...

Plant plasma membrane proteins are organized into distinct domains; however, the principles that govern this spatial organization are not fully understood. HYPERSENSITIVE-INDUCED REACTION (HIR) protei...

Nemec-Venza et al. show how mechanical signals, such as tissue tension, can activate gene expression in epidermal cells at the surface of Arabidopsis roots. The expression of the edge-specific growth ...