iiinova — where your digital self keeps evolving

Steven Banik @stevenbanik.bsky.social · 01/09/2026

Excited our ratiometric transcriptional activation (RTA) work led by postdoc Dr. Melissa Gray is out online today in Cell @cp-cell.bsky.social! Measurements determine what we can discover in biology; we use RTA to turn protein abundance changes into amplified signals in live cells.

cell.com

Ratiometric transcriptional activation by protein degradation

By tethering a protein of interest to anti-CRISPR, protein degradation is transformed into amplified and programmable transcriptional outputs via Cas-based transcription factors, with sensitivity to p...

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Steven Banik @stevenbanik.bsky.social · 20/05/2026

Excited to share our work on a new way to sense protein abundance changes. Protein loss has been a defining phenotype for biological, and more recently, small molecule discovery, and we wondered what we could discover w/ greater scale+sensitivity.

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Steven Banik @stevenbanik.bsky.social · 03/02/2026

Excited to share our latest preprint on work led by postdoc Robert Lusi (@rflusi.bsky.social)! Introducing ALTER (AGO-Led Targeted Editing of RNA) for non-downregulatory RNA manipulation by repurposing hAGO2, non-immunogenic and capitalizing on evolution. www.biorxiv.org/content/10.6...

biorxiv.org

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Reposted by Steven Banik

St. Jude Children's Research Hospital @stjuderesearch.bsky.social · 14/07/2025

Attend the 2025 Bringing Chemistry to Medicine Symposium to learn from leading experts in transcription, chromatin regulation, computational biology and chemical biology. Registration is free and available both in-person and virtually.

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Steven Banik @stevenbanik.bsky.social · 29/05/2025

Incredibly proud of @christineisadora.bsky.social for defending her PhD work today! The first PhD from the Banik lab, and an amazing story on targeted protein relocalization and TRAMs! Her PhD work spans small molecules, neurobiology, cell engineering, and computational method development.

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Reposted by Steven Banik

Women in TPD & Induced Proximity @womenintpd.bsky.social · 24/01/2025

Congratulations to @alesalerno.bsky.social from University of Dundee CeTPD and Christine Ng from @stanford-chemh.bsky.social who have been selected as recipients of our conference travel scholarships to attend the Proximity-based Therapeutics Keystone conference @keystonesymposia.bsky.social!

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Steven Banik @stevenbanik.bsky.social · 13/01/2025

Amazing to see the LYTAC technology get to this point, catalytic extracellular degraders could open many new therapeutic opportunities or perhaps even become standard of care compared to antagonistic antibodies alone. Congrats to Lycia Tx!

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