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Isa Manrique

@isamanrique.bsky.social
136 followers 307 following 2 posts

Postdoctoral researcher at @uniofnottingham.bsky.social Plant N-degron pathways | PTMs | Oxygen and NO sensing From Palencia, living in Nottingham

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Reposted by Isa Manrique
International Society for Plant Low Oxygen Research @isplore.bsky.social · 16/09/2026
Hierarchical regulation of oxygen-sensing through coupled transducers in Arabidopsis thaliana www.nature.com/articles/s41... New #plantscience work by @isamanrique.bsky.social @charlene-kunaka.bsky.social @gunjansharma88.bsky.social @n-end-rules.bsky.social
nature.com
Hierarchical regulation of oxygen-sensing through coupled transducers in Arabidopsis thaliana - Nature Communications
The PLANT CYSTEINE OXIDASE (PCO) N-degron pathway contributes to oxygen sensing in plants. Here the authors identify HYPOXIA TRANSDUCER1 (HYT1) as a substrate of PCO and show it forms a coherent feed-...
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Isa Manrique @isamanrique.bsky.social · 16/09/2026
Our paper is out! 🤩 HYT1, a new Cys2- substrate of the #Ndegron pathway to add to the list! 🌱 Thanks to @n-end-rules.bsky.social @charlene-kunaka.bsky.social @gunjansharma88.bsky.social , Susana and all the people involved in this work! You can read it on @natcomms.nature.com👇🏼
nature.com
Hierarchical regulation of oxygen-sensing through coupled transducers in Arabidopsis thaliana - Nature Communications
The PLANT CYSTEINE OXIDASE (PCO) N-degron pathway contributes to oxygen sensing in plants. Here the authors identify HYPOXIA TRANSDUCER1 (HYT1) as a substrate of PCO and show it forms a coherent feed-...
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Reposted by Isa Manrique
International Society for Protein Termini (ISPT) @ispt-proteinterm.bsky.social · 13/09/2026
Rubisco, a CO2-fixing enzyme and a major reservoir of nitrogen and carbon in plant leaves, requires a unique N-terminal maturation pathway | Dong Xie et al. @giglionelab.bsky.social @ifink-lab.bsky.social www.science.org/doi/10.1126/...
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Reposted by Isa Manrique
Mariana Schuster @marischuster.bsky.social · 07/09/2026
I'm excited to share that my newly funded #ERCStG FRONTERA is recruiting two postdoctoral researchers at @ipbhalle.bsky.social 🌱🔬 If you are passionate about plant immunity, proteolysis, membrane proteins, or proteomics, I'd love to hear from you. 🧵 Please RT/share!
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Reposted by Isa Manrique
Daan Weits @daanweits.bsky.social · 31/08/2026
Our work, Progressive oxygenation of developing leaves directs morphogenesis, is now out in Science Advances! We found that developing leaves oxygenate from tip to base, strikingly mirroring their developmental axis, and this drives leaf dev. www.science.org/doi/10.1126/sciadv.aef2430 #plantscience
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Reposted by Isa Manrique
Jorge Vicente @yorgsvicen.bsky.social · 27/07/2026
Our new preprint shows that metacaspase-mediated proteoform generation and N-degron pathway-dependent proteoform stability act together to diversify UBP6 function during Arabidopsis immunity www.biorxiv.org/content/10.6...
biorxiv.org
Functional diversification of UBP6 in plant immunity through N‑degron pathway regulation
Deubiquitylases are key proteolytic regulators of ubiquitin-dependent cellular processes, catalyzing the removal or remodelling of ubiquitin modifications on substrate proteins, including those target...
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Reposted by Isa Manrique
Tamara Hernández-Verdeja @tamara-hverdeja.bsky.social · 03/07/2026
First selected talk by Sara Gomez Jiménez on decoding PAN-dependent transcriptional networks in the root stem cell niche #RBMP2026
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Reposted by Isa Manrique
Sjon Hartman @hartman-plantlab.com · 05/05/2026
So happy and proud to share our lab’s first #plantscience research article, revealing that angiosperms have the capacity to encode memory of flooding stress. A heroic effort by @aidamaric.bsky.social in collaboration with @djgibbs.bsky.social and others. A brief 🧵 www.biorxiv.org/content/10.6...
biorxiv.org
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Reposted by Isa Manrique
Plant Energy Biology Lab @schwarzlanderlab.bsky.social · 22/04/2026
We knew PCOs & ERFVIIs regulated plant hypoxia, but this work shows they also manage the 'reoxygenation' stress. www.nature.com/articles/s41... @biology.ox.ac.uk @ox.ac.uk @uni-muenster.de
nature.com
H2O2 repurposes plant O2 sensing to regulate post-hypoxia responses - Nature
Experiments in Arabidopsis demonstrate that group VII ethylene response factors show differential responses to different stimuli, enabling plants in flood-prone environments to adapt to both submergen...
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N End Rules @n-end-rules.bsky.social · 16/04/2026
The N-degron pathways move from basic to applied science. This pathway will prove to be of key importance for agricultural improvement. Very happy to have been a part of this work led by Chen Lin and colleagues. #plantscience #nendrule #hypoxia nph.onlinelibrary.wiley.com/doi/10.1111/...
nph.onlinelibrary.wiley.com
Generation of Brassica napus with enhanced Sclerotinia sclerotiorum resistance through CRISPR/Cas9‐mediated inhibition of the PROTEOLYSIS6 N‐degron pathway
Click on the article title to read more.
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Reposted by Isa Manrique
Mikel Lavilla-Puerta @mikellavi.bsky.social · 11/03/2026
Finally officially out!! www.pnas.org/doi/10.1073/... We moved the main oxygen sensing machinery from plants to yeast and we learned a few things!
pnas.org
A synthetic ERFVII-dependent circuit in yeast sheds light on the regulation of early hypoxic responses of plants | PNAS
Plants face hypoxic conditions either chronically, as particular tissues are characterized by fluctuating or stable low oxygen levels, or acutely, ...
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N End Rules @n-end-rules.bsky.social · 12/02/2026
Surprisingly: "Conditional stability of HY5 through the ATE N-degron pathway regulates environmental responses in Arabidopsis thaliana". The shining bounds of N-degron pathway influence expands! @charlene-kunaka.bsky.social www.biorxiv.org/content/10.6...
biorxiv.org
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Retraction Watch @retractionwatch.com · 30/01/2026
Forget pickles and ice cream. I published a fake paper on pregnancy cravings for prime numbers.
retractionwatch.com
Guest post: Forget pickles and ice cream. I published a fake paper on pregnancy cravings for prime numbers
Image generated by Google Gemini I had grown weary of the constant stream and abuse of spam invitations to submit manuscripts to journals and to attend fake conferences on the other side of the wor…
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Reposted by Isa Manrique
Iñigo Sáenz de Ugarte @iugarte.bsky.social · 03/01/2026
No puedes dejar de reír por la ironía. En 2003 hubo una intensa polémica sobre si EEUU invadía Irak por el petróleo. Ahora ya no hay dudas. El propio Trump lo ha confirmado con sus palabras. A ver cómo sales después con el discurso de la democracia en Venezuela.
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Reposted by Isa Manrique
Osvaldo Chara @osvaldo-chara.bsky.social · 26/11/2025
Thrilled to have contributed to this @nature.com study on ethylene and cell wall mechanics in root compaction responses!! — Featuring Jiao Zhang, Lucas Peralta Ogorek, @borgesaugust.bsky.social , Bipin Pandey, Staffan Persson, Wanqi Zhang, Malcolm Bennett & more!! www.nature.com/articles/s41...
nature.com
Ethylene modulates cell wall mechanics for root responses to compaction - Nature
Soil compaction traps ethylene around roots, which causes transcriptional upregulation of Auxin Response Factor1, resulting in decreased root cortical cell wall thickness and thereby promoting root ra...
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Isa Manrique @isamanrique.bsky.social · 23/11/2025
🏔️🌧️ 🧬 We wrote this Expert View on oxygen sensing, you can read it here! 👇🏼
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Reposted by Isa Manrique
bioRxiv Plant Bio @biorxiv-plants.bsky.social · 16/10/2025
TGA family of transcription factors are nitric oxide sensors in the root stem cell niche www.biorxiv.org/content/10.1101/202…
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Reposted by Isa Manrique
Andrea Paterlini (he/him) @apaterlini.bsky.social · 09/11/2025
Few Plant science programmes are left in the UK and they are critical to train the next generation. This move by @uniofnottingham.bsky.social goes against recommendations made in the recent PS Education manifesto. Big mistake! Sign the petition! nph.onlinelibrary.wiley.com/doi/10.1002/...
nph.onlinelibrary.wiley.com
A manifesto for plant science education
Plants provide oxygen, food, shelter, medicines and environmental services, without which human society could not exist. Tackling pressing and global challenges requires well-trained plant scientists...
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Reposted by Isa Manrique
N End Rules @n-end-rules.bsky.social · 08/11/2025
Reconsider the potential suspension of Plant Biology Courses at UoN - Sign the Petition! c.org/p5jy2GXHcX via @UKChange
c.org
Sign the Petition
Reconsider the potential suspension of Plant Biology Courses at UoN
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Reposted by Isa Manrique
International Society for Plant Low Oxygen Research @isplore.bsky.social · 23/09/2025
In the last session before lunch we have @n-end-rules.bsky.social open the Hypoxia sensing and signalling session describing a novel oxygen sensing substrate 🌱🌊 Exciting!
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Marta Peirano @minipetite.bsky.social · 08/02/2025
Estoy muy contenta! Hoy abro @elpais.com y el Babelia con Calculando Imperios, el mapa-ensayo-mural de @katecrawford.bsky.social y Vladan Joler. Muestra cómo los avances tecnológicos han sido utilizados desde el s.XVI para centralizar el poder y controlar a la población. elpais.com/babelia/2025...
elpais.com
De Gutenberg a Elon Musk: historia, poder y tecnología
‘Calculating Empires’, la premiada obra de Kate Crawford y Vladan Joler, traza un apasionante mapa de la estrecha relación entre poder y tecnología a lo largo de los siglos como instrumento de dominac...
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Reposted by Isa Manrique
International Society for Plant Low Oxygen Research @isplore.bsky.social · 29/01/2025
New review in the current @plantphys.bsky.social special issue on hypoxia by @isamanrique.bsky.social @emilyflashman.bsky.social @oscarlorenzos.bsky.social et al. Check it out! academic.oup.com/plphys/artic...
academic.oup.com
Destined for destruction: The role of methionine aminopeptidases and plant cysteine oxidases in N-degron formation
Abstract. The cysteine/arginine (Cys/Arg) branch of the N-degron pathway controls the stability of certain proteins with methionine (Met)-Cys N-termini, in
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