Alveolar rhabdomyosarcoma is an aggressive childhood cancer, and many children with this disease carry a mutation that combines two different proteins, PAX3 and FOXO1, into one protein, PAX3-FOXO1. Th...

Sweeping proposed rule, now open for comments, would also restrict foreign collaborations and remove federal funding for open-access fees

Langstein-Skora, Schmid, Huth et al. propose that intrinsically disordered region functionality can be driven by the interplay between linear binding motifs and contextual chemical characteristics suc...

Cohesin folds genomes into chromatin loops, the roles of which are under debate. We found that double-strand breaks (DSBs) induce de novo formation of chromatin loops in human cells, with the loop bas...

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