Nicoli’s lab discovered mRNA that changes how proteins behave. Now she wants to turn it into medicine, starting with diseases of the blood vessels.

Call for Abstracts for the 12th SCZI is now open!

Epithelial tissues serve as critical physical barriers that protect organs, making their efficient repair essential upon damage. To achieve this, tissues must quickly react, forcing cells to rearrange...

Analysing the dynamic behaviour of specific RNAs using MS2 stem-loop arrays bound by fluorescently tagged proteins, provides important insights into their biological function. However, high levels of ...

Nature - Intestinal bacterium secretes a molecule that reduces cholesterol production, according to a mouse study.

Häkkinen et al. show that zebrafish neural crest cells encounter increased tissue-scale confinement along the body axis. Despite nuclear deformation, migrating neural crest cells experience neither nu...

Nicoli’s lab discovered mRNA that changes how proteins behave. Now she wants to turn it into medicine, starting with diseases of the blood vessels.

The conference will discuss the development of nucleic acid medicines including recent clinical successes, and current and upcoming challenges. By bringing together academics in basic and translationa...

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All cells experience mechanical forces, yet how they increase energy production to meet the demands of force response remains incompletely understood. This

Protein synthesis declines with age across many tissues, but whether this decline actively contributes to physiological aging remains unclear. Oocytes may be particularly vulnerable because they rely ...

Lennartz et al. evaluate lipid enrichment in clathrin-coated pits and observe that the differential lipid partitioning into clathrin-coated pits is largely driven by the lipid asymmetry of the plasma ...

Small-molecule modulators of protein synthesis are invaluable tools for dissecting the translation apparatus. This Review summarizes the mechanisms of molecules that disrupt translation in an amino ac...

Mitochondrial DNA (mtDNA) encodes core subunits of the oxidative phosphorylation machinery, and its expression is spatially organized, with the genome packaged into nucleoids around which transcriptio...

Le et al. show that in Xenopus embryos, local ectodermal tissue flows provide a directional cue that polarizes and guides embryonic myeloid cells migration via cell-on-cell interactions.

The abundance of mRNA sets a ceiling on a cell’s capacity to produce protein and carry out its functions. Here, we describe a pathological decline in absolute mRNA abundance that occurs in most cell t...

Bacterial ribosomes can synthesize proteins encoded within their own RNA.

The Golgi is a well-established cytoplasmic hub, yet its coordination with the nucleus remains poorly understood. Systematic analysis of Golgi–nuclear prot

The detailed study of membrane contact sites is challenging owing to their small size and highly dynamic nature. This Review highlights advanced imaging methods and available biosensors that can be us...

Nature - The country singer was an advocate for vaccines, public health, literacy and marginalized communities.

Zmuda et al. show that microscale defects on soft collagen-IV stall epithelial migration via filopodial sensing and intercellular communication of cytoskeletal disruption. Stiffer matrices, switching ...

Mammalian oocytes undergo an extended growth phase, during which transcription gradually declines. To sustain meiotic divisions and early embryonic development, growing oocytes must accumulate materna...

Unlike adult humans, zebrafish can regenerate their hearts after injury. After cardiac injury, the epicardium is rapidly activated to contribute both signaling factors and progenitor cells that are es...

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Epithelial cells remodel their shape during phagocytosis while preserving tissue cohesion. Here, authors show that the E-cadherin/catenin adhesion complex is repurposed at phagocytic contacts, where i...

Gao et al. show that yeast grow faster by proportionally increasing mRNA and ribosome concentrations to increase actively translating ribosomes, while elongation remains constant. A mass-action model ...

Cavanaugh et al. show that embryos from aged mice have increased contractility and tissue viscosity on embryonic day 4.5, which leads to poor spreading and attachment. Similar age-associated mechanica...

This study reveals how cells translate substrate stiffness and curvature into biological responses through focal adhesion tilting, uncovering a mechanical equivalence that opens new routes for designi...

Coronary collateral arteries have been proposed to form de novo through artery reassembly, a process in which arterial endothelial cells (ECs) migrate away from preexisting arteries and reassemble int...

Programmed −1 ribosomal frameshifting (PRF) is a translational control mechanism used by RNA viruses to regulate the relative abundance of proteins en…

Cell biologists have long known that mechanical forces, such as tension and compression, influence tissue differentiation. Now, advanced methods are letting them observe and manipulate these forces in...