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Chris H. Hill

@chillzaa.bsky.social
2.1K followers 760 following 63 posts

Wellcome Sir Henry Dale Fellow and PI at the University of York, UK. He/him 🏳️‍🌈 Interested in #RNA, #ribosomes, #cryo-EM, #crystallography and #virus gene expression, 🔬🧬 www.hill-lab.co.uk Also piano 🎹🎶 www.youtube.com/@chillzaa

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Reposted by Chris H. Hill
Beckmann Lab @beckmannlab.bsky.social · 01/09/2026
Preprint alert: a helicase watching the ribosomal A-site 👀🧬 Our cryo-EM structure reveals how yeast Dhx29 senses mRNA hairpins forming in the A-site and positions its helicase at the mRNA entry channel to resolve them during translation elongation: doi.org/10.64898/202... #cryoEM #ribosome #RNA
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Chris H. Hill @chillzaa.bsky.social · 24/08/2026
Thrilled to share that our paper describing protein-dependent frameshifting is now out in Molecular Cell @cellpress.bsky.social. Huge congratulations to @jemmabetts.bsky.social for publishing the first research paper from her PhD 🧬🧪🥳 www.sciencedirect.com/science/arti... 1/8
sciencedirect.com
A protein-dependent riboswitch activates ribosomal frameshifting in cardioviruses
Programmed −1 ribosomal frameshifting (PRF) is a translational control mechanism used by RNA viruses to regulate the relative abundance of proteins en…
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Reposted by Chris H. Hill
Jamie Blaza @jnb-lab.bsky.social · 10/08/2026
Permanent academic position as a Lecturer in cryo-ET open at York. We are looking for someone to lead a research program making the most of the stunning advances occurring in cryo-ET. It's a research and teaching post but with a focus on research in the early years. jobs.york.ac.uk/vacancy/lect...
jobs.york.ac.uk
Jobs - The University of York
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Chris H. Hill @chillzaa.bsky.social · 11/08/2026
🚨 👇 Come and join us in York as a new lecturer (assistant professor) in cryo-ET! This is a research and teaching appointment to the York Structural Biology Laboratory (YSBL). From personal experience it's a fantastic place to start a group. Please share widely! jobs.york.ac.uk/vacancy/lect...
jobs.york.ac.uk
Jobs - The University of York
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Chris H. Hill @chillzaa.bsky.social · 11/08/2026
Some very exciting news - cryo FIB-SEM instrumentation will soon be coming to the University of York cryo-EM facility, thanks to funding from @ukri.org BBSRC ALERT. This will enable technically demanding cryo-CLEM and in situ structural biology workflows for multiple projects ❄️🦠🧫
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Chris H. Hill @chillzaa.bsky.social · 06/08/2026
I'm thrilled to share that I've received a Career Development Award from the Wellcome Trust to support my laboratory @biologyatyork.bsky.social over the next eight years. Very excited for this next phase of my research journey, and looking forward to lots of twists and turns along the way! 🧬
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Reposted by Chris H. Hill
The Daum Lab @daumlab.bsky.social · 02/06/2026
We are looking for an enthusiastic postdoc to investigate molecular mechanisms of microsporidian infection using soft X-ray tomography, cryo FIB-SEM, and cryoET. If you are interested, do not hesitate to get in touch and check out the application link. The closing date: 21st June 2026.
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Chris H. Hill @chillzaa.bsky.social · 16/05/2026
We just had our second -80 freezer failure in four years... On a Friday evening of course. All samples transferred safely, thanks to the amazing dedication of my team. Eppendorf CryoCube is disappointing in every possible way - it's neither a cube, nor does it stay cold.
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Chris H. Hill @chillzaa.bsky.social · 30/04/2026
Abstract submission for @biochemsoc.bsky.social Translation UK 2026 closes at 🚨MIDNIGHT 🚨 tonight! Please join us in Leeds for this fantastic meeting 👇 www.eventsforce.net/biochemsoc/f...
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Chris H. Hill @chillzaa.bsky.social · 20/04/2026
Two weeks left for abstract submission - please do register; it's a great UK meeting, and lots of opportunities for ECRs to share their work 👇
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Chris H. Hill @chillzaa.bsky.social · 17/04/2026
The @biochemsoc.bsky.social Translation UK 2026 meeting will be at @universityofleeds.bsky.social from 30th June - 2nd July. Fantastic keynote speakers including @jbquerido.bsky.social, @nickywhiffin.bsky.social, Nicolas Locker Register and submit your abstract here: tinyurl.com/muy5kvax
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Reposted by Chris H. Hill
Exciting Instruments @ei-science.bsky.social · 10/04/2026
🤔 How do #proteins reshape RNA dynamics? Static structures tell only half the story. Using smFRET on the EI-FLEX, the @chillzaa.bsky.social lab at @yorkuniversity.bsky.social mapped viral protein–dependent RNA pseudoknot formation - revealing it as a binary, protein-triggered event > buff.ly/IVQYK72
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Chris H. Hill @chillzaa.bsky.social · 06/01/2026
🚨Last chance to apply for two PhD projects in my lab, applying structural biology and single molecule biophysics to investigate gene expression in RNA viruses: www.findaphd.com/phds/?Keywor...
findaphd.com
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Chris H. Hill @chillzaa.bsky.social · 28/11/2025
🚨👇One week left to apply for this fully-funded PhD project to study RNA-protein complexes regulating enterovirus genome replication: www.findaphd.com/phds/project...
findaphd.com
MRC DiMeN Doctoral Training Partnership: Understanding molecular mechanisms of protein-primed genome replication in enteroviruses at University of York on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: Understanding molecular mechanisms of protein-primed genome replication in enteroviruses at University of York, listed on FindAPhD.com
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Reposted by Chris H. Hill
Chris H. Hill @chillzaa.bsky.social · 13/11/2025
🚨Attention prospective PhD students🚨 Are you interested in molecular mechanisms, RNA viruses, structural biology or biophysics? 🧬🦠🧪 We have THREE fully-funded PhD projects available for October 2026 entry: www.findaphd.com/phds/?Keywor... Please share/repost, and get in touch if you're interested
findaphd.com
chris hill PhD Projects, Programmes & Scholarships - 3 PhDs Listed
FindAPhD. Search Funded PhD Projects, Programmes & Scholarships in chris hill. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world.
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Chris H. Hill @chillzaa.bsky.social · 13/11/2025
🚨Attention prospective PhD students🚨 Are you interested in molecular mechanisms, RNA viruses, structural biology or biophysics? 🧬🦠🧪 We have THREE fully-funded PhD projects available for October 2026 entry: www.findaphd.com/phds/?Keywor... Please share/repost, and get in touch if you're interested
findaphd.com
chris hill PhD Projects, Programmes & Scholarships - 3 PhDs Listed
FindAPhD. Search Funded PhD Projects, Programmes & Scholarships in chris hill. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world.
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Chris H. Hill @chillzaa.bsky.social · 07/10/2025
Enteroviruses cause over a billion infections each year, but the details of how their genomes capture host ribosomes have remained elusive. I'm pleased to share a new preprint from Miguel in our group, providing some new insights into this problem: www.biorxiv.org/content/10.1...
biorxiv.org
Structural and mechanistic insights into translation initiation on the enterovirus Type 1 IRES
Enteroviruses are a widespread and diverse set of pathogens responsible for over ~1 billion human infections annually. Upon cell entry, translation of the virus genome is mediated by an internal ribos...
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Reposted by Chris H. Hill
Oli Clarke @olibclarke.bsky.social · 13/09/2025
This one is a bit of a departure from the usual and definitely a work in progress! We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below. Read on for details... 1/x
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Chris H. Hill @chillzaa.bsky.social · 30/07/2025
Ever struggled with low PNK efficiency on a highly structured piece of RNA? Sarah solved this problem by using a DNA scaffold to make the 5' end more accessible, improving the efficiency of end labelling. This enabled us to make smFRET measurements on the SARS-CoV-2 pseudoknot 🧬🔴🟢
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Chris H. Hill @chillzaa.bsky.social · 19/07/2025
New preprint alert! 🚨👇 I'm delighted to share the latest research from @jemmabetts.bsky.social in our group: ‘A new protein-dependent riboswitch activates ribosomal frameshifting’. Huge congratulations to Jemma for the first manuscript of her PhD! ✨ www.biorxiv.org/content/10.1...
biorxiv.org
A new protein-dependent riboswitch activates ribosomal frameshifting
Programmed -1 ribosomal frameshifting (PRF) is a ubiquitous translational control mechanism in RNA viruses, allowing them to change the relative abundance of proteins encoded in different reading fram...
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Chris H. Hill @chillzaa.bsky.social · 20/06/2025
I'm thrilled and honoured to receive the 2025 Lister Prize, along with seven other fantastic biomedical scientists 🔬🦠🧬 This award will enable us to determine high-resolution structures of viral protein synthesis inside infected cells
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Reposted by Chris H. Hill
Eugene Valkov @eugenevalkov.bsky.social · 06/05/2025
A tribute to George Sheldrick and SHELX and the impact on macromolecular and small-molecule crystallography journals.iucr.org/a/issues/202...
journals.iucr.org
George M. Sheldrick (1942–2025)
In memory of George Sheldrick.
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Chris H. Hill @chillzaa.bsky.social · 10/06/2025
Last day to apply for the CCP4 Structural Biology Summer School 2025! 31 July to 8 August at University of York. The programme will focus on X-ray crystallography but many model-building, refinement and validation aspects also relevant to cryo-EM 💎❄️ ccp4.github.io/summer-schoo...
ccp4.github.io
CCP4 Summer School 2025
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Reposted by Chris H. Hill
Steve Quinn @steve-quinn-lab.bsky.social · 02/06/2025
Congratulations to Dr Sarah Graham @york.ac.uk #Physicsoflife group for successfully defending her thesis! Thanks also to Dr Tara Sabir & @agnesnoy.bsky.social for doing the honours as examiners, @bpsiyork.bsky.social for co-supervising & @chillzaa.bsky.social for all the help along the way!
media.tenor.com
a cartoon of snoopy jumping with the words yay congratulations below him
ALT: a cartoon of snoopy jumping with the words yay congratulations below him
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Reposted by Chris H. Hill
Yi-Wei Chang @yiweichang.bsky.social · 15/05/2025
Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals. www.science.org/doi/10.1126/...
science.org
Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis
Influenza viruses replicate and transcribe their genome in the context of a conserved ribonucleoprotein (RNP) complex. By integrating cryo–electron microscopy single-particle analysis and cryo–electro...
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Chris H. Hill @chillzaa.bsky.social · 20/04/2025
a little É(as)tude... 🎹🐣 Happy holidays everyone!
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Reposted by Chris H. Hill
Peter O'Toole @yorkbioimaging.bsky.social · 16/04/2025
It's here. The lumicks C-Trap is up and running with real samples from Durham, Hull, Newcastle and York consortium. Thanks @ukri.org #BBSRC for funding. @chillzaa.bsky.social
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Chris H. Hill @chillzaa.bsky.social · 16/04/2025
Super excited for the arrival of our brand new Lumicks C-Trap in Biology at York @yorkbioimaging.bsky.social, funded by @ukri.org BBSRC. This state-of-the-art optical tweezers / confocal microscope will enable us to probe the dynamics of structured viral RNAs, one molecule at a time 🔆🧬🔆
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Reposted by Chris H. Hill
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 12/03/2025
Foam film vitrification for cryo-EM www.biorxiv.org/content/10.1101/202…
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Chris H. Hill @chillzaa.bsky.social · 21/03/2025
New cryo-EM/ET story - a brilliant collaboration with Sergey Melnikov's lab in Newcastle @sergeymelnikov.bsky.social and Stefan Pfeffer's lab in Heidelberg @pfeffercryolab.bsky.social. Great work in particular by Karla Helena-Bueno and @sophiekopetschke.bsky.social www.nature.com/articles/s41...
nature.com
Structurally heterogeneous ribosomes cooperate in protein synthesis in bacterial cells - Nature Communications
Cells can simultaneously produce structurally dissimilar ribosomes, suggesting functional specialization of distinct ribosome populations. Here, the authors show that distinct ribosomes cooperate rath...
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Chris H. Hill @chillzaa.bsky.social · 28/01/2025
👀📅👇One week left to apply for this fully-funded UK PhD - closing date 3rd February. Come and join my lab in beautiful York to work on protein-RNA interactions in FMDV, then follow up with virology experiments at the world-leading Pirbright Institute🧬 Please share widely!
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Chris H. Hill @chillzaa.bsky.social · 20/01/2025
🚨 I'm delighted to announce a fully-funded PhD studentship (October 2025 entry) in collaboration with the Pirbright Institute. Are you interested in FMDV genome replication and packaging? Fascinated by structure and RNA-protein interactions? More info here: www.findaphd.com/phds/project...
findaphd.com
Probing the Function of RNA Structural Elements in the FMDV Genome using Biophysical and Genetic Approaches at The Pirbright Institute on FindAPhD.com
PhD Project - Probing the Function of RNA Structural Elements in the FMDV Genome using Biophysical and Genetic Approaches at The Pirbright Institute, listed on FindAPhD.com
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Chris H. Hill @chillzaa.bsky.social · 12/12/2024
🚨⏰One day left to apply for this fully-funded MRC DiMeN PhD to join me, @Steve_Quinn_Lab and Purba Mukherjee at the University of York. Apply here: www.dimen.org.uk/how-to-apply
dimen.org.uk
How to apply | DiMeN DTP
Dates for applications, what you need to apply, course specific questions, and details about the application process.
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Reposted by Chris H. Hill
Kate Michie @kmichie.bsky.social · 29/11/2024
Beautiful work! 🧬🧶 www.science.org/doi/10.1126/...
science.org
Molecular basis of mRNA delivery to the bacterial ribosome
Protein synthesis begins with the formation of a ribosome-messenger RNA (mRNA) complex. In bacteria, the small ribosomal subunit (30S) is recruited to many mRNAs through base pairing with the Shine-Da...
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Reposted by Chris H. Hill
Julie @rna-julie.bsky.social · 26/11/2024
Delighted to be advertising 2 exciting PhD projects 1) lncRNA derived micropeptides & their contribution to brain cancers with James Poulter & Lucy Stead 2) mechanisms of translational regulation by specialised ribosomes. @chillzaa.bsky.social & Ade Whitehouse www.findaphd.com/phds/?Keywor...
findaphd.com
aspden PhD Projects, Programmes & Scholarships
FindAPhD. Search Funded PhD Projects, Programmes & Scholarships in aspden. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world.
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Reposted by Chris H. Hill
Neil Ranson @naranson.bsky.social · 18/11/2024
I am about to be recruiting two post-docs to work on cryoEM and cryoET of amyloid aggregates... Anyone interested please drop me a line while the wheels of our HR department turn.............
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Reposted by Chris H. Hill
Michael Plevin @mjplevin.bsky.social · 14/11/2024
Hey, that’s me! Please do spread the word about this project and get in touch if you’re interested in finding out more. XH-🥧 interactions are the best!
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Chris H. Hill @chillzaa.bsky.social · 13/11/2024
We have a fully-funded 4 year PhD position in the lab, for October 2025 entry. Both UK and international students are eligible to apply. Please share and get in touch if you're interested 🧬🧪🦠 www.findaphd.com/phds/project...
findaphd.com
MRC DiMeN Doctoral Training Partnership: Understanding molecular mechanisms of protein-primed genome replication in enteroviruses at University of York on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: Understanding molecular mechanisms of protein-primed genome replication in enteroviruses at University of York, listed on FindAPhD.com
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Chris H. Hill @chillzaa.bsky.social · 13/11/2024
I'm a structural and molecular biologist and research group leader. We work on mechanisms of pathological translation in viral infection (e.g. IRES initiation, frameshifting, stop codon readthrough). Interested in RNA biology, ribosomes, host-pathogen interactions and regulation of gene expression.
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Chris H. Hill @chillzaa.bsky.social · 12/11/2024
Hello world 🎉
Picture of Clifford's Tower in York, with a sunset in the background
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