Protein synthesis declines with age across many tissues, but whether this decline actively contributes to physiological aging remains unclear. Oocytes may be particularly vulnerable because they rely ...

Lennartz et al. evaluate lipid enrichment in clathrin-coated pits and observe that the differential lipid partitioning into clathrin-coated pits is largely driven by the lipid asymmetry of the plasma ...

Small-molecule modulators of protein synthesis are invaluable tools for dissecting the translation apparatus. This Review summarizes the mechanisms of molecules that disrupt translation in an amino ac...

Mitochondrial DNA (mtDNA) encodes core subunits of the oxidative phosphorylation machinery, and its expression is spatially organized, with the genome packaged into nucleoids around which transcriptio...

Le et al. show that in Xenopus embryos, local ectodermal tissue flows provide a directional cue that polarizes and guides embryonic myeloid cells migration via cell-on-cell interactions.

The abundance of mRNA sets a ceiling on a cell’s capacity to produce protein and carry out its functions. Here, we describe a pathological decline in absolute mRNA abundance that occurs in most cell t...

Bacterial ribosomes can synthesize proteins encoded within their own RNA.

The Golgi is a well-established cytoplasmic hub, yet its coordination with the nucleus remains poorly understood. Systematic analysis of Golgi–nuclear prot

The detailed study of membrane contact sites is challenging owing to their small size and highly dynamic nature. This Review highlights advanced imaging methods and available biosensors that can be us...

Nature - The country singer was an advocate for vaccines, public health, literacy and marginalized communities.

Zmuda et al. show that microscale defects on soft collagen-IV stall epithelial migration via filopodial sensing and intercellular communication of cytoskeletal disruption. Stiffer matrices, switching ...

Mammalian oocytes undergo an extended growth phase, during which transcription gradually declines. To sustain meiotic divisions and early embryonic development, growing oocytes must accumulate materna...

Unlike adult humans, zebrafish can regenerate their hearts after injury. After cardiac injury, the epicardium is rapidly activated to contribute both signaling factors and progenitor cells that are es...

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Epithelial cells remodel their shape during phagocytosis while preserving tissue cohesion. Here, authors show that the E-cadherin/catenin adhesion complex is repurposed at phagocytic contacts, where i...

Gao et al. show that yeast grow faster by proportionally increasing mRNA and ribosome concentrations to increase actively translating ribosomes, while elongation remains constant. A mass-action model ...

Cavanaugh et al. show that embryos from aged mice have increased contractility and tissue viscosity on embryonic day 4.5, which leads to poor spreading and attachment. Similar age-associated mechanica...

This study reveals how cells translate substrate stiffness and curvature into biological responses through focal adhesion tilting, uncovering a mechanical equivalence that opens new routes for designi...

Coronary collateral arteries have been proposed to form de novo through artery reassembly, a process in which arterial endothelial cells (ECs) migrate away from preexisting arteries and reassemble int...

Programmed −1 ribosomal frameshifting (PRF) is a translational control mechanism used by RNA viruses to regulate the relative abundance of proteins en…

Cell biologists have long known that mechanical forces, such as tension and compression, influence tissue differentiation. Now, advanced methods are letting them observe and manipulate these forces in...

Stress granules (SGs) are dynamic RNA condensates that assemble rapidly in response to cellular stress following translational arrest, thereby promoting adaptation and influencing disease pathogenesis...

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Animals capable of whole-body regeneration can heal virtually any wound. Here they show that Hofstenia miamia accomplishes this feat through variable morphogenetic strategies that depend on which epit...

Alternate RNA decoding, an understudied process, leads to peptide sequence modifications that can have substantial functional effects on protein stability, tissue-specific proteomes and dise...

Using dynamic SILAC proteomics, Matsuda et al. show that protein degradation is globally slower in human than in mouse segmentation clock cells. Glycolysis inhibition in mouse partially phenocopies the human protein stability profile, linking metabolism, protein stability, and developmental tempo.

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Prolonged translational arrests caused by defective mRNAs activate the ribosome-associated protein quality control (RQC) pathway, which marks harmful incomplete proteins for degradation. Multipass tra...

Lee and Kim et al. generate elongating heart organoids (EHOs) from human induced pluripotent stem cells. EHOs undergo elongation and looping-like morphogenesis and establish venous-arterial axial patterning with venous pole-initiated contractile propagation. EHOs provide a human platform to study early cardiac morphogenesis and congenital heart disease.

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...