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Epilepsia Journal @epilepsiajournal.bsky.social · 16/01/2026

Trials including participants with high SF could include either fewer participants or shorter maintenance phase. doi.org/10.1002/epi.... #epilepsy #ILAE #epilepsia #antiepilepticdrugs #clinicaltrials #Lrelationship #timetoevent

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Epilepsia Journal @epilepsiajournal.bsky.social · 16/01/2026

The DAME score predicts the risk of epilepsy in patients with autoimmune encephalitis-associated NORSE. doi.org/10.1002/epi.... #epilepsy #ILAE #epilepsia #autoimmuneencephalitis #etiology #NORSE #statusepilepticus

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Epilepsia Journal @epilepsiajournal.bsky.social · 16/01/2026

Epilepsia is pleased to welcome our new Associate Editors. We thank them for their willingness to serve and for the expertise they bring to the journal. View the full editorial team - onlinelibrary.wiley.com/page/journal...

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Epilepsia Journal @epilepsiajournal.bsky.social · 15/01/2026

Prolonged ASM exposure increased malformation risk, and valproate- or some lamotrigine-based dual therapies showed higher malformation risks associated with these combinations. doi.org/10.1002/epi.... #epilepsy #ILAE #epilepsia #AntiSeizureMedications #Pregnancy #FetalOutcomes #DrugSafety

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Epilepsia Journal @epilepsiajournal.bsky.social · 15/01/2026

For optimal uptake, AI should be used as a tool that complements human-centered care and clinical judgment. doi.org/10.1002/epi.... #epilepsy #ILAE #epilepsia #AIethics #computationalintelligence #datascience #deeplearning #IGAP #machineintelligence #machinelearning #syntheticintelligence

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Epilepsia Journal @epilepsiajournal.bsky.social · 12/01/2026

New in Epilepsia – January 10, 2026 mailchi.mp/ilae/new-art... Subscribe - eepurl.com/iLSrNc #epilepsy #epilepsia #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch

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Epilepsia Journal @epilepsiajournal.bsky.social · 12/01/2026

A 1-unit serum S100B increase (in μg/L) after traumatic brain injury was associated with a 46% higher epilepsy risk. doi.org/10.1002/epi.... #epilepsy #ILAE #epilepsia #epidemiology #observationalstudy #posttraumatic #S100B #TBI

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Epilepsia Journal @epilepsiajournal.bsky.social · 08/01/2026

The symmetrical claustrum sign demonstrates high specificity in FIRES diagnosis and is considered a potential diagnostic marker. doi.org/10.1002/epi.... #epilepsy #ILAE #epilepsia #SCS #FIRES #claustrum #prognosis

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Epilepsia Journal @epilepsiajournal.bsky.social · 08/01/2026

Combining MRI and interictal iEEG abnormalities significantly improved outcome differentiation. doi.org/10.1111/epi.... #epilepsy #ILAE #epilepsia #epilepsysurgery #graymatter #iEEG #multimodal #superficialwhitematter

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Epilepsia Journal @epilepsiajournal.bsky.social · 06/01/2026

Carbamazepine was associated with increased interictal activity, while valproate–lamotrigine was associated with reduced activity in the IGEs. doi.org/10.1002/epi.... #epilepsy #ILAE #epilepsia #ambulatory #EEG #antiseizuremedication #IGE #interictalepileptiformdischarges #vEEG

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Epilepsia Journal @epilepsiajournal.bsky.social · 06/01/2026

Cluster analysis based on electronic medical records reveals dynamic phenotypic clustering reflecting the evolving nature of SCN8A-related disorders throughout the first 10 years of childhood. doi.org/10.1002/epi.... #epilepsy #ILAE #epilepsia #EMRs #ASM #developmentalskills #pediatric

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Epilepsia Journal @epilepsiajournal.bsky.social · 15/12/2025

New in Epilepsia – December 13, 2025 mailchi.mp/ilae/new-art... Subscribe - eepurl.com/iLSrNc #epilepsy #epilepsia #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch

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Epilepsia Journal @epilepsiajournal.bsky.social · 15/12/2025

Prioritization of candidate genes reveals high-quality candidates that are known to influence neurodevelopment and synaptic plasticity and be druggable. doi.org/10.1111/epi.... #epilepsy #ILAE #epilepsia #drugtargetprioritization #genomewideassociationstudy #multispeciesanalysis #systemsbiology

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Epilepsia Journal @epilepsiajournal.bsky.social · 12/12/2025

The updated ILAE seizure classification proved fully applicable at secondary referral centers. doi.org/10.1002/epi.... #epilepsy #ILAE #epilepsia #applicability #feasibility #seizureclassification

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Epilepsia Journal @epilepsiajournal.bsky.social · 12/12/2025

This study establishes that early symptoms such as dysphagia, neurodevelopmental concerns, seizures, and hyperkinetic movement disorders are consistent and early clinical biomarkers of the GABRG2 p.(Ala106Thr) GoF variant. doi.org/10.1111/epi.... #epilepsy #ILAE #epilepsia #GABAAreceptor

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Epilepsia Journal @epilepsiajournal.bsky.social · 12/12/2025

Largest reported series highlighting rare but serious sEEG-related pseudoaneurysms and the need for prompt imaging and treatment. doi.org/10.1002/epi.... #epilepsy #ILAE #epilepsia #complication #epilepsysurgery #SEEG

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Epilepsia Journal @epilepsiajournal.bsky.social · 11/12/2025

Medial pulvinar entropy changes during seizures predict clinical response to deep brain stimulation in drug-resistant epilepsy. doi.org/10.1111/epi.... #epilepsy #ILAE #epilepsia #DBS #permutationentropy #pulvinar #SEEG

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Epilepsia Journal @epilepsiajournal.bsky.social · 11/12/2025

Acute PHM is a clinically heterogeneous disorder with significant diagnostic and therapeutic challenges and a poor prognosis. doi.org/10.1111/epi.... #epilepsy #ILAE #epilepsia #cardiacarrest #LanceAdamssyndrome #myoclonicstatusepilepticus #perampanel #postanoxicmyoclonus

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Epilepsia Journal @epilepsiajournal.bsky.social · 10/12/2025

Theory of Mind appears preserved in juvenile myoclonic epilepsy after accounting for cognitive and mood factors, highlighting broader vulnerabilities. doi.org/10.1111/epi.... #epilepsy #ILAE #epilepsia #cognition #executivefunction #neuropsychologicaltests #psychology

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Epilepsia Journal @epilepsiajournal.bsky.social · 10/12/2025

A new method called ME-MAGMA is designed to identify genes influenced by epigenetic regulators associated with epilepsy. doi.org/10.1111/epi.... #epilepsy #ILAE #epilepsia #epigenetics #geneticgeneralizedepilepsy #GWAS #MAGMA #transcriptomics

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Epilepsia Journal @epilepsiajournal.bsky.social · 09/12/2025

Interrater agreement of retrospective chart reviews is highly dependent upon documentation quality. doi.org/10.1111/epi.... #epilepsy #ILAE #epilepsia #datareporting #drugresistantepilepsy #interraterreliability #neuromodulation #vagusnervestimulation

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Epilepsia Journal @epilepsiajournal.bsky.social · 08/12/2025

SEEG offers a unique framework for prospective white matter functional mapping in epilepsy patients. doi.org/10.1111/epi.... #epilepsy #ilae #epilepsia #epilepsysurgery #SEEG #whitematter #anatomy

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Epilepsia Journal @epilepsiajournal.bsky.social · 08/12/2025

New in Epilepsia – December 6, 2025 mailchi.mp/ilae/new-art... Subscribe - eepurl.com/iLSrNc #epilepsy #epilepsia #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch

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Epilepsia Journal @epilepsiajournal.bsky.social · 04/12/2025

Risks can be minimized by avoiding bright flashing lights, covering one eye, wearing dark glasses, and staying far back from screens. doi.org/10.1111/epi.... #epilepsy #ILAE #epilepsia #guidelines #patternsensitiveseizures #photoparoxysmalresponse #photosensitiveseizures #reflexepilepsy

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Epilepsia Journal @epilepsiajournal.bsky.social · 04/12/2025

PIPs for antiseizure medications have mainly focused on focal seizures so far. Limited compliance and incomplete trials represent ongoing challenges in pediatric antiseizure drug development. doi.org/10.1111/epi.... #epilepsy #ILAE #epilepsia #antiseizuremedication #drugdevelopment #seizure

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Epilepsia Journal @epilepsiajournal.bsky.social · 21/11/2025

This study evaluated the implementation and clinical effectiveness of a mental health care workflow for inpatients with epilepsy. doi.org/10.1111/epi.... #epilepsy #ILAE #epilepsia #antidepressants #anxiety #comorbidities #depression #healthrelatedqualityoflife #psychotherapy #seizurefrequency

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Epilepsia Journal @epilepsiajournal.bsky.social · 21/11/2025

Combining polygenic risk scores with rare variant data has potential to refine diagnostic accuracy and improve genetic counseling. doi.org/10.1111/epi.... #epilepsy #ILAE #epilepsia #DEE #genetics #penetrance #polygenic #PRS

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Epilepsia Journal @epilepsiajournal.bsky.social · 21/11/2025

This is the first placebo-controlled cenobamate efficacy study to use the globally approved cenobamate titration schedule. doi.org/10.1111/epi.... #epilepsy #ILAE #epilepsia #antiseizuremedication #efficacy #refractory #titration #cenobamate

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Epilepsia Journal @epilepsiajournal.bsky.social · 20/11/2025

Cenobamate demonstrates sustained seizure freedom and a favorable safety profile in patients with drug-resistant epilepsy. doi.org/10.1111/epi.... #epilepsy #ILAE #epilepsia #antiepileptic #cenobamate #drugresistantepilepsy #seizurefreedom

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Epilepsia Journal @epilepsiajournal.bsky.social · 20/11/2025

Vagus nerve stimulation (VNS) showed a 90.5% responder rate and 20.5% seizure freedom in pediatric drug-resistant epilepsy over long-term follow-up doi.org/10.1111/epi.... #epilepsy #ILAE #epilepsia #prognosticfactors #seizurefreedom #ultrarapiddutycycling #vagusnervestimulation

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Epilepsia Journal @epilepsiajournal.bsky.social · 19/11/2025

TBC1D24-related disorders encompass a wide spectrum of neurological phenotypes, but the longitudinal trajectories remain unexplored. doi.org/10.1111/epi.... #epilepsy #ILAE #epilepsia #DEE #genetics #HumanPhenotypeOntology #TBC1D24

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Epilepsia Journal @epilepsiajournal.bsky.social · 19/11/2025

Plasma biomarkers APOC4, SLC4A1, and S100B support early diagnosis of status epilepticus. doi.org/10.1111/epi.... #epilepsy #ILAE #epilepsia #biomarkers #earlydiagnosis #statusepilepticus

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Epilepsia Journal @epilepsiajournal.bsky.social · 18/11/2025

We review here the electrophysiological and pharmacological features of SD in models of epileptiform synchronization. doi.org/10.1111/epi.... #epilepsy #ILAE #epilepsia #ictogenesis #seizures #spreadingdepolarization #SUDEP

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Epilepsia Journal @epilepsiajournal.bsky.social · 18/11/2025

Findings reveal a positive association between the use of ASMs and survival in patients with PSE. doi.org/10.1111/epi.... #epilepsy #ILAE #epilepsia #antiseizuremedications #Italy #mortality #poststrokeepilepsy #publichealth

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Epilepsia Journal @epilepsiajournal.bsky.social · 17/11/2025

New in Epilepsia – November 15, 2025 mailchi.mp/ilae/new-art... Subscribe - eepurl.com/iLSrNc #epilepsy #epilepsia #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch

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Epilepsia Journal @epilepsiajournal.bsky.social · 17/11/2025

Treating epilepsy with ASMs is thus akin to playing chess—a game in which strategic decisions must be made at each point in time and constantly reevaluated to beat the opponent. doi.org/10.1111/epi.... #epilepsy #ILAE #epilepsia #antiseizuremedications #chessboardgame #strategicdecisions

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Epilepsia Journal @epilepsiajournal.bsky.social · 13/11/2025

We observed an increased PVS volume fraction in the basal ganglia across all epilepsy types considered. doi.org/10.1111/epi.... #epilepsy #ILAE #epilepsia #glymphaticsystem #MRI #perivascularspaces

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Epilepsia Journal @epilepsiajournal.bsky.social · 13/11/2025

Lennox–Gastaut syndrome (LGS) management requires regular assessments and multidisciplinary care. doi.org/10.1111/epi.... #epilepsy #ILAE #epilepsia #LennoxGastaut #multidisciplinarycare #patientadvocacy

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Epilepsia Journal @epilepsiajournal.bsky.social · 12/11/2025

Letter to the Editor Electroencephalographic signal dimension provides the necessary stability of measurements for the unbiased evaluation of ASMs, unlike seizure frequency: Overcoming drawbacks of seizure occurrence variability doi.org/10.1111/epi.... #epilepsy #ILAE #epilepsia #seizure

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Epilepsia Journal @epilepsiajournal.bsky.social · 11/11/2025

Five de novo heterozygous SRCAP variants are identified in five patients with DEE, and six biallelic variants are identified in six patients with focal epilepsy. doi.org/10.1111/epi.... #epilepsy #ILAE #epilepsia #SRCAP #denovovariants #DEE #geneticdependentquantity #genotypephenotypecorrelations

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Epilepsia Journal @epilepsiajournal.bsky.social · 11/11/2025

LOF Slc35a2 in oligodendrocytes results in severe hypomyelination, a reduction of oligodendrocytes, and reactive gliosis. doi.org/10.1111/epi.... #epilepsy #ILAE #epilepsia #hypomyelination #malformations #corticaldevelopment #MOGHE #Slc35a2

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Epilepsia Journal @epilepsiajournal.bsky.social · 10/11/2025

New in Epilepsia – November 8, 2025 mailchi.mp/ilae/new-art... Subscribe - eepurl.com/iLSrNc #epilepsy #epilepsia #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch

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Epilepsia Journal @epilepsiajournal.bsky.social · 07/11/2025

Pilocarpine-induced SE elevates the respiratory rate and ventilation. doi.org/10.1111/epi.... #epilepsy #ILAE #epilepsia #apnea #cholinergicactivation #EEG #plethysmography #seizureinducedmortality

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Epilepsia Journal @epilepsiajournal.bsky.social · 07/11/2025

Absence seizures in monogenic epilepsies often show early onset, atypical features, drug-resistance, and poor developmental outcomes. doi.org/10.1111/epi.... #epilepsy #ILAE #epilepsia #atypicalabsence #epilepsyclassification #monogenic #neurodevelopment #nextgenerationsequencing

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Epilepsia Journal @epilepsiajournal.bsky.social · 07/11/2025

The effects of astrocyte Gq-coupled Designer Receptors Exclusively Activated by Designer Drugs modulation were investigated in a mouse model of temporal lobe epilepsy. doi.org/10.1111/epi.... #epilepsy #ILAE #epilepsia #astrocytes #chemogeneticmodulation #DREADDs #metabolomics #temporallobe

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Epilepsia Journal @epilepsiajournal.bsky.social · 06/11/2025

De novo missense variants in BAIAP2 identified in six patients with severe DEEs, featuring refractory epilepsy, developmental delays, and intellectual disability. doi.org/10.1111/epi.... #epilepsy #ILAE #epilepsia #BAIAP2 #IRSp53 #DEE #intellectualdisability #wholeexomesequencing

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Epilepsia Journal @epilepsiajournal.bsky.social · 06/11/2025

Cluster analysis reveals distinct profiles based on age at onset, symptoms, cognitive level, presence of developmental and epileptic encephalopathy, disease mechanism, and treatment response. doi.org/10.1111/epi.... #epilepsy #ILAE #epilepsia #geneticepilepsy #pediatric #pediatricmovementdisorders

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