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Gord Fishell

@gordfishell.bsky.social
1.3K followers 535 following 105 posts

labs at HMS Neurobiology and the Stanley center at the Broad, doing our best to understand cortical interneurons through developmental genetics and physiology.

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Gord Fishell @gordfishell.bsky.social · 04/07/2026
Had my first publication with my son Will Fishell ....and my second on using SNNs and inhibition to improve AI computation with Suraj Honnuraiah iopscience.iop.org/article/10.1...
iopscience.iop.org
Feedforward spiking neural networks are not transformers (yet): a learning-theoretic framework for long-range dependencies and biological efficiency
Feedforward spiking neural networks are not transformers (yet): a learning-theoretic framework for long-range dependencies and biological efficiency, Fishell, William Peter, Fishell, Gord, Honnuraiah, Suraj
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Gord Fishell @gordfishell.bsky.social · 07/06/2026
I had the privilege of working with Dionnet on this work. Such a pleasure! Pay attention to this one!
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Gord Fishell @gordfishell.bsky.social · 10/03/2026
Thoughts on Anthropic and the pentagon....The US military has 3000 strikes in Iran, all determined using Claude's help -assume 94% accuracy and 0 hallucinations. So 180 errors in targeting. How many civilians are killed in those errors? That is why we can't autonomize warfare!
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Gord Fishell @gordfishell.bsky.social · 22/01/2026
Excited to be on the organization meeting for the 6th annual NCM conference on Neural Circuits in Health & Disease. Terrific line up of speakers!
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Gord Fishell @gordfishell.bsky.social · 22/01/2026
Excited for the publication of our recent work on how pyramidal cells shape the identity of interneurons in the Cortex! Big shout out to @artofbiology and Sherry Jingjing wu! www.nature.com/articles/s41...
nature.com
Pyramidal neurons proportionately alter cortical interneuron subtypes - Nature
Pyramidal neuron-driven mechanisms actively promote the survival and terminal differentiation of their associated interneuron subtypes.
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Gord Fishell @gordfishell.bsky.social · 11/12/2025
Thrilled to see our PNAS paper featured in @giacomoi.bsky.social commentary. A fantastic recognition of how biologically grounded cortical microcircuits can accelerate the next generation of NeuroAI—and a meaningful step connecting it to neuroscience www.pnas.org/doi/10.1073/...
pnas.org
Biological fidelity: The engine driving the neuromorphic renaissance | PNAS
Biological fidelity: The engine driving the neuromorphic renaissance
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Gord Fishell @gordfishell.bsky.social · 29/11/2025
Excited to report the publication of LARIS, a program that can predict spatiotranscriptic LIgand-Receptor interactions. This work was led by @artofbiology (Min Dai in my lab) with Fei Chen's lab at the Broad. www.biorxiv.org/content/10.1...
biorxiv.org
LARIS enables accurate and efficient ligand and receptor interaction analysis in spatial transcriptomics
Advances in spatially resolved transcriptomics provide unprecedented opportunities to characterise intercellular communication pathways. However, robust and computationally efficient incorporation of ...
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Gord Fishell @gordfishell.bsky.social · 04/11/2025
And now the Neuromorphic piece has been picked up a one of the 10 most notable AI papers this week! Exciting! Well done Suraj!! aiworld.eu/story/this-w...
aiworld.eu
This Week's 10 Most Notable AI Research Papers - Week 41
This week’s AI research highlights how technological innovation and societal responsibility are increasingly intertwined. Studies range from AI-driven advances ...
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Gord Fishell @gordfishell.bsky.social · 04/11/2025
Well to complement my son's efforts here is some background into my own first foray into neuromorphic computing. The original article can be seen in PNAS! A big shout out to Suraj Honnuraiah, who made it all happen! www.growkudos.com/publications...
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Gord Fishell @gordfishell.bsky.social · 03/11/2025
Well when it rains it pours. My son Will @fishell_will , just published a paper on biorxiv, much closer to my heart with my lab member Suraj Honnuraiah on spiking neural networks and understanding why they struggle as LLMs. www.biorxiv.org/content/10.1...
biorxiv.org
SNNs Are Not Transformers (Yet): The Architectural Problems for SNNs in Modeling Long-Range Dependencies
Spiking Neural Networks (SNNs) have gained increasing attention for their ability to operate on low-power neuromorphic hardware, offering a pathway toward energy-efficient large language models (LLMs)...
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Gord Fishell @gordfishell.bsky.social · 03/11/2025
In a whimsical review of his arXiv.org paper, my son Will discusses the use of TempoBench in evaluating LLMs. I particularly enjoyed the faux ad for the TempoBench "product". You go Will! wfishell.github.io/landing.html
arxiv.org
arXiv.org e-Print archive
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Gord Fishell @gordfishell.bsky.social · 03/11/2025
Really excited to see my son Will @fishell_will publish his first work Tempobench that measures temporal causality and reasoning in LLMs. arxiv.org/abs/2510.27544
arxiv.org
Mechanics of Learned Reasoning 1: TempoBench, A Benchmark for Interpretable Deconstruction of Reasoning System Performance
Large Language Models (LLMs) are increasingly excelling and outpacing human performance on many tasks. However, to improve LLM reasoning, researchers either rely on ad-hoc generated datasets or formal...
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Gord Fishell @gordfishell.bsky.social · 25/08/2025
New updated on how pyramidal neurons impact interneuron subtypes. Turns out spontaneous activity, Wnt signaling in PV Interneurons and integrin-signaling in SST neurons are the culprits! Also see how optimal transport tracks identity.https://www.biorxiv.org/content/10.1101/2024.07.20.604399v2
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Gord Fishell @gordfishell.bsky.social · 16/06/2025
I am so excited about this combined analysis of the selective CRHR2 population within the lateral septum and how they control defensive behavior. Dionnet was truly a gifted graduate student. Keep your eyes on this one!
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Gord Fishell @gordfishell.bsky.social · 14/06/2025
At my last year of attending the McKnight conference. Such an amazing group of scientists. A big shout out to Lauren Orefice who gave an amazing talk this morning!
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Gord Fishell @gordfishell.bsky.social · 14/06/2025
Here is a chat with Bosilijka Tasic and myself about the enhancer-mediated AAVs that we were both centrally involved in publishing. I truly believe these approaches are fundamentally important for both basic and clinical approaches! braininitiative.nih.gov/news-events/...
braininitiative.nih.gov
From the BRAIN Director: Q&A With Dr. Gordon Fishell and Dr. Bosiljka Tasic on Precise Brain Cell Delivery Systems | BRAIN Initiative
Newly published work funded by the NIH BRAIN Initiative offers a precision toolkit for accessing cells in the brain and spinal cord with unprecedented accuracy. The new delivery tools, about 1,000 in ...
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Gord Fishell @gordfishell.bsky.social · 03/06/2025
So I open up the NYtimes and there is my pal @ardemp.bskyverified.social saying that despite funding cuts he is staying in this country that he loves. Keep the faith you all!.... www.nytimes.com/2025/06/03/u...
nytimes.com
The U.S. Lit a Beacon for Science. Under Trump, Scientists Fear It’s Dimming
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Salvatore Lacava @salvatorelacava.bsky.social · 22/05/2025
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Cell Press @cellpress.bsky.social · 22/05/2025
"Exploring brain circuits, one cell type—or more— at a time" www.cell.com/neuron/fullt... Bosiljka Tasic & @gordfishell.bsky.social ‬ @cp-neuron.bsky.social
cell.com
Exploring brain circuits, one cell type—or more— at a time
This issue of Neuron, with accompanying papers in Cell, Cell Genomics, Cell Reports, and Cell Reports Methods, contains studies describing methods for access to neuronal and non-neuronal cell types wi...
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Gord Fishell @gordfishell.bsky.social · 22/05/2025
Yep, glad people in europe are taking notice. Hey guys, we are having a giant fire sale! Top scientists looking for relocation to the other side of the pond. Sad!
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Stein Aerts @steinaerts.bsky.social · 21/05/2025
One thousand candidate enhancers tested in vivo in the mouse brain! A massive resource and oh so useful as validation set for genome-wide enhancer prediction methods. Super fun to be involved in one of the papers: ‘the prediction challenge paper’ by Nelson&Niklas et al www.cell.com/cell-genomic...
cell.com
Evaluating methods for the prediction of cell-type-specific enhancers in the mammalian cortex
Johansen et al. report the results of a community challenge to predict functional enhancers targeting specific brain cell types. By comparing multi-omics machine learning approaches using in vivo data...
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Gord Fishell @gordfishell.bsky.social · 21/05/2025
Here is the collective effort of 12 labs, lead by my own at the Broad to target the range of cortical interneuron subtypes! These tools should be a game changer for all of you using NHP and other less genetically amenable species! Have at it! urldefense.proofpoint.com/v2/url?u=htt...
urldefense.proofpoint.com
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Gord Fishell @gordfishell.bsky.social · 21/05/2025
Check out the neuroview and all the great articles of new tools to target different cell types with enhancer-mediated AAVs!
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Gord Fishell @gordfishell.bsky.social · 15/05/2025
Even though it is spring....it seems to have gotten dark lately...."Within the last several days, Harvard University has received letters from most federal agencies indicating that nearly all of HMS’s active, direct federal grants have been terminated."
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Gord Fishell @gordfishell.bsky.social · 04/05/2025
I will fly to anywhere in the United States on my own dime to talk to people about basic science! I encourage all of you, particularly senior scientists to make this commitment. If you are looking for material ask @karalmarshall.bsky.social She has put together an amazing basic talk!
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Gord Fishell @gordfishell.bsky.social · 04/05/2025
OK inspired by @karalmarshall.bsky.social I am reaching out to the public where ever I can. Traditionally Republicans have been incredibly supportive of science. We as scientists need to reach out to people across the spectrum to rally their support for basic science!
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Gord Fishell @gordfishell.bsky.social · 04/05/2025
Ask Kara for this talk! It is an amazing walk through for the general public.mmI am going to give a general talk to the public every time I am traveling through the USA. I have had a wonderful career. It is my students and postdocs I am worried about 🥺. Come help out!
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Kara Marshall @karalmarshall.bsky.social · 03/05/2025
Gave a talk at my parents’ retirement community to describe how science is done, and what is at stake. There was a ton of interest, and anyone can do this. Get the word out about how science affects everyone. I’m happy to share slides with anyone who asks- just get in touch! youtu.be/BY_SFgi-Cig
youtu.be
Kara Marshall PHD-History of Science in America - Trilogy at Tehaleh 04/27/25
YouTube video by Steve Lawson
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Gord Fishell @gordfishell.bsky.social · 03/05/2025
Given all that is going on consider this quote from Bertram Russell's 1930 book The conquest of Happiness: “The man who can be interested in the structure of atoms or the way in which a beetle navigates, is likely to get a joy in life which no amount of success in the pursuit of power can give. ”
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Gord Fishell @gordfishell.bsky.social · 02/05/2025
Heads up: A ton of papers from my group at the Broad, Pittsburgh, Irvine, Caltech, Duke, Berkeley and especially the Allen are on deck for a big consortium publication on new methods to target range of specific neuronal and non-neuronal cells coming out in Neuron and associated journals May 20th!
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Gord Fishell @gordfishell.bsky.social · 22/04/2025
Nuff said...https://www.harvard.edu/president/news/2025/the-promise-of-american-higher-education/
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Gord Fishell @gordfishell.bsky.social · 17/04/2025
Color in the lines of your favorite proteins....can't wait to see David Ginty's full chest tattoo of a Pacinian corpsule!!!
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Gord Fishell @gordfishell.bsky.social · 17/04/2025
The time has come for all of America to reflect where they stand on the question of academic freedom...
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Gord Fishell @gordfishell.bsky.social · 16/04/2025
Take a look at the harvard web site...We have our break-throughs and next generation drugs on full display! Come take a look at the new wonders of medicine! So proud to be a part of it!!! Harvard.edu
harvard.edu
Harvard University
Harvard University is devoted to excellence in teaching, learning, and research, and to developing leaders who make a difference globally.
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Barack Obama @barackobama.bsky.social · 15/04/2025
Harvard has set an example for other higher-ed institutions - rejecting an unlawful and ham-handed attempt to stifle academic freedom, while taking steps to make sure students can benefit from an environment of intellectual inquiry, rigorous debate and mutual respect. Let’s hope others follow suit.
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Gord Fishell @gordfishell.bsky.social · 15/04/2025
And so the fight begins in earnest!
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Gord Fishell @gordfishell.bsky.social · 15/04/2025
As Sun Tzu said "Do not press a desperate enemy too hard. Leave him a way of escape." After what happened to Columbia, it's pretty clear capitulation is not a viable option.
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Gord Fishell @gordfishell.bsky.social · 15/04/2025
Harvard takes a stand, although after Columbia it is not clear what other choice they had.
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Gord Fishell @gordfishell.bsky.social · 09/04/2025
We all owe america so much! I arrived in NYC from Canada in 1989 with ambition and a dream! I hope America keeps letting us all keep paying it forward!
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Gord Fishell @gordfishell.bsky.social · 09/04/2025
Great idea! Let's see more people follow @imprida.bsky.social lead
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Gord Fishell @gordfishell.bsky.social · 08/04/2025
Following up on @lmprida.bsky.social with my very first paper on striatal patch cells during development from 1987: starting my 38 year journey to explore how cells create pattern. c.f. this to my latest biorxiv on interneurons. www.jneurosci.org/content/7/7/... www.biorxiv.org/content/10.1...
jneurosci.org
Pattern formation in the striatum: developmental changes in the distribution of striatonigral neurons
The striatum of the mammalian forebrain can be divided into 2 compartments, the patches and the matrix. We have investigated embryonic events involved in the formation of these compartments in rats. E...
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Gord Fishell @gordfishell.bsky.social · 06/04/2025
I love the retrospective of our lives. The journey from Physics to brain function. Got to love it!!❤️
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Gord Fishell @gordfishell.bsky.social · 31/03/2025
Me too. This storm may take all of us down but I came to the United States for science and have never lived without democracy. Keep the faith!!
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Gord Fishell @gordfishell.bsky.social · 31/03/2025
To reiterate: without democracy and science....what do we really have left?
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Gord Fishell @gordfishell.bsky.social · 22/03/2025
  If democracy and science go away, what do we have left?
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Gord Fishell @gordfishell.bsky.social · 22/03/2025
And then sent on to others “Hi All, I received this like many or all of you.  Personally, I was on the fence about signing onboard but in discussing this with Alex Schier we went over the words of Martin Niemöller “First they came for the Communists, and I did not speak out” and decided to sign."
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Gord Fishell @gordfishell.bsky.social · 22/03/2025
I was asked to sign a letter by a bunch of national academy of science people arguing against Trump’s attacks on science and after a bit of hesitation did.
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Gord Fishell @gordfishell.bsky.social · 11/03/2025
Posted a lot about my concerns about science in the USA. I am going to take a break and focus on questions. Just posted two things that puzzle me on GRNs and non-autonomous signaling and quantitive analysis of cortical circuits. Take a breath and consider some tough questions!
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Gord Fishell @gordfishell.bsky.social · 11/03/2025
With regards to GRNs...We find that interneurons alter their identity when apposed to different pyramidal neurons (Wu et al. Biorxiv 2024). How do surface signals alter TF expression to change GRNs? Linking this will explain a lot of how cortical circuits are so precise!
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Gord Fishell @gordfishell.bsky.social · 11/03/2025
Working on understanding the diversity of neuronal circuits. Myh8 SST interneurons qualitatively target 66% ET and 33% IT but how much variance is there in specific individual neurons....we need a quantitive answer to this for distinct neuronal types.
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