Subiculum, the primary output structure of the hippocampus, remains an enigmatic structure in spatial processing. Here the authors reimagine subicular spatial responses as emerging from behaviour and ...

Mouse experiments show that Alzheimer’s disease and corticobasal degeneration tau filaments retain their distinct structures during templated seeding, supporting strain-specific tau propagation a...

A 3D optogenetics method can mimic natural rhythms of neural activity, rendering previously unanswerable questions amenable to inquiry — including questions about autism.

How prefrontal circuits build lasting memories and shape the ways experience guides behavior.

Neural manifold properties can help us understand how animal brains deal with complex information, execute flexible behaviors and reuse common computations.

The Transmitter and Neuromatch surveyed more than 300 early-career neuroscientists to better understand their unique challenges, career aspirations and support needs.

Neural sequences, characterized by neurons or groups of neurons that fire one after the other, have been observed in multiple brain regions, across species, and are known to underlie a diversity of br...

The authors use recurrent neural networks to predict how structured prior experience shapes neural dynamics as mice learn flexible timing strategies during complex context-dependent behavior.

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Whole-brain activity mapping, targeted cell manipulations and electrophysiology in mice identify wake-activated neuronal populations that are crucial for sleep drive and can persistently red...

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Using in vivo whole-cell recordings during goal-directed navigation, Bhatia, Adel, and Grienberger identify plateaus as a prominent feature of subiculum activity. These events preferentially occur nea...

To make flexible decisions, the brain needs to make inferences between events that were not directly experienced together. In sharp-wave ripple (SWR) events, during periods of rest and sleep, spiking ...

How past experiences are reconstructed from memory remains unclear. Here the authors used intracranial EEG to show that hippocampal ripples reshape the geometry of cortical representations, supporting...

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Code and slides for 2026 FENS Chen Summer School on Learning with spikes - neural-reckoning/cambridge-fens-chen-summer-school-2026

It is unusual for cognitive neuroscientists to reach consensus around which computations a brain region implements, what algorithms are used to achieve those computations and how the algorithms are im...

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive impairments in episodic and spatial memory, as well as circuit an…

Neuronal and glial mitochondria support neuronal circuit function and plasticity through the supply of energetic substrates and the regulation of cellular physiology. Sandi and colleagues describe how...

Stable and flexible neural representations of space in the hippocampus are crucial for navigating complex environments, yet how they emerge from the u…