iiinova — where your digital self keeps evolving

Reposted by Jungsu Kim

Sandro Da Mesquita @da-mesquita.bsky.social · 17/02/2026

The Da Mesquita lab at Mayo Clinic (www.mayo.edu/research/lab...) is looking for a postdoctoral researcher to work on projects investigating the role(s) of the meningeal lymphatic vasculature in models of neurodegenerative diseases. Please spread the word and contact me in case you are interested! 😃

mayo.edu

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Jungsu Kim @jungsukim77.bsky.social · 17/02/2026

Congrats @handekarahan.bsky.social & our team members! A potential new drug target for Alzheimer's disease. Targeting the APOE pathway more effectively. Might also enhance neuroprotective pathways, offering resilience against disease progression. alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

alz-journals.onlinelibrary.wiley.com

Deletion of neuronal Idol ameliorates Alzheimer's disease–related pathologies via APOE receptors

INTRODUCTION Overexpression of the low-density lipoprotein receptor (LDLR) is known to decrease apolipoprotein E (APOE) levels and alleviate amyloid beta (Aβ) pathology. We hypothesized that inhibit...

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Jungsu Kim @jungsukim77.bsky.social · 22/11/2025

NIH funding "Consider investigator career stage and promote sustainability of the biomedical research workforce" "Promote broad distribution and geographic balance of funding, considering the total amount and type of NIH funding already available to each investigator" grants.nih.gov/grants-proce...

grants.nih.gov

Implementing a Unified NIH Funding Strategy to Guide Consistent and Clearer Award Decisions | Grants & Funding

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Reposted by Jungsu Kim

Bess Frost @bessfrost.bsky.social · 14/11/2025

Frost lab paper alert! This study was led by Dr. Paul Ramirez, Lead Biostatistician for the Brown University Center for Alzheimer’s Disease Research: alz-journals.onlinelibrary.wiley.com/doi/epdf/10.... 1/9

alz-journals.onlinelibrary.wiley.com

Long‐read sequencing reveals genomic and epigenomic variation in the dark genome of human Alzheimer's disease

You have to enable JavaScript in your browser's settings in order to use the eReader.

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Reposted by Jungsu Kim

Shannon Macauley @macauleylab.bsky.social · 13/11/2025

Our new review is out today! 𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀 We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility. onlinelibrary.wiley.com/doi/10.1111/...

onlinelibrary.wiley.com

The Energetic Collapse of the Alzheimer's Brain: Metabolic Inflexibility Across Cells and Networks

Metabolic inflexibility in Alzheimer's disease. Schematic illustrating the biphasic trajectory of metabolic activity relative to canonical Alzheimer's disease (AD) biomarkers. In the presymptomatic p...

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Jungsu Kim @jungsukim77.bsky.social · 12/11/2025

"Years after Brigham-Harvard scandal, U.S. pours millions into tainted stem-cell field" www.reuters.com/investigates... A bit outdated news Fabricated data in most research fields Reminds me of the following article "Why Most Published Research Findings Are False" journals.plos.org/plosmedicine...

reuters.com

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Jungsu Kim @jungsukim77.bsky.social · 02/11/2025

A very expensive R21 grant paid off well 🤩

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Reposted by Jungsu Kim

Celeste Karch @karchlab.bsky.social · 21/10/2025

Excited to share new work from the lab showing that loss of AD risk gene Ms4a4a promotes abeta clearance and protects against amyloid plaque accumulation in a mouse model 🧠🐭 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

alz-journals.onlinelibrary.wiley.com

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Jungsu Kim @jungsukim77.bsky.social · 06/10/2025

An interesting behind story. From a random mutant MOUSE 🐁 model To a HUMAN disease! Of course, Mouse models can be useful for understanding peripheral immune in Humans too. www.nobelprize.org/prizes/medic...

nobelprize.org

Nobel Prize in Physiology or Medicine 2025

The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

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Jungsu Kim @jungsukim77.bsky.social · 20/09/2025

"But given the growing emphasis on funding in many quarters as the sine qua non of academic achievement, we may reach the point where faculty members' obituaries will read along the lines of, "Professor X didn't leave much of an intellectual legacy, but he/she sure brought in a lot of grant money""

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Jungsu Kim @jungsukim77.bsky.social · 16/09/2025

"FlyBase’s now-uncertain future highlights just how interconnected and interdependent research efforts are and how the effects of funding cuts to one institution can ripple worldwide. More than 4,000 labs use FlyBase." share.google/vYzdfRwVpnHb...

share.google

Trump's Harvard cuts threaten a giant in biomedical research: A database about the tiny fruit fly

This spring, the Trump administration rescinded a grant that maintained FlyBase, a pillar of global basic research, as part of its broader $2.2 billion funding cuts at Harvard.

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Jungsu Kim @jungsukim77.bsky.social · 14/09/2025

Nevertheless, these two brief papers in BBRC, although not viewed as potentially seminal in the months after their publication, turned out to provide both the factual and conceptual underpinnings for all subsequent research on β-amyloidosis in AD By Masters & Selkoe pubmed.ncbi.nlm.nih.gov/22675658/

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Jungsu Kim @jungsukim77.bsky.social · 28/08/2025

🤯 Postmortem vs Living brain Due to the unavailability of brain tissue from living people, most such studies are performed using tissue from postmortem brain. "Expression levels differed significantly for nearly 80% of genes,"🤯 www.nature.com/articles/s41...

nature.com

A study of gene expression in the living human brain - Molecular Psychiatry

Molecular Psychiatry - A study of gene expression in the living human brain

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Jungsu Kim @jungsukim77.bsky.social · 22/08/2025

"it’s hard for me to believe that damaging the greatest biomedical research system in the world is the way to solve any problems, let alone the problem of antisemitism."

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Jungsu Kim @jungsukim77.bsky.social · 20/08/2025

End the unchecked growth of publishing fees and the overreliance on unpaid peer review A proposed NIH policy to limit allowable publication costs is a good start — but more must be done Peer reviewers should be paid for their considerable labor | STAT share.google/YXf4iuUCa9Zp...

share.google

End the unchecked growth of publishing fees and the overreliance on unpaid peer review

High publishing costs and a crumbling peer review infrastructure are symptoms of deeper structural issues in research.

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Jungsu Kim @jungsukim77.bsky.social · 31/07/2025

"hyperphosphorylated tau PREVENTS the age-related decline in whole-body metabolism by preserving glucose tolerance and mitigating shifts in fuel utilization (respiratory exchange ratio; RER),"

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Reposted by Jungsu Kim

Annika Barber @annikabarber.bsky.social · 22/07/2025

😡 The amount of bureaucratic barriers being thrown up for me to host an URM student from an urban high school and pay her a small stipend so she can afford to take this opportunity is making me absolutely stabby. Barriers to participation in STEM are real and undiminished.

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Jungsu Kim @jungsukim77.bsky.social · 22/07/2025

Highly recommend everyone take a look! I especially like "Transcriptomic reprogramming represents a promising strategy for treating complex diseases"😍 Title: Cell-type-directed network-correcting combination therapy for Alzheimer’s disease www.cell.com/cell/fulltex...

cell.com

Cell-type-directed network-correcting combination therapy for Alzheimer’s disease

A multi-cell-type drug discovery strategy targeting dysregulated gene networks in neurons and glia identified letrozole and irinotecan as a combination therapy that significantly improved memory and r...

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Jungsu Kim @jungsukim77.bsky.social · 20/07/2025

More than a decade-old story, but it resonates again now. "NIA is in an exceptional predicament. In recent years, it has made big commitments to costly clinical trials and large group projects." www.nature.com/articles/468... The value of top-down big projects needs to be reevaluated, especially now

nature.com

Funding crisis hits US ageing research - Nature

Shortfalls hamper scientists' efforts to address a predicted epidemic of age-related diseases.

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Jungsu Kim @jungsukim77.bsky.social · 19/07/2025

"It also calls on Duke’s highest paid administrators and athletic personnel — those making over $500,000 — to consider voluntary, temporary pay cuts to offset the costs of a reduced budget, as opposed to laying off staff." www.dukechronicle.com/article/2025...

dukechronicle.com

American Association of University Professors calls on Duke to 'immediately halt' its employee buyout program

The statement, signed by AAUP president Todd Wolfson, alleges that Duke did not consult faculty and staff in decision-making prior to rolling out the VSIP and has not been transparent with its cost-cu...

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Reposted by Jungsu Kim

Jose Conejo-Garcia @conejo-garcia.bsky.social · 08/07/2025

In immunology, for instance, experiments can only be done in vivo to capture the complex interactions of multiple cell types, cytokines and chemokines. No computer will predict immune subsets and mediators that we do not fully understand yet.

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Reposted by Jungsu Kim

Karen James @kejames.bsky.social · 08/07/2025

NIH was already pushing and investing in NAMs before this but had concluded, "Alternative approaches cannot completely replace the use of animals at this time." grants.nih.gov/policy-and-c...

Screengrab: "Though these alternative approaches exist, and advances are being made every day, research with animals continues to be essential for understanding human diseases, biological processes, and developing treatments. Alternative approaches cannot completely replace the use of animals at this time. The alternatives simply cannot accurately replicate or model all the biologic and behavioral aspects of human disease. Until that time, animal models will remain integral for live-saving NIH-supported research. However, NIH and NIH funded scientists are continually working to reduce animal use and improve the welfare for animals that are essential for scientific progress."

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Jungsu Kim @jungsukim77.bsky.social · 03/07/2025

"Publishing with journals that do NOT make their content immediately, publicly available is allowed, as long as the Author Accepted Manuscript is submitted to PMC upon acceptance, for public availability without embargo upon the Official Date of Publication." 🤔🤔🤔 grants.nih.gov/faqs#/public...

grants.nih.gov

Frequently Asked Questions (FAQs) | Grants & Funding

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Jungsu Kim @jungsukim77.bsky.social · 03/07/2025

"Accumulation of Aβ should not be regarded as a benign consequence of aging; these findings support the amyloid-cascade hypothesis and suggest that therapies aimed at reducing Aβ may be of relevance for the older population."

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Jungsu Kim @jungsukim77.bsky.social · 19/06/2025

"In conclusion, a simple PGS captures the AD-specific genetic information that is common to populations of different ancestries" Keywords: Common!!!

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Jungsu Kim @jungsukim77.bsky.social · 12/06/2025

Publishing industry "We argue that financial motivations central to most publishing distort how research is presented, how it is assessed and even what research is undertaken, leading to a system that hinders, rather than facilitates, scientific progress." onlinelibrary.wiley.com/doi/full/10....

onlinelibrary.wiley.com

Toward Science‐Led Publishing

Click on the article title to read more.

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Jungsu Kim @jungsukim77.bsky.social · 11/06/2025

Met him once briefly at a conference this year (I have known his outstanding work for years, though.) Please support his lab

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Reposted by Jungsu Kim

The New York Times @nytimes.com · 04/06/2025

President Trump has slashed funding for medical research, threatening a longstanding alliance between the federal government and universities that helped make the U.S. the world leader in medical science. Here are the nearly 2,500 grants that have been canceled or delayed. trib.al/iBstU2B

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Reposted by Jungsu Kim

Tal Nuriel, PhD @talnuriel.bsky.social · 29/05/2025

Remember that time Trump got COVID (before the vaccines), and his life was saved by an experimental new monoclonal antibody therapy created using a revolutionary mouse technology invented by a former Assistant Professor at Columbia University?

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Jungsu Kim @jungsukim77.bsky.social · 27/05/2025

"Neuroscience needs to empower early-career researchers, not fund moon shots" "Large-scale projects run the risk of stifling scientific independence. Instead, let’s explore alternative mechanisms of collaboration." www.thetransmitter.org/funding/neur...

thetransmitter.org

Neuroscience needs to empower early-career researchers, not fund moon shots

Large-scale projects run the risk of stifling scientific independence. Instead, let’s explore alternative mechanisms of collaboration.

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Jungsu Kim @jungsukim77.bsky.social · 22/05/2025

The 5th International Research Conference on Neurodegenerative Diseases Please join us! During oral presentations by trainees, we will have only that session. When the invited PIs present, we will have concurrent sessions. All trainees are plenary speakers😍 gasnd.org/ircnd/2025/i...

gasnd.org

IRCND 2025

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Jungsu Kim @jungsukim77.bsky.social · 22/05/2025

Different anti-amyloid antibodies have different in vitro binding characteristics to different synthetic Aβ aggregates, leading to the assumption that they bind different species in the human brain. Lecanemab is hypothesized to bind "protofibrils," but these are not well-characterized in human brain

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Jungsu Kim @jungsukim77.bsky.social · 20/05/2025

"Diseases like cancer, diabetes, and Alzheimer’s are incredibly complicated. They involve many different parts of the body working together — or sometimes failing to do so. Researchers simply can’t get the full picture from cells in a dish or computer models alone."

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Jungsu Kim @jungsukim77.bsky.social · 14/05/2025

“We work in a very horizontal way,” says Renzo. “We share the weight of decision-making. That culture of openness and equality is what makes CMN special.” Indeed, sounds very special! So glad to see that Rosa has been doing well since her departure from the Mayo Clinic. She was so supportive of me!

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Jungsu Kim @jungsukim77.bsky.social · 03/05/2025

Institutions will be required to place (tenured) faculty on probation if they do not meet the standards set through the review process. According to the legislation, that probation “may result in dismissal.” www.wishtv.com/news/educati...

wishtv.com

Indiana budget bill curbs university faculty power, ties tenure to ‘productivity’ reviews

Sweeping changes to public university governance in Indiana's 2025 budget bill have been passed quietly, limiting faculty autonomy and academic freedom.

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Celeste Karch @karchlab.bsky.social · 01/05/2025

Everyone should contact their us congress members and tell them not to cut SNAP (food stamps). secure.everyaction.com/lmBv70YdQkCu...

secure.everyaction.com

URGENT ACTION ALERT: Historic Threat to SNAP – Keep The Pressure On

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Jungsu Kim @jungsukim77.bsky.social · 27/04/2025

Brain developmental trajectories of #Drosophila, #zebrafish, #mouse, and human www.annualreviews.org/content/jour...

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