We recently calculated attributable fractions (AFs) suggesting that up to 92.7% of Alzheimer’s disease may not occur without the contribution of risk alleles in the gene APOE. Among commentators who w...

Abstract A wide range of disciplines, including epidemiology, psychiatry, and the biomedical sciences, increasingly use genetic and molecular data to study

Abstract This course covers the fundamental developments in Mendelian randomization and gives practical explanations about how to apply MR to applied resea

An epidemiology study finds variations in one gene, APOE, play a major role in determining the risk of Alzheimer’s disease.

Visscher et al. recently published a thought-provoking analysis to summarise the prospects of heritable gene editing for reducing the incidence of various chronic diseases in populations in Nature. Am...

This course covers the latest developments in causal inference methods and provides practical explanations for applying them to real research questions.

Project Code MRCPHS26Br Nivard Project Type Dry lab Research Theme Population Health Science Project Summary Download Summary Complex traits such as body mass index and height are influenced by a mixt...

Preprint servers are a low-cost mechanism for providing free access to research findings, and can also significantly accelerate research itself by making results available immediately. This Perspectiv...

David Lammy has joined other foreign ministers in condemning the Israeli government for depriving Gazans "of human dignity" as they called on the war to "end now".

Background Vascular dementia (VaD) is the second most common cause of dementia, yet its risk factors and biological mechanisms remain poorly understood. Objective To identify causes and consequences ...

This course covers the fundamental developments in Mendelian randomization and gives practical explanations about how to apply MR to applied research questions.

Abstract This course covers the fundamental developments in Mendelian randomization and gives practical explanations about how to apply MR to applied resea

Objective To estimate the proportions of Alzheimer's disease (AD) and all-cause dementia burden attributable to the common risk alleles ε3 and ε4 in the APOE gene Design Genetic association analyses i...