Low-affinity transcription factor binding sites are functionally important but difficult to map and mechanistically poorly understood. In this issue of Cell Genomics, Weilert et al. leverage sequence-...

Peer Bork, one of the most influential computational biologists of his generation, died on 16 January 2026 from natural causes (EMBL 2026). He was 62 years

Abstract. Ewing sarcoma, a pediatric cancer of bone and soft tissue, is driven in most cases by an abnormal oncogenic fusion of the N-terminal region of EW

A coordinated sequence of RNA helicases and associated factors dismantles normal and defective spliceosome complexes to enable intron degradation and ensure accurate gene expression.

PIN-FORMED (PIN) auxin transporters are essential for plant development, relying on asymmetric localization at the plasma membrane. While the centr...

Cancer cells tolerate mitotic errors to sustain proliferation, yet the molecular dependencies enabling this tolerance remain poorly understood and largely unexploited therapeutically. UBASH3B ensures ...

A mechanistic basis for how the hormone salicylic acid promotes transcriptional activation during plant immune responses is described.

Cell Death & Differentiation - DeSUMOylation switches Kaiso from activator to repressor upon hyperosmotic stress

A mechanistic basis for how the hormone salicylic acid promotes transcriptional activation during plant immune responses is described.

Nature Structural & Molecular Biology, Published online: 14 September 2026; doi:10.1038/s41594-026-01885-6Ciapponi et al. determine the cryo-electron microscopy structure of the canonical Polycomb repressive complex 1 holocomplex and show how its architecture coordinates complex assembly, H2A monoubiquitination and genomic targeting.

An exciting postdoctoral position is available to research the role of epigenetic marks in gene regulation.

Cryo-EM captures FAT10 activation and transfer from UBA6 to E2 UBE2Z, revealing FAT10 monopolises UBA6. Efficient transfer requires E2 engagement of both FAT10 UBL domains, particularly UBL2, and co-o...