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HittingerLab

@hittingerlab.bsky.social
519 followers 654 following 68 posts

Yeast evolutionary genomics with applications in brewing and bioenergy at the University of Wisconsin-Madison. Moderated by Hittinger Lab members. Opinions do not necessarily belong to anyone. Lab website: hittinger.genetics.wisc.edu.

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University of Guelph News @uofguelphnews.bsky.social · 21/05/2026
Resistance to antifungal medications is growing. Now, #UofG researchers have developed a faster way to identify the genetic vulnerabilities of Candida fungi, which could lead to brand new treatments. @uofgcbs.bsky.social @uofgresearch.bsky.social uoguel.ph/vze5i
uoguel.ph
Faster Gene Screening Method Targets Deadly Fungus
U of G researchers are using CRISPR interference to spot genetic vulnerabilities in Candida albicans, a leading cause of life-threatening infections.
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HittingerLab @hittingerlab.bsky.social · 31/08/2026
I am honored to be chosen as the new Eddie Goldenberg Research Chair of Canada in Biodiscovery, Biodesign, and Bioproduction at University of Guelph as part of the Canada Global Impact+ Research Talent Initiative! @UofGuelphNews, @UofG, @UofGResearch
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University of Guelph @uofguelph.bsky.social · 27/08/2026
Backed by $8M in federal funding, Dr. Chris Todd Hittinger will be the new Eddie Goldenberg Research Chair of Canada in Biodiscovery, Biodesign and Bioproduction at #UofG as part of the Canada Global Impact+ Research Talent Initiative. His appointment begins on July 1, 2027: uoguel.ph/3nw8s
Dr. Chris Todd Hittinger stands against a dark background, smiling slightly at the camera.
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HittingerLab @hittingerlab.bsky.social · 14/07/2026
Our recent work with @linder-surprise.bsky.social and the @rokaslab.bsky.social has been featured as a research highlight on the Great Lakes Bioenergy Research Center (GLBRC) page: www.glbrc.org/research/hig...
glbrc.org
Trait syndrome links cell structure to metabolic efficiency across yeast subphylum
Researchers analyzed a dataset of glucose-induced extracellular acidification rates — as a proxy for glycolytic rates — and phenotypic variation across 282 species with Saccharomycotina to test whethe...
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HittingerLab @hittingerlab.bsky.social · 08/07/2026
A tenure-track research position is available for application at the Westerdijk Fungal Biodiversity Institute @westerdijkinst.bsky.social located in Utrecht Science Park in the Netherlands. Please share with colleagues and see the link below for more info: wi.knaw.nl/news/details...
wi.knaw.nl
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HittingerLab @hittingerlab.bsky.social · 24/06/2026
A new study out with @linder-surprise.bsky.social and @rokaslab.bsky.social in iScience across ~300 yeast species confirms the correlation between glucose uptake rate and cell surface-to-volume (SA:V) ratio, but suggests a link to other traits (growth rates and genome size). doi.org/10.1016/j.is...
sciencedirect.com
A trait syndrome ties cell morphology to glycolysis across the yeast subphylum
Co-variation of traits provides fundamental insights into constraints governing their evolution. An inverse correlation between glucose uptake rates (…
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HittingerLab @hittingerlab.bsky.social · 24/06/2026
Check out this new first-author paper from our new postdoctoral lab member @alyahussain.bsky.social! 🎉 This work is from her PhD in the Michael McMurray lab at CU Anschutz.
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HittingerLab @hittingerlab.bsky.social · 08/06/2026
Two members of the Hittinger Lab received awards during the annual All-Wisconsin Energy Institute (WEI) meeting. Our lab manager, Amanda Hulfachor, won the Excellence Award and Sam Davison, a CMB graduate student, won the award for Community Impact. Congrats to both - we are very proud!⭐⭐⭐
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HittingerLab @hittingerlab.bsky.social · 09/05/2026
Reminder that the Early Bird registration rate for the 9th Conference on Physiology of Yeasts and Filamentous Fungi (PYFF9) in Valencia (Spain) will expire on May 24th! 👉 Register here: yeastfungi.efbiotechnology.org @pyff-9.bsky.social
yeastfungi.efbiotechnology.org
Conference on Physiology of Yeasts and Filamentous Fungi (PYFF) - September 2026, Valencia (Spain)
The Conference on Physiology of Yeasts and Filamentous Fungi (PYFF) is a leading international event gathering experts in the physiology, metabolism, genetics, and biotechnology of yeasts and filament...
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Physiology of Yeasts and Filamentous Fungi @pyff-9.bsky.social · 04/11/2025
#PYFF9 is coming to Valencia! 🇪🇸 Join us for the 9th International Conference on Physiology of Yeasts and Filamentous Fungi (PYFF9), Sept 8–11, 2026! ✨ Cutting-edge science, vibrant networking, and the charm of the Mediterranean—don’t miss it! 🔗 Learn more: efbiotechnology.org/pyff
efbiotechnology.org
PYFF
Physiology of Yeasts and Filamentous Fungi (PYFF) conference will take place in Valencia, Spain. It brings together researchers from academia and industry who are engaged in the study of the physiolog...
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Linda Horianopoulos @linder-surprise.bsky.social · 30/04/2026
There's a story behind every project that doesn't get fully captured in the final paper. Check out our "behind the paper" accompanying our paper on convergent evolution of aerobic fermentation in yeast. communities.springernature.com/posts/learni... @hittingerlab.bsky.social @rokaslab.bsky.social
communities.springernature.com
Learning the rules of metabolic innovation in yeast evolution
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HittingerLab @hittingerlab.bsky.social · 22/04/2026
With @linder-surprise.bsky.social and the @rokaslab.bsky.social, we evaluated glycolytic rates in 299 species using a newly developed ECAR assay. Genes retained by S. cerevisiae were highly expressed in Sat. dispora, indicating the CE of aerobic fermentation. link.springer.com/article/10.1...
link.springer.com
Convergent evolution of aerobic fermentation through divergent mechanisms acting on key shared glycolytic genes - The EMBO Journal
As the tree of life becomes increasingly accessible to molecular investigations, describing mechanisms underlying evolutionary convergence and constraint will be crucial to understanding diversificati...
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Linda Horianopoulos @linder-surprise.bsky.social · 13/04/2026
So pleased to share that this project identifying convergent evolution of aerobic fermentation in a poorly characterized genus of yeasts (Saturnispora) is now out in @embojournal.org @hittingerlab.bsky.social @rokaslab.bsky.social @glbioenergy.bsky.social link.springer.com/article/10.1...
link.springer.com
Convergent evolution of aerobic fermentation through divergent mechanisms acting on key shared glycolytic genes - The EMBO Journal
As the tree of life becomes increasingly accessible to molecular investigations, describing mechanisms underlying evolutionary convergence and constraint will be crucial to understanding diversificati...
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The EMBO Journal @embojournal.org · 10/04/2026
Convergent evolution of aerobic fermentation through divergent mechanisms acting on key shared glycolytic genes @hittingerlab.bsky.social , @linder-surprise.bsky.social et al show how distinct genetic routes can converge on the same genetic outcome link.springer.com/article/10.1...
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HittingerLab @hittingerlab.bsky.social · 26/02/2026
Congratulations to @maxhaase.bsky.social on his recent publication from his time in the Boeke Lab at NYU, where he used methods from the Y1000+ consortium! 🥳 We are very proud to have had him as an undergraduate student in our lab. med.nyu.edu/research/boe...
med.nyu.edu
Boeke Lab Team | NYU Langone Health
NYU Langone’s Boeke Lab comprises faculty, postdoctoral fellows, graduate students, and research staff who synthesize an engineered yeast genome.
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HittingerLab @hittingerlab.bsky.social · 04/02/2026
With the @rokaslab.bsky.social, three novel whole genome duplication (WGD) events were discovered in the Saccharomycotina yeast species in the Dipodascales clade. Before now, only four WGD events were known in fungi. This work suggests WGD may be underreported. www.sciencedirect.com/science/arti...
sciencedirect.com
Discovery of additional ancient genome duplications in yeasts
Whole-genome duplication (WGD) has had profound macroevolutionary impacts on diverse lineages,1,2 preceding adaptive radiations in vertebrates,3,4,5 t…
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HittingerLab @hittingerlab.bsky.social · 27/01/2026
We're excited to announce that Chris will be attending the Yeast Genetics Meeting organized by the Genetics Society of America (GSA) @genetics-gsa.bsky.social in CA on June 13-17! #Yeast26 If you are interested in attending or presenting, follow this link to register! genetics-gsa.org/yeast-2026/
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HittingerLab @hittingerlab.bsky.social · 23/01/2026
How much do growth morphologies in the Saccharomycotina subphylum vary? 🤔 With the @rokaslab.bsky.social, integrated datasets of 1,051 species were examined to assess filamentation evol. history and variation. ML models predicted morphologies with 70% accuracy. academic.oup.com/femsyr/advan...
media.tenor.com
a group of people are standing next to each other in front of a wall .
ALT: a group of people are standing next to each other in front of a wall .
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HittingerLab @hittingerlab.bsky.social · 15/01/2026
In collaboration with the Pfleger Lab, Josh Dietrich et al. investigated 2-ketoacid decarboxylase (KDC) substrate specificities to identify KDCs with preference for 2-ketoisovalerate over pyruvate. This work will help guide future S. cerevisiae engineering efforts. urldefense.com/v3/__http://...
urldefense.com
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HittingerLab @hittingerlab.bsky.social · 09/12/2025
Congratulations to our wonderful PI, Chris Todd Hittinger, on receiving the Vilas Mid-Career Investigator Award from the UW–Madison Laboratory of Genetics! This recognition highlights his continued excellence in research, teaching, training, and mentorship. 🎉 genetics.wisc.edu/2025/12/09/d...
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HittingerLab @hittingerlab.bsky.social · 08/12/2025
We were featured in the Yeast Newsletter, published in June and December every year with Western University, serving as an informal communication method for those interested in all things yeast-biology. Checkout pages 18-23! www.uwo.ca/biology/Yeas...
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HittingerLab @hittingerlab.bsky.social · 08/12/2025
New preprint with @rokaslab.bsky.social! We used genomic, metabolic, environmental, and phenotypic data sets from 1,154 Saccharomycotina strains to asses filamentation variability and predict filamentation types across the subphylum. 🧩 www.biorxiv.org/content/10.1...
biorxiv.org
The Macroevolution of Filamentation Morphology Across the Saccharomycotina Yeast Subphylum
Saccharomycotina yeasts are a highly diverse and widely distributed subphylum of ascomycete fungi that exhibit diversity in their asexual growth morphologies; the human commensal yeast Candida albican...
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Reposted by HittingerLab
Molecular Biology and Evolution @molbioevol.bsky.social · 25/11/2025
Gonçalves, @rokaslab.bsky.social @hittingerlab.bsky.social et al. surveyed 1,154 yeast genomes to examine gene repertoires linked to genome stability and elevated evolutionary rates, showing hypermutators persist across macroevolutionary timescales. 🔗 doi.org/10.1093/molbev/msaf285 #evobio #molbio
doi.org
Stable Hypermutators Revealed by the Genomic Landscape of Genes Involved in Genome Stability Among Yeast Species
Abstract. Mutator phenotypes are short-lived due to the rapid accumulation of deleterious mutations. Yet, recent observations reveal that certain fungi can
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HittingerLab @hittingerlab.bsky.social · 11/11/2025
New work led by members of the @rokaslab.bsky.social! ☺️ 1,154 yeast genomes in the Saccharomycotina subphylum were surveyed for their relationship between reduced gene repertoires broadly associated with genome stability functions and elevated evolutionary rates.🧬 academic.oup.com/mbe/advance-...
academic.oup.com
Stable hypermutators revealed by the genomic landscape of genes involved in genome stability among yeast species
Abstract. Mutator phenotypes are short-lived due to the rapid accumulation of deleterious mutations. Yet, recent observations reveal that certain fungi can
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HittingerLab @hittingerlab.bsky.social · 11/11/2025
With @linder-surprise.bsky.social and the @rokaslab.bsky.social, we recently expanded upon an analysis where glucose uptake rates were inversely correlated with the cell surface area-to-volume ratio, testing 282 species in the Saccharomycotina yeast subphylum. www.biorxiv.org/content/10.1...
biorxiv.org
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HittingerLab @hittingerlab.bsky.social · 07/10/2025
In a preprint with the @rokaslab.bsky.social , @linder-surprise.bsky.social developed a high-throughput extracellular acidification rate (ECAR) assay to evaluate glycolytic rate. We highlight how genetic traits, such as aerobic fermentation, can arise convergently with strong constraints. 🧬
biorxiv.org
Convergent evolution of aerobic fermentation through divergent mechanisms acting on key shared glycolytic genes
As the tree of life becomes increasingly accessible to molecular investigations, describing mechanisms underlying evolutionary convergence and constraint will be crucial to understanding diversificati...
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Reposted by HittingerLab
HittingerLab @hittingerlab.bsky.social · 07/10/2025
This work has also been featured on the DOE Science News Source initiative, Newswise, which promotes credible research news to the public. By publishing accessible summaries of recent studies that reach thousands of media outlets, it helps experts share their work with a broader audience.
newswise.com
Machine Learning Reveals Genes That Help Yeasts Resist Stress
Scientists used machine learning to analyze the genetic blueprints of hundreds of yeasts. This analysis allowed them to identify which groups of genes are most important for resistance to reactive oxy...
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HittingerLab @hittingerlab.bsky.social · 07/10/2025
We are honored to share that our work, led by @katarina-aranguiz.bsky.social and @linder-surprise.bsky.social, has been featured as a Science Highlight on the DOE's Office of Science website. 200 articles are selected annually to be highlighted. Check it out! 🧫 www.energy.gov/science/ber/...
energy.gov
Machine Learning Reveals Genes That Help Yeasts Resist Stress
Study provides a framework for connecting genetic mechanisms and trait variation across diverse yeast species.
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Linda Horianopoulos @linder-surprise.bsky.social · 06/10/2025
What started as a project characterizing variation in metabolic rates across yeasts turned into an interesting story about convergent evolution acting on the same key genes through distinct molecular mechanisms with @hittingerlab.bsky.social & @rokaslab.bsky.social. www.biorxiv.org/content/10.1...
biorxiv.org
Convergent evolution of aerobic fermentation through divergent mechanisms acting on key shared glycolytic genes
As the tree of life becomes increasingly accessible to molecular investigations, describing mechanisms underlying evolutionary convergence and constraint will be crucial to understanding diversificati...
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Linda Horianopoulos @linder-surprise.bsky.social · 05/09/2025
We often talk about THE whole genome duplication in yeasts, but we find new evidence of additional whole genome duplications in other yeast species! Check out this preprint led by @kylethedavid.bsky.social www.biorxiv.org/content/10.1...
biorxiv.org
Discovery of additional ancient genome duplications in yeasts
Whole genome duplication (WGD) has had profound macroevolutionary impacts on diverse lineages, preceding adaptive radiations in vertebrates, teleost fish, and angiosperms. In contrast to the many know...
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HittingerLab @hittingerlab.bsky.social · 17/09/2025
Checkout our new preprint with the @rokaslab.bsky.social!: www.biorxiv.org/content/10.1... doi: doi.org/10.1101/2025...
biorxiv.org
Discovery of additional ancient genome duplications in yeasts
Whole genome duplication (WGD) has had profound macroevolutionary impacts on diverse lineages[1][1],[2][2], preceding adaptive radiations in vertebrates[3][3]–[5][4], teleost fish[6][5],[7][6], and an...
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HittingerLab @hittingerlab.bsky.social · 04/09/2025
With the Opulente Lab at Villanova Univ., we describe a new yeast species: Lachancea rosae sp. nov. f.a., isolated from the hip bud of a wild California rose 🌹. This species unique traits adds to the biodiversity of the Lachancea genus. Open access article: onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Taxogenomic Analysis of a Novel Yeast Species, Lachancea rosae Sp. Nov. F.A., Isolated From the Wild Rose Rosa californica
The discovery, description, and taxogenomic analysis of a novel species of Lachancea revealed correlations between gene content and carbon and nitrogen physiological assays.
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Yeast Journal @yeast-journal.bsky.social · 02/09/2025
New #Yeast paper out from the series #FantasticYeasts!!! @hittingerlab.bsky.social , Dana Opulente & team describe a novel species, Lachancea rosae, isolated from the wild rose Rosa californica 🌹 onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Taxogenomic Analysis of a Novel Yeast Species, Lachancea rosae Sp. Nov. F.A., Isolated From the Wild Rose Rosa californica
The discovery, description, and taxogenomic analysis of a novel species of Lachancea revealed correlations between gene content and carbon and nitrogen physiological assays.
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HittingerLab @hittingerlab.bsky.social · 14/08/2025
We’re excited to share our latest paper, an international collaboration led by Katharina O. Barros and Jassim Al-Oboudi, describing Pichia senei sp. nov., a novel yeast species isolated from cactus necrosis and bromeliad phytotelmata in Brazil’s Cerrado ecosystem. 🌵🇧🇷
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Great Lakes Bioenergy Research Center (GLBRC) @glbioenergy.bsky.social · 11/08/2025
WE ARE #HIRING‼️ Join the @hittingerlab.bsky.social to study yeast evolution, ecology, and bioenergy applications of yeast species as a Research Associate. Apply by August 15 www.glbrc.org/about/job-op... #research #job
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HittingerLab @hittingerlab.bsky.social · 01/08/2025
Two more weeks to apply for this postdoctoral training position!📆
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HittingerLab @hittingerlab.bsky.social · 10/07/2025
We have an opening for postdoctoral training! Please apply by 15th August 2025 for full consideration. Here is the ad: hittinger.genetics.wisc.edu/People/Join/...
hittinger.genetics.wisc.edu
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HittingerLab @hittingerlab.bsky.social · 09/07/2025
In another fruitful collaboration with the @rokaslab.bsky.social, Hittinger Lab members @katarina-aranguiz.bsky.social and @linder-surprise.bsky.social , et al. established a ML framework to identify gene families in the yeast subphylum Saccharomycotina whose copy numbers predicted ROS resistance.
nature.com
Machine learning reveals genes impacting oxidative stress resistance across yeasts - Nature Communications
Yeasts are exposed to oxidative stress during routine metabolism, bioproduction, and interactions with other organisms. Here, the authors use a machine learning classifier to identify genes that are p...
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HittingerLab @hittingerlab.bsky.social · 02/07/2025
Congrats to @emuthemycologist.bsky.social for presenting her first talk at #MSAfungi25!
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HittingerLab @hittingerlab.bsky.social · 02/07/2025
Hey #MSAfungi25, check out @emuthemycologist.bsky.social's presentation "Galactose growth in the Saccharomycotina yeasts lacking the canonical GAL pathway" today at 3:45pm in the Genetics and Genomics session! @msafungi.bsky.social
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Miguel Morard @mmorard.bsky.social · 17/06/2025
Now @hittingerlab.bsky.social introducing their great applied projects.
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Miguel Morard @mmorard.bsky.social · 17/06/2025
Having fantastic days of Science with @stelkens.bsky.social and @hittingerlab.bsky.social in the @iatacsic.bsky.social. So inspiring. Great research and better persons ! Thanks to @dperisn.bsky.social @fungialab.bsky.social for organizing it.
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HittingerLab @hittingerlab.bsky.social · 06/06/2025
Convergent evolution occurs when similar traits arise independently in different lineages. In collaboration with the @rokaslab.bsky.social at Vanderbilt University, we studied the convergent evolution of metabolic traits and gene families in 993 Saccharomycotina yeasts. www.pnas.org/doi/10.1073/...
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Great Lakes Bioenergy Research Center (GLBRC) @glbioenergy.bsky.social · 27/05/2025
Graduate student Sam Davison is the recipient of the 2025 GLBRC Outreach & Education award for his dedication to programming and outreach events! Davison is a regular volunteer at outreach events where he builds connections through imagination and creativity. Huge congrats, Sam!
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Kyle T David @kylethedavid.bsky.social · 04/06/2025
How many paths lead to evolutionary innovation? How versatile are genomic toolkits? Excited to announce my new @pnas.org paper addressing these questions in collaboration with @rokaslab.bsky.social, @hittingerlab.bsky.social, and the Pennell lab! www.pnas.org/doi/10.1073/...
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FunGIALab @fungialab.bsky.social · 02/06/2025
🧬 Microbial Marvels: Biodiversity & Evolution of Yeasts Top scientists @hittingerlab.bsky.social & @stelkens.bsky.social reveal how yeasts evolve, adapt, and speciate. @uv.es @upv.es Don’t miss this inspiring workshop! 📅 June 16 📍 @iatacsic.bsky.social🔗https://bit.ly/4mytSC2 #YeastScience
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CanFunNet @canfunnet.bsky.social · 23/05/2025
Register for the 5th Virtual CanFunNet Conference: From Local to Global. Join us August 6 - 8th for an amazing line of Plenary Speakers and awesome topics in fungal research. Submit your abstracts by Friday, May 30!
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HittingerLab @hittingerlab.bsky.social · 27/05/2025
Just out - a collaborative effort examining gene family evolution across yeast species. We found that fast-evolving yeasts lose more genes - especially ones for splicing, metabolism, and cell division. This is consistent with their narrow metabolic niche breadth. www.embopress.org/doi/full/10....
embopress.org
Unique trajectory of gene family evolution from genomic analysis of nearly all known species in an ancient yeast lineage | Molecular Systems Biology
imageimageLarge-scale comparison of gene families across 1154 Saccharomycotina genomes revealed that gene gains and losses drive yeast evolution. Faster-evolving lineages lose more genes and speciate ...
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HittingerLab @hittingerlab.bsky.social · 23/05/2025
Check out the latest issue of the Yeast Newsletter: urldefense.com/v3/__https:/... In this issue there are announcements about recent research, upcoming meetings, and excerpts from the newsletter 50 years ago!
urldefense.com
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HittingerLab @hittingerlab.bsky.social · 23/05/2025
Taxogenomics allowed us to evaluate a large collection of Torulaspora isolates and formally describe 12 new species! This was an exciting collaborative project by researchers from 3 continents! See our new paper in Persoonia @westerdijkinst.bsky.social www.ingentaconnect.com/content/nhn/...
ingentaconnect.com
A taxogenomic view of the genus T...n from ten to twenty-two species: Ingenta Connect Fast Track Article
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