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Melanie Blokesch

@mblokesch.bsky.social
2.5K followers 413 following 195 posts

Professor of Life Sciences @EPFL_en. Passionate about science 🤩 Views are my own.

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Reposted by Melanie Blokesch
Dorentina Humolli @humollidorentina.bsky.social · 25/09/2026
Very happy to share that HIDEN-SEQ is now out in @natmicrobiol.nature.com! Using this technique, we recapitulated decades of established phage genetics and uncovered new gene functions, including previously unknown anti-defense factors against several defense systems. www.nature.com/articles/s41...
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Alexander Harms @aharms485.bsky.social · 25/09/2026
The final version of our manuscript on TnSeq in bacteriophages (“HIDEN-SEQ”) is out today – if you have an interesting phage phenotype and want to know the underlying genetic basis, this one is for you! 1/4
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Giovanni D’Angelo @giodang.bsky.social · 23/09/2026
#lipidtime: It's a lipid universe. Today in Nature we publish the Lipid Brain Atlas, the first map of membrane lipid composition across the entire mouse brain, a layer of organisation that cell-type and transcript maps had left out. #lipidomics #neuroscience #BrainAtlas
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Swiss National Science Foundation (SNSF) @snsf.ch · 22/09/2026
🏆 Biochemist Martin Jinek is the winner of the Swiss Science Prize #MarcelBenoist 2026, considered the Swiss #Nobel Prize. He contributed to the development of molecular scissors, namely CRISPR-Cas9 technology. Read more ➡️ sohub.io/3hs4
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Zamin Iqbal @zaminiqbal.bsky.social · 20/09/2026
Yes! Wonderful! also , can't resist, we proposed the same model (we called it fusion- fragmentation) in our paper on the Murray collection, where we look at how those plasmids end up in fusions, or fragmented. www.science.org/doi/10.1126/...
science.org
Pre- and postantibiotic epoch: The historical spread of antimicrobial resistance
Plasmids are now the primary vectors of antimicrobial resistance, but our understanding of how human industrialization of antibiotics influenced their evolution is limited by a paucity of data predati...
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Gc Rox @gcrox.bsky.social · 12/09/2026
Postdoctoral position studying Neisseria gonorrhoeae genetics, genomics, physiology, or pathogenesis. Please email h-seifert@northwestern.edu or apply at careers.northwestern.edu/psp/hrnu_er/... Please Repost
careers.northwestern.edu
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Reposted by Melanie Blokesch
Nature Microbiology @natmicrobiol.nature.com · 03/09/2026
Out Now! High-throughput recovery of integron cassettes for gene discovery screens #MicroSky
go.nature.com
High-throughput recovery of integron cassettes for gene discovery screens
Nature Microbiology, Published online: 03 September 2026; doi:10.1038/s41564-026-02474-5Integron insertion sites engineered into counterselection markers allow large-scale and high-throughput capture of integron-encoded genes from genetically tractable bacteria or DNA samples.
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Filipa Trigo da Roza @filipatr.bsky.social · 03/09/2026
It’s out! 🥹🎉 We’re so incredibly happy and proud to see this work out in the world. And once again, a huge thank you to the great mastermind @jaescudero.bsky.social and all the co-authors; this wouldn’t have been possible without you! doi.org/10.1038/s415... @natmicrobiol.nature.com
doi.org
High-throughput recovery of integron cassettes for gene discovery screens - Nature Microbiology
Integron insertion sites engineered into counterselection markers allow large-scale and high-throughput capture of integron-encoded genes from genetically tractable bacteria or DNA samples.
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Jose A Escudero @jaescudero.bsky.social · 03/09/2026
Filipa, you did an amazing job in the delivery. We went through a lot together to make it work, indeed. But you did great! And our collaborators took it to the next level. Thanks to @mblokesch.bsky.social @mredrejo.bsky.social and @lopezigual.bsky.social!! But Filipa, you are the star!🌟 Tiramisu!!!
static.klipy.com
Tiramisu Bread Dessert with Fork
ALT: Tiramisu Bread Dessert with Fork
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Institute of Science and Technology Austria (ISTA) @istaresearch.bsky.social · 02/09/2026
Congratulations to ISTA’s @jpkbravo.bsky.social​, named a 2026 Vallee Scholar! 🎉 The award supports innovative, curiosity-driven biomedical research. Bravo’s lab studies bacterial immune systems and how they distinguish self from non-self. Read more: shorturl.at/FyLbw
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Jan-Willem Veening @veeninglab.com · 26/08/2026
The 2026 paper's core observation is that MapZ sets plane orientation, not midcell selection, and the chromosome supplies the underlying spatial information. This is exactly the central claim of our 2017 paper...
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Tracy Palmer @proftracypalmer.bsky.social · 25/08/2026
Happy to see this work preprinted! Only our second foray into the mycobacterial T7SS
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Paul Rainey @paulbrainey.bsky.social · 21/08/2026
A third-year student draws poster PS3.20.305 -- far corner, farthest wall -- and commits to standing there two hours. Barely anyone makes it that far. Two floors up, a senior colleague is having the week of his life. Same conference. A new essay. academicrenewal.substack.com/p/why-we-sti...
academicrenewal.substack.com
Why we still fly
The scientific conference was invented to solve a transport problem we no longer have. What is it for now?
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Cell Host & Microbe @cp-cellhostmicrobe.bsky.social · 22/06/2026
CBASS limits phage at no expense A CBASS type encoding a phospholipase (CapV) effector limits the late stage of phage replication while maintaining Pseudomonas aeruginosa cell viability. CBASS limits packaged phage DNA, reducing virion production www.cell.com/cell-host-mi...
cell.com
CBASS limits bacteriophage production while maintaining cell viability in Pseudomonas aeruginosa
Huiting, Shmidov, et al. report on a CBASS type encoding a phospholipase (CapV) effector that can successfully limit the late stage of phage replication while maintaining cell viability, rather than i...
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Nicole Dubilier @nicoledubilier.bsky.social · 13/08/2026
Hiding in plain sight: Animals eat the natural bioplastic PHA We discovered that many animals can break down PHA. And many of these enzymes had been sitting unnoticed in genome databases. www.nature.com/articles/s41...
nature.com
Animal degradation of microbial storage polyhydroxyalkanoates - Nature Ecology & Evolution
This study shows that the degradation of microbial storage polyhydroxyalkanoates is not just restricted to microorganisms by finding that some animals also have the enzymes required to break down thes...
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Jackie Knee @jackieknee.bsky.social · 12/08/2026
Job alert! Join our fantastic cholera research team & work with colleagues at LSHTM, University of Geneva, & DRC. Closing August 30. Details and application here: jobs.lshtm.ac.uk/vacancy.aspx... @lshtm-ehg.bsky.social @gddynamics.bsky.social @lshtm.bsky.social @lshtmamrcentre.bsky.social
jobs.lshtm.ac.uk
Job Opportunity at LSHTM: Research Fellow
The London School of Hygiene & Tropical Medicine (LSHTM) is one of the world’s leading public health universities. Our mission is to improve health and health equity in the UK and worldwide; working i...
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Landon Getz @landongetz.bsky.social · 06/08/2026
DNA glycosylases are repair enzymes, essential to all cellular life. They find chemically damaged bases and remove them so DNA can be repaired. Today in Nature Microbiology, we show bacteria have repeatedly repurposed them into antiviral immune systems 🧵 www.nature.com/articles/s41...
nature.com
Antiviral defence is a conserved function of diverse bacterial DNA glycosylases - Nature Microbiology
DNA glycosylases, typically used for DNA repair, can also protect bacteria against phages that would otherwise evade host immunity by incorporating modified bases into their genomes.
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Paul Rainey @paulbrainey.bsky.social · 04/08/2026
I'm not allowed to boil a kettle in my office; the electricity is public money. This rule can be justified in a sentence. Most of what lands on my desk has never had to be. New post on unnecessary bureaucracy. academicrenewal.substack.com/p/the-one-wa...
academicrenewal.substack.com
The one-way audit
Researchers are required to account for their time and money. Administrative procedures rarely include any account of the research time they consume.
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Dr. Lucky Tran @luckytran.com · 29/07/2026
Record outbreak of diarrhea-causing parasite 20M eggs recalled due to salmonella Worst air quality in world from wildfire smoke UN says world risks HIV resurgence due to funding cuts Most measles cases in 35 years They’re going after Fauci to distract you from current public health failures
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Vivek Mutalik @vivekmutalik.bsky.social · 29/07/2026
🎉final print version in PLOS Genetics @sullivan-lab.bsky.social @biosci.lbl.gov journals.plos.org/plosgenetics...
journals.plos.org
Cross-family and phage-specific gene requirements for Klebsiella infection revealed by scalable RB-TnSeq genetic screens
Author summary Bacteriophages, or phages, are viruses that infect bacteria and play central roles in shaping microbial communities across ecosystems. Despite their ecological importance, the bacterial...
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ProPublica @propublica.org · 28/07/2026
John Gai carried his sick father to a nearby clinic in a wheelbarrow, but he died from cholera on the way. Gai then pushed the wheelbarrow for hours through the camp to take him to the cemetery: “Nobody should have to carry a dead body among the living.” (Published December 2025)
propublica.org
Trump Officials Celebrated With Cake After Slashing Aid. Then People Died of Cholera.
Behind closed doors in Washington, top advisers made a series of decisions that had devastating repercussions for the poorest country on earth. We went to South Sudan and found people who died as a re...
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Infect-Net @infect-net.bsky.social · 27/07/2026
Remember to register for our 7th Infect-Net network meeting in Würzburg. Registration Deadline is 31.08.2026 Registration link: www.hygiene.uni-wuerzburg.de/formulare/7t...
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Kai Kupferschmidt @kakape.bsky.social · 24/07/2026
Another massive jump in Ebola cases in DRC (reflecting new cases as well as "data harmonization"). Now 2,905 cases including 1,269 deaths. I find it harder every day to square the size and speed of spread of this outbreak with the lack of attention it is getting. insp.cd/sitrep-n069-...
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sbulgheresi.bsky.social @sbulgheresi.bsky.social · 22/07/2026
Our new preprint is out! We investigate chromosome organization in obligate mammalian symbionts and show that these bacteria maintain stable chromosome orientations while displaying conserved lifestyle-associated chromosome architectures across species. www.biorxiv.org/cgi/content/...
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Rafael Pinilla-Redondo (Rafa) @rafomics.bsky.social · 21/07/2026
1/4 Every good defence needs a backup! 🛡️⚔ Out now in @natrevmicro.nature.com our Comment on "𝗶𝗺𝗺𝘂𝗻𝗲 𝘀𝗮𝗳𝗲𝗴𝘂𝗮𝗿𝗱𝗶𝗻𝗴"! 🎉 🔗 www.nature.com/articles/s41...
nature.com
Immune safeguarding as a conserved principle of antiviral defence - Nature Reviews Microbiology
All organisms defend against viral infections through active immunity mechanisms that clear the virus or population-level mechanisms that cause regulated cell death. Recent research increasingly shows...
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Aude Bernheim @audeber.bsky.social · 21/07/2026
Out @cp-cellhostmicrobe.bsky.social, natural products meet bacterial immunity! We used genomics to identify lanthivirins: a family of >2,000 lanthipeptide BGCs that protect Actinobacteria against phages. Led by @hshomar.bsky.social & @mariegllm.bsky.social www.sciencedirect.com/science/arti...
sciencedirect.com
A family of lanthipeptides with anti-phage function
Bacteria produce natural products to adapt to their environments, with phage interactions as major ecological and evolutionary drivers. While some nat…
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Rafael Pinilla-Redondo (Rafa) @rafomics.bsky.social · 16/07/2026
1/10 🚨Preprint! One RING to rule them all (phages)👑💍⚔️ Bacteria build giant DNA-scaffolded RNase rings (larger than the ribosome!) to shut down viral infection🧬🧵👇 biorxiv.org/content/10.6...
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Sorek Lab @soreklab.bsky.social · 09/07/2026
Our paper out in Science today: The Metis defense system senses molecular byproducts released when a phage degrades the bacterial genome, and then prevents replication of the phage in the infected cell Congratulations @ostermanilya.bsky.social and co-authors!
science.org
Bacteria sense virus-induced genome degradation via methylated mononucleotides
Phages often degrade the genome of their bacterial host to individual nucleotides. Here we describe Metis, a bacterial defense system that directly senses phage-mediated host genome degradation. Metis...
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Géraldine Laloux @lalouxlab.bsky.social · 09/07/2026
New preprint! We show that the bacterial predator B. bacteriovorus deploys a unipolar Tad nanomachine for irreversible attachment to prey and invasion. @coralietesseur.bsky.social used CRISPRi+microfluidics to overcome barriers associated with essential systems in an obligate predatory lifestyle 🦠
biorxiv.org
A polarity-controlled Tad nanomachine enables prey invasion in a bacterial predator
Type IV pili are dynamic surface appendages assembled by envelope-spanning nanomachines that mediate diverse bacterial interactions, yet how these systems are adapted to predatory lifestyles remains p...
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Kimberly Kline 🏔 @kimingeneva.bsky.social · 09/07/2026
🚨Join us at the University of Geneva! We're seeking an outstanding junior researcher to apply for an ERC or SNSF Starting Grant with our institutional support in host–pathogen interactions, bacteriology, virology, parasitology, or mycology. www.unige.ch/medecine/mim... Please share!
unige.ch
Open call : MIMOL Junior Group Leader’s application for a Starting Grant - Microbiology and molecular medicine - UNIGE
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Paula Navarro @navarropaula.bsky.social · 03/07/2026
🚨 New in @natmicrobiol.nature.com! We reveal how the antibiotic target PBP1b fortifies the E.coli division site against osmotic rupture. Proud this was completed in our independent labs @dmf-unil.bsky.social, with @avettiger.bsky.social. Congratulations to all authors! 🦠❄️🔬 #teamtomo bit.ly/3SCbOg1 👇
doi.org
The penicillin-binding protein PBP1b fortifies the Escherichia coli division site against osmotic rupture - Nature Microbiology
A specific isoform of PBP1b functions independently of the activator protein, LpoB, to drive generation of a wedge-like peptidoglycan structure that strengthens the division site in Escherichia coli.
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Melanie Blokesch @mblokesch.bsky.social · 02/07/2026
Thanks to my lab for the b'day cake🎂 & gifts!🥰 Aperol🍹+chocolate🍫(they know me way too well!)-plus promising new data🤓 Tuesday was also my last day before rotating off my Institute Directorship, so hopefully more time back at the bench... assuming turning 5️⃣0️⃣ doesn't immediately come with back pain 😂
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Emma Slack @mucosalimmunology.bsky.social · 01/07/2026
We are recruiting a lab manager for my group in Oxford. This is a lovely team doing great things, and you could be an important part of it! See here: www.path.ox.ac.uk/vacancy/lab-... Please spread the word!
path.ox.ac.uk
Lab Manager - Molecular Immunology - Dunn School
Laboratory Manager/Senior Scientist position in the Molecular Mucosal Immunology group at Oxford
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Melanie Blokesch @mblokesch.bsky.social · 29/03/2026
Open postdoc position in my lab on HGT and interbacterial competition. We seek candidates with a PhD in microbiology (or related fields)+ strong 1st-author publications. Curious, highly motivated, and dedicated team players ready to contribute fully are encouraged to apply. Details: tiny.cc/cz01101
tiny.cc
Open Positions
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brunolemaitre.bsky.social @brunolemaitre.bsky.social · 17/06/2026
A short, informal intro to Drosophila genetics (with a French accent 🇫🇷): key concepts & techniques for new lab members. www.epfl.ch/labs/lemaitr...
epfl.ch
Short Introduction to Drosophila_Engl
If you like French accent:A short and informal introduction to Drosophila genetics, covering the basic knowledge and techniques that may be helpful when working with Drosophila. This series of short l...
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Tracy Palmer @proftracypalmer.bsky.social · 24/06/2026
Check out our latest T7SS toxin story. These reverse toxins aren’t as rare as we thought!
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Patrick Moynihan @pmoyniha.bsky.social · 24/06/2026
New paper in collaboration with @proftracypalmer.bsky.social, @lislowe.bsky.social and many more. We show that mycobacteria produce Type VII secreted anti-bacterial protein toxins. Excited to explore this new area of mycobacterial biology. www.nature.com/articles/s41...
nature.com
A Type VII-secreted toxin enables inter-mycobacterial competition - Nature Communications
Mycobacteria have not yet been reported to engage in interbacterial competition via secretion of proteinaceous toxins. Here, Benedict et al. show that some mycobacteria can use their type-VII secretio...
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Harmit Singh Malik @harmitmalik.bsky.social · 24/06/2026
I know it seems like a heretical idea, but one way to figure out if a preprint is really interesting (to you) is... to read the preprint. Then, in the spirit of sharing, send a note to authors: a simple kudos or a more detailed question. I do this a dozen times a year. It's awesome. Try it.
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Gc Rox @gcrox.bsky.social · 23/06/2026
Are restriction/modification modules only used for host defense? @selmamhm.bsky.social shows an alternative use. "Restriction-modification systems are required for Neisseria gonorrhoeae pilin antigenic variation" www.pnas.org/doi/10.1073/pnas.2602688123 #Microd #Microsky. #Microbiology
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Emmanuele Severi @emmseveri.bsky.social · 11/06/2026
#microsky #phagesky #phage #synbio www.nature.com/articles/s41...
nature.com
Synthetically designed anti-defense proteins overcome barriers to bacterial transformation and phage infection - Nature Communications
Bacterial defense systems act as barriers to phage infection and plasmid transformation. Here, Garb et al. designed synthetic proteins that disable bacterial defense systems, enabling phages to infect...
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Malcolm White @mfwhite2.bsky.social · 23/06/2026
Abi is over-diagnosed
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Lucas A. Meirelles @la-meirelles.bsky.social · 23/06/2026
Our newest preprint is out! 🧫 Can pathogens affect epithelial regeneration? And if so, what are the consequences for the tissue and pathogen physiology? We used pyocyanin, a Pseudomonas aeruginosa metabolite, to start addressing this. www.biorxiv.org/content/10.64898/2026.06.15.732350v1 🧵
biorxiv.org
Pyocyanin disrupts airway regeneration to favor chronic Pseudomonas aeruginosa infection
During chronic infections, host tissues undergo repeated cycles of injury and repair while being exposed to bacterial products. Although many virulence factors trigger immune responses, whether bacter...
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Jesse Shapiro @bjesseshapiro.bsky.social · 15/06/2026
How useful are phages in explaining cholera disease severity? Accordingly to our latest little paper, possibly quite useful — up there with patient age and hospital location, and possibly more important than antibiotic exposures!
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Science Magazine @science.org · 09/06/2026
"The real work is not convincing myself I belong …. Instead, the challenge is rewiring my own perspectives and my responses to the subtle and persistent messages telling me I’m not what a professor looks like." #ScienceWorkingLife scim.ag/4xdo4TI
An illustration of a woman looking at herself in two mirrors, in one she looks small and in the other she looks life size. The text reads: I may not ‘look like’ a professor, but now I know I belong
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Patricia Bernal @pbernalt6ss.eurosky.social · 31/05/2026
Excessive paperwork and inefficient systems are sabotaging scientific progress. Really proud to be part of this global manifesto spearheaded by @kentimmis.bsky.social. We need action at all levels to tackle the root causes. Our analysis & proposals @microbiotech.bsky.social: doi.org/10.1111/1751...
doi.org
Scientists' Warning to Humanity: Unnecessary Bureaucracy Is a Global Impediment to Productivity, Advancement of Human and Planetary Wellbeing, Science and Sustainability
Unnecessary bureaucracy is a global impediment to progress and productivity that increases stress and lowers workplace morale and motivation. In research it smothers creativity and innovation that ar....
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Melanie Blokesch @mblokesch.bsky.social · 28/05/2026
Super happy to have hosted Jack @jpkbravo.bsky.social this week for our Institute's seminar series. Fantastic presentation with exciting work currently ongoing in this lab 👏. Thanks so much for the visit, Jack 🤩!!!
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Didier Mazel @amazeld.bsky.social · 28/05/2026
A great opportunity! www.linkedin.com/pulse/join-u...
linkedin.com
Join us in Paris: Systems and Synthetic Biology x AI and health - Inserm Tenuring Position and Starting Package
I'm delighted to announce that we - ELiS Lab / Inserm U1338 at the nascent Paris Biofoundry and the Computational, Quantitative, Synthetic Biology Dept. at the Sorbonne Université - are recruiting an ...
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Jakob T Rostøl @jakob-tr.bsky.social · 20/05/2026
Like a prophage being awakened from its slumber, the phage field has seen a lot of renewed activity during the last decade. Check out our new @natrevmicro.nature.com review on the temperate phage life cycle here to stay up-to-date 🧫🦠 www.nature.com/articles/s41...
nature.com
Revisiting the life cycle of temperate phages - Nature Reviews Microbiology
The life cycle of temperate bacteriophages involves lytic or lysogenic cycles and has historically served as a model for studying genetic regulation. This Review provides an updated overview of these ...
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Sonja-Verena Albers @archaellum.bsky.social · 20/05/2026
New preprint! Cell division has to happen at the right place but how Archaea pick that place is unknown. We now identified a three-protein system, Dip, that positions the divisome at midcell in H. volcanii and is broadly conserved across Archaea. A thread 🧵 www.biorxiv.org/content/10.6...
biorxiv.org
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Julia Frunzke @frunzkelab.bsky.social · 18/05/2026
Registration opened for our International Symposium of SPP 2330! This is going to be phage-tastic meeting in Berlin! Highlight of the second funding period! @spp2330.bsky.social, @dfg.de
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