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This #FluorescenceFriday we have an Endosome sorting itself out! 37min of PI(3)P (green) positive sorting endosome with fluorescent Transferrin in Magenta. The sorting of Transferrin is tightly interlinked with PI(3)P intensity. Soon we will publish how cargo sorting controls PI(3)P levels!

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Hannes Maib @maiblab.bsky.social · 01/10/2026

Hopefully the reputational damage of being on the front line international news will make @healthcare.nikon.com reconsider how they deal with this disgrace to the microscopy community and their inaptitude to adhere to their own rules www.bbc.co.uk/news/article...

bbc.co.uk

Tiny image sparks big backlash in Nikon photo contest

Dr Ning Xu denies he broke the rules of Nikon's annual Small World In Motion contest.

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Hannes Maib @maiblab.bsky.social · 19/09/2026

It’s amazing how much some mathematical modelling can add to a cell biology problem. When I hired my first postdoc two years ago I took a bit of a gamble by hiring someone with computational background and little wet lab experience and I think it’s was the best decision ever.

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Hannes Maib @maiblab.bsky.social · 26/08/2026

Finally reached the point where I completely hate the paper I have been writing and working on for the last three years! This means we must be getting close....

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Hannes Maib @maiblab.bsky.social · 15/07/2026

I know I am probably very late to realising this but I really don’t like the layout of @embojournal.org website since they joined with springer. Makes it look just like another run down the mill Springer journal and has lost its own identity

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Hannes Maib @maiblab.bsky.social · 11/06/2026

Starting to write up the first mechanistic paper from my lab about regulation of endosomal PI(3)P. We see retromer tubules (Vps35) budding from PI(3)P positive sorting endosomes with Actin at the neck. When PI(3)P homeostasis is perturbed this organisation breaks down and cells cant recycle cargo.

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Hannes Maib @maiblab.bsky.social · 29/05/2026

Nothing better for procrastination than going through some live cell imaging of Endosomes... Today we have the fusion of two equally sized PI(3)P positive endosomes. This is at 5s framerate, wish I had taken it at higher temporal resolution but still super cool to see

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Hannes Maib @maiblab.bsky.social · 09/05/2026

How do Endosomes dance? Looks like a waltz? Or maybe the more of a cèilidh? Cells expressing the PI(3)P probe imaged every 5s for ~15min. Currently preparing a really exciting paper about the regulation of endosomal PI(3)P homeostasis. Stay tuned!

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Hannes Maib @maiblab.bsky.social · 01/04/2026

Starting to put together an exciting paper about endosomal membrane identity and PowerPoint's AI knows exactly what I am up to: "A collage of different spots". Sums up this whole paper pretty well 😅

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Hannes Maib @maiblab.bsky.social · 30/01/2026

Great resource and evaluation on everything to do with preprints in the life sciences! Preprints have been transformational and there is a lot of good work being done at @ripplingideas.bsky.social !

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Hannes Maib @maiblab.bsky.social · 21/01/2026

Imaging phosphoinositides during mitosis ! Cells stained against PI(4,5)P2 using recombinant biosensors (tinyurl.com/447fabz8) PI(4,5)P2 is up regulated for cortex-membrane attachment. Also notice the membranes being shed and taken up by non-mitotic bystanders. #blebbisomes @mag2art.bsky.social?

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Dr Helen Weavers @helenweavers.bsky.social · 19/01/2026

We're hiring! Enjoyed @jackholcombe.bsky.social PhD Prize talk @edrc2025.bsky.social @fly-eds.bsky.social? We're recruiting a #postdoc to explore how cell biology is patterned in the #Drosophila renal system. Come join us for live-imaging, molecular cell biology and omics! Deadline 25th January.

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Fran Bottanelli @franbottanelli.bsky.social · 06/01/2026

Early bird deadline in 10 days!! This is going to be amazing!

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Lisa Smith @plantylisasmith.bsky.social · 05/01/2026

Two days left to apply for a PhD position in plant development with me, Sam Amsbury and Andrew Fleming!!

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Hannes Maib @maiblab.bsky.social · 23/12/2025

While this does not solve the underlying issues with for-profit entities exploiting the free labour of academics, it does make my life easier in the short term. At the moment funders require me to publish open access while refusing to pay for the APC (a bit of a catch22). So this will help with that

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Fran Bottanelli @franbottanelli.bsky.social · 03/12/2025

#membrane seminars are back this THURSDAY for a super session with @dr-downes.bsky.social from the @giuliazanetti.bsky.social lab and Xin Zhou from the Ikonen lab! @felixmendu.bsky.social @ishier.bsky.social

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Hannes Maib @maiblab.bsky.social · 23/11/2025

This is making the rounds and people are be worried about fake data being published. I don’t see the point. All data can already be faked. All graphs and numerical data can freely be made up. Controls and samples can be switched. If we can trust scientists and institutions we might as well stop.

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Hannes Maib @maiblab.bsky.social · 22/09/2025

Really glad to show our recent work using recombinant phosphoinositide probes to investigate membrane identity changes during endosomal trafficking. Should be a great mini symposium to highlight the power of fluorescent microscopy techniques for cell biology!

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Max Planck Institute for Medical Research @mpi-mr.bsky.social · 03/07/2025

📣Paper alert! Interested in faster and brighter protein labeling than before? 👀 @steffi-k.bsky.social & other colleagues have developed an improved tool for labeling proteins with synthetic fluorophores for bioimaging. Also works in STED microscopy 🤩🔬 Congratulations!🥳 www.nature.com/articles/s41...

nature.com

SNAP-tag2 for faster and brighter protein labeling - Nature Chemical Biology

SNAP-tag is a widespread tool for labeling protein for bioimaging. Now, Kühn et al. report SNAP-tag2 with increased labeling kinetics and brightness, which translates into a better performance in live...

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Hannes Maib @maiblab.bsky.social · 19/05/2025

In all my interactions with @jacoates.bsky.social I can vouch for his sincere commitment and drive towards open science and engagement. Moving on from his role with ASAPbio will be a great opportunity for whomever he will work with next!

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European Commission @ec.europa.eu · 08/05/2025

Choose Science. Choose Europe. A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open. With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond. Apply by 10 September → europa.eu/!fBTMgF

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Martin Loose @nartimsoole.bsky.social · 10/04/2025

Looking for a student or postdoc! Want to combine evolutionary analysis + structural modeling with in vitro biochemistry & fluorescence microscopy? Help us uncover new protein-protein interactions — from in silico to in vitro. Join us at @istaresearch.bsky.social 👉 looselab.org 🧬💡🔬🎡

looselab.org

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Andreas Prokop @poppi62.bsky.social · 10/04/2025

If using Bloomigton #Drosophila Stock Center stocks, pls. acknowledge them & their NIH funding (P40 OD018537). Papers listing this no. are being harvested as evidence. We massively depend on the @bdsc.bsky.social & they need our support in these dire times! @flybase.bsky.social @fly-eds.bsky.social

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adam grieve @adamgrieve.bsky.social · 09/04/2025

Pls re-skeet! There's a postdoc job available to join us in Bristol! We're looking for a molecular cell biologist to help us investigate plasma membrane proteostasis in neurons. Apply here by 23 April: www.jobs.ac.uk/job/DMO097/r.... If interested, do contact me and check out grieve-lab.com! Thanks!

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Hannes Maib @maiblab.bsky.social · 07/03/2025

Only 10 days left to apply! We are looking for a passionate protein biochemist for the reconstitution of lipid kinases. We have long term funding and you will be trained in the use of supported lipid bilayers. If you are interested just get in touch or apply directly!

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Hannes Maib @maiblab.bsky.social · 26/02/2025

First time playing around with single molecule STORM imaging of PI3P on endosomes using recombinant biosensors. This was great fun with our new fellow Ruby Peters and I see lots of potential for this in the future!

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Hannes Maib @maiblab.bsky.social · 21/02/2025

🚨Long term postdoc position available on the reconstitution of lipid kinases!🚨 Do you have a passion for protein reconstitution and lipid signalling? You will reconstitute lipid kinases from eukaryotic expression systems to determine their kinetic regulation. www.jobs.ac.uk/job/DLW981/r...

jobs.ac.uk

Research Associate in Reconstitution of Lipid Kinases at University of Sheffield

An opportunity for an academic position as a Research Associate in Reconstitution of Lipid Kinases is available, as advertised on jobs.ac.uk. Apply now and explore other academic job openings.

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Fran Bottanelli @franbottanelli.bsky.social · 12/11/2024

Registration is open for the 2025 iteration of the wonderful @EMBOevents workshop on cell polarity and membrane dynamics #EMBOcellPolarity25 I am organizing with Ed Munro! Wonderful lineup wonderful please please sign up and share! meetings.embo.org/event/25-cel...

meetings.embo.org

Cell polarity and membrane dynamics

The ability of cells to polarize is essential for organismal development and physiology, and its impairment underlies numerous diseases. The establishment and maintenance of cell polarity requires a …

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Hannes Maib @maiblab.bsky.social · 11/12/2024

Incredibly honoured to have my first paper as PI highlighted in this collection! The idea was do a quick tool paper as my start into independence and it turned out to be much more useful than I thought. Read about how to use recombinant biosensors to stain for lipids in fixed cells!

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Hannes Maib @maiblab.bsky.social · 10/12/2024

I want to share one of my favourite #microscopy images with you all: Epithelial cells in a monolayer (NMuMG) after undergoing EMT stained for N-Cadherin and actin show beautifully interdigitated cell junctions. Bonus points for spotting the actin asters ⭐

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Stephane Vassilopoulos @stefvass.bsky.social · 03/12/2024

Clathrin-coated pits, plaques, and adhesion... This post is dedicated to Christien Merrifield, who left us far too soon around this time in 2017. His memory continues to inspire 🔬 doi.org/10.1016/j.js...

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the Node @the-node.bsky.social · 26/11/2024

*Last few days to apply!* We're looking for a #DevBio researcher interested in gaining #SciComm experience to join us at @biologists.bsky.social Biologists @ 100 conference. We're open to any ideas💡If selected, we'll work with you to develop your ideas and assist you at the conference. More info👇

thenode.biologists.com

Apply to become a reporter at the Biologists @ 100 conference! - the Node

Keen to get more science communication experience? Is your research related to developmental and stem cell biology? The Node is looking for a reporter to attend and report from the Biologists @ 100 co...

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ASAPbio @asapbio.bsky.social · 28/11/2024

#Preprints allowed @maiblab.bsky.social ✍️ disseminate research to the community 🗯️ get valuable information about how well it is received 💡 highlight to journals that there is a strong interest in Hannes' work 📄 made it easier to get past the editor's desk

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Natalie Thiex @thiex.bsky.social · 23/11/2024

Trying this out for #fluorescencefriday. 🧪 AktPH through an isosurface mesh of the plasma membrane. From this lattice lightsheet collaboration with @minesbioimaging.bsky.social: www.nature.com/articles/s41...

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David Drubin @drubin.bsky.social · 23/11/2024

Congratulations to Meiyan Jin on her beautiful publication out today. www.sciencedirect.com/science/arti...

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Haucke lab @volkerhaucke-lab.bsky.social · 22/11/2024

Great opportunity for postdocs interested in molecular neuroscience/ biochemistry to study presynapse formation in human neurons funded by the ERC (see www.leibniz-fmp.de/haucke; Rizalar et al Haucke (2023) Science). We are a certified green lab. Apply now to haucke@fmp-berlin.de before 5 Dec 2024.

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Hannes Maib @maiblab.bsky.social · 18/11/2024

In my first real post I want to show the key experiment that revealed to me what I want my own lab to be about: The conversion of phosphoinositides! By using fluorescent biosensors and membrane coated beads I was able to reconstitute the real time kinetics of PI(4)P to PI(4,5)P2 conversion by PIP5K

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Hannes Maib @maiblab.bsky.social · 18/11/2024

New to this place. How do I share all the beautiful GIFs of my cells and membrane reconstitution? It looks like it should be able to do it in the preview but then just posts still images of the first frame!

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