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Jack Holcombe

@jackholcombe.bsky.social
1.2K followers 422 following 135 posts

Science, data and climbing jackholcombe.com

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Jack Holcombe @jackholcombe.bsky.social · 30/09/2026
Something magical about a station tap
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Kendall Clay @kendallbclay.bsky.social · 21/09/2026
How does an organism capable of whole body regeneration make the right types of neurons in the correct ratios? The answer is a heavily coordinated suite of genes precisley timed to ensure the birth and maintenance of new neurons! www.nature.com/articles/s41...
nature.com
Combinatorial mechanisms specify cellular location and neurotransmitter identity during planarian neurogenesis - Nature Communications
During regeneration, new neurons need to be made in a way that reproduces both neuronal diversity and organization. Here the authors show that a combination of factors works cooperatively to direct ne...
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Jack Holcombe @jackholcombe.bsky.social · 23/09/2026
*At their holiday home on the island lol
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Gianmarco Soresi @gianmarcosoresi.bsky.social · 21/09/2026
If you’re moved by this guy crying boy oh boy are there some other images and videos you should check out
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Nicolas Di-Poi @nicolasdipoi.bsky.social · 22/09/2026
Our collaborative paper on snake coiling is now out in the latest issue of @currentbiology.bsky.social and featured on the cover! 🎉 Delighted to see our work highlighted this way. You can read it here: authors.elsevier.com/c/1ni9h3QW8S... @helsinki-biotech.bsky.social @helsinki.fi
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Corinna Gebehart @corinnagebehart.bsky.social · 14/09/2026
This article is so frustrating to read. First, this is not just “google’s brain” - there has been so much effort made by scientists around the world to get these connectomes to where they are today, and none of that is recognized here, instead it’s all turned into “big tech company 👍🏻”. And second -
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Russell Garwood @russellgarwood.co.uk · 15/09/2026
Interested in how species diversity is split between major animal groups? Here is the infographic for you! 🧪⚒️🦀🦑 #evosky
An infographic showing the number of described and estimated species for major animal groups. There are more insects than anything else. Of the remaining groups, arachnids and nematodes are the most diverse.
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Jack Holcombe @jackholcombe.bsky.social · 11/09/2026
They really need to start making a distinction between ebikes (pedal assisted, legal etc) and these (eMotorbikes). We are just going to end up in a situation where a sustainable form of transport gets lumped in with unlicensed electric motorbikes www.bbc.co.uk/news/article...
bbc.co.uk
E-bike crime crackdown leads to 187 arrests in Westminister
Footage released by the Met shows officers using high-powered Sur-Ron bikes to pursue suspects.
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Misha Ahrens @mishaahrens.bsky.social · 09/09/2026
Whole-body cellular activity imaging in zebrafish, headed by Virginie Ruetten @vmsruetten.bsky.social - new paper is out: www.nature.com/articles/s41...
nature.com
Imaging cellular activity across all organs reveals body-wide circuits - Nature
An imaging system developed to record cellular activity throughout the whole body of zebrafish captures cellular organ dynamics and identifies multiple distributed circuits.
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Philippe Batut @philippebatut.bsky.social · 10/09/2026
🧬🔬 Why are enhancers transcribed and how does that impact gene regulation? I’m really excited to share our new paper in @science.org showing that noncoding RNAs control the timing of gene activation in embryos. With Mike Levine #ScienceResearch @columbiamed.bsky.social A few highlights below... 🧵👇
science.org
Noncoding transcription controls the developmental dynamics of long-range gene regulation
The genomic regions regulating gene expression are often themselves transcribed into a variety of noncoding RNAs (ncRNAs). However, the regulatory roles of this noncoding transcription remain largely ...
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Roland Pierik @roleo.eurosky.social · 08/09/2026
The number of cases of cervical cancer reported in Scotland among women given the HPV vaccine at 12-13 years of age is now zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. www.bbc.com/news/article...
bbc.com
No cervical cancer cases in fully HPV-vaccinated women in Scotland
A study published by Public Health Scotland finds that the HPV vaccine is "highly effective".
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Irene Miguel-Aliaga @irenemiguel-aliaga.bsky.social · 11/08/2026
Read about our latest work here www.cell.com/cell/fulltex... or let Alessandro tell you all about it (link below)!
cell.com
The sex and reproductive plasticity of intestinal muscles instruct gut size
Adult intestinal size plasticity is driven not only by epithelial stem cells but also by remodeling of the surrounding visceral musculature. Sex- and reproduction-dependent muscle remodeling controls ...
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HappyToast @happytoast.co.uk · 14/08/2026
#Clacton
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Zack Polanski @zackpolanski.bsky.social · 31/07/2026
Everywhere I look today I keep seeing: 1) deadly wildfires ripping through our communities 2) people desperately trying to get by as energy costs soar 3) record oil & gas profits When will we see that these three things are connected? www.wsj.com/business/ene...
wsj.com
Big Oil Is Reaping Rewards From the Chaos in Energy Markets
ExxonMobil’s earnings doubled and Chevron posted its highest quarterly earnings on record as energy prices soared during the prolonged closure of the Strait of Hormuz.
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Yanlan Mao @yanlanmao.bsky.social · 30/07/2026
This epic paper, which has been a heroic 10 year journey for the lead author, Ricardo Barrientos, is finally out in Cell today! Many thanks to all co-authors, especially Billie Meadowcroft and Andela Saric for their beautiful MD simulations www.cell.com/cell/fulltex...
cell.com
Basement membrane turnover controls cell shape
Basement membranes are scaffolds of proteins, like collagen, that give organs shape. During development, basement membranes must adapt to the growing organ. We infer how fast the basement membrane ada...
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Jack Holcombe @jackholcombe.bsky.social · 31/07/2026
*World-Famous abuser Nims Purja www.nytimes.com/2024/05/31/s...
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MwahahahahahadScientist @mads100tist.bsky.social · 30/07/2026
Super cool mechanism tbh
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Carole Cadwalladr @carolecadwalla.bsky.social · 29/07/2026
Big new story from @annaisaac.bsky.social. Cottrell transferred $2m to his mother before she made Reform & Tice donations. The even bigger question now is where did Cottrell’s money come from? And this is where I think a very big problem lies.. www.theguardian.com/politics/202...
theguardian.com
Revealed: George Cottrell transferred $2m to his mother days before her donations to Reform UK
Exclusive: Sources say Fiona Cottrell told bankers the transfers, received 24-72 hours before her donations to Reform, came from her son
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Maria Antonietta Tosches @matosches.bsky.social · 27/07/2026
Excited to share a new preprint from the lab, by @andrewmatheson.bsky.social and team, where we dive into the superpower of newts: plasticity! www.biorxiv.org/content/10.6... Like many good projects, this started with a serendipitous observation... 🧵1/5
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Vicky & The Sleight Lab @vs-marine.bsky.social · 27/07/2026
Please share, I am hiring an evo devo postdoctoral research fellow! 📍: The Sleight Lab, University of Aberdeen, Scotland (5th oldest University in UK & English-speaking world) 📅: start after 1st December 2026 🐌: Evolution and Development (molluscs) ⌛: 3 year contract sleightlab.com/vacancies/
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Jack Holcombe @jackholcombe.bsky.social · 24/07/2026
*Company that directly financially benefits from war warns us that we are not giving them enough money
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Jack Holcombe @jackholcombe.bsky.social · 21/07/2026
Ridiculous sweeping statement (written by a psychologist)
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Jack Holcombe @jackholcombe.bsky.social · 19/07/2026
Love to see it, Argentina were a complete disgrace 🇪🇸🎉
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Parody Nigel Farage @parodypm.bsky.social · 07/07/2026
I trust the people of Clacton to judge me on my record. Apart from the record that shows I have visited American more times than Clacton, have never held a constituency surgery and rarely bother to drag my arse into Parliament to do my actual job.
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Austin Seroka @austinseroka1.bsky.social · 06/07/2026
We're excited to present a single-cell atlas of vertebrate cranial motor neuron development, the first story from my postdoctoral work in the Moens lab, up now on bioRxiv!
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Jack Holcombe @jackholcombe.bsky.social · 06/07/2026
Nope
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Bahl Lab @bahllab.bsky.social · 05/07/2026
We are excited to share our collaboration with @pheereynolds.bsky.social, Robert Hindges & team on retinal plasticity, now out in Neuron! This work shows how visual experience during early development changes the anatomical and functional properties of amacrine cells and ultimately behavior!
cell.com
Early visual experience elicits cellular and functional plasticity in the retina and alters behavior
The understanding of experience-dependent plasticity in the vertebrate retina is largely incomplete. Reynolds et al. discovered that raising animals in differently patterned visual environments change...
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Matthew Freeman @mjafreeman.bsky.social · 01/07/2026
The awesome trio of @lmescu.bsky.social @fpichaud.bsky.social and Fernando Casares (and their teams) are on fire Fly eyes represent 'programmable metamaterials'; human engineering principles pre-exist in biology www.nature.com/articles/s41...
nature.com
A natural programmable metamaterial controls 3D curvature of compound eyes - Nature Communications
This article uncovers a natural, programmable metamaterial in the developing Drosophila eye. The precise 3D curvature of the adult compound eye is programmed during development by a microscopic, 2D tr...
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Matt Towers @matt-towers.bsky.social · 02/07/2026
Pleased to share our latest! We show that the chick limb can be directed to recapitulate key stages in mammalian evolution, providing a unifying model for digit patterning across amniotes. Preprint: www.biorxiv.org/content/10.6... Video summary: www.youtube.com/watch?v=fvL_...
biorxiv.org
Transforming avian to mammalian modes of digit patterning
How a conserved embryonic organiser-the Sonic hedgehog (Shh)-expressing Zone of Polarising Activity (ZPA)-generates diverse limb architectures in amniotes remains a central problem in evolutionary and...
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Jack Holcombe @jackholcombe.bsky.social · 26/06/2026
Key details missing - how much did he pay in income tax vs capital gains? Why do they still get a sovereign grant whilst owning billions in property/land?
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Dirk Eddelbuettel @eddelbuettel.com · 21/06/2026
BBC article about Brian Ripley of the #RStats Core team given this week's excellent news concerning 2026 Rousseeuw Price for Statistics recognition for him and the core team. www.bbc.com/news/article...
bbc.com
Prof Brian Ripley on developing R to manage the world's data
Prof Brian Ripley has spent the past three decades working on a computer software that analyses data.
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Jack Holcombe @jackholcombe.bsky.social · 18/06/2026
Spoiler: probably not 75% of the time
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Jack Holcombe @jackholcombe.bsky.social · 10/06/2026
This is what happens when we allow people like Fromage to gain a voice and stir up hatred...
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Tessa Montague @tessamontague.bsky.social · 06/06/2026
Do you know an outstanding aquarist? We're hiring a Senior Aquarist to help run our cephalopod facility at Columbia University. Our team maintains a colony of 250+ cuttlefish, develops new husbandry techniques (inc transgenics) & studies cuttlefish camouflage and social behavior. 1/3 [Pls repost!]
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Science News @scinews.bsky.social · 19/05/2026
Both caffeinated and decaf coffee altered gut bacteria in ways linked to better mood and lower stress. Decaf even improved learning and memory, while caffeine boosted focus and reduced anxiety.
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Jack Holcombe @jackholcombe.bsky.social · 16/05/2026
Back in Alicante with my partner because I enjoyed it for @edrc2025.bsky.social so much! 🇪🇸
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Ali Seleit @aliseleit.bsky.social · 05/05/2026
(3/15) Eels are basal teleosts with elongated bodies. Many species have massively expanded vertebral counts (Japanese eel: 120 vertebrae). The Aulehla Lab studies somitogenesis — the embryonic process that gives rise to vertebrae — and we wanted to understand how this unfolds in eels.
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Elizabeth Rideout @ejrideout.bsky.social · 14/04/2026
Beyond delighted to share our amazing collaboration with Thierry Alquier's lab @alquierthierry.bsky.social on a conserved role for neuronal lipid droplets in regulating energy homeostasis in vivo led by Celena Cherian, Romane Manceau, Danie Majeur, and Colin Miller www.nature.com/articles/s42... /1
nature.com
Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis - Nature Metabolism
In vivo regulation of neuronal lipid droplet formation mediates whole-body energy homeostasis in a sex-specific manner in Drosophila and mice.
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Jack Holcombe @jackholcombe.bsky.social · 17/04/2026
Glad the BBC are prioritising the most important global stories on the front page this morning.
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Magdalena Skipper @magdalenaskipper.bsky.social · 13/04/2026
Why do people respond differently to GLP-1 weight-loss drugs? Genetics has the answer - provided in this genome wide association study led by @adamauton.bsky.social www.nature.com/articles/s41... 🧪 www.nature.com/articles/d41...
nature.com
Genetics reveal why people respond differently to GLP-1 weight-loss drugs
Genetic variants in GLP1R and GIPR, which encode targets of GLP-1-based medications, offer insights into why responses to these drugs vary and who might face adverse effects.
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Jack Holcombe @jackholcombe.bsky.social · 18/03/2026
Well thats awkward www.cell.com/cell-reports...
cell.com
MitoTracker transfers from astrocytes to neurons independently of mitochondria
The mitochondrial dye MitoTracker is commonly used to investigate intercellular mitochondrial transfer (IMT), particularly between astrocytes and neurons. Hole et al. compare MitoTracker with a geneti...
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Jenny Regan @jennyregan.bsky.social · 17/03/2026
Like #hemocytes? I'm advertising a 3 year, BBSRC #postdoc position, in #Edinburgh, using #Drosophila & human cells to understand sex differences in the regulation of #macrophage function, an exciting collaboration with the Bénézech and Wood labs. Please share! 🪰🏴󠁧󠁢󠁳󠁣󠁴󠁿 www.jobs.ac.uk/job/DQU604/p...
jobs.ac.uk
Postdoctoral Research Associate at The University of Edinburgh
Discover an exciting academic career path as a Postdoctoral Research Associate at jobs.ac.uk. Don't miss out on this job opportunity - apply today!
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The Onion @theonion.com · 05/03/2026
Netanyahu: ‘These So-Called Genocide Experts Have Probably Never Committed A Genocide In Their Lives’ theonion.com/netanyahu-these-so-cal…
Netanyahu: ‘These So-Called Genocide Experts Have Probably Never Committed A Genocide In Their Lives’
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Seth Abramson @sethabramson.bsky.social · 05/03/2026
Hegseth has admitted that America has *no interest* in "fighting fair." And what it did to that warship near India was an obvious war crime; even the Nazis rescued drowning sailors. So one would have to be naive to say the US-IDF alliance "wouldn't" issue strategic drone strikes.
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Javi Ibarrondo @jibarrondo.bsky.social · 05/03/2026
Thirty-six solutions to stabilize Earth’s climate | Science www.science.org/doi/10.1126/... 🧪
science.org
Thirty-six solutions to stabilize Earth’s climate
An updated visual assessment tool can bridge the gap between climate research and political action
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Ben Ewen-Campen @benforward3.bsky.social · 03/03/2026
My paper on how the fruit fly foregut uses a modified cell cycle to respond to tissue damage and cell loss is now published :) www.nature.com/articles/s41... #proventriculus #drosophila
Screen shot of my paper Figure 6Figure 7
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Peter Stefanovic @peterstefanovic.bsky.social · 27/02/2026
'I didn't grow up wanting to be a politician, I'm a plumber' The green Party's Hannah Spencer has won the Gorton and Denton, with Reform in second and Labour finished third
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Jack Holcombe @jackholcombe.bsky.social · 27/02/2026
First bike to work without a coat this year! (Also whats that weird colour in the sky???)
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Toby Andrews @tobyandrews.bsky.social · 02/02/2026
Job alert! 📣 I’m looking for a research assistant to join my new team @idrm.ox.ac.uk Were using #zebrafish to understand gene-environment interactions that shape the heart 🫀generate natural diversity 🐸🐭 and contribute to congenital defects ❤️‍🩹 Full info below, and please share! 🫶🏻 bit.ly/467TO0M
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