iiinova — where your digital self keeps evolving

Reposted by David Shechter

Max Kozlov @maxkozlov.bsky.social · 19/03/2026

Yes, confirming reports that OMB has processed its full-year apportionment to NIH, giving the agency the ability to obligate funds from the spending bill signed into law on Feb 3! From what I can tell, there are no footnotes that would indicate OMB is further delaying the process.

openomb.org

National Library of Medicine and 24 other accounts | 11511545

Apportionment file 11511545 (National Library of Medicine and 24 other accounts) retrieved from OMB public records

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Max Kozlov @maxkozlov.bsky.social · 27/02/2026

Congress rejected massive cuts to US science budgets for 2026, but much of the money still isn’t flowing to researchers. The culprit? The White House Office of Management and Budget (OMB) is quietly slow-walking the release of funds. 🧵👇

nature.com

White House stalls release of approved US science budgets

The US Congress rejected sweeping cuts to science agencies. But the NIH, the NSF and NASA have had their spending slowed.

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Aaron Rupar @atrupar.com · 22/01/2026

Jack Smith: "My fear is that we have seen the rule of law function in our country for so long that many of us have come to take it for granted. The rule of law is not self-executing. It depends on our collective commitment to apply it."

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Dr Kathleen Millen @neurodevkathy.bsky.social · 16/01/2026

Reminder for those applying for #NIH grants using the #ScienCV templates. You can format the text sections using html codes: paragraph break line bold italics

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David Shechter @dshechter.bsky.social · 13/10/2025

How does PRMT5 link splicing to mRNA export? Out in Mol Cell: by methylating Sm proteins, PRMT5 releases mRNAs that would otherwise remain trapped on chromatin. Meet GRIPPs: Genomically Retained Incompletely Processed Polyadenylated Transcripts. 🔗 authors.elsevier.com/a/1lwyj3vVUP...

authors.elsevier.com

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David Shechter @dshechter.bsky.social · 13/10/2025

authors.elsevier.com

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Oded Rechavi @odedrechavi.bsky.social · 09/09/2025

"We added the requested experiments and thank the reviewers for their helpful suggestions"

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EPIGENETIC HULK @epigenetichulk.bsky.social · 13/06/2025

EPIGENETIC HULK READY TO SMASH AGAIN! GET IN LOSERS!

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Gregg Gonsalves @gregggonsalves.bsky.social · 28/08/2025

#NIH is hanging by a thread. The #CDC has been decimated. #RFK Jr. and Russell #Vought are psychopaths--I don't say this frivolously--they are cold, calculating, inflicting violence on millions through public policy. It is where we are right now. These men are not normal. 1/

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Radley Balko @radleybalko.bsky.social · 24/08/2025

We’re 7 months in, and “Pentagon plans military deployment in Chicago” is a headline in the Washington Post. And because it’s city number three, we’re already numbing to it. If you read this about any other democracy in the world, you’d conclude that it was well on the road to a dictatorship.

washingtonpost.com

Pentagon plans military deployment in Chicago as Trump eyes crackdown

President Donald Trump said Chicago is his next likely target to crack down on urban crime. Military planning has been ongoing for weeks, officials say.

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Jen Bendery @jbendery.bsky.social · 14/08/2025

Situation on 14th St and W St. NW, with federal agents -- no specific agency identified -- pulling cars over for checks. They arrested a Black woman in this car. BIG crowd of people shouting at police. "Fuck you!" "What is wrong with you!" "You don't need to terrorize people like this!"

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Eric Michael Garcia @ericmgarcia.bsky.social · 05/08/2025

Release from HHS: HHS will wind down its development of the mRNA vaccine development activities under the Biomedical Advanced Research and Development Authority (BARDA).

HHS Winds Down mRNA Vaccine Development Under BARDA

WASHINGTON, DC—AUGUST 5, 2025—The U.S. Department of Health and Human Services (HHS) today announced the beginning of a coordinated wind-down of its mRNA vaccine development activities under the Biomedical Advanced Research and Development Authority (BARDA), including the cancellation and de-scoping of various contracts and solicitations. The decision follows a comprehensive review of mRNA-related investments initiated during the COVID-19 public health emergency.

“We reviewed the science, listened to the experts, and acted,” said HHS Secretary Robert F. Kennedy, Jr. “BARDA is terminating 22 mRNA vaccine development investments because the data show these vaccines fail to protect effectively against upper respiratory infections like COVID and flu. We’re shifting that funding toward safer, broader vaccine platforms that remain effective even as viruses mutate.”

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Don Moynihan @donmoyn.bsky.social · 30/07/2025

Shout out to the WSJ journalists who reported on Vought’s impoundment by footnote, causing the White House to walk it back. Impact journalism!!

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David Shechter @dshechter.bsky.social · 10/07/2025

Why can’t cells live without PRMT5? Our new transformative work inspired and led by @jacobroth13.bsky.social (who defends his thesis tomorrow!) shows that this arginine methyltransferase is critical for histone production and genome stability. Full story: www.biorxiv.org/content/10.1... 1/5

biorxiv.org

PRMT5 activity sustains histone production to maintain genome integrity

Histone proteins package DNA into nucleosomes, forming chromatin and thereby safeguarding genome integrity. Proper histone expression is essential for cell proliferation and chromatin organization, ye...

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David Shechter @dshechter.bsky.social · 10/07/2025

biorxiv.org

PRMT5 activity sustains histone production to maintain genome integrity

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Christopher Webb @cwebbonline.com · 12/06/2025

Powerful statement by Sen. Alex Padilla. Please notice that anytime senators or representatives try to conduct oversight, they’re blocked. In this case, a sitting US senator was tackled to the ground and handcuffed—for asking a question. Where the hell has Chuck Schumer been on this?

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David Shechter @dshechter.bsky.social · 12/05/2025

For all my NYC Chromatin / Epigenetics / Gene Expression colleagues - the registration and abstract deadline for our Summer '25 symposium is this Friday. Attendance is free (lunch and coffee breaks provided), but we need you to sign up! See here: mailchi.mp/cbee4a4e6267...

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Yael David @yaeldavidmsk.bsky.social · 05/05/2025

Excited for this summer’s NYC Chromatin Club! Grad students & postdocs: submit your abstracts for a chance to present a poster or talk. Come connect w/ fellow epigenetic New Yorkers! #NYCChromatinClub @dshechter.bsky.social @vivrisca.bsky.social @epicypher.bsky.social @kjarmache.bsky.social

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bioRxivpreprint @biorxivpreprint.bsky.social · 10/04/2025

TTLL4 glutamyltransferase is a therapeutic target for NPM1-mutated acute myeloid leukemia www.biorxiv.org/content/10.1101/202…

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bioRxiv Cancer Bio @biorxiv-cancer.bsky.social · 10/04/2025

TTLL4 glutamyltransferase is a therapeutic target for NPM1-mutated acute myeloid leukemia www.biorxiv.org/content/10.1101/202…

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David Shechter @dshechter.bsky.social · 10/04/2025

We discovered a new AML vulnerability: TTLL4 glutamylates NPM1c and helps leukemia cells thrive. Knock it down and cells differentiate and survival improves. Collab between our lab and @Gritsman_lab—funded by NIH and DoD/CDMRP. Preprint: bit.ly/42oZl09 /1

bit.ly

TTLL4 glutamyltransferase is a therapeutic target for NPM1-mutated acute myeloid leukemia

NPM1-mutated acute myeloid leukemia (AML) is defined by aberrant cytoplasmic localization of the mutant NPM1c protein, and therapeutic strategies targeting this specific disease remain limited. Here, ...

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Mike the Mad Biologist and Trump's Press Corps Approver @mikethemadbiol.bsky.social · 09/04/2025

Every post Trump makes about tariffs sounds like a late night used car commercial. Waiting for the post that starts with “I just spoke to my manager and I think we can get you down to ten percent…”

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John Wallingford @jbwallingford.bsky.social · 02/04/2025

Director of the Nat'l Institute of Child Health and Human Development (NICHD) was summarily dismissed yesterday. So here's your reminder that birth defects kill twice as many American kids as cancer. But there is no St. Jude's for birth defects. Only the NICHD. www.nature.com/articles/d41...

nature.com

‘One of the darkest days’: NIH purges agency leadership amid mass layoffs

In shock move, four institute directors at the US biomedical agency are removed from their posts.

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Jeremy Berg @jeremymberg.bsky.social · 29/03/2025

Analysis of Terminated NIH Grants with Word Clouds First, using the titles of grants not to Columbia... Gender and DEI predominate

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Mark Peifer (He, him) @peiferlabunc.bsky.social · 26/03/2025

14 pages of terminated NIH grants--everyone should read through the list. The sweep is VERY broad, including "The Impact of the Herpes Zoster Vaccine on Herpes Zoster Ophthalmicus" & "Mitochondrial-based Determinants of Sex Differences in Acute Kidney Injury"🧪 1/n taggs.hhs.gov/Content/Data...

taggs.hhs.gov

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Yell In a War @jelenawoehr.bsky.social · 24/03/2025

Jeffrey Goldberg thinking he was being pranked and then realizing he was actually just in the war plans group chat is such a good microcosm of how it feels to be alive right now, everything seems fake until you realize it’s actually real and incredibly stupid

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David Atkins @davidoatkins.bsky.social · 15/03/2025

Trump and Musk are basically trying to deskill America: 1) kill all white-collar jobs and replace them with AI 2) kill universities 3) use tariffs to turn the U.S. into an economic island manufacturing, oil and ag hub 4) empty the cities 5) push men into manual labor & women back into the kitchen

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Derek Lowe @dereklowe.bsky.social · 05/03/2025

Another “Continuing Crisis” post, this one covering some larger principles and explaining why I’m doing these in general:

science.org

The Continuing Crisis, Part VII: An Overview

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Jeremy Berg @jeremymberg.bsky.social · 02/03/2025

I am not going to call this a Bluetorial, because I do not want to sully that term (which, at least I, find joyful). Let’s call it a Orwellial.

media.tenor.com

a cartoon of homer simpson holding a card

ALT: a cartoon of homer simpson holding a card

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Jeremy Berg @jeremymberg.bsky.social · 22/02/2025

Bluetorial: The path to a new pain medication with little potential for addiction Perhaps a good story to share with folks who want to learn about how biomedical research works and where advances come from.

media.tenor.com

a cartoon says hey everybody an old man 's talking while bart simpson looks on

ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on

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Jeremy Berg @jeremymberg.bsky.social · 21/02/2025

I have heard from several sources (although details are vague) it appears that NIH is back to blocking NoA release while awaiting development of plans for dealing language, perhaps pertaining to DEI issues, in these awards. If this is occurring, it seems like a clear violation of the TRO. 1/n

media.tenor.com

patrick star and spongebob squarepants from spongebob squarepants are standing next to each other in a dark room .

ALT: patrick star and spongebob squarepants from spongebob squarepants are standing next to each other in a dark room .

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Derek Lowe @dereklowe.bsky.social · 20/02/2025

Want a moral? Lawlessness is not just an exciting chance to make big money. Autocrats won’t always be on your side. You are better off under the boring, confining rule of law, because once it’s been demolished you are not in control of anything. Perhaps no one is. Especially not you. (8/8)

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Jeremy Berg @jeremymberg.bsky.social · 21/02/2025

The only conclusion that I can draw is that their answer to this question is: Yeah, what about it? They just don’t care or think the private sector can do this, without realizing the complementary interests and skills of the public and private sectors. 3/n

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Derek Lowe @dereklowe.bsky.social · 19/02/2025

This is absolutely pathetic. Saying nothing was bad enough, but this?

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Rick Huganir @rhuganir.bsky.social · 15/02/2025

I have been talking to the media, Time, Fortune, NBC, etc., to explain how the onslaught on science and NIH will impact the health of all Americans. Everyone knows someone who has cancer, heart disease, or depression. Spread the word about how cutting science impacts all. time.com/7216299/nih-...

time.com

Experts Call NIH Budget Cuts an 'Apocalypse' for Science

The reductions target indirect costs that cover administrative and equipment costs.

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Jeremy Berg @jeremymberg.bsky.social · 15/02/2025

They are absolutely cutting science! Folks in the NIH intramural program are gone. Folks in extramural programs. These include PhD and MD scientists who help make NIH function as a granting agency. They are depict this as cutting easily replaceable bureaucrat. There aren't many of those at NIH.

media.tenor.com

a cartoon of a man with a beard and the words " they are liars " below him

ALT: a cartoon of a man with a beard and the words " they are liars " below him

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Mark Cuban @mcuban.bsky.social · 09/02/2025

This is the most relevant article to NIH and research cuts I’ve seen. Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !” globalnews.ca/news/9793403...

globalnews.ca

How a Canadian scientist and a venomous lizard helped pave the way for Ozempic - National | Globalnews.ca

In 1984, Dr. Daniel Drucker, an endocrinologist from the University of Toronto, discovered a hormone that helped pave the way for popular diabetes drugs such as Ozempic.

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David Shechter @dshechter.bsky.social · 12/08/2024

Have you ever wondered how PRMT5 actually influences gene expression? See our new work - “Productive mRNA Chromatin Escape is Promoted by PRMT5 Methylation of SNRPB”. Preprint here: doi.org/10.1101/2024... 1/5 #MolecularBiology

doi.org

Productive mRNA Chromatin Escape is Promoted by PRMT5 Methylation of SNRPB

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

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