Sign in

Lüders Lab

@luderslab.bsky.social
262 followers 227 following 52 posts

Professional #microtubule organizers and #centrosome deconstructors @irbbarcelona.bsky.social

PostsRepliesMedia
Lüders Lab @luderslab.bsky.social · 04/10/2026
An eye-opener!
000
Reposted by Lüders Lab
Dan Jagger @auditorynerves.bsky.social · 01/10/2026
The winning entry of a prestigious scientific photography competition is being re-evaluated following criticism from other scientists that it was made with AI. Well done @christlet.bsky.social & others for pushing this. 🧪🔬🤖 www.bbc.co.uk/news/article...
bbc.co.uk
Tiny image sparks big backlash in Nikon photo contest
Dr Ning Xu denies he broke the rules of Nikon's annual Small World In Motion contest.
22510
Reposted by Lüders Lab
Nature Cell Biology @natcellbio.nature.com · 28/09/2026
☕Meiring, Mahapatra et al. show that expanded microtubule lattice conformations, such as those induced by small-molecule taxanes, can lead to the release of GEF-H1 and thus induce RhoA activation. www.nature.com/articles/s41...
nature.com
Taxane-induced conformational changes in the microtubule lattice activate GEF-H1-dependent RhoA signalling - Nature Cell Biology
Meiring, Mahapatra et al. show that expanded microtubule lattice conformations, such as those induced by small-molecule taxanes, can lead to the release of GEF-H1 and thus induce RhoA activation.
0106
Reposted by Lüders Lab
xavier salvatella @xsalvatella1.bsky.social · 21/09/2026
PhD fellowship open in our lab at @irbbarcelona.org to work on intrinsically disordered proteins — activities, disease mutations, and druggability. Deadline: 28 Oct. 🔗 irbbarcelona.org/en/careers/young-scientists/irb-barcelona-international-phd-fellowships-extraordinary-call-2026
irbbarcelona.org
IRB Barcelona International PhD Fellowships - Extraordinary call 2026
The following will be offered in this call:Up to 8 FPI positions associated with the “Proyectos de Generación de Conocimiento 2025” Call (funded by the Agencia Estatal de Investigación AEI- MICINN).Ch...
067
Lüders Lab @luderslab.bsky.social · 19/09/2026
Indeed!
010
Reposted by Lüders Lab
Centre de Regulació Genòmica (CRG) @crg.eu · 15/09/2026
We are at a critical moment for the future of European science. As @eu-life.bsky.social founder, and together with 100s of institutes and universities across the continent, we call for an ambitious funding pot for FP10. See Luis Serrano's comments in El Mundo. www.mundoamerica.com/entertainmen...
mundoamerica.com
European science calls for ambitious investment in research: "Current decisions determine Europe's future. We are falling behind China and the USA"
"To remain global leaders, a competitive economic power, and a sovereign actor, Europe needs strong science and innovation." Seven scientific organizations, representing...
066
Reposted by Lüders Lab
Sergey Ovchinnikov @sokrypton.org · 14/09/2026
Finally a more intuitaive way to learn pLDDT/pAE? 😎 sokrypton.github.io/protein_figh... (Character idea from @hannes-stark.bsky.social & Alex Waldherr)
727698
Lüders Lab @luderslab.bsky.social · 01/09/2026
Taking a journey across scales with my colleague @nek6789.bsky.social, from the #Matterhorn to the #centrosome meeting in Lausanne.
 Biking at the Matterhorn
010
Reposted by Lüders Lab
Paul & Virginie - Centriole Lab @centriolelab.bsky.social · 27/08/2026
Very happy to see our Nature Reviews Molecular Cell Biology Roadmap out! A fantastic collective effort, led by Carsten Janke and Zdenek Lansky, together with an amazing group of colleagues, and sparked by inspiring discussions at the Fondation des Treilles. www.nature.com/articles/s41...
nature.com
Towards a systems-level view of the microtubule cytoskeleton and its functions in physiology and disease - Nature Reviews Molecular Cell Biology
Microtubules are essential components of the cytoskeleton, yet important links between their molecular properties and organismal functions remain unresolved. In this Roadmap, Janke et al. discuss key ...
16128
Reposted by Lüders Lab
Denis Chrétien @dchretien.bsky.social · 28/08/2026
Dear #CryoEM and #Microtubule enthusiasts, I’m thrilled to have been part of this exciting journey: www.biorxiv.org/content/10.6... We discovered and characterized a manchette-like microtubule machinery in Xenopus spermatids, likely involved in sperm reshaping and membrane reorganization. (1/3)
33014
Lüders Lab @luderslab.bsky.social · 09/08/2026
A 30 cm layer of beautiful #Sphagnum #moss contributes to the stunning shades of green in the highland #peatlands on Flores island, Azores.
Sphagnum mossPeatlands around crater lakes Caldeira Funda and Caldeira Rasa, Flores Island, Azores
030
Lüders Lab @luderslab.bsky.social · 08/08/2026
Sun setting at the westernmost point of Europe (islands included).
Sunset, Fajã Grande, Flores, AzoresSunset, Fajã Grande, Flores, AzoresSunset, Fajã Grande, Flores, Azores
020
Reposted by Lüders Lab
Andreas Prokop @poppi62.bsky.social · 08/08/2026
Over 15 years of our work consistently supports a cohesive model of neurodegeneration providing useful concepts and directions for future research: "the dependency cycle of local axon homeostasis". Enjoy the read of our completely revamped manuscript: doi.org/10.1101/2025... (PDF fixed)
02415
Lüders Lab @luderslab.bsky.social · 28/07/2026
Still time to register for the #Bioimaging #Meeting 👇🏼 SPAOM2026 | Vic, Spain, October 6–9, 2026 | 10th Anniversary | Workshops Edition www.spaom2026.org
SPAOM 2026 workshop
022
Lüders Lab @luderslab.bsky.social · 08/07/2026
The data suggest a speculative model where ALMS1 adopts information (memory of centriole architecture) from CSs at the time of their disassembly during mitosis, and, after cell division, conveys that memory to CSs during their re-assembly!
010
Lüders Lab @luderslab.bsky.social · 08/07/2026
When ALMS1 is depleted and re-introduced, diverse, abnormal, yet heritable centriole architectures arise. Thus, centriole biogenesis relies on cues/templates that are extrinsic to centrioles and their constituents, and are propagated through CS assembly-disassembly cycles mediated by ALMS1.👇
100
Lüders Lab @luderslab.bsky.social · 08/07/2026
CS form during interphase and disassemble during mitosis (correlating with cartwheel disassembly), a process that involves interaction with the ciliopathy protein ALMS1. ALMS1 is required for CS assembly and centriole biogenesis, but is not present at centrioles when daughter centrioles form.👇
100
Lüders Lab @luderslab.bsky.social · 08/07/2026
Moreover, CSs can exist without centrioles and the information that they carry is inheritable. Normally they are wrapped around mother centrioles, driving canonical daughter centriole biogenesis, but in cells lacking centrioles, they drive de novo assembly in the cytoplasm.👇
110
Lüders Lab @luderslab.bsky.social · 08/07/2026
The study identifies protein composites of CEP152/CEP63 that function as seeds for the cartwheel, a scaffold at the base of newly forming centrioles that has recognisable 9-fold symmetry, just as centrioles have. Strikingly, the cartwheel seeds also have an intrinsic 9-fold symmetry!👇
100
Lüders Lab @luderslab.bsky.social · 08/07/2026
How are complex #protein #structures such as #centrioles built? Fortunate to have participated in this study headed by Bryan Tsou’s lab! Rather than self-assembly, #centriole #biogenesis is driven by an inheritable template! 👀 🧵 Thread below👇 Full story: 🔗 doi.org/10.1038/s41467-026-74821-3
nature.com
Adaptable centriole biogenesis via the intrinsically disordered protein ALMS1 - Nature Communications
Centriole biogenesis is regarded as template-free, variation-free, and genetically determined. Here, the authors describe an adaptable process where inheritance and selection both opera...
161
Lüders Lab @luderslab.bsky.social · 30/04/2026
😂
000
Reposted by Lüders Lab
Vladimir Volkov 🇺🇦 @vladimirvolkov.bsky.social · 20/03/2026
Happy to see the first paper from the lab published in the EMBO J today: link.springer.com/article/10.1... In it, we reconstitute self-assembling cooperative oligomers of human Ndc80 and Ska kinetochore complexes that stabilise microtubule ends, and study these samples using cryoET and TIRF
link.springer.com
Microtubule end stabilisation by cooperative oligomers of Ska and Ndc80 complexes - The EMBO Journal
During mitosis, properly aligned chromosomes stabilise microtubule ends with the help of kinetochores to ensure timely segregation of chromosomes. Microtubule-binding components of the human outer kin...
37826
Lüders Lab @luderslab.bsky.social · 08/02/2026
View from afternoon #bike ride - Which one is the tallest? 🧐 #building #Barcelona
View of Barcelona from CollserolaThe “three chimneys” view from CollserolaView of Sagrada Família and other tall buildings in Barcelona from Collserola
010
Reposted by Lüders Lab
Manuel Thery @manuelthery.bsky.social · 21/01/2026
The mother of all meetings is here: meetings.embo.org/event/26-cen...
meetings.embo.org
Centrosomes: From fundamentals to diseases
Centrosomes are critical microtubule organizing centers comprising centrioles surrounded by PeriCentriolar Material (PCM). Centrioles also template the axoneme of cilia and flagella. As a result of t…
091
Reposted by Lüders Lab
Gaspar Jekely @jekely.biologists.social.ap.brid.gy · 20/01/2026
Flexible tool use by a cow. Best video I have seen in a while, including the closing statement by the farmer. Veronika for #President! www.cell.com/current-biology/fullte…
Pictures of a cow (Bos taurus), Veronika, who uses a deck brush to self-scratch.
192
Reposted by Lüders Lab
EMBO @embo.org · 16/01/2026
The EMBO Workshop "#Centrosomes: From fundamentals to diseases" in #Lausanne, Switzerland, 1–4 September 2026 will highlight the advances in the field of centrosome #research. Register now! Deadline: 1 June meetings.embo.org/event/26-centroso… #EMBOCentrosomes #EMBOevents #conference 🧪
03622
Reposted by Lüders Lab
Mill_lab @cilialab.bsky.social · 24/12/2025
We must have been #ExtraNice this year- our #cilia & #centrosome 🧪 community- 🎅 Santa just dropped the 1st session of 2026 line-up @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social e-symposia- www.eventbrite.co.uk/e/bscb-genso... See you on the other side! Happy Holidays!
eventbrite.co.uk
BSCB GenSoc UK Cilia and Centrosome Network e-Symposia Series
BSCB GenSoc UK Cilia and Centrosome Network e-Symposia Series
0144
Lüders Lab @luderslab.bsky.social · 12/12/2025
There are other things like making the last 5 years of all social media activity accessible through setting profiles public and providing handles. Including WhatsApp - would kill many ESTA applications - and including this thread 😬
010
Reposted by Lüders Lab
Ben Engel @cellarchlab.com · 10/12/2025
Happy to share our fun team-up with @centriolelab.bsky.social & @stearnslab.bsky.social to reveal the architecture of the mammalian centriole’s Distal Ring 🛟. Very cool multiscale integration of #UExM 📏🔬with #CryoET ❄️🔬. Congrats to @ebertiaux.bsky.social & @computingcaitie.bsky.social #TeamTomo 🧪
05318
Reposted by Lüders Lab
Paul & Virginie - Centriole Lab @centriolelab.bsky.social · 10/12/2025
🥳 Our new paper on C2CD3 is out in @plosbiology.org With the labs of @cellarchlab.com , @chgenoud.bsky.social , and @stearnslab.bsky.social , we revealed the mammalian centriole Distal Ring architecture by combining #UExM and in situ #CryoET. Big congrats to @ebertiaux.bsky.social and all involved.
07120
Lüders Lab @luderslab.bsky.social · 06/12/2025
Congratulations Dr. Fariña-Mosquera!!! A new doctor in the @luderslab.bsky.social!!! Big thanks to tribunal members Isabelle Vernos, Virginie Hamel @centriolelab.bsky.social , and Fernando Romero-Balestra!
Marcos Fariña thesis defense presentationMarcos Fariña thesis defense with Flowers and tribunal members
031
Lüders Lab @luderslab.bsky.social · 29/11/2025
You mean when only centromes are lost? Yes, because of the Golgi MTOC. The Rios lab paper actually showed it first, check Fig 7 - centrinone + AKAP450 KO destroys both centrosome and Golgi MTOC, and MTs become disorganized, clearly different from WT. www.embopress.org/doi/full/10....
embopress.org
The dual role of the centrosome in organizing the microtubule network in interphase | EMBO reports
image image During interphase, microtubules can be generated from a variety of microtubule‐organizing centers (MTOCs) the activity of which is regulated in a hierarchical manner. The centrosome (CTR)...
020
Lüders Lab @luderslab.bsky.social · 29/11/2025
This nice paper by Anna Akhmanova’s group does not address anchoring specifically, but organizing function. The problem is that if you remove centrioles, PCM still clusters or the Golgi takes over. If you prevent that (centrinone + AKAP450 KO) MT are completely disorganized. doi.org/10.7554/eLif...
doi.org
Self-assembly of pericentriolar material in interphase cells lacking centrioles
In the absence of centrioles, components of pericentriolar material can self-organize into a single compact microtubule-organizing center through dynein-mediated transport of pericentrin-containing pr...
110
Lüders Lab @luderslab.bsky.social · 29/11/2025
Not saying motors, plus end regulators, MAPs don’t contribute. I believe some microtubules are anchored, but others are perhaps released - shown for the centrosome. Could be pulling by motors or loss of anchoring/nucleation without anchoring. Quite a knowledge gap here, I would say.
000
Lüders Lab @luderslab.bsky.social · 28/11/2025
It does not only nucleate, it also anchors minus ends. This determines microtubule orientation (all minus ends at MTOC, all plus ends away from it). Because of this, modulating the shape and distribution of the MTOCs, also controls the overall shape of the network.
210
Lüders Lab @luderslab.bsky.social · 27/11/2025
Doesn’t nucleation + anchoring of minus ends control microtubule orientation and, through shape and distribution of the MTOC, overall microtubule network shape and polarity? I agree it isn’t always the “center”, but I still think it has organizing activity.
120
Lüders Lab @luderslab.bsky.social · 27/11/2025
What about their function in anchoring minus ends?
100
Lüders Lab @luderslab.bsky.social · 09/11/2025
Congrats @araujolabub.bsky.social, make the flies breathe!
110
Lüders Lab @luderslab.bsky.social · 01/11/2025
I see 6 fold symmetry and 9 fold asymmetry
030
Reposted by Lüders Lab
Rui Zhang @ruizhangmt.bsky.social · 31/10/2025
Happy Halloween everyone! 🎃
0183
Lüders Lab @luderslab.bsky.social · 31/10/2025
Congratulations to the @estebanezlab.bsky.social lab and collaborators!!! A great story on the surprising repertoire of nuclear receptor oligomeric configurations and their regulatory roles.
120
Lüders Lab @luderslab.bsky.social · 11/10/2025
Harder to focus on the science if it is poorly presented, I’d say.
130
Lüders Lab @luderslab.bsky.social · 30/08/2025
Salt marshes ‘ Las Salinas’, Cabo de Gata Natural Park, Spain
020
Reposted by Lüders Lab
Marco MILAN LAB @milanlab.bsky.social · 16/08/2025
Why would anyone want to be a scientist? url: journals.biologists.com/jcs/article/...
journals.biologists.com
Why would anyone want to be a scientist?
It is difficult to fathom why anyone intelligent enough to be a scientist would actually choose to be one. Doing good science requires the utmost exertion of body, mind and spirit, yet is consistently...
044
Reposted by Lüders Lab
Simone Reber @simonereber.bsky.social · 15/08/2025
FINALLY! Challenging to publish but we believe it is an important discovery: rdcu.be/eATFz 💚 Thanks to the team ‪@biswashere.bsky.social‬, Omar Muñoz, ✨Q✨ C. Hoege, B. Lorton, R. Nikolay ‪@matthewkraushar.bsky.social‬ @dshechter.bsky.social @gucklab.bsky.social @vasilyzaburdaev.bsky.social‬ 💚
rdcu.be
Conserved nucleocytoplasmic density homeostasis drives cellular organization across eukaryotes
Nature Communications - Cells can regulate their mass density. Here, the authors demonstrate how eukaryotes establish and maintain a lower density in the nucleus than in the cytoplasm via pressure...
15525
Reposted by Lüders Lab
MwahahahahahadScientist @mads100tist.bsky.social · 13/07/2025
See? There's money! What would be great, instead, is to increase the budget for the existing schemes, though 🧪
sciencebusiness.net
ERC to introduce seven-year €7 million ‘super grants’ in 2026
The European Research Council (ERC) is set to launch its first seven-year €7 million super grant call in May next year.The grants, called ERC+, will be open to researchers at all career stages and in ...
118418
Reposted by Lüders Lab
Graham Dellaire @docdellaire.bsky.social · 13/07/2025
"Super level" funding programs IMO are a huge waste of money - they benefit big labs at the cost of defunding others. We had big "Foundation grants" in Canada (albeit at a much smaller scale than similar programs in the USA/EU)... TL;DR it nearly ruined the sustainability of our research ecosystem
143
Lüders Lab @luderslab.bsky.social · 09/07/2025
…as wobbly tentacles that capture you?
010
Reposted by Lüders Lab
Toni Gabaldón @tonigabaldon.bsky.social · 09/07/2025
The #ESEB2025 meeting in Barcelona is getting closer, there are still places available but time for registration is running up. Are you going to miss the main evolutionary biology event in Europe this year? 👇 eseb2025.com/registration/
156
Reposted by Lüders Lab
Elias Spiliotis @septinlab.bsky.social · 06/07/2025
Woah! Sick reconstitution work showing that MAP6d1 recruits tubulin to form B tubules on A tubule templates, and ALSO intra-luminal protofilaments, which apparently are present in neuronal microtubules. So not only actin inside microtubules, but also additional tubulin protofilaments?!? Wild!
0126