"To remain global leaders, a competitive economic power, and a sovereign actor, Europe needs strong science and innovation." Seven scientific organizations, representing...

Here the authors show that CM1 activates human γTuRC by facilitating its complete closure as the nascent microtubule assembles: high-resolution cryo-EM identifies interactions that promote and stabili...

Evolutionarily related ‘proto-point’ centromeres providing resolution to the evolutionary origins of point centromeres are identified in yeast, and comparison shows they evolved in an ancestor with re...

Around the world, governments are demanding that research funding follow broader political priorities. They should be careful what they wish for.

PDB-101: Training, Outreach, and Education portal of RCSB PDB

Data detectives see validation in deal with U.S. government that penalizes Dana-Farber Cancer Institute for misrepresenting data in NIH grant applications

Activation of PLK1, a master mitotic kinase, requires phosphorylation of its activation segment on Thr210, within a basic consensus sequence for Aurora kinases. Aurora B-dependent phosphorylation of T...

Research Group Leader Tenure Track Starting Salary £65,940 to £74,448 per annum MRC Laboratory of Molecular Biology, Cambridge, UK

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Tollervey et al. use cryo-electron tomography to capture 3D snapshots of centrosomes at molecular resolution in their near-native state inside embryonic C. elegans cells in different stages of cell division. They characterize structural features of centrioles during their assembly and of a disordered matrix that nucleates and organizes mitotic spindle microtubules.

The AlphaFold Protein Structure Database (AFDB) contains more than 214 million predicted protein structures composed of domains, which are independently folding units found in multiple structural and ...