iiinova — where your digital self keeps evolving

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Alex Hughes Lab @hugheslabpenn.bsky.social · 02/07/2026

Congrats to Hughes lab PhD student Ronald Canlla and all other ASN KidneyCure Fellowship/Grant recipients! Ronald's work is achieving remote control over epithelial morphogenesis using light, focusing on the kidney's ureteric bud. www.kidneycure.org/pages/qa.aspx

kidneycure.org

KidneyCure | Spotlights/Q&A - Who We Fund

Learn more about who KidneyCure funds.

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jared toettcher @toettch.bsky.social · 24/07/2026

New Toettchlab paper alert! Harrison Oatman just published his beautiful work combining software design for "smart" microscopy+optogenetics and some really beautiful work understanding EGFR-driven collective cell migration. www.cell.com/cell-systems...

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Bethany Brookshire @beebrookshire.bsky.social · 29/06/2026

You may have heard about the OMB rule change that will put politics over federal grants. However bad you think it is? It's probably worse. Thanks to @theverge.com for letting me report this one out. There is still time to comment. bit.ly/4v2X4nQ

bit.ly

The war against ‘woke’ could end US science as we know it

“Everyone will be affected, not just scientists. Every community in the country.“

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James Briscoe @jamesbriscoe.bsky.social · 19/06/2026

In our latest editorial @amjeve.uk & I take on the dreaded impact factor Like Monday mornings no one likes them but you can't ignore them & they keep coming around However there are things we should all do as authors, reviewers & editors journals.biologists.com/dev/article/...

journals.biologists.com

The elephant in the room: impact factor

Summary: This Editorial offers an honest look at impact factor trends in developmental biology, explains how Development serves its community, and makes the case that sustaining developmental biology ...

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Mir Lab @mirlab.bsky.social · 07/06/2026

1/🧵 Can transcription factor condensate formation be explained without phase separation? Our new preprint introduces SPARK, a simulation tool that reproduces condensate behavior (clustering, fusion, FRAP) from diffusion & binding kinetics alone. Movie: 60 sec FRAP sim www.biorxiv.org/content/10.6...

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Girish Kale @girishkalephd.bsky.social · 28/05/2026

Our latest manuscript on (Harry Potter and) the effect of elevated temperature on embryonic development in flies. Even a small increase in temperature causes developmental defects, indicating problems in the face of global warming! www.nature.com/articles/s41...

nature.com

Elevated temperature fatally disrupts nuclear divisions in the early Drosophila embryo - Nature Communications

Kale et al. show that nuclear divisions are defective at elevated temperature, leading to gastrulation defects and embryo lethality. Their work finds that F-actin – microtubule interactions during mit...

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Bailey Weatherbee @bailweatherbee.bsky.social · 01/05/2026

It's difficult to succinctly summarize a entire germ layer, but Aaron Zorn, Scott Rankin and I tried recently! Our "Endoderm at a Glance" review with @dev-journal.bsky.social is out now. shorturl.at/kHf9Y

Multipanel poster of "vertebrate endoderm development"

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Lori O'Brien @llobrienlab.bsky.social · 24/04/2026

For #FluorescenceFriday, an E10 embryo showing Pax2 localization. #DevelopmentalBiology

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Michalis Averof @michalis-averof.bsky.social · 19/04/2026

These images show live embryos of animals (jellyfish, crustacean, worm, sea urchin, sea squirt, beetle) and one of animals closest single-celled relatives. They were captured taking advantage of fluorescent proteins localised on the outer membrane of cells, allowing us to observe cell outlines. 1/9

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Denis Wirtz @deniswirtz.bsky.social · 14/04/2026

Mapping nerves in a whole embryos. We find that across species and development stages, embryonic nerves display (beautiful) fractal geometry. More here: www.biorxiv.org/content/10.6...

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Swapna Krishna @swapnakrishna.com · 07/04/2026

Earthset from Artemis II. I am overcome.

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Alex Hughes Lab @hugheslabpenn.bsky.social · 03/04/2026

@lsprahl.bsky.social and Ronald Canlla in the lab just published a detailed study on remote-controlled epithelial budding morphogenesis. We can direct budding, tubule elongation, and perhaps branching in human kidney organoids via a light-activated RET receptor. www.biorxiv.org/content/10.6...

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Miki Ebisuya @ebisuyamiki.bsky.social · 01/04/2026

New preprint from the lab! How do tissue shapes influence cell fate decisions? By manipulating brain organoid geometry, we show that lumen rounding directs apical progenitor division mode and promotes the emergence of basal progenitors. www.biorxiv.org/content/10.6... 1/

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austin (he/him) @austinjgraham.bsky.social · 10/03/2026

organs develop in a dynamic environment where their boundaries are constantly changing shape, relaxing, compressing, etc. in synchrony with the embryo. see how this inspired us to create a material for optimal organoid bioprinting & self-organization! www.nature.com/articles/s41...

nature.com

Stress-relaxing granular bioprinting materials enable complex and uniform organoid self-organization - Nature Materials

A tunable granular biomaterial matrix is developed to support long-term bioprinting. Stress relaxation at high strains and long timescales is shown to be important for tissue self-organization in inte...

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Manning Research Group @manningresearch.bsky.social · 10/02/2026

Excited to highlight a new preprint about mechanical contributions to tissue homeostasis, from the Manning group in collaboration with the amazing Carien Niessen and Sara Wickstrom @sarawickstrom.bsky.social labs, spearheaded by Dr. Somiealo Azote: www.biorxiv.org/content/10.6...

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Alex Hughes Lab @hugheslabpenn.bsky.social · 07/01/2026

If you are considering where to publish new research on extracellular/non-autonomous/geometric/physical cause and effect in development, consider our @dev-journal.bsky.social special issue, with @rashmi-priya.bsky.social!

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Development @dev-journal.bsky.social · 10/02/2026

Submit your latest research to our upcoming special issue – The Extracellular Environment in Development, Regeneration and Stem Cells Guest Editors: Alex Hughes (@hugheslabpenn.bsky.social) & Rashmi Priya (@rashmi-priya.bsky.social) Deadline: 1 March 2026 journals.biologists.com/dev/pages/ex...

Special Issue
The Extracellular Environment in Development, Regeneration and Stem Cells
Guest Editors
Alex Hughes (University of Pennsylvania)
Rashmi Priya (The Francis Crick Institute)

Submission deadline: 1 March 2026.

Development call for papers. Image of magenta and teal cells in a jawbone.

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epithelial mechanics fan club @epimechfc.bsky.social · 31/01/2026

How do cells orchestrate themselves to achieve a directional movement as a group? Hi, I’m @sayukihirano.bsky.social. In this thread, I’ll highlight key mechanisms of how cells communicate with each other to perform directional collective migration.

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Maik Bischoff @maikbischoff.bsky.social · 15/12/2025

🚨 PhD Position Available 🚨 I’m recruiting a PhD student to join my lab at the Multiscale Imaging Centre (MIC), Münster, Germany. www.bischofflab.com/jobs Fully funded ✅ #Cellbio #Morphogenesis #Microscopy #Drosophila #PhD (Details Below) Original Posting: stellen.uni-muenster.de/jobposting/d...

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Joel Boerckel @jboerckel.bsky.social · 11/01/2026

Defending PhD student, looking over their thesis: “If I knew then what I know now, I could’ve done all of this in like 9 months.” A thread about my favorite pioneering cave explorers and why I don’t think AI will ever “solve” biology.

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Max Planck Institute of Molecular Cell Biology and Genetics @mpi-cbg.de · 09/01/2026

With Byung Ho Lee and Kana Fuji as first/lead authors, @anne-grapin.bsky.social group, @utokyoofficial.bsky.social, Inst. of Physics of Academia Sinica, & @igbmc.bsky.social found the shape of lumens in the developing pancreas is controlled by pressure & proliferation. www.mpi-cbg.de/news-outreac...

mpi-cbg.de

Engineering the development of the pancreas

Researchers found that the shape of the fluid-filled cavities in the developing pancreas is controlled by pressure and the rate cells divide.

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Virtual Gastrulation Zoom Talks @vgzt2021.bsky.social · 05/01/2026

🎉 Happy New Year! We’re kicking off 2026 with an exciting VGZT seminar! 🗓️ Thursday, January 8th ⏰ 9:30 PST / 12:30 EST / 17:30 UTC / 17:30 GMT / 18:30 CET Our speakers are 👉 Jan Jakub Zylicz (@jzylicz.bsky.social) 👉 Anahi Binagui-Casas (@abinagui.bsky.social) See you there 👋

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Arjun Raj @arjunraj.bsky.social · 30/12/2025

Blog post: Just quit Quitting projects in science is hard, but we should be doing a lot more of it. open.substack.com/pub/arjunraj...

open.substack.com

Just quit

Quitting projects in science is hard, but we should be doing a lot more of it.

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Lukasz Bugaj @bugajlab.bsky.social · 17/12/2025

🚨Preprint 2/2: Several studies implicate condensates in RTK fusion onco-signaling. So we were surprised to find that condensates are entirely dispensable😮(!). A study from proteins to mice, by dynamic duo @davidgonzmar.bsky.social and @trmumford.bsky.social. www.biorxiv.org/content/10.6... 👇

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Lukasz Bugaj @bugajlab.bsky.social · 16/12/2025

🚨New preprint(1/2)! We show that RTK fusion oncoproteins broadly suppress EGFR signaling. How? Sequestration of adapters as the shared principle. Led by superb PhD student Carol Gao. www.biorxiv.org/content/10.1... Implications for drug tolerance/resistance, and includes one big surprise🫧.👇

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Denis Wirtz @deniswirtz.bsky.social · 18/12/2025

We wrote two reviews on cell migration, published today in Nature Methods. They provides practical guidelines how to select a cell-migration assay and how to analyze cell-migration data Review 1: nature.com/articles/s41... Review 2: nature.com/articles/s41...

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FocalPlane @focalplane.bsky.social · 19/12/2025

We’ve highlighted some wonderful images and researchers in our ‘Featured image’ series in 2025. To celebrate, we’re inviting you to vote for your favourite in our image competition! #FluorescenceFriday Check them out here: focalplane.biologists.com/2025/12/19/v...

focalplane.biologists.com

Vote for your favourite 'Featured image' from 2025 - FocalPlane

Vote for your favourite 'Featured image' from 2025 - News

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epithelial mechanics fan club @epimechfc.bsky.social · 19/12/2025

Leybova, L., Biswas, A., Sharan, R., Trejo, B. M., Kim, K., ..., Phillips, B. K., & Devenport, D. (2024). Radially patterned morphogenesis of murine hair follicle placodes ensures robust epithelial budding. Developmental cell, 59(24), 3272–3289.e5. #EpithelialMechanics buff.ly/z1wX1O6

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the Node @the-node.bsky.social · 18/12/2025

Apply for Development's Pathway to Independence programme The programme aims to support a small number of researchers in the fields of developmental biology, stem cells and regeneration as they transition from postdoc to group leader. Read more ⬇️ thenode.biologists.com/apply-for-de...

thenode.biologists.com

Apply for Development's Pathway to Independence programme - the Node

Development are currently welcoming applications for our Pathway to Independence (PI) programme, which aims to support a small number of researchers in

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Agathe Chaigne @agathechaigne.bsky.social · 18/12/2025

My lab is hiring a postdoc (ERC funded)! If you're interested, get in touch!

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International Society of Developmental Biology @isdb.bsky.social · 17/12/2025

❗PREPRINT ALERT❗ doi.org/10.64898/202... The lab of M. Lisa Manning at @syracuseu.bsky.social in collaboration with Ale Mongera at @ucl-cdb.bsky.social show that in the avian presomitic mesoderm, Contact Inhibition of Locomotion has a tissue-wide effect, making tissue act like a fluid under tension.

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Virtual Gastrulation Zoom Talks @vgzt2021.bsky.social · 16/12/2025

🎄 Final VGZT seminar before Christmas! 🎄 We’re excited to welcome keynote speaker Olivier Pourquié ✨ “Recapitulating human somitogenesis in vitro” 🗓️ Thursday, December 18th ⏰ 9:30 PST / 12:30 EST / 17:30 UTC / 17:30 GMT / 18:30 CET

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Xavier Trepat @xaviertrepat.bsky.social · 15/12/2025

📢 New extended abstract submission deadline: 6 January 2026! Outstanding speaker list, plus many slots for short talks by students, postdocs, and junior PIs. Join us in March in Barcelona! events.ibecbarcelona.eu/embl-ibec-co...

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Mark Peifer (He, him) @peiferlabunc.bsky.social · 14/12/2025

To build the body plan of an animal, cells must adhere to one another via cell-cell junctions. We now know these assemble as punctate protein complexes containing thousands of proteins, but how this occurs remains mysterious. 1/n 🧪 www.molbiolcell.org/doi/full/10....

Image of cell junction puncta from
https://www.molbiolcell.org/doi/full/10.1091/mbc.E23-03-0077

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Maik Bischoff @maikbischoff.bsky.social · 27/11/2025

So excited to share this as a new junior PI: My brand-new lab website! 🎉🪰🌀 www.bischofflab.com Please pass it on to young, motivated researchers looking for PhD positions 😊 And for the #FluorescenceFriday community: don’t miss the SciArt Gallery! #CellBio #DevBio #PhDjob #PhDposition #Science

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epithelial mechanics fan club @epimechfc.bsky.social · 14/12/2025

Cells can sense the geometry of their environment, from tiny subcellular features to whole-tissue patterns. How can we engineer environments to systematically probe these responses? 🧵 I'm @lhinderling.bsky.social from @olivierpertz.bsky.social lab, let’s do a short tour on microfabrication!

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Louis Prahl @lsprahl.bsky.social · 13/12/2025

Super cool new work from my @hugheslabpenn.bsky.social colleagues on rhythmic nephron-forming signals in the developing kidney!

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Alex Hughes Lab @hugheslabpenn.bsky.social · 13/12/2025

*New preprint alert* uncovering a mechanical pacemaker that synchronizes nephron formation with branching of the kidney's epithelial tubule tree. Read below to learn about this twisty journey lead by Sam Grindel and Sachin Davis in the lab. [Movie by Nils Lindstrom] www.biorxiv.org/content/10.1...

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Andy Moore @aaandmoore.bsky.social · 12/12/2025

This movie shows lysosomes (orange) and keratin (gray) in a cultured cell over 10 minutes.

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Joel Boerckel @jboerckel.bsky.social · 13/11/2025

Very excited to see our paper, led by @amilangscience.bsky.social, out today in @pnas.org! This one was a true adventure, filled with surprises at every turn. “Erythroid precursors regulate local oxygen tension and repair outcomes in the bone marrow niche.” www.pnas.org/eprint/NJ8XC...

pnas.org

Erythroid precursors regulate local oxygen tension and repair outcomes in the bone marrow niche | PNAS

Oxygen tension dynamically regulates stem cell fate and tissue regeneration, yet how local oxygen availability is controlled within the bone marrow...

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Richard Sever @richardsever.bsky.social · 06/12/2025

ASCB President Mary Munson awards Francis Collins the ASCB Public Service award, noting this is the first time it’s been awarded for defense of science #cellbio2025

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Chrystal Starbird @drstarbird.bsky.social · 08/12/2025

Attending #CellBio2025? Come join the Signaling Squad at our mini symposium on “Spatiotemporal Control of Cell Signaling Across Scales” in Room 120 from 9-11 am! I’m not saying we’re the best because there are so many great sessions, but it may be a save the best for last situation 😉

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American Society for Cell Biology @ascbiology.bsky.social · 06/12/2025

Celebrating #ASCB leadership at #CellBio2025 with four Presidents across the years: Elizabeth Chen (2027), Sandra Ann Murray (2024), Mary Munson (current), and Rong Li (incoming). Learn more: www.ascb.org/cellbio2025/

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Nat Clarke @natclarke.bsky.social · 08/12/2025

Interested in cell adhesion, evolution of multicellularity, or developing tools for emerging marine models? My lab at UM is hiring a postdoc, and the application is now open: 🔗 tinyurl.com/28jvu4aa If you know anyone looking for a postdoc, please pass this along!

tinyurl.com

Post Doctoral Associate - Biology

Current Employees: If you are a current Staff, Faculty or Temporary employee at the University of Miami, please click here to log in to Workday to use the internal application process. To learn how to...

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