Synonymous codon usage controls global gene expression in both prokaryotic and eukaryotic species. Nonoptimal codons are known to induce mRNA decay; however, the underlying molecular mechanism remains...

We are looking for a highly motivated and dynamic computational postdoc for a 3-year position to join the Lund Group. Our research Our team aims to understand h

The eukaryotic vault particle is a giant ribonucleoprotein complex that assembles into an iconic barrel-like cage. Its cellular function has remained elusive despite extensive characterization. Using ...

Despite a growing interest in the ribotoxic stress response (RSR), it remains unknown how the upstream p38 and JNK-activating MAP3 kinase ZAKα senses translational impairment. Combining Alphafold3 pre...

We demonstrate that the translation initiation factor eIF2B, best known for its guanine nucleotide exchange (GEF) function in mRNA translation initiation, also acts as a potent inducer of mutant KRAS ...

PhD Project - Funded PhD: Understanding the role of the ribosomal P-stalk in immune responses at University of Bristol, listed on FindAPhD.com

Selenocysteine, incorporated into polypeptides at recoded termination codons, plays an essential role in redox biology. Using GPX1 and GPX4, selenoenzymes that mitigate oxidative stress, as reporters,...

PhD Project - Funded PhD: Understanding the role of the ribosomal P-stalk in immune responses at University of Bristol, listed on FindAPhD.com

The extracellular space is a critical environment for discriminating self versus non-self nucleic acids and initiating the appropriate immune responses through signaling cascades to relay information ...

During nutrient deprivation, activation of the protein kinase GCN2 regulates cell survival and metabolic homeostasis. In addition to amino acid stress, GCN2 is activated by a variety of cellular stres...

Cycling instead of driving has been linked with a lower risk of dementia and Alzheimer’s disease, a large study has found.

Abstract. The presentation of peptides on HLA molecules is essential to CD8+ T cell responses. Here, we show that loss of uL14 significantly downregulates

Protein complexes are essential for cell function. Here, authors show that paired ribosomes can help each other’s nascent chains fold correctly, enabling proper dimer assembly and preventing misfoldin...

With vital studies being shelved and foreign experts turning down jobs, leading charity urges ministers to act

Evolution has shaped the genetic code, with subtle pressures leading to preferences for some synonymous codons over others. Codons are translated at different speeds by the ribosome, imposing constrai...

Abstract. Mitochondrial gene expression needs to be balanced with cytosolic translation to produce oxidative phosphorylation complexes. In yeast, translati

The noncanonical translation initiation factor eIF2A plays critical roles in diverse cellular processes, including the integrated stress response, neurodegeneration and tumorigenesis. However, the pre...

Abstract. Translational regulation at the stage of initiation can impact the number of ribosomes translating each mRNA molecule. However, the translational

Abstract. It has become clear in recent years that ribosomes regularly stall during translation. Such translation impairment has many causes, including exp

Eukaryotic ribosome assembly is an intricate process that involves four ribosomal RNAs, 80 ribosomal proteins, and over 200 biogenesis factors that pa…

m6A is a potent inducer of ribosome stalling and collisions that trigger YTHDF-mediated mRNA degradation, a process that highlights the ribosome as a critical sensor linking translation dynamics to m6...

Aberrant peptides presented by major histocompatibility complex (MHC) molecules are targets for tumor eradication, as these peptides can be recognized…

Using high-throughput functional profiling, how disordered regions control mRNA stability and translation is explored.

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Cells can simultaneously produce structurally dissimilar ribosomes, suggesting functional specialization of distinct ribosome populations. Here, the authors show that distinct ribosomes cooperate rath...

Ribosome profiling faces issues with rRNA contamination and measurements of ribosome numbers on transcripts. Here, the authors develop Ribo-FilterOut and Ribo-Calibration, methods which can be used to...

Hyperactive WNT signaling is a potent cancer driver, but clinical translation of WNT inhibitors has been hampered on-target toxicities. WNT signaling can be constrained through inhibition of the PARP ...

Millions of ribosomes are packed within mammalian cells, yet we lack tools to visualize them in toto and characterize their subcellular composition. In this study, we present ribosome expansion micros...

Recent advances in the fields of RNA translation and ribosome biology have demonstrated the heterogeneous nature of ribosomes. This manifests not only across different cellular contexts but also withi...

This is "Roving Scientist at NKI_ENGsub" by Antoni van Leeuwenhoek on Vimeo, the home for high quality videos and the people who love them.

Ribosomes cooperate through transient collisions to ensure efficient translation.

NAC regulates the ribosome localization, metabolic profile, and fate of intestinal stem cells.

Working in sensory neurons, Smith et al. show that the translation elongation regulator eEF2K is capable of inducing the integrated stress response through ribosome-dependent activation of GCN2. This suppresses global protein synthesis, but it enables the preferential translation of the neuromodulator BDNF. Inhibition of this mechanism or BDNF translation diminishes pain-associated behaviors in vivo.