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Reposted by Yardena Samuels

EACR - European Association for Cancer Research @helloeacr.bsky.social · 16/06/2025

EACR President @yardenasamuels.bsky.social‬ delivers the #EACR2025 Opening Address!

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Reposted by Yardena Samuels

Carlos Caldas 🇵🇹🇮🇱🇪🇺🇬🇧 @carloscaldas1960.bsky.social · 16/06/2025

@yardenasamuels.bsky.social opening #EACR2025! Amazing grace! @eacr.org is very lucky to have Yardena as its president!

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Reposted by Yardena Samuels

American Association for Cancer Research (AACR) @theaacr.bsky.social · 14/05/2025

Targeting the Cancer Ecosystem: Presenters addressed microenvironmental and host-level changes that accompany tumor progression during an #AACR25 Plenary Session. Read a recap in AACR Annual Meeting News: www.aacrmeetingnews.org/news/fourth-... @yardenasamuels.bsky.social

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Yardena Samuels @yardenasamuels.bsky.social · 29/04/2025

Thanks AACR25 this has been an amazing honor

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Yardena Samuels @yardenasamuels.bsky.social · 29/04/2025

Thank you AACR25 for inviting me to give a plenary talk this morning! An absolute honor!

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Reposted by Yardena Samuels

ACIR @acir-org.bsky.social · 02/04/2025

Translation dysregulation may serve as a new source for identifying cancer-associated antigens, and may also help to predict responses to checkpoint blockade bit.ly/3E4OMY8 #CheckpointBlockade #CancerImmunotherapy @wellerchen.bsky.social @Samuels-lab.bsky.social @yardenasamuels.bsky.social

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Reposted by Yardena Samuels

Chris McGinnis @cmcginnis.bsky.social · 29/03/2025

With great collaborators @wellerchen.bsky.social @yardenasamuels.bsky.social and many others!

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Reposted by Yardena Samuels

Parker Institute for Cancer Immunotherapy (PICI) @parkerici.bsky.social · 27/03/2025

What if a “mistake” made tumors easier to find? New PICI-funded study from co-first author @cmcginnis92 at @stanfordmedicine shows that removing TYW2 scrambles protein translation—producing signals that help the immune system detect and attack cancer. 🔗 www.cell.com/cancer-cell/...

cell.com

Translation dysregulation in cancer as a source for targetable antigens

Weller et al. substantiate the role of translation dysregulation in mediating anti-tumor immunity by demonstrating that TYW2 loss in melanoma cells induces aberrant peptide MHC presentation, increasin...

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Yardena Samuels @yardenasamuels.bsky.social · 27/03/2025

Thanks Chris! @cmcginnis.bsky.social‬ great working with you-looking forward to many more collaborations!

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Yardena Samuels @yardenasamuels.bsky.social · 27/03/2025

and all our amazing collaborators H. Palashati, D. Malko, M.D. Shmueli, P. Poulis, M.J. Zemanek, M.M. Nielsen, A. Khatib, Y. Levin, Y. Pilpel, M. Rodnina, J. Cox, Y. Merbl, F. Erhard, T. Suzuki, A.R. Buskirk and whole team!

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Yardena Samuels @yardenasamuels.bsky.social · 27/03/2025

✨ We are thankful to the @CancerCell editorial team and the reviewers for their constructive comments, and I am grateful to have such a wonderful team. (7/7)

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Yardena Samuels @yardenasamuels.bsky.social · 27/03/2025

🏥 Patient data completed the picture: Primary melanoma tumors with low TYW2 showed enhanced responses to ICB, even in patients with low TMB (@Tiangen). Translation fidelity defects may help predict immunotherapy responders, opening new paths for precision cancer treatment. (6/7)

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Yardena Samuels @yardenasamuels.bsky.social · 27/03/2025

Together with Yaron Carmi, we identified FS peptides that triggered robust T cell responses. Moreover, these peptides elicited de novo T cell responses specifically in TYW2-KO tumor-bearing mice! (5/7)

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Yardena Samuels @yardenasamuels.bsky.social · 27/03/2025

🐭 In mice, TYW2 loss increased tumor immunogenicity, specifically in immunocompetent mice. scRNA-seq revealed that TYW2-KO tumors were enriched for exhausted T cells. Indeed, TYW2-KO tumor-bearing mice were sensitive to immune checkpoint blockade (ICB) therapy.

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Yardena Samuels @yardenasamuels.bsky.social · 27/03/2025

Furthermore, in vitro T cell stimulation assays (@Johannaolweus & team) demonstrated that these aberrant peptides are potent immune triggers! Could translation errors fuel anti-tumor immunity? (3/7)

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Yardena Samuels @yardenasamuels.bsky.social · 27/03/2025

🧬 Loss of TYW2, a tRNA modifier, disrupts translation fidelity—causing ribosomes to pause at Phe codons and increasing frameshift (FS) events. This generates out-of-frame peptides, which are presented by MHC class I molecules. (2/7)

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Yardena Samuels @yardenasamuels.bsky.social · 27/03/2025

Thrilled to share our latest work in Cancer Cell! 🚨 Led by @chenweller, Osnat Bartok, with amazing collaborators @Chrismcginnis, @AnsumanSatpathy, Andreas Schlosser, @EytanRuppin & more, we reveal that impaired translation fidelity enhances anti-tumor immunity!🧵(1/7)

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