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Luisa Cochella

@lcochella.bsky.social
670 followers 711 following 11 posts

Proud worm researcher. Interested in miRNAs, all RNAs really, and gene regulation in general. A biochemist turned geneticist trying to think about questions of cell biology. Lucky to lead a lab at Johns Hopkins School of medicine. cochellalab.org

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Reposted by Luisa Cochella
Society for Developmental Biology @socdevbio.bsky.social · 01/05/2026
✨ Excited to host invited speaker Luisa Cochella (@lcochella.bsky.social) at #2026SDB in Las Vegas! 🎰🃏 Her research explores cell diversification and RNA-based mechanisms controlling development. 🧬✨ #devbio
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cgc-worms.bsky.social @cgc-worms.bsky.social · 08/04/2026
The worm community has lost a true legend with the passing of Don Moerman. Don's impact on C. elegans research is beyond measure. A friend to many of us here in MN, his work has been invaluable, contributing >5,400 strains (VC & DM) to the CGC, 20% of our collection!
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Jordan Ward @gotworms.bsky.social · 23/02/2026
Come join us! This meeting is going to be awesome!
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Gavin Woodruff @weirdworms.bsky.social · 23/11/2025
Recurrent evolution of selfishness from an essential tRNA synthetase in Caenorhabditis tropicalis www.nature.com/articles/s41...
nature.com
Recurrent evolution of selfishness from an essential tRNA synthetase in Caenorhabditis tropicalis - Nature Ecology & Evolution
In Caenorhabditis tropicalis, three toxin–antidote elements arose via gene duplication from the essential tRNA-synthetase subunit FARS-3. The ancestral antidote probably acquired affinity for FARS-3, ...
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 12/10/2025
I'm very excited to announce that UNC Biology has 6 faculty positions open this year! The first is for an Asst Professor who studies organismal resilience using an integrative approach 1/n unc.peopleadmin.com/postings/307...
Poster with QR code linking to the position
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Ulrich Hohmann @hohmannulrich.bsky.social · 12/10/2025
Thrilled to share that I’ll be joining @imbmainz.bsky.social in February 2026 to start my own group! We will explore new mechanisms in eukaryotic gene expression, leveraging ‘evolutionary play’ to uncover how regulation, repurposing, and hijacking shape RNA biology. PhD positions available!
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Ishmail Abdus-Saboor @ishmailsaboor.bsky.social · 08/10/2025
Congrats to the winners! Its notable that Omar Yaghi was a refugee. Refugees and immigrants once again making American science great!
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Gurdon Institute, University of Cambridge @gurdoninstitute.bsky.social · 08/10/2025
It is with great sadness that we share the news of the death of our founder, colleague, mentor and friend, Professor Sir John Gurdon. His vision and dedication will continue to inspire generations of scientists. 🔗 www.gurdon.cam.ac.uk/nobel-laurea...
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Max Kozlov @maxkozlov.bsky.social · 30/09/2025
Staff members at the NIH seem to have done the impossible: spend the agency's $48 billion budget. “Everyone has been rallying together to clean up the mess, but it’s a mess that did not need to be made,” an NIH program officer told me. www.nature.com/articles/d41...
nature.com
NIH races to spend its 2025 grant money — but fewer projects win funding
Despite political obstacles, officials are on track to disburse all of the research funds allocated to US biomedical behemoth.
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Pam Davis-Kean, PhD @umpamdk.bsky.social · 29/09/2025
Thank you all the program officers at NIH that persisted through the 2025 fiscal year and were able to fund 99% of the total FY2024 budget. I know this has take a toll on everyone at NIH. Thank you for supporting important health and behavior science and helping to keep the U.S. a leader in science.
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Surojit Sural @surojitsural.bsky.social · 24/09/2025
Very excited to share this finding from my postdoctoral work that is now published in #ScienceAdvances. We show how the gut’s epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes. www.science.org/doi/10.1126/... Thread ⬇️ (1/n)
science.org
Gut epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes
Gut epithelium modulates output from distinct enteric circuits by altering secretion of insulin and noninsulin peptides.
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Grosshans Lab @labgrosshans.bsky.social · 08/09/2025
Thanks for highlighting - thread to follow. Mini-summary: beyond assigning oscillatory genes expression by scRNA-seq to individual cell types, we also show that chromatin opens rhythmically and that we can predict this (and gene expression) with a small set of TFs in a mathematical model.
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Max Heiman @heiman.bsky.social · 07/09/2025
New preprint! How are developmental cycles coordinated across cell types? It turns out that, like Geppetto's cuckoo clocks in the GIF below, individual cell types are each performing their own little crazy routine, but all in sync with each other.
media.tenor.com
a bunch of clocks are hanging on a wall including one that says ' 3:00 ' on it
ALT: a bunch of clocks are hanging on a wall including one that says ' 3:00 ' on it
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Current Biology @currentbiology.bsky.social · 07/09/2025
David Baltimore, giant of molecular biology, has died.
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W. Brent Derry @wbderry.bsky.social · 06/09/2025
Go Mei!
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paveltomancak.bsky.social @paveltomancak.bsky.social · 04/09/2025
We are all super happy and proud to see our work on the function and evolution of the #cephalic #furrow published in @nature.com. Let me say a few things about the background and history of this work on the #Evolution_of_Morphogenesis (1/12)
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Luisa Cochella @lcochella.bsky.social · 03/09/2025
Our work on the function of miR-51/miR-100 is out! miR-100 is widely conserved across eumetazoans but its function has been mysterious. Emilio Santillán found in worms it regulates signaling and extracellular matrix genes, some of which seem to be conserved targets! www.science.org/doi/10.1126/...
science.org
An ancient and essential miRNA family controls cellular interaction pathways in C. elegans
A microRNA that arose at the origin of eumetazoans regulates cell adhesion and signaling in C. elegans through conserved targets.
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Petr Svoboda @svobodalab.bsky.social · 28/08/2025
The Argonautes 2025 - we made a special gift for participants - a card set with 32 different Argonautes + an extension pack with four Nobel prize winners from the small RNA field. Mello, Fire, Ambros & Ruvkun as jokers :-) #argonautes2025
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Max Heiman @heiman.bsky.social · 02/07/2025
Huge thanks to Cathy Savage-Dunn @cswormlab.bsky.social and Baris Tursun @baristursun.bsky.social for an amazing #worm25 !! I want to call out the OUTSTANDING meeting they created! Talks and posters were A+++. Most of all they brought us together in one of the most challenging times we've had.
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Baris Tursun @baristursun.bsky.social · 02/07/2025
Special thanks to Ahna Skop, Morris Maduro, and Curtis Loer for bringing so much joy to the meeting! Also, big thanks to GSA and Anne Marie Mahoney for making #worm25 happen despite the challenging times. Thank you also to USDavis for hosting us and the delicious food.
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Baris Tursun @baristursun.bsky.social · 02/07/2025
We are looking forward to the Worm Meeting 2027 and thank Suhong Xu(Zhejiang University School of Medicine, Hangzhou, China), Kavita Babu (Indian Institute of Science, Bangalore, India), and Erik Andersen (Johns Hopkins University Baltimore, USA) for organising. #worm25
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Luisa Cochella @lcochella.bsky.social · 03/07/2025
Congrats to all, including Lo-Yu Chang from our lab 😁
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versteegga.bsky.social @versteegga.bsky.social · 01/05/2025
New paper out in @natcomms.nature.com! A surprising story of a "non-conserved" protein that's vital for human cell fitness! Fantastic work by Alexandra Shulkina in collaboration with the @lcochella.bsky.social & @clausenlab.bsky.social labs.
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Jeff Coller @jmcoller.bsky.social · 14/03/2025
Our dean is taking the message to where it needs to hit. www.foxnews.com/opinion/cutt...
foxnews.com
Cutting NIH funding isn’t how to defeat disease, it’s surrender
Plans to cut NIH funding undermine America's incredible record of medical success. Scientific research has helped win many battler against horrible diseases. We should be proud.
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Denis Wirtz @deniswirtz.bsky.social · 13/03/2025
"Funding from the NIH was contributed to 354 of 356 drugs (99.4%) approved from 2010 to 2019 totaling $187 billion" Reference: jamanetwork.com/journals/jam...
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Itai Yanai @itaiyanai.bsky.social · 09/03/2025
Much will be written about how 4 PhD students and a PhD –Colette Delawalla, Sam Goldstein, Emma Courtney, Leslie Berntsen & JP Flores – organized @standupforscience.bsky.social to unite scientists in the US and worldwide. Now let's keep the momentum going to defend science! bsky.app/starter-pack...
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Philip Bender @scienceetc.bsky.social · 13/02/2025
Of course times are tough, but is anyone (or does anyone know) of anyone in the DC-VA-MD area with openings for a masters-level researcher with experience in molecular biology, RNA and DNA work, transcriptomics, and specific experience with both plant and nematode genomics?
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Jeremy Berg @jeremymberg.bsky.social · 13/02/2025
Bluetorial: The rationale for the “NIH” indirect cost “plan” is based on misunderstood (unintentional or intentional) accounting and math The value of real government transparency
media.tenor.com
a cartoon of homer simpson holding a card
ALT: a cartoon of homer simpson holding a card
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Stand Up for Science! @standupforscience.net · 12/02/2025
Welcome to the Bluesky account for Stand Up for Science 2025! Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide! #scienceforall #sciencenotsilence
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Keystone Symposia @keystonesymposia.bsky.social · 12/02/2025
You've waited for it, now it's finally here ... On-Demand is now available for our joint meeting on RNA Mediated Regulation of Immunity / Non-Coding RNA Biology! Purchase at keysym.us/KSRNAImmune2... or keysym.us/KSNCRNA25OD. #KSRNAImmune25 #KSNCRNA25 @skadener.bsky.social @lcochella.bsky.social
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Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · 27/01/2025
Booster RNAs from the Coller lab!
media.tenor.com
a cartoon superhero is holding a lightning bolt in his right hand
ALT: a cartoon superhero is holding a lightning bolt in his right hand
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Jeremy Berg @jeremymberg.bsky.social · 27/01/2025
While I realize this is not relevant to many of the present day discussions, the remarkable similarity of organisms at the biochemical, genetic, cellular, and physiological levels is not understood by many people. 1/n
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Piali Sengupta @senguptalab.bsky.social · 26/01/2025
💯 We need people trained in evidence-based critical and logical thinking in all kinds of fields. Politics included - see current disaster in the US. PhDs/PDs from my lab are pursuing careers in diverse areas - policy, education, writing, law, as well as industry & academia. And that's a win for all.
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BK. Titanji @boghuma.bsky.social · 25/01/2025
Every week, I check the CDC's Mortality and Morbidity Weekly Report. This week for the first time in its 60 years it was not published on schedule. American healthcare workers all over the country are less informed about health crises that affect their patients. CDC led reports matter a 🧵
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 24/01/2025
The rapid actions of the Trump Administration to shut down all communication by NIH, thus putting both study sections and councils on hold, is challenging for all of us. We can make our voices known. Below is an example email I sent to both NC Senators (text in alt text) 1/2 🧪
Bipartisan support for NIH and biomedical research is key to retaining US leadership
Dear Sen. Tillis,
I am a constituent, a Professor at UNC-Chapel Hill and a biomedical researcher with 33 years of funding from NIH.  You have been a strong supporter of NIH and  biomedical research, recognizing the impact of the more than $2 billion in funding NIH brings to NC Universities and its broader economic impact.  The US has led in biomedical research for many decades, yielding impressive improvements in treatment of cancer and heart disease, and stunning new opportunities to use gene therapy in diseases like Type 1 diabetes and sickle cell disease.  In the last 10 years, China has massively increased investment in science, and is threatening our lead.  To remain competitive, we need to continue our investment.  The actions this week by the Trump Administration to shut down NIH study sections and pause funding sent shock waves through our community.  We need to resume bipartisan support for NIH or lose a generation of scientists.  I would like to connect with the aide in the Tillis office who handles HHS and NIH and have a conversation about these issues--please have them email me.
Thank you for your past support
Mark Peifer
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Development @dev-journal.bsky.social · 23/01/2025
Apply to our Pathway to Independence programme by 31 January The programme aims to support postdocs going on the job market in 2025 with training, mentorship, profile-raising and networking opportunities. journals.biologists.com/dev/pages/p… #DevBio #StemCells🧪
Text reads "Pathway to independence: a new initiative supporting postdocs on the job market"; image shows a person working from a lab bench with a microscope to an office desk with a lamp
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Judith Yanowitz @yanoworm.bsky.social · 23/01/2025
Fellow worm breeders: instead of fretting alone at home about the current state of the NIH, I encourage you to write to your Senators and Congressmen and the President touting why basic research fuels our economy and that the constraints placed on the NIH this week will stifle scientific progress.
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Jeremy Berg @jeremymberg.bsky.social · 23/01/2025
Started off this morning emailing my Senators and Congressman about the NIH and the potential damage being done by unnecessary disruptions. They need to hear from us loud and clear. Constituents matter to them as one of the primary purposes of a politician is to get re-elected (and its their job).
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Christophe 🔬 Leterrier @christlet.bsky.social · 11/12/2024
Buenos Aires is beautiful and I keep posting about how I'm having a great time, but don't forget the tragic situation for science in Argentina at the moment. Argentinian scientists are working despite this and they deserve our full support! www.nature.com/articles/d41...
nature.com
‘There will be nothing left’: researchers fear collapse of science in Argentina
One year into President Javier Milei’s presidency, scientists are exiting the country in the face of big budget cuts.
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Ardem Patapoutian @ardemp.bskyverified.social · 09/12/2024
I joined 75+ @nobelprize.bsky.social laureates urging US Senators to oppose RFK Jr.'s confirmation as DHHS Secretary. If you’re in a state with GOP senators, PLEASE reach out to them! I’d deeply appreciate it if you amplified this post! 🙏 www.nytimes.com/2024/12/09/h...
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Arjun Raj @arjunraj.bsky.social · 30/11/2024
Science is big enough (especially biomedical) that you have the opportunity to shape your project to match as many of your innate talents, passions, and proclivities as possible. Highly encourage leaning into those strengths when you choose a project: rajlaboratory.blogspot.com/2024/06/proj...
rajlaboratory.blogspot.com
Project choice: Lean into your strengths
A blog from the Raj Lab for systems biology
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The Fromm Lab @frommlab.bsky.social · 30/11/2024
MirGeneDB 3.0 is published. Great teamwork and substantial improvement of database, Taxon sampling and we took over nomenclature of novel genes and families, too academic.oup.com/nar/advance-...
academic.oup.com
MirGeneDB 3.0: improved taxonomic sampling, uniform nomenclature of novel conserved microRNA families and updated covariance models
Abstract. We present a major update of MirGeneDB (3.0), the manually curated animal microRNA gene database. Beyond moving to a new server and the creation
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Itai Yanai @itaiyanai.bsky.social · 29/11/2024
Which one are you? Among scientists are collectors, classifiers, and compulsive tidiers-up; many are detectives by temperament and many are explorers; some are artists and others artisans. There are poet-scientists and philosopher-scientists and even a few mystics. –Peter Medawar
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Harmit Singh Malik @harmitmalik.bsky.social · 29/11/2024
If you had a mentor in school, college or grad school who (positively) changed your outlook or the course of your career, why not consider thanking them this Thanksgiving? Send them a letter or email. If you feel comfortable, post on here to share the positive vibes.
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Javier F Caceres @javierfcaceres.bsky.social · 19/11/2024
Join us in San Diego. A great meeting and also featuring the RNA Journal
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Jordan Raff @jordanraff.bsky.social · 28/11/2024
The Company of Biologists @biologists.bsky.social have been such great supporters of the biology community in the UK and around the world. Celebrating 100yrs at a meeting/party in Liverpool next year. Some great speakers (and me too).
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Aakanksha Singhvi @singhvilabglia.bsky.social · 26/11/2024
Hi worm world! We are looking for promoters that label hyp 4-6 (in any combination/subset). Do you have any leads? Have not gotten clean promoter bashed version from alr-1, so would love any help. Thank you in advance! #celegans #worm
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Maureen Barr @barrlab.bsky.social · 27/11/2024
WormBook has Worm Breeder's Gazettes from 1975 - 2014! So much history. Here's a cover from 1986 (posted by Dave Pilgrim on C. elegans FB group) wbg.wormbook.org/about/archiv...
Cartoon of C. elegans Eastworm Film Festival from November 1968 Worm Breeder's Gazette
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Piali Sengupta @senguptalab.bsky.social · 26/11/2024
🧪 Lab's latest!! Work by PD (and now PI) Alison Philbrook. C. elegans sensory neurons have gorgeous #cilia. We’ve always thought that a) no cilia = no sensory responses, & b) no IFT = no cilia. Punchline is we thought wrong. Read paper for more! #neuroscience journals.plos.org/plosbiology/...
journals.plos.org
Cilia structure and intraflagellar transport differentially regulate sensory response dynamics within and between C. elegans chemosensory neurons
The relative contributions of intraflagellar transport (IFT) and cilia structure to sensory neuron responses remains unclear. This study reveals unexpected complexity in the contribution of IFT and ci...
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Zeynep Baharoglu @zeynepbaharoglu.bsky.social · 24/11/2024
The ribosome comes to life www.cell.com/cell/fulltex...
cell.com
The ribosome comes to life
The ribosome is an ancient molecular machine that coverts the genetic information carried by mRNA into protein, a crucial step in linking genotype to phenotype. This review discusses landmark advances...
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