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versteegga.bsky.social

@versteegga.bsky.social

versteegga.bsky.social @versteegga.bsky.social · 17/02/2026

Our paper is out in @natcomms.nature.com! APOBEC3s drive mutagenesis in cancer. We uncover a novel pathway keeping them in check. The key is APOBEC3 binding of cellular RNAs, which simultaneously controls their nuclear localization and shields them from degradation. Read it here: rdcu.be/e4qaa

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versteegga.bsky.social @versteegga.bsky.social · 01/07/2025

Our latest study is now out in @narjournal.bsky.social‬: we identify a post-transcriptional bottleneck in interferon gamma signaling that hinges on proper maturation of JAK2 mRNA. Paper: academic.oup.com/nar/article/...

academic.oup.com

ERH regulates type II interferon immune signaling through post-transcriptional regulation of JAK2 mRNA

Abstract. Type II interferon (IFNγ) signaling is essential for innate immunity and critical for effective immunological checkpoint blockade in cancer immun

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versteegga.bsky.social @versteegga.bsky.social · 01/05/2025

New paper out in @natcomms.nature.com! A surprising story of a "non-conserved" protein that's vital for human cell fitness! Fantastic work by Alexandra Shulkina in collaboration with the @lcochella.bsky.social & @clausenlab.bsky.social labs.

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