SC-β and SC-MReg coaggregates have improved insulin secretion, metabolic function, and reverse hyperglycemia in diabetic mice.

Engineered T cell therapies have transformed cancer treatment and similar principles are being applied in autoimmunity and transplantation. In this review Levings and colleagues discuss strategies to ...

Halvorson et al. characterize the variability associated with AIM assays and present strategies to minimize technical variability. Box-Cox-based correction for background signals, optimized AIM protocols for CD4+ and CD8+ T cells and Tregs, and automated gating software reduce unwanted variability and enhance signal detection, streamlining AIM assays for clinical adoption.

Dendritic cells (DCs) facilitate the maintenance of immunological tolerance in the steady state. We report that transcription factor Etv3 is preferentially expressed in mature DCs, including tissue-de...

Sabatino and colleagues examine expanded CD8+ T cell clonotypes from a small cohort of multiple sclerosis patients. They identified several cognate peptide epitopes that derive from Epstein–Barr virus...

Postdoctoral Fellow - Innate Lymphoid Cells and Spatial Genomics in Type 1 Diabetes, Crome Lab, Terry Fox Laboratory BC Cancer Vancouver, BC We are recruiting a highly motivated Postdoctoral Fellow to...

Jones et al. demonstrate that Notch signaling suppresses CD4+ (helper) T cell induction from PSCs and that manipulating TCR and Notch signaling enables control over CD4+ vs. CD8+ (cytotoxic) T cell pr...

This study shows that T cell cross-reactivity is influenced by the co-signalling molecules CD5, CD8 and CD4, and that cytotoxic T cells with a CD8→CD4 co-receptor switch show reduced cross-reactivity ...

Aims/hypothesis Islet amyloid contributes to beta cell failure in type 2 diabetes through several mechanisms, one being the potent induction of local islet inflammation through activating inflammatory...

Engineered β cells with a mutant CD155 help evade immune attack, offering a promising therapeutic approach for type 1 diabetes.

Nature Immunology - Brown and colleagues review the heterogeneity of mucosal antigen-presenting cells that orchestrate T cell immunity to intestinal antigens.

This week, we will discuss the use of creating chimeras to induce immune tolerance and its potential to decrease or eliminate the need for immunosuppression in kidney transplant recipients.

Massively parallel reporter assay in primary human CD4+ T cells and bulk and single-cell CRISPR-interference screens identify candidate causal variants linked to autoimmune disease risk that modulate ...

Nature Reviews Endocrinology, Published online: 11 September 2025; doi:10.1038/s41574-025-01182-0Antigen-specific Treg cells induce infectious tolerance

Join leading scientists and emerging researchers in the field of innate lymphoid cells (ILCs) at the 6th international ILC meeting. This event will bring together global experts to discuss groundbreaking advances, foster collaborations, and drive innovation in ILC biology and immunology.

Regulatory T cells keep the immune system in check to maintain homeostasis and restrain inflammation. This Review discusses strategies to harness these cells therapeutically for autoimmunity, transpla...

Fully differentiated stem cell-derived islets (SC-islets) are proven to normalise blood glucose in type 1 diabetic patients. However, the presence of off-target cell types and the immature SC-islet fu...