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Nature Reviews Endocrinology

@natrevendo.nature.com
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We publish Reviews and opinion articles on all aspects of endocrinology and metabolism. www.nature.com/nrendo

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Nature Reviews Endocrinology @natrevendo.nature.com · 27/09/2026
ICYMI: New content online: Adipocyte-derived oxylipin suppresses breast cancer growth
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Adipocyte-derived oxylipin suppresses breast cancer growth
Nature Reviews Endocrinology, Published online: 25 September 2026; doi:10.1038/s41574-026-01310-4Adipocyte-derived oxylipin suppresses breast cancer growth
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Nature Reviews Endocrinology @natrevendo.nature.com · 25/09/2026
New content online: Adipocyte-derived oxylipin suppresses breast cancer growth
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Adipocyte-derived oxylipin suppresses breast cancer growth
Nature Reviews Endocrinology, Published online: 25 September 2026; doi:10.1038/s41574-026-01310-4Adipocyte-derived oxylipin suppresses breast cancer growth
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Nature Reviews Endocrinology @natrevendo.nature.com · 25/09/2026
ICYMI: New content online: Diagnosis and management of Silver–Russell syndrome: second international consensus statement
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Diagnosis and management of Silver–Russell syndrome: second international consensus statement
Nature Reviews Endocrinology, Published online: 23 September 2026; doi:10.1038/s41574-026-01303-3Silver–Russell syndrome (SRS) is a genomic imprinting disorder associated with prenatal and postnatal growth restriction, and has specific management requirements. This international Consensus Statement provides updated guidance on the diagnosis and life-long management of patients with SRS.
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Nature Reviews Endocrinology @natrevendo.nature.com · 23/09/2026
ICYMI: New content online: The causes of cachexia: key signals and the brain
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The causes of cachexia: key signals and the brain
Nature Reviews Endocrinology, Published online: 21 September 2026; doi:10.1038/s41574-026-01302-4Cachexia is a systemic condition of progressive weight loss and muscle and adipose tissue wasting, often seen in cancer and associated with poor prognosis. This Review explores the connection between circulating signalling factors and the brain in the development of cachexia and argues for the importance of pathways within the brain as both drivers of key features of cancer cachexia and promising therapeutic targets.
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Nature Reviews Endocrinology @natrevendo.nature.com · 23/09/2026
New content online: Diagnosis and management of Silver–Russell syndrome: second international consensus statement
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Diagnosis and management of Silver–Russell syndrome: second international consensus statement
Nature Reviews Endocrinology, Published online: 23 September 2026; doi:10.1038/s41574-026-01303-3Silver–Russell syndrome (SRS) is a genomic imprinting disorder associated with prenatal and postnatal growth restriction, and has specific management requirements. This international Consensus Statement provides updated guidance on the diagnosis and life-long management of patients with SRS.
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Nature Reviews Endocrinology @natrevendo.nature.com · 21/09/2026
New content online: The causes of cachexia: key signals and the brain
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The causes of cachexia: key signals and the brain
Nature Reviews Endocrinology, Published online: 21 September 2026; doi:10.1038/s41574-026-01302-4Cachexia is a systemic condition of progressive weight loss and muscle and adipose tissue wasting, often seen in cancer and associated with poor prognosis. This Review explores the connection between circulating signalling factors and the brain in the development of cachexia and argues for the importance of pathways within the brain as both drivers of key features of cancer cachexia and promising therapeutic targets.
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Nature Reviews Endocrinology @natrevendo.nature.com · 20/09/2026
ICYMI: New content online: Nutrition transitions, obesity and T2DM in the Middle East and North Africa
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Nutrition transitions, obesity and T2DM in the Middle East and North Africa
Nature Reviews Endocrinology, Published online: 18 September 2026; doi:10.1038/s41574-026-01301-5Many places in the Middle East and North Africa (MENA) region are undergoing changes in dietary patterns that affect the prevalence of obesity and type 2 diabetes mellitus. In this Review, the authors discuss the role of these nutrition transitions and other related factors in the epidemiology of these diseases across the MENA region.
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Nature Reviews Endocrinology @natrevendo.nature.com · 18/09/2026
New content online: Nutrition transitions, obesity and T2DM in the Middle East and North Africa
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Nutrition transitions, obesity and T2DM in the Middle East and North Africa
Nature Reviews Endocrinology, Published online: 18 September 2026; doi:10.1038/s41574-026-01301-5Many places in the Middle East and North Africa (MENA) region are undergoing changes in dietary patterns that affect the prevalence of obesity and type 2 diabetes mellitus. In this Review, the authors discuss the role of these nutrition transitions and other related factors in the epidemiology of these diseases across the MENA region.
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Nature Reviews Endocrinology @natrevendo.nature.com · 18/09/2026
ICYMI: New content online: Monitoring corticosteroid levels in primary aldosteronism
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Monitoring corticosteroid levels in primary aldosteronism
Nature Reviews Endocrinology, Published online: 15 September 2026; doi:10.1038/s41574-026-01307-zMonitoring corticosteroid levels in primary aldosteronism
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Eder Zavala @ederzavala.bsky.social · 16/09/2026
A new Research Highlight featuring our work has just been published in @natrevendo.nature.com www.nature.com/articles/s41...
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Monitoring corticosteroid levels in primary aldosteronism - Nature Reviews Endocrinology
Nature Reviews Endocrinology - Monitoring corticosteroid levels in primary aldosteronism
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Nature Reviews Endocrinology @natrevendo.nature.com · 16/09/2026
New content online: Monitoring corticosteroid levels in primary aldosteronism
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Monitoring corticosteroid levels in primary aldosteronism
Nature Reviews Endocrinology, Published online: 15 September 2026; doi:10.1038/s41574-026-01307-zMonitoring corticosteroid levels in primary aldosteronism
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Nature Reviews Endocrinology @natrevendo.nature.com · 14/09/2026
Here, this international Consensus Statement by Maria Fleseriu et al provides guidelines on the management of pituitary incidentalomas go.nature.com/4itSjB3 #EndoSky #MedSky
Figure showing an algorithm for assessment of an incidentally discovered pituitary adenoma on imaging managed conservatively.
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Nature Reviews Endocrinology @natrevendo.nature.com · 14/09/2026
In this article, Qiong A. Wang and colleagues outline the in endocrine and metabolic function that occur in various adipose tissue depots during ageing (£) go.nature.com/4gSSbdl #EndoSky #MedSky
Figure showing cellular alterations in WAT during the early stage of ageing.
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Nature Reviews Endocrinology @natrevendo.nature.com · 14/09/2026
Here, Francisca L. Henriques, Irina Buckle & Josephine M. Forbes review strategies for type 1 diabetes mellitus prevention (£) go.nature.com/4gT9Stf #EndoSky #MedSky
Figure showing a selection of therapeutic approaches in phase Ib–III clinical trials aiming to prevent ongoing β-cell damage and destruction during the development and progression of T1DM.
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Nature Reviews Endocrinology @natrevendo.nature.com · 14/09/2026
In this Review, Anne-Simone Parent et al discuss the potential effects of endocrine-disrupting chemicals in female reproductive health (£) bit.ly/4r8Lx5U #EndoSky #MedSky
Figure showing female reproductive development and functions susceptible to perturbation by endocrine-disrupting chemicals.
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Nature Reviews Endocrinology @natrevendo.nature.com · 12/09/2026
ICYMI: New content online: UCP1 gets a transport mechanism and a challenge
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UCP1 gets a transport mechanism and a challenge
Nature Reviews Endocrinology, Published online: 10 September 2026; doi:10.1038/s41574-026-01304-2UCP1 gets a transport mechanism and a challenge
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Nature Reviews Endocrinology @natrevendo.nature.com · 12/09/2026
ICYMI: New content online: High-fat diet promotes tumour formation in the epithelium
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High-fat diet promotes tumour formation in the epithelium
Nature Reviews Endocrinology, Published online: 10 September 2026; doi:10.1038/s41574-026-01306-0High-fat diet promotes tumour formation in the epithelium
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Nature Reviews Endocrinology @natrevendo.nature.com · 10/09/2026
New content online: UCP1 gets a transport mechanism and a challenge
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UCP1 gets a transport mechanism and a challenge
Nature Reviews Endocrinology, Published online: 10 September 2026; doi:10.1038/s41574-026-01304-2UCP1 gets a transport mechanism and a challenge
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Nature Reviews Endocrinology @natrevendo.nature.com · 10/09/2026
New content online: High-fat diet promotes tumour formation in the epithelium
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High-fat diet promotes tumour formation in the epithelium
Nature Reviews Endocrinology, Published online: 10 September 2026; doi:10.1038/s41574-026-01306-0High-fat diet promotes tumour formation in the epithelium
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Nature Reviews Endocrinology @natrevendo.nature.com · 09/09/2026
ICYMI: New content online: Adjusting α-cell metabolism induces β-cell features
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Adjusting α-cell metabolism induces β-cell features
Nature Reviews Endocrinology, Published online: 07 September 2026; doi:10.1038/s41574-026-01305-1Adjusting α-cell metabolism induces β-cell features
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Nature Reviews Endocrinology @natrevendo.nature.com · 09/09/2026
From our latest issue - a Journal Club from Fadi Khalaf looking at how local catecholamine catabolism blunts lipolysis in ageing adipose tissue (£) go.nature.com/4cyylRX
Against a blue background, white text reads "This was a landmark observation because it reframed adipose tissue ageing as a problem of neural–immune–metabolic communication."
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Nature Reviews Endocrinology @natrevendo.nature.com · 09/09/2026
In our October issue, Chuang Liu and colleagues present a Comment on mRNA-LNP therapeutics for obesity (£) go.nature.com/4h1syFT #EndoSky #MedSky
Figure showing mRNA-LNPs for application in obesity treatment.
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Nature Reviews Endocrinology @natrevendo.nature.com · 09/09/2026
From our October issue: Leonardo de Assis et al discuss the transition from postdoctoral researcher to independent investigator rdcu.be/pggtNCksJtHa #EndoSky #MedSky
Screenshot of a text box titled 'Insights from the DDEA Postdoc Summit 2025'.
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Nature Reviews Endocrinology @natrevendo.nature.com · 09/09/2026
In this Perspective, Soo Lim et al advocate for an approach to assessments for obesity in Asian populations that takes ethnicity-specific factors into account (£) go.nature.com/4dr6NhA #EndoSky #MedSky
Figure showing the clinical features of Asian people with obesity.
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Nature Reviews Endocrinology @natrevendo.nature.com · 09/09/2026
In our latest issue: Christofer Juhlin and colleagues discuss how molecular alterations in thyroid cancer affect iodine uptake and describe redifferentiation strategies that aim to improve the effectiveness of radioiodine administration (£) go.nature.com/4qZ1Ty2 #EndoSky #MedSky
Figure showing an overview of thyroid hormonogenesis.
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Nature Reviews Endocrinology @natrevendo.nature.com · 09/09/2026
In our latest issue: Tony Lam and colleagues outline how lipid sensing triggers hormonal and neural mechanisms that regulate satiety and glucose homeostasis and how these pathways are affected by obesity and metabolic disease (£) go.nature.com/4yte0WF #EndoSky #MedSky
Figure showing mechanisms of small intestinal lipid sensing in glucose regulation.
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Nature Reviews Endocrinology @natrevendo.nature.com · 09/09/2026
From our October issue: Tadataka Tsuji & Yu-Hua Tseng discuss the adipose humoral and neuronal pathways that operate through inter-organ communication to regulate systemic metabolism rdcu.be/pCN8xZHMZuua #EndoSky #MedSky
Figure showing integration of humoral and neuronal pathways linking adipose tissue to systemic metabolism.
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Nature Reviews Endocrinology @natrevendo.nature.com · 09/09/2026
The @natrevendo.nature.com October issue is now online! Featuring articles on adipose tissue, lipid sensing, thyroid cancer, clinical obesity and more -> www.nature.com/nrendo/ #EndSky #MedSky
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Nature Reviews Endocrinology @natrevendo.nature.com · 07/09/2026
New content online: Adjusting α-cell metabolism induces β-cell features
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Adjusting α-cell metabolism induces β-cell features
Nature Reviews Endocrinology, Published online: 07 September 2026; doi:10.1038/s41574-026-01305-1Adjusting α-cell metabolism induces β-cell features
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Nature Reviews Endocrinology @natrevendo.nature.com · 06/09/2026
ICYMI: New content online: The comparative cell physiology of stem cell-derived and primary human β cells
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The comparative cell physiology of stem cell-derived and primary human β cells
Nature Reviews Endocrinology, Published online: 04 September 2026; doi:10.1038/s41574-026-01295-0In this Review, the authors summarize current knowledge of the diverse range of human primary β cell phenotypes, describe the progress and challenges in making stem cell-derived β cells (SCβ cells) to closely mimic these phenotypes, and offer thoughts on combining new and established technologies to study functional maturity as an important path towards improving SCβ cell functionality.
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Nature Reviews Endocrinology @natrevendo.nature.com · 04/09/2026
New content online: The comparative cell physiology of stem cell-derived and primary human β cells
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The comparative cell physiology of stem cell-derived and primary human β cells
Nature Reviews Endocrinology, Published online: 04 September 2026; doi:10.1038/s41574-026-01295-0In this Review, the authors summarize current knowledge of the diverse range of human primary β cell phenotypes, describe the progress and challenges in making stem cell-derived β cells (SCβ cells) to closely mimic these phenotypes, and offer thoughts on combining new and established technologies to study functional maturity as an important path towards improving SCβ cell functionality.
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Nature Reviews Endocrinology @natrevendo.nature.com · 03/09/2026
ICYMI: New content online: CheckCausesObesity.com: a screening and monitoring tool for obesity
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CheckCausesObesity.com: a screening and monitoring tool for obesity
Nature Reviews Endocrinology, Published online: 01 September 2026; doi:10.1038/s41574-026-01300-6CheckCausesObesity.com (CCO) is a science-based screening and monitoring tool, developed by multidisciplinary experts and consistent with international guidelines. CCO systematically screens for potential obesity causes and contributing factors across seven categories, including lifestyle and medical factors, alongside selected comorbidities as well as anthropometric, demographic and socioeconomic characteristics. CCO supports individualized assessment, treatment and population-level monitoring.
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Nature Reviews Endocrinology @natrevendo.nature.com · 01/09/2026
New content online: CheckCausesObesity.com: a screening and monitoring tool for obesity
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CheckCausesObesity.com: a screening and monitoring tool for obesity
Nature Reviews Endocrinology, Published online: 01 September 2026; doi:10.1038/s41574-026-01300-6CheckCausesObesity.com (CCO) is a science-based screening and monitoring tool, developed by multidisciplinary experts and consistent with international guidelines. CCO systematically screens for potential obesity causes and contributing factors across seven categories, including lifestyle and medical factors, alongside selected comorbidities as well as anthropometric, demographic and socioeconomic characteristics. CCO supports individualized assessment, treatment and population-level monitoring.
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Nature Reviews Endocrinology @natrevendo.nature.com · 28/08/2026
ICYMI: New content online: At the Bone Research Society Annual Meeting 2026
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At the Bone Research Society Annual Meeting 2026
Nature Reviews Endocrinology, Published online: 26 August 2026; doi:10.1038/s41574-026-01299-wAt the Bone Research Society Annual Meeting 2026
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Nature Reviews Endocrinology @natrevendo.nature.com · 27/08/2026
ICYMI: New content online: Anaplastic thyroid cancer: genomic landscape, molecular drivers and novel therapeutics
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Anaplastic thyroid cancer: genomic landscape, molecular drivers and novel therapeutics
Nature Reviews Endocrinology, Published online: 25 August 2026; doi:10.1038/s41574-026-01293-2Anaplastic thyroid cancer (ATC) is a rare, highly aggressive and treatment-resistant form of cancer, with one of the worst prognoses across all cancer types. This Review discusses advances in ATC research in areas of tumour genetics, metabolism and immunology, as well as the development of novel therapies.
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Nature Reviews Endocrinology @natrevendo.nature.com · 27/08/2026
ICYMI: New content online: Genetic testing in pituitary adenomas: a Pituitary Society International Consensus Statement
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Genetic testing in pituitary adenomas: a Pituitary Society International Consensus Statement
Nature Reviews Endocrinology, Published online: 25 August 2026; doi:10.1038/s41574-026-01291-4This Consensus Statement provides evidence-based guidance on the clinical application of genetic tests in pituitary adenomas (focusing on germline genetic testing), with recommendations regarding genes for inclusion in panel testing, test indications, pre-test counselling, test methodologies, and result interpretation and follow-up.
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Nature Reviews Endocrinology @natrevendo.nature.com · 26/08/2026
New content online: At the Bone Research Society Annual Meeting 2026
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At the Bone Research Society Annual Meeting 2026
Nature Reviews Endocrinology, Published online: 26 August 2026; doi:10.1038/s41574-026-01299-wAt the Bone Research Society Annual Meeting 2026
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Nature Reviews Endocrinology @natrevendo.nature.com · 25/08/2026
New content online: Genetic testing in pituitary adenomas: a Pituitary Society International Consensus Statement
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Genetic testing in pituitary adenomas: a Pituitary Society International Consensus Statement
Nature Reviews Endocrinology, Published online: 25 August 2026; doi:10.1038/s41574-026-01291-4This Consensus Statement provides evidence-based guidance on the clinical application of genetic tests in pituitary adenomas (focusing on germline genetic testing), with recommendations regarding genes for inclusion in panel testing, test indications, pre-test counselling, test methodologies, and result interpretation and follow-up.
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Nature Reviews Endocrinology @natrevendo.nature.com · 25/08/2026
New content online: Anaplastic thyroid cancer: genomic landscape, molecular drivers and novel therapeutics
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Anaplastic thyroid cancer: genomic landscape, molecular drivers and novel therapeutics
Nature Reviews Endocrinology, Published online: 25 August 2026; doi:10.1038/s41574-026-01293-2Anaplastic thyroid cancer (ATC) is a rare, highly aggressive and treatment-resistant form of cancer, with one of the worst prognoses across all cancer types. This Review discusses advances in ATC research in areas of tumour genetics, metabolism and immunology, as well as the development of novel therapies.
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Nature Reviews Endocrinology @natrevendo.nature.com · 22/08/2026
ICYMI: New content online: Diagnosis of hypochondroplasia: international Delphi consensus recommendations
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Diagnosis of hypochondroplasia: international Delphi consensus recommendations
Nature Reviews Endocrinology, Published online: 20 August 2026; doi:10.1038/s41574-026-01296-zHypochondroplasia is a rare genetic condition resulting in disproportionate short stature and relative macrocephaly. Owing to its phenotypic variability and often subtle presentation, diagnosis of hypochondroplasia can often be delayed. This Consensus Statement provides expert-led recommendations for the diagnosis of hypochondroplasia through a combination of clinical, radiological and genetic approaches.
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Nature Reviews Endocrinology @natrevendo.nature.com · 21/08/2026
ICYMI: New content online: Appetite-suppressing effects of GIPR agonism and antagonism work through different brain regions
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Appetite-suppressing effects of GIPR agonism and antagonism work through different brain regions
Nature Reviews Endocrinology, Published online: 19 August 2026; doi:10.1038/s41574-026-01298-xAppetite-suppressing effects of GIPR agonism and antagonism work through different brain regions
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Nature Reviews Endocrinology @natrevendo.nature.com · 20/08/2026
New content online: Diagnosis of hypochondroplasia: international Delphi consensus recommendations
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Diagnosis of hypochondroplasia: international Delphi consensus recommendations
Nature Reviews Endocrinology, Published online: 20 August 2026; doi:10.1038/s41574-026-01296-zHypochondroplasia is a rare genetic condition resulting in disproportionate short stature and relative macrocephaly. Owing to its phenotypic variability and often subtle presentation, diagnosis of hypochondroplasia can often be delayed. This Consensus Statement provides expert-led recommendations for the diagnosis of hypochondroplasia through a combination of clinical, radiological and genetic approaches.
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Nature Reviews Endocrinology @natrevendo.nature.com · 20/08/2026
ICYMI: New content online: Endocannabinoids and related lipids in host metabolism–gut microbiome signalling
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Endocannabinoids and related lipids in host metabolism–gut microbiome signalling
Nature Reviews Endocrinology, Published online: 18 August 2026; doi:10.1038/s41574-026-01289-yIn this Review, the authors discuss how endocannabinoids, endocannabinoid-related lipids and the gut microbiome respond to factors such as diet. Research into gut microbiota production of lipids within the endocannabinoidome, endocannabinoidome signalling and the potential implications of these functions for host metabolism are also covered.
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Nature Reviews Endocrinology @natrevendo.nature.com · 19/08/2026
New content online: Appetite-suppressing effects of GIPR agonism and antagonism work through different brain regions
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Appetite-suppressing effects of GIPR agonism and antagonism work through different brain regions
Nature Reviews Endocrinology, Published online: 19 August 2026; doi:10.1038/s41574-026-01298-xAppetite-suppressing effects of GIPR agonism and antagonism work through different brain regions
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Nature Reviews Endocrinology @natrevendo.nature.com · 18/08/2026
New content online: Endocannabinoids and related lipids in host metabolism–gut microbiome signalling
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Endocannabinoids and related lipids in host metabolism–gut microbiome signalling
Nature Reviews Endocrinology, Published online: 18 August 2026; doi:10.1038/s41574-026-01289-yIn this Review, the authors discuss how endocannabinoids, endocannabinoid-related lipids and the gut microbiome respond to factors such as diet. Research into gut microbiota production of lipids within the endocannabinoidome, endocannabinoidome signalling and the potential implications of these functions for host metabolism are also covered.
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Reposted by Nature Reviews Endocrinology
Nature Portfolio @natureportfolio.nature.com · 17/08/2026
The final agenda for Reframing Precision Medicine is live. Join 400+ attendees in London this October to tackle a defining question: how do we turn precision medicine into real clinical impact? Curated by Nature editors. See the final full agenda: go.nature.com/45ZA6nn #RPM26 #PrecisionMedicine 🧪
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2026 Agenda
This session will explore the evolving role of epidemiology in precision medicine, highlighting how population-level data, risk prediction, and emerging analytical approaches are shaping more personal ...
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Nature Reviews Endocrinology @natrevendo.nature.com · 16/08/2026
ICYMI: New content online: mRNA-LNP therapeutics for obesity: weight loss with metabolic repair
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mRNA-LNP therapeutics for obesity: weight loss with metabolic repair
Nature Reviews Endocrinology, Published online: 14 August 2026; doi:10.1038/s41574-026-01297-yObesity involves dysfunction in metabolic tissues that is not always fully corrected by weight loss. An mRNA-lipid nanoparticle platform might offer a programmable approach for in situ production of therapeutic proteins directly in target tissues, enabling endocrine signalling, adipose remodelling and multi-pathway metabolic regulation.
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Nature Reviews Endocrinology @natrevendo.nature.com · 15/08/2026
ICYMI: New content online: Leadership for the postdoctoral to independent investigator transition
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Leadership for the postdoctoral to independent investigator transition
Nature Reviews Endocrinology, Published online: 13 August 2026; doi:10.1038/s41574-026-01294-1The transition from postdoctoral researcher to independent investigator is marked by complex decision-making and uncertainty. At the Danish Diabetes and Endocrine Academy Postdoc Summit 2025, we discussed these challenges, as well as strategies to support this transition.
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Nature Reviews Endocrinology @natrevendo.nature.com · 14/08/2026
ICYMI: New content online: Model-free multiparametric analysis of SHG images reveals collagen signatures in breast cancer
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Model-free multiparametric analysis of SHG images reveals collagen signatures in breast cancer
Nature Reviews Endocrinology, Published online: 12 August 2026; doi:10.1038/s41598-026-62801-yModel-free multiparametric analysis of SHG images reveals collagen signatures in breast cancer
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Nature Reviews Endocrinology @natrevendo.nature.com · 14/08/2026
ICYMI: New content online: AlzheiNN: a convolutional neural network-based model for Alzheimer’s disease classification
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AlzheiNN: a convolutional neural network-based model for Alzheimer’s disease classification
Nature Reviews Endocrinology, Published online: 12 August 2026; doi:10.1038/s41598-026-64954-2AlzheiNN: a convolutional neural network-based model for Alzheimer’s disease classification
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