Inflammation induces interchromosomal DNA interactions that bring parent genes into close proximity, facilitating the formation of chimeric mRNAs that encode physiologically relevant, functional prote...

Tertiary lymphoid structures (TLSs) are associated with immunotherapy response, yet the mechanisms controlling their formation and maintenance remain unclear. Using spatial transcriptomics and multipl...

Phages often degrade the genome of their bacterial host to individual nucleotides. Here we describe Metis, a bacterial defense system that directly senses phage-mediated host genome degradation. Metis...

Salmonella-invaded intestinal stem cells activate an inflammasome-driven differentiation program toward antimicrobial Paneth cells, revealing a protective stem cell defense mechanism that helps restri...

Sabatino and colleagues examine expanded CD8+ T cell clonotypes from a small cohort of multiple sclerosis patients. They identified several cognate peptide epitopes that derive from Epstein–Barr virus...

Nature - Ontogeny and transcriptional regulation of Thetis cells

Cancer immunotherapy benefits from antibody-lectin chimeras that block glyco-immune checkpoints.

Tissue-resident memory CD4+ T cells (TRM) are key sentinels of the adaptive immune response that provide a rapid, robust inflammatory response upon reactivation in non-lymphoid tissues. While CD4+ TRM...

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Dalit, Tan and colleagues provide a multiomic profile of T follicular helper (TFH) cells responses to diverse pathogens, revealing a blueprint for transcriptional flexibility and new tools to interrog...

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Nature - A coordinated cellular network regulates tolerance to food

Nature - A coordinated cellular network regulates tolerance to food

Shruti Naik, an immunologist and a strong advocate for diversity in science, has joined forces with Aaron Mertz, who leads programmes that help to explain, connect and maximize the benefits of science...

Deleting a regulatory element in the Rorc gene depletes RORγt+ dendritic cells from the intestine in mice, leading to a reduction of regulatory T cells and impaired oral tolerance to antigens. This wo...

Profiling of the location and transcriptome of tissue-resident memory CD8 T cell formation at single-transcript resolution finds regionalized signalling as the basis of immune diversity in t...

Get ready for an unforgettable summer experience that could shape your scientific future! This is a unique opportunity to work alongside world-renowned…

Anti-inflammatory sialylated IgG is enriched in younger people and in mild influenza patients. Chakraborty, Yik-Ling Cheng, Edwards, Gonzalez, et al. define a mechanism by which sialylated IgG induces...

The immune system recognizes a multitude of innocuous antigens from food and intestinal commensal microbes toward which it orchestrates appropriate, n…