This Review discusses how transcript elongation by RNA polymerase II is regulated and how obstacles such as nucleosomes are overcome. Also discussed are the roles of transcription surveillance machine...

Ledig stilling ved RNA-biologi og -innovation, Aarhus Universitet

Biochemical, structural and cell biological analyses reveal that UAP56 (DDX39B) assembles with a TREX-2–like module that redirects non-functional polyadenylated RNAs from export to degradati...

A nascent group of researchers sees planetary health as an urgent reason to bridge the molecular and planetary scales. This is shaping their strategies, methods, collaborations and outlook about their...

Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University

Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University

Thank you for your interest in our seminar series! We use a variety of different session formats but, in general, trainees can plan for a ~15 min talk + 5min Q/A and PIs can plan for a ~25min talk +...

SF3B1, a component of the U2 snRNP pre-mRNA splicing factor, plays a critical role in splicing and is frequently mutated in cancer, particularly hematologic malignancies. We investigated the effects…

We invite applicants for a postdoctoral fellow position in the Brown lab at Harvard Medical School in Boston, Massachusetts. The Brown lab uses structural, biophysical, and biochemical approaches to d...

Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational...

A biophysical model uses knockdown or overexpression data to infer splicing factor activity.

Most eukaryotic mRNAs contain a poly(A) tail, which in post-embryonic cells enhances their stability. Many cytoplasmic RNA viruses also harbor poly(A) tails on their genomic RNA and mRNAs. Here, we re...

Transcriptional initiation and termination decisions drive messenger RNA (mRNA) isoform diversity but the relationship between them remains poorly understood. By systematically profiling joint usage o...

In contrast to living organisms, viruses were long thought to lack protein synthesis machinery and instead depend on host factors to translate viral transcripts. Here, we discover that giant DNA virus...

Yim et al. use single-cell transcriptomics to elucidate the molecular outcomes of Chd8 haploinsufficiency in the mouse cortex. Their results provide insight into dynamic, cell-type-biased transcriptio...

Eukaryotic genomes generate a plethora of polyadenylated (pA+) RNAs[1][1],[2][2], that are packaged into ribonucleoprotein particles (RNPs). To ensure faithful gene expression, functional pA+ RNPs, in...

Job #AJO30607, WDR-00055221 Assistant Professor, Molecular Biology & Genetics, Cornell University, Ithaca, New York, US

Are you excited about studying the crucial process of transcription? Join our supportive, young and growing team!