Reposted by Valentina Baderna
🚨Happy to share that the first part of my PhD is out on @cp-devcell.bsky.social!
This has been an exciting project in the lab of @eileen-furlong.bsky.social @embl.org, studying the regulation of Pol II pausing across embryogenesis and its impact on gene expression dynamics.
tinyurl.com/5n88ykk7
tinyurl.com
Chromatin context shapes SPT5 regulation of promoter-proximal Pol II, fine-tuning gene expression changes during Drosophila embryogenesis
Using rapid SPT5 depletion, Dulja et al. uncover different molecular phenotypes at
different embryonic stages. In early embryos, SPT5 depletion shifts Pol II from the
pausing site to the +1 nucleosome...
