Singh et al. reveal that the lipid-handling autophagy proteins ATG9A and ATG2 regulate extracellular vesicle production by shaping cellular lipid composition and controlling whether cargo is degraded ...

CRISPR–Cas9 screening identifies CLCC1 as a factor that increases neutral lipid flux to prevent hepatic steatosis and promotes nuclear pore complex assembly by promoting membrane bending and fusi...

Acylation of DNAJC5 by PAT facilitates its association with the Golgi apparatus, enhancing the secretion of abnormal cytosolic proteins via unconventional protein secretion.

Trophoblast cells line the surface of placental villi, facilitating the exchange of nutrients, gases, and wastes between the maternal and fetal circulations. The fusion of cytotrophoblast (CTB) cells into the surrounding multinucleated syncytiotrophoblast (STB), is accompanied by a shift in cellular …

Lipid droplets have key roles in energy storage and lipid metabolism. This Review discusses tools used for assessing lipid droplet heterogeneity, and how their heterogeneous composition and interactio...

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Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach,...

Trailblazing chimp researcher and conservationist Jane Goodall died on October 1 at 91.

VPS13A and VPS13C are bridge-like lipid transport proteins with distinct subcellular localization and function, and their absence is linked with chorea-acanthocytosis and Parkinson's disease, respecti...

Eukaryotic genomes generate a plethora of polyadenylated (pA+) RNAs[1][1],[2][2], that are packaged into ribonucleoprotein particles (RNPs). To ensure faithful gene expression, functional pA+ RNPs, in...

An approach combining bioorthogonal chemistry with genetically encoded fluorogen-activating proteins enables subcellular imaging of phospholipids and glycans, as well as the visualization of lipid tra...

A UCP1-independent mechanism of thermogenesis involving ATP-consuming metabolism of monomethyl branched-chain fatty acids in peroxisomes is described and a previously unrecognized role for peroxisomes...

Blastoids are stem cell-derived structures that mimic natural blastocysts by incorporating all three lineages: trophectoderm, epiblast, and primitive endoderm. However, current methods often yield inc...

The autophagy-related protein ATG9A is integral to cellular autophagy and lipid mobilization, yet its importance in mammalian physiology remains underexplored. Using a liver-specific conditional At...

17β-oestradiol establishes an anti-ferroptotic state in female kidney tubules.

Join us at the Keystone Symposia on Autophagy: Mechanisms to Therapy, February 2026, in Keystone, with field leaders!

Macroautophagy, a major self-degradation pathway in eukaryotic cells, utilizes autophagosomes to transport self-material to lysosomes for degradation. While microtubular transport is crucial for the p...

Newburgh, New York, is one of 10 communities involved in a CDC-led study to understand the effects of PFAS—forever chemicals—on health.

NIH's Dr. Carlos Guardia studies the placenta. He and his team strive to understand the effects of maternal obesity and other environmental stressors on the future health of the baby.

Some cancer cells exhibit high loads of reactive iron in lysosomes, and this feature is exploited by using fentomycin-1, a newly developed small molecule, to induce ferroptosis.