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asmitasingh.bsky.social

@asmitasingh.bsky.social
26 followers 131 following 2 posts
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Carlos Guardia @charlyguardia.bsky.social · 02/08/2026
New issue of the #PlacentalCellBio Report by @biomednews.bsky.social biomed.news/bims-placeb/... Subscribe to receive weekly issues of this report by going to biomed.news/bims-placeb!
biomed.news
bims-placeb 2026-08-02 papers
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Carlos Guardia @charlyguardia.bsky.social · 22/07/2026
(1/9) 🚨 Our lab’s first major paper is now out in Nature Communications! We show that ATG9A and ATG2A/B act as lipid-dependent gatekeepers linking autophagosome/amphisome formation to small extracellular vesicle (sEV) secretion.
doi.org
Lipid-manager autophagy proteins ATG2 and ATG9 regulate extracellular vesicle secretion via amphisome biogenesis and cell lipidome modulation - Nature Communications
Singh et al. reveal that the lipid-handling autophagy proteins ATG9A and ATG2 regulate extracellular vesicle production by shaping cellular lipid composition and controlling whether cargo is degraded ...
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James M. Ward @jmw86069.bsky.social · 23/07/2026
Elegant paper from the Guardia lab, first of many major papers to be sure! Congrats to @asmitasingh.bsky.social as well, great work!
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Jackson Hoffman @jxhoffman.bsky.social · 22/07/2026
Congrats to @charlyguardia.bsky.social and @asmitasingh.bsky.social on the new paper! Awesome work out of RDBL here at NIEHS!
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James Olzmann @olzmannlab.bsky.social · 25/02/2026
Sooo happy to share our new paper in @nature.com “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” A terrific collaboration with @arrudalab.bsky.social, led by co–first authors Alyssa Mathiowetz and Emily Maymand. www.nature.com/articles/s41...
nature.com
CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly - Nature
CRISPR–Cas9 screening identifies CLCC1 as a factor that increases neutral lipid flux to prevent hepatic steatosis and promotes nuclear pore complex assembly by promoting membrane bending and fusi...
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Cell Biology J-Club @cellclub.bsky.social · 09/02/2026
Palmitoyl Acyltransferases Control the Membrane Localization of DNAJC5 to Regulate Unconventional Protein Secretion onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
Palmitoyl Acyltransferases Control the Membrane Localization of DNAJC5 to Regulate Unconventional Protein Secretion
Acylation of DNAJC5 by PAT facilitates its association with the Golgi apparatus, enhancing the secretion of abnormal cytosolic proteins via unconventional protein secretion.
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Carlos Guardia @charlyguardia.bsky.social · 08/02/2026
New issue of the #PlacentalCellBio reports by @biomednews.bsky.social biomed.news/bims-placeb/... My fav pick is this comprehensive review on the evolution of the study of the ultrastructure of the placenta using EM <3
pubmed.ncbi.nlm.nih.gov
Exploring placental ultrastructure: A review of electron microscopy techniques and emerging methods for resolving 3D organelle architecture - PubMed
Trophoblast cells line the surface of placental villi, facilitating the exchange of nutrients, gases, and wastes between the maternal and fetal circulations. The fusion of cytotrophoblast (CTB) cells into the surrounding multinucleated syncytiotrophoblast (STB), is accompanied by a shift in cellular …
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Henne lab @hennelab.bsky.social · 16/01/2026
With so many great reviews on LDs already out, do we need another? Sarah @cohenlaboratory.bsky.social and I were approached by @natrevmcb.nature.com to do a review on LD heterogeneity and inter-organelle contacts...topics in reviews, but not a focus. Fun project! www.nature.com/articles/s41...
nature.com
Heterogeneity, dynamics and organelle interactions of lipid droplets - Nature Reviews Molecular Cell Biology
Lipid droplets have key roles in energy storage and lipid metabolism. This Review discusses tools used for assessing lipid droplet heterogeneity, and how their heterogeneous composition and interactio...
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Carlos Guardia @charlyguardia.bsky.social · 25/11/2025
Thanksgiving edition of the publications in the #PlacentalCellBio section of @biomednews.bsky.social biomed.news/bims-placeb/... Cheers!
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bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 01/12/2025
Lipid Droplet Remodeling Safeguards Redox Balance through the DGAT1-PANK2-NRF2 Axis in Mammalian Oocytes and Drives Age-Associated Decline www.biorxiv.org/content/10.1101/202…
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Elias Adriaenssens @elias-adriaenssens.bsky.social · 31/10/2025
Our latest review is now online! 👇 @martenslab.bsky.social Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal www.embopress.org/doi/full/10....
embopress.org
Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
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Cell Biology J-Club @cellclub.bsky.social · 26/10/2025
VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair www.biorxiv.org/content/10.1...
biorxiv.org
VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair
Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach,...
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UNC Biochemistry and Biophysics department @unc-bcbp.bsky.social · 15/10/2025
UNC Core Facility Technology Talks Monday, October 20, 2025 | 1 - 4 PM Join us in 3112 Mary Ellen Jones building or virtually. @oor-unc.bsky.social www.med.unc.edu/corefaciliti...
text "Core Facility Technology Talks 2025
A UNC Chapel Hill 2025 Research Week Event
UNC Chapel Hill core facilities provide centralized access to expertise, technology, and instrumentation. New services and equipment are added every year. These technology talks, held during the 2025 UNC Research Week, will highlight some of the new capabilities of our core facilities" green and blue image of cells
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Science Friday @scifri.bsky.social · 02/10/2025
In memory of Dr. Jane Goodall, we're releasing a special podcast episode today. Ira Flatow shares his memories of the renowned primatologist, including a 2002 interview in which they discussed her groundbreaking discoveries and hopes for a better future.
sciencefriday.com
Remembering Primatologist Jane Goodall
Trailblazing chimp researcher and conservationist Jane Goodall died on October 1 at 91.
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Merja Joensuu @joensuulab.bsky.social · 01/10/2025
🌟 Thrilled to share that my lab’s first publication is now out in @natmetabolism.nature.com. Congrats to the team 🎉 🧠 We discovered that neurons use endogenous fatty acids as an energy fuel, challenging long-standing models of sugars being the exclusive energy source for neurons. 1/3
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De Camilli Lab @pdc-lab.bsky.social · 29/09/2025
"Impaired hematopoiesis and embryonic lethality at midgestation of mice lacking both lipid transfer proteins VPS13A and VPS13C" out now in PLOS Biology journals.plos.org/plosbiology/...
journals.plos.org
Impaired hematopoiesis and embryonic lethality at midgestation of mice lacking both lipid transfer proteins VPS13A and VPS13C
VPS13A and VPS13C are bridge-like lipid transport proteins with distinct subcellular localization and function, and their absence is linked with chorea-acanthocytosis and Parkinson's disease, respecti...
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Ulrich Hohmann @hohmannulrich.bsky.social · 23/09/2025
How are RNAs sorted for export vs. degradation in the nucleus? In collaboration with @heick.bsky.social’s lab we (@clemensplaschka.bsky.social and @juliusbrennecke.bsky.social labs) discovered a direct mechanistic link between the export and decay machineries: www.biorxiv.org/content/10.1... (1/x)
biorxiv.org
Molecular basis of polyadenylated RNA fate determination in the nucleus
Eukaryotic genomes generate a plethora of polyadenylated (pA+) RNAs[1][1],[2][2], that are packaged into ribonucleoprotein particles (RNPs). To ensure faithful gene expression, functional pA+ RNPs, in...
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John Ngo @johntngo.bsky.social · 22/09/2025
🚀 Our new paper is out @natmethods.nature.com! Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells. 🔗 www.nature.com/articles/s41... 🧬 www.addgene.org/John_Ngo/
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Itay Budin @ibudin.bsky.social · 15/09/2025
Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...
nature.com
Leaflet-specific phospholipid imaging using genetically encoded proximity sensors - Nature Chemical Biology
An approach combining bioorthogonal chemistry with genetically encoded fluorogen-activating proteins enables subcellular imaging of phospholipids and glycans, as well as the visualization of lipid tra...
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Christian Frezza @frezzalab.bsky.social · 17/09/2025
Peroxisomal metabolism of branched fatty acids regulates energy homeostasis www.nature.com/articles/s41...
nature.com
Peroxisomal metabolism of branched fatty acids regulates energy homeostasis - Nature
A UCP1-independent mechanism of thermogenesis involving ATP-consuming metabolism of monomethyl branched-chain fatty acids in peroxisomes is described and a previously unrecognized role for peroxisomes...
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Carlos Guardia @charlyguardia.bsky.social · 14/09/2025
Here are the curated lists of pubs in the #PlacentalCellBio @biomednews.bsky.social report from the last two weeks! biomed.news/bims-placeb/... biomed.news/bims-placeb/... My personal choice: this resource from the Zernicka-Goetz's lab! pubmed.ncbi.nlm.nih.gov/40882624/ Enjoy!
pubmed.ncbi.nlm.nih.gov
Efficient stem cell-derived mouse embryo models for environmental studies - PubMed
Blastoids are stem cell-derived structures that mimic natural blastocysts by incorporating all three lineages: trophectoderm, epiblast, and primitive endoderm. However, current methods often yield inc...
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Carlos Guardia @charlyguardia.bsky.social · 03/09/2025
Excited to share the first paper from the lab! 🥳 The ATG9 and lipid droplets saga continues! Open source!
doi.org
Liver-specific loss of Atg9a perturbs lipid metabolism and hepatocyte integrity
The autophagy-related protein ATG9A is integral to cellular autophagy and lipid mobilization, yet its importance in mammalian physiology remains underexplored. Using a liver-specific conditional At...
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bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 29/08/2025
Differential inclusion formation of an aggregation-prone protein reveals differences in the proteostasis capacity of neuronal cell lines www.biorxiv.org/content/10.1101/202…
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Andreas Linkermann @linkermannlab.bsky.social · 19/08/2025
Happy to start at Bluesky with a post on our recent manuscript at @nature.com: www.nature.com/articles/s41... Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.
nature.com
Multiple oestradiol functions inhibit ferroptosis and acute kidney injury - Nature
17β-oestradiol establishes an anti-ferroptotic state in female kidney tubules.
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annesimonsen.bsky.social @annesimonsen.bsky.social · 15/08/2025
Working with a great team to organize @keystoneSymposia.bsky.social #Autophagy : Mechanisms to Therapy, this February! Join us to explore emerging research in Keystone! keysym.us/KSAutophagy26 #KSAutophagy26
keysym.us
Autophagy: Mechanisms to Therapy | Keystone Symposia
Join us at the Keystone Symposia on Autophagy: Mechanisms to Therapy, February 2026, in Keystone, with field leaders!
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Cell Biology J-Club @cellclub.bsky.social · 17/08/2025
www.biorxiv.org/content/10.1...
biorxiv.org
The Rab7-Epg5 and Rab39-ema modules cooperatively position autophagosomes for efficient lysosomal fusions
Macroautophagy, a major self-degradation pathway in eukaryotic cells, utilizes autophagosomes to transport self-material to lysosomes for degradation. While microtubular transport is crucial for the p...
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Science Friday @scifri.bsky.social · 12/07/2025
Toxic PFAS from firefighting foam contaminated a town’s water supply for decades. Now, early data from a CDC-led study is illuminating the forever chemicals’ effects on its residents.
sciencefriday.com
How PFAS From A Military Base Has Sickened Nearby Residents
Newburgh, New York, is one of 10 communities involved in a CDC-led study to understand the effects of PFAS—forever chemicals—on health.
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asmitasingh.bsky.social @asmitasingh.bsky.social · 23/06/2025
Check out this fantastic Review from the @charlyguardia.bsky.social lab!!
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asmitasingh.bsky.social @asmitasingh.bsky.social · 06/06/2025
Very interesting!!!!!
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Carlos Guardia @charlyguardia.bsky.social · 09/05/2025
A little glimpse into our lab at NIEHS/NIH! 👋🏽
nihrecord.nih.gov
Guardia Studies Role of Environmental Stressors on Fetal Development
NIH's Dr. Carlos Guardia studies the placenta. He and his team strive to understand the effects of maternal obesity and other environmental stressors on the future health of the baby.
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Barbara Marte @barbmarte.bsky.social · 07/05/2025
new out in Nature, very cool story www.nature.com/articles/s41...
nature.com
Activation of lysosomal iron triggers ferroptosis in cancer - Nature
Some cancer cells exhibit high loads of reactive&nbsp;iron in lysosomes, and this feature is exploited by&nbsp;using fentomycin-1, a newly developed small molecule, to induce ferroptosis.
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cryoEM papers @cryoempapers.bsky.social · 26/04/2025
Structural basis of lipid transfer by a bridge-like lipid-transfer protein pubmed.ncbi.nlm.nih.gov/40269155/ #cryoEM
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eLife @elife.bsky.social · 20/04/2025
Mouse egg cells stash endosomes, lysosomes, and autophagy regulators in giant structures called ELYSAs. After fertilisation, they break down, timing the embryo’s cleanup and recycling systems for early development. buff.ly/aM5oMxt
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