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Kashyap Chhatbar

@kashyapchhatbar.bsky.social
110 followers 382 following 15 posts

Bioinformatician II, AskBio Inc. Previously Bioinformatics Researcher, Adrian Bird Lab University of Edinburgh

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Reposted by Kashyap Chhatbar
Nute @nutedawn.bsky.social · 19/07/2026
Ok this is very good
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Stephen Turner @stephenturner.us · 03/05/2026
Free and open-source images, icons, and tools for creating scientific illustrations doi.org/10.59350/5zt... 🧪
doi.org
Free and open-source images, icons, and tools for creating scientific illustrations
Phylopic, NIH Bioart, Bioicons, Scidraw, Open Science Art, Health Icons, Servier Medical Art, Biodiversity Heritage Library, the Noun Project, Segment Anything, Excalidraw, draw.io, Biographics
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Papa Woof und Krampus und Bleaken @papawoof.bsky.social · 25/04/2026
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MwahahahahahadScientist @mads100tist.bsky.social · 18/11/2024
'Look, it's going to be an easy paper. Trust me. Six months. Tops'
A wooden statue of a monk being embraced by an skeleton in a "trust me bro" kind of attitude
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Duncan Sproul @sproullab.bsky.social · 10/04/2026
Very pleased to say that the paper version of our study examining the role of de novo DNMTs in cancer-associated hypomethylation is now out in @plos.org Genetics 🎉: doi.org/10.1371/jour... You can read more on the previous thread but here is a summary of the main updates! #epigenetics 🧵 1/9
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FragileNucleosome @fnucleosome.bsky.social · 05/04/2026
Join us this Wednesday to hear about fascinating research from @kashyapchhatbar.bsky.social and @a-radzisheuskaya.bsky.social! If you're not already registered, click here to sign up: us06web.zoom.us/webinar/regi... you can also join the conversation at our discord: discord.com/invite/dXqT89r
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Phil Ewels @ewels.bsky.social · 02/04/2026
Super excited to be launching two things today: #RustQC 🦀🧬 and rewrites.bio 🚀 I used AI to rewrite 15 RNA-seq QC tools into a single Rust binary (I've never written any Rust). It ended up being over 60x faster. Here's the story 🧵 seqeralabs.github.io/RustQC/
seqeralabs.github.io
Welcome to RustQC
Fast quality control tools for sequencing data, written in Rust.
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Johan Duchêne @johanduchene.bsky.social · 30/04/2025
Antibodies don't work. NLRP3 is by far the most studied inflammasome — yet <30% of commercial antibodies were specific. Only 4 of 14 tested antibodies detected NLRP3 specifically. Antibodies must be validated before use. Full report by @ycharos.bsky.social : zenodo.org/records/1162...
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sina b @sina.bio · 03/02/2026
If you work in AI for Science, take a moment to familiarize yourself with a common failure mode: paranormal citations (or paracites). Our paper describes them.
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Reposted by Kashyap Chhatbar
Aaron Quinlan (he/him) @aaronquinlan.bsky.social · 02/12/2025
We are thrilled to announce the first official release (v0.1.8) of #𝗯𝗲𝗱𝗱𝗲𝗿, the successor to one of our flagship tool, #𝗯𝗲𝗱𝘁𝗼𝗼𝗹𝘀! Based on ideas we conceived of long ago (!), this was achieved thanks to the dedication of Brent Pedersen. 1/n
quinlanlab.org
Intro to Bedder – The Quinlan Lab
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Kashyap Chhatbar @kashyapchhatbar.bsky.social · 26/11/2025
An amazing experience to be a part of this multi-disciplinary project within the Bird Lab! 🐦✨ We brought together molecular biology🧩⛓️, genomics🧬🧶, and explainable machine learning📈🖥️🤖 to understand mechanisms of SALL4 function. So proud of this team effort! 🤝🙌 Check out the full breakdown below 🧵👇
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Duncan Sproul @sproullab.bsky.social · 25/11/2025
🚨 Multiple #PhD opportunities for lab or computational applicants. Do you want to understand the molecular basis of #epigenetic dysfunction in human disease? Come work with our group at the fantastic, collaborative @uoe-igc.bsky.social in a beautiful, liveable city. 🧵 1/4 Please repost 🙏
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Raphaël Pantier @r-pantier.bsky.social · 30/10/2025
1/5 Glad to share our latest work with Ian Chambers’ lab published @embojournal.org in which we investigated the role of TET DNA de-methylases during cell fate transitions. Great team effort, many thanks to Sara Gonzalez Brito @ebarbieri.bsky.social @edinuni-irr.bsky.social doi.org/10.1038/s443...
embopress.org
TET knockout cells transit between pluripotent states and exhibit precocious germline entry | The EMBO Journal
imageimageThe roles of TET DNA demethylases during early development remain poorly defined. This work uncovers independence of early mouse embryonic stem cell (ESC) transitions from TET proteins but a...
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Kashyap Chhatbar @kashyapchhatbar.bsky.social · 24/10/2025
Integrator and Restrictor act sequentially to control transcription! Great set of experiments to complement some of the Integrator-Restrictor overlap hypotheses proposed here doi.org/10.1371/jour...
doi.org
Modelling transcription with explainable AI uncovers context-specific epigenetic gene regulation at promoters and gene bodies
Author summary Genes are turned on or off through complex processes involving many proteins that interact with DNA wrapped histones and modify their structure. These changes, known as epigenetic modif...
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Kashyap Chhatbar @kashyapchhatbar.bsky.social · 24/10/2025
🚀 Excited to share my latest paper on using SHAP, to predict direct target genes of chromatin-associated factors! Check it out for insights into gene regulation and the power of explainable AI in genomics! #XAI #SHAP #Genomics doi.org/10.1371/jour... Let's break down what we found! 👇
doi.org
Modelling transcription with explainable AI uncovers context-specific epigenetic gene regulation at promoters and gene bodies
Author summary Genes are turned on or off through complex processes involving many proteins that interact with DNA wrapped histones and modify their structure. These changes, known as epigenetic modif...
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Kashyap Chhatbar @kashyapchhatbar.bsky.social · 05/02/2025
Excited to share my latest preprint! 🚀 We infer regulatory relationships between chromatin-associated proteins and transcriptional control.
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Jess Kelley @jesskelley.bsky.social · 26/11/2024
Very excited that our paper describing a critical role for the PNUTS-PP1 phosphatase complex in transcription pause release is up online! This was a massive team effort with @edimitrova.bsky.social and the rest of the @robklose.bsky.social lab www.cell.com/molecular-ce... A short thread: (1/8)
cell.com
The PNUTS phosphatase complex controls transcription pause release
Kelley et al. discover that the PNUTS phosphatase complex plays an essential role in gene transcription by controlling RNA polymerase II pause release. PNUTS achieves this through its TND, which recog...
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Rob Klose @robklose.bsky.social · 25/11/2024
Looking forward to sharing a new publication from the lab tomorrow! Something a bit different from us this time around. Stay tuned….
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Madhu Pai, MD, PhD @madhupai.bsky.social · 24/11/2024
Non-native English speakers need 50% more time to write a paper When they do, they face a 2.5 times higher chance of being rejected because of language journals.plos.org/plosbiology/...
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Surfin' NuRD @surfinnurd.bsky.social · 23/11/2024
Loved being back in Edinburgh. Such a beautiful city, such great science. Great to catch up with Adrian, @cathyabbott.bsky.social @cellysally.bsky.social @hannahlong.bsky.social @kashyapchhatbar.bsky.social @r-pantier.bsky.social et al. Thanks Cath+Adrian for the hospitality and Congrats Sara!
Edinburgh skyline with Calton Hill
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