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Jonas Wietek

@jwietek.bsky.social
2.3K followers 593 following 624 posts

Synapse modulation, biophysics, optogenetics, opsins, optoGPCRs & channelrhodopsins... garden stuff, photography, cats, cycling, parenting...still postdocing. Patch-clamper with imaging ambitions scholar.google.com/citations?user=4…

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Jonas Wietek @jwietek.bsky.social · 29/09/2026
@bwjones.bsky.social
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Jonas Wietek @jwietek.bsky.social · 25/09/2026
Science: Brain development starts from two progenitors. Media: We have two brains. Me:
static.klipy.com
Inhale Exhale Breathing Exercise
ALT: Inhale Exhale Breathing Exercise
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Jonas Wietek @jwietek.bsky.social · 24/09/2026
Two cillia, no AI, enjoy.
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Jonas Wietek @jwietek.bsky.social · 24/09/2026
Glutamate 🧠
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Jonas Wietek @jwietek.bsky.social · 23/09/2026
​New personal record: A 2-month work contract. TWO MONTHS! 🏆 ​Pretty sure the administrative costs and paperwork fees will comfortably exceed my actual salary. But hey, a record is a record! 😅 #loveacademia
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Takuya Sasatani @takuyasasatani.bsky.social · 14/09/2026
Miniscope Zero, the first fully wireless Miniscope, is on @biorxivpreprint.bsky.social! Wireless power + data enable neural recordings in enclosed mazes, 3D environments & from two animals at once! @miniscope.bsky.social Paper: doi.org/10.64898/202... Wiki: miniscope.org/wiki/Minisco...
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Jonas Wietek @jwietek.bsky.social · 12/09/2026
Trying to close Pandoras Box darioamodei.com/post/we-must...
darioamodei.com
Dario Amodei — We Must Pace the Frontier
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Johannes Vierock @johvierock.bsky.social · 11/09/2026
Happy to announce that the #VierockLab is moving to #Goettingen joining the new #Else-Kröner-Fresensius-Center-for-Optogenetic-Therapies and a vibrant Optogenetics Community in their goal to bring Optogenetics to the clinic! In the #OpsinEngineeringLab we have Openings - please share and apply! 🚀☺️🎊
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Jonas Wietek @jwietek.bsky.social · 06/09/2026
Zieht das LIN jetzt nach Berlin oder wie ist der Plan 🤔
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Jonas Wietek @jwietek.bsky.social · 29/08/2026
In two months, I will look fwd to the next day and think: wow, tomorrow will be the last day of being employed. I was pushing hard but it seems to have not been enough & it feels wrong in a weird way. Sometimes you are at the right place at the right time. I think I haven't in the recent years.
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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 28/08/2026
Hippocampal CA2 Inhibition Disrupts Prefrontal and Thalamic Connectivity www.biorxiv.org/content/10.64898/20…
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Jonas Wietek @jwietek.bsky.social · 21/08/2026
Nice use of ❤️Chrimson-PdCO💜 to investigate the synaptic connectivity and its topographical organization between the BLA and mPFC along the rostro-caudal axis. 🧠🧪 doi.org/10.64898/202... PdCO resources: docs.google.com/spreadsheets...
Figure 4 from https://doi.org/10.64898/2026.08.14.744891
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Yulong Li Lab @yulonglilab.bsky.social · 13/08/2026
A long-standing question in neuroscience is why the eCB system uses two ligands for the same receptors and how their release differs. To address it, we’re happy to share a pair of selective GRAB sensors that detect 2-AG and AEA, respectively, in real time. biorxiv.org/content/10.6...
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Jonas Wietek @jwietek.bsky.social · 12/08/2026
Camera obscura part II (max eclipse 85%)
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Jonas Wietek @jwietek.bsky.social · 12/08/2026
Camera obskure doesn't fail
Solar eclipse seen by a tree
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Peter Rupprecht @ptrrupprecht.bsky.social · 07/08/2026
Excited to share our work now in Nature Methods! We wrote this manuscript to help others better analyze and interpret calcium imaging data. As a central aspect, we show why nonlinear behavior of calcium indicators matters in practice. Very happy about this work!
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Jonas Wietek @jwietek.bsky.social · 05/08/2026
www.nature.com/articles/s41...
nature.com
Getting over ANOVA: estimation graphics for multi-group comparisons - Nature Methods
Nature Methods - Getting over ANOVA: estimation graphics for multi-group comparisons
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Jonas Wietek @jwietek.bsky.social · 03/08/2026
www.biorxiv.org/content/10.6... nice stuff!
biorxiv.org
A highly Ca2+-permeable channelrhodopsin from the ancyromonad Nutomonas longa enables optogenetic control of Ca2+ signaling
Ca²⁺ is a ubiquitous regulator of cellular function, linking electrical activity to gene expression, secretion, metabolism, and synaptic plasticity. Yet, tools for its direct, time-resolved optical ma...
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Jonas Wietek @jwietek.bsky.social · 03/08/2026
light-activated tetanus neurotoxin (LATeNT) by the @aliceyting.bsky.social lab. Includes a comparison with the light-switchable PdCO (www.nature.com/articles/s41...), showing a long lasting inhibition for 1h hour post illumination. www.nature.com/articles/s41...
nature.com
Light-activated tetanus neurotoxin for conditional proteolysis and inducible synaptic inhibition in vivo - Nature Methods
LATeNT is a light-activatable form of tetanus neurotoxin that can be used for spatiotemporally precise inhibition of exocytosis in neurons and other cells. It can inhibit synaptic transmission in vivo...
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Jonas Wietek @jwietek.bsky.social · 06/07/2026
Hola Barcelona #FENS2026
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Jonas Wietek @jwietek.bsky.social · 05/07/2026
En Router to #FENS2026 CU in Barcelona
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Jonas Wietek @jwietek.bsky.social · 01/07/2026
Just imagine that fair wages inspire excellent performance.
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Jonas Wietek @jwietek.bsky.social · 01/07/2026
I know them very well ☺️
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Sonja Blumenstock @sblumenstock.bsky.social · 01/07/2026
What if part of Huntington's disease wasn't just damage, but a circuit stuck in the wrong pattern? Our new paper, out today in Nature, tests that idea.
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Jonas Wietek @jwietek.bsky.social · 30/06/2026
Whats going on @fens.org ? Please lift this restriction. This tool was of incredible value!!!
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John Tuthill @tuthill.bsky.social · 30/06/2026
My department, Neurobiology and Biophysics at the University of Washington (nbio.uw.edu), is hiring a new tenure-track Assistant Professor, application deadline 09/30/26. It's a broad search — molecular to organismal, all of neuroscience/physiology/biophysics welcome. apply.interfolio.com/187735
NBIO department logo
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Jonas Wietek @jwietek.bsky.social · 30/06/2026
bssst bssst CU @ #FENS26
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Jonas Wietek @jwietek.bsky.social · 30/06/2026
congrasts @labnir.bsky.social for getting an @erc.europa.eu Proof of Concept '26
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Jonas Wietek @jwietek.bsky.social · 30/06/2026
@ptrrupprecht.bsky.social can you give an estimate for the difference in baseline brightness between GCaMP8s and 6f?
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Jonas Wietek @jwietek.bsky.social · 30/06/2026
just an axon coming along
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Jonas Wietek @jwietek.bsky.social · 29/06/2026
Have fun you all. I probably won't be there 😢
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Jonas Wietek @jwietek.bsky.social · 28/06/2026
Erything is fine 🔥
My outdoor thermometer reading 45°C in the shade yesterday
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Jonas Wietek @jwietek.bsky.social · 25/06/2026
static.klipy.com
The Mandalorian (Book of Boba Fett): This Is The Way
ALT: The Mandalorian (Book of Boba Fett): This Is The Way
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Jonas Wietek @jwietek.bsky.social · 23/06/2026
congratulations @oyiz.bsky.social @weizmann.ac.il for securing and @erc.europa.eu AdG on Neural circuits for Early-Life Social Trajectories (NEST)
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Yulong Li Lab @yulonglilab.bsky.social · 17/06/2026
Excited to share our first red ACh sensor! 🔴 We developed GRAB_rACh1h, the first genetically encoded red fluorescent sensor for recording acetylcholine dynamics in vivo. (1/3)
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Jonas Wietek @jwietek.bsky.social · 15/06/2026
Wow!... next year: 12photon wireless!
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Jonas Wietek @jwietek.bsky.social · 11/06/2026
Anthrax anthrax AKA mood
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Nikolas Karalis @nikolaskaralis.bsky.social · 11/06/2026
With #FENS2026 just around the corner, our unofficial @fens.org abstract explorer is back: fens2026.neuronaldynamics.eu • Search abstracts by author, keyword, affiliation, and more • Discover related work using abstract similarity • Save favorites, add notes and tags, and build your own itinerary
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Jonas Wietek @jwietek.bsky.social · 10/06/2026
So, cat's are human after all.
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Jonas Wietek @jwietek.bsky.social · 08/06/2026
A red-emitting, genetically encoded indicator for two-photon voltage recording in vivo www.biorxiv.org/content/10.6...
biorxiv.org
A red-emitting, genetically encoded indicator for two-photon voltage recording in vivo
Genetically encoded voltage indicators (GEVIs) enable minimally invasive, cell‑type‑specific optical measurements of neuronal membrane potential with millisecond temporal resolution. Red‑shifted GEVIs...
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Michael Lin, MD PhD @michaelzlin.bsky.social · 02/06/2026
Excited to announce big steps for electrical imaging in the brain! In 4 preprints, we and collaborators present 2 new GFP-based voltage sensors: ASAP6c for high-throughput spike recordings, and ASAP7y for subthreshold 1P and 2P imaging bit.ly/4x3k3kX bit.ly/3RKZhq3 bit.ly/4o4fKl3 bit.ly/4uHXuk3 🧵
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Matteo Carandini @carandinilab.net · 01/06/2026
Neuropixels + Optogenetics = Neuropixels Opto Combining high-resolution electrophysiology and optogenetics. 960 sites, 28 emitters, 2 colors. Today in @natmethods.nature.com doi.org/10.1038/s415... Thanks to @wellcometrust.bsky.social, @alleninstitute.org, @hhmijanelia.bsky.social & team.
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Zoe McElligott @nanopharmnc.bsky.social · 21/05/2026
the technician position in my lab is now posted! Please pass this along: unc.peopleadmin.com/postings/319...
unc.peopleadmin.com
Laboratory Research Technician
The Research Technician will assist with lab management operations and assist the Principal Investigator and members of the laboratory with experiments involving molecular biology, behavior, biochemis...
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JasonKeays 🇨🇦 @jasonkeays.bsky.social · 20/05/2026
6750081904
Jonas Wietek @jwietek.bsky.social · 21/05/2026
Great opportunity!
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Tristan Shuman @tristanshuman.bsky.social · 20/05/2026
Apply for our Paris Miniscope Workshop this summer: July 1-3, 2026. Come learn to record and analyze calcium imaging data with open source Miniscopes! Applications due this Friday May 22. Apply here: docs.google.com/forms/d/e/1F...
docs.google.com
2026 Paris Miniscope Workshop Application
We're excited to invite applications for the 2026 Paris Miniscope Workshop, hosted at ESPCI Paris and organized by Daniel Aharoni (UCLA), Denise Cai and Tristan Shuman (Icahn School of Medicine Mount ...
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Jonas Wietek @jwietek.bsky.social · 20/05/2026
​Nothing says "motivation" like having 5 months left on a contract, zero institutional or PI support, and the crushing reality of the current grant climate. 🙃
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Ana Dorrego Rivas @adorrego.bsky.social · 18/05/2026
Excitatory synapses onto axonic spines jump-start action potentials and route information flow www.nature.com/articles/s41...
nature.com
Excitatory synapses onto axonic spines jump-start action potentials and route information flow - Nature Neuroscience
The axon initial segment was known to receive GABAergic synaptic inputs. Yang et al. show that it can be excited directly via specialized ‘axonic spines’. These spines thus boost neuronal firing and a...
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Eduardo Maristany de las Casas @maristanye.bsky.social · 08/05/2026
1/10 When the going gets tough, the dendrites get going. Here is a summary on our new paper just published in @science.org on flexible learning in frontal motor cortex. With @mattlark.bsky.social 🔬. #neuroskyence #neuroscience 🔗 doi.org/10.1126/scie...
doi.org
Tuft dendrites in frontal motor cortex enable flexible learning
Flexible learning relies on integrating sensory and contextual information to adjust behavioral output in different environments. The anterolateral motor cortex (ALM) is a frontal area critical for ac...
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UCLA Miniscope Project @miniscope.bsky.social · 30/04/2026
Applications open for 2026 Paris Miniscope Workshop! July 1-3, hosted at ESPCI. Apply here: forms.gle/4CWh7MeMchLS...
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