Jonas Wietek @jwietek.bsky.social · 25/09/2026Science: Brain development starts from two progenitors. Media: We have two brains. Me:static.klipy.comInhale Exhale Breathing ExerciseALT: Inhale Exhale Breathing Exercise 040
Jonas Wietek @jwietek.bsky.social · 23/09/2026New personal record: A 2-month work contract. TWO MONTHS! 🏆 Pretty sure the administrative costs and paperwork fees will comfortably exceed my actual salary. But hey, a record is a record! 😅 #loveacademia 060
Reposted by Jonas WietekTakuya Sasatani @takuyasasatani.bsky.social · 14/09/2026Miniscope Zero, the first fully wireless Miniscope, is on @biorxivpreprint.bsky.social! Wireless power + data enable neural recordings in enclosed mazes, 3D environments & from two animals at once! @miniscope.bsky.social Paper: doi.org/10.64898/202... Wiki: miniscope.org/wiki/Minisco... 48934
Jonas Wietek @jwietek.bsky.social · 12/09/2026Trying to close Pandoras Box darioamodei.com/post/we-must...darioamodei.comDario Amodei — We Must Pace the Frontier 011
Reposted by Jonas WietekJohannes Vierock @johvierock.bsky.social · 11/09/2026Happy to announce that the #VierockLab is moving to #Goettingen joining the new #Else-Kröner-Fresensius-Center-for-Optogenetic-Therapies and a vibrant Optogenetics Community in their goal to bring Optogenetics to the clinic! In the #OpsinEngineeringLab we have Openings - please share and apply! 🚀☺️🎊 1197
Jonas Wietek @jwietek.bsky.social · 06/09/2026Zieht das LIN jetzt nach Berlin oder wie ist der Plan 🤔 110
Jonas Wietek @jwietek.bsky.social · 29/08/2026In two months, I will look fwd to the next day and think: wow, tomorrow will be the last day of being employed. I was pushing hard but it seems to have not been enough & it feels wrong in a weird way. Sometimes you are at the right place at the right time. I think I haven't in the recent years. 390
Reposted by Jonas WietekbioRxiv Neuroscience @biorxiv-neursci.bsky.social · 28/08/2026Hippocampal CA2 Inhibition Disrupts Prefrontal and Thalamic Connectivity www.biorxiv.org/content/10.64898/20… 052
Jonas Wietek @jwietek.bsky.social · 21/08/2026Nice use of ❤️Chrimson-PdCO💜 to investigate the synaptic connectivity and its topographical organization between the BLA and mPFC along the rostro-caudal axis. 🧠🧪 doi.org/10.64898/202... PdCO resources: docs.google.com/spreadsheets... 050
Reposted by Jonas WietekYulong Li Lab @yulonglilab.bsky.social · 13/08/2026A long-standing question in neuroscience is why the eCB system uses two ligands for the same receptors and how their release differs. To address it, we’re happy to share a pair of selective GRAB sensors that detect 2-AG and AEA, respectively, in real time. biorxiv.org/content/10.6... 1239
Reposted by Jonas WietekPeter Rupprecht @ptrrupprecht.bsky.social · 07/08/2026Excited to share our work now in Nature Methods! We wrote this manuscript to help others better analyze and interpret calcium imaging data. As a central aspect, we show why nonlinear behavior of calcium indicators matters in practice. Very happy about this work! 16017
Jonas Wietek @jwietek.bsky.social · 05/08/2026www.nature.com/articles/s41...nature.comGetting over ANOVA: estimation graphics for multi-group comparisons - Nature MethodsNature Methods - Getting over ANOVA: estimation graphics for multi-group comparisons 062
Jonas Wietek @jwietek.bsky.social · 03/08/2026www.biorxiv.org/content/10.6... nice stuff!biorxiv.orgA highly Ca2+-permeable channelrhodopsin from the ancyromonad Nutomonas longa enables optogenetic control of Ca2+ signalingCa²⁺ is a ubiquitous regulator of cellular function, linking electrical activity to gene expression, secretion, metabolism, and synaptic plasticity. Yet, tools for its direct, time-resolved optical ma... 031
Jonas Wietek @jwietek.bsky.social · 03/08/2026light-activated tetanus neurotoxin (LATeNT) by the @aliceyting.bsky.social lab. Includes a comparison with the light-switchable PdCO (www.nature.com/articles/s41...), showing a long lasting inhibition for 1h hour post illumination. www.nature.com/articles/s41...nature.comLight-activated tetanus neurotoxin for conditional proteolysis and inducible synaptic inhibition in vivo - Nature MethodsLATeNT is a light-activatable form of tetanus neurotoxin that can be used for spatiotemporally precise inhibition of exocytosis in neurons and other cells. It can inhibit synaptic transmission in vivo... 0206
Jonas Wietek @jwietek.bsky.social · 01/07/2026Just imagine that fair wages inspire excellent performance. 021
Reposted by Jonas WietekSonja Blumenstock @sblumenstock.bsky.social · 01/07/2026What if part of Huntington's disease wasn't just damage, but a circuit stuck in the wrong pattern? Our new paper, out today in Nature, tests that idea. 34320
Jonas Wietek @jwietek.bsky.social · 30/06/2026Whats going on @fens.org ? Please lift this restriction. This tool was of incredible value!!! 131
Reposted by Jonas WietekJohn Tuthill @tuthill.bsky.social · 30/06/2026My department, Neurobiology and Biophysics at the University of Washington (nbio.uw.edu), is hiring a new tenure-track Assistant Professor, application deadline 09/30/26. It's a broad search — molecular to organismal, all of neuroscience/physiology/biophysics welcome. apply.interfolio.com/187735 110789
Jonas Wietek @jwietek.bsky.social · 30/06/2026congrasts @labnir.bsky.social for getting an @erc.europa.eu Proof of Concept '26 030
Jonas Wietek @jwietek.bsky.social · 30/06/2026@ptrrupprecht.bsky.social can you give an estimate for the difference in baseline brightness between GCaMP8s and 6f? 252
Jonas Wietek @jwietek.bsky.social · 25/06/2026static.klipy.comThe Mandalorian (Book of Boba Fett): This Is The WayALT: The Mandalorian (Book of Boba Fett): This Is The Way 000
Jonas Wietek @jwietek.bsky.social · 23/06/2026congratulations @oyiz.bsky.social @weizmann.ac.il for securing and @erc.europa.eu AdG on Neural circuits for Early-Life Social Trajectories (NEST) 121
Reposted by Jonas WietekYulong Li Lab @yulonglilab.bsky.social · 17/06/2026Excited to share our first red ACh sensor! 🔴 We developed GRAB_rACh1h, the first genetically encoded red fluorescent sensor for recording acetylcholine dynamics in vivo. (1/3) 35419
Reposted by Jonas WietekNikolas Karalis @nikolaskaralis.bsky.social · 11/06/2026With #FENS2026 just around the corner, our unofficial @fens.org abstract explorer is back: fens2026.neuronaldynamics.eu • Search abstracts by author, keyword, affiliation, and more • Discover related work using abstract similarity • Save favorites, add notes and tags, and build your own itinerary 1179
Jonas Wietek @jwietek.bsky.social · 08/06/2026A red-emitting, genetically encoded indicator for two-photon voltage recording in vivo www.biorxiv.org/content/10.6...biorxiv.orgA red-emitting, genetically encoded indicator for two-photon voltage recording in vivoGenetically encoded voltage indicators (GEVIs) enable minimally invasive, cell‑type‑specific optical measurements of neuronal membrane potential with millisecond temporal resolution. Red‑shifted GEVIs... 184
Reposted by Jonas WietekMichael Lin, MD PhD @michaelzlin.bsky.social · 02/06/2026Excited to announce big steps for electrical imaging in the brain! In 4 preprints, we and collaborators present 2 new GFP-based voltage sensors: ASAP6c for high-throughput spike recordings, and ASAP7y for subthreshold 1P and 2P imaging bit.ly/4x3k3kX bit.ly/3RKZhq3 bit.ly/4o4fKl3 bit.ly/4uHXuk3 🧵 14715
Reposted by Jonas WietekMatteo Carandini @carandinilab.net · 01/06/2026Neuropixels + Optogenetics = Neuropixels Opto Combining high-resolution electrophysiology and optogenetics. 960 sites, 28 emitters, 2 colors. Today in @natmethods.nature.com doi.org/10.1038/s415... Thanks to @wellcometrust.bsky.social, @alleninstitute.org, @hhmijanelia.bsky.social & team. 115753
Reposted by Jonas WietekZoe McElligott @nanopharmnc.bsky.social · 21/05/2026the technician position in my lab is now posted! Please pass this along: unc.peopleadmin.com/postings/319...unc.peopleadmin.comLaboratory Research TechnicianThe Research Technician will assist with lab management operations and assist the Principal Investigator and members of the laboratory with experiments involving molecular biology, behavior, biochemis... 03036
Reposted by Jonas WietekTristan Shuman @tristanshuman.bsky.social · 20/05/2026Apply for our Paris Miniscope Workshop this summer: July 1-3, 2026. Come learn to record and analyze calcium imaging data with open source Miniscopes! Applications due this Friday May 22. Apply here: docs.google.com/forms/d/e/1F...docs.google.com2026 Paris Miniscope Workshop ApplicationWe're excited to invite applications for the 2026 Paris Miniscope Workshop, hosted at ESPCI Paris and organized by Daniel Aharoni (UCLA), Denise Cai and Tristan Shuman (Icahn School of Medicine Mount ... 01010
Jonas Wietek @jwietek.bsky.social · 20/05/2026Nothing says "motivation" like having 5 months left on a contract, zero institutional or PI support, and the crushing reality of the current grant climate. 🙃 290
Reposted by Jonas WietekAna Dorrego Rivas @adorrego.bsky.social · 18/05/2026Excitatory synapses onto axonic spines jump-start action potentials and route information flow www.nature.com/articles/s41...nature.comExcitatory synapses onto axonic spines jump-start action potentials and route information flow - Nature NeuroscienceThe axon initial segment was known to receive GABAergic synaptic inputs. Yang et al. show that it can be excited directly via specialized ‘axonic spines’. These spines thus boost neuronal firing and a... 01911
Reposted by Jonas WietekEduardo Maristany de las Casas @maristanye.bsky.social · 08/05/2026 1/10 When the going gets tough, the dendrites get going. Here is a summary on our new paper just published in @science.org on flexible learning in frontal motor cortex. With @mattlark.bsky.social 🔬. #neuroskyence #neuroscience 🔗 doi.org/10.1126/scie...doi.orgTuft dendrites in frontal motor cortex enable flexible learningFlexible learning relies on integrating sensory and contextual information to adjust behavioral output in different environments. The anterolateral motor cortex (ALM) is a frontal area critical for ac... 46922
Reposted by Jonas WietekUCLA Miniscope Project @miniscope.bsky.social · 30/04/2026Applications open for 2026 Paris Miniscope Workshop! July 1-3, hosted at ESPCI. Apply here: forms.gle/4CWh7MeMchLS... 074