iiinova — where your digital self keeps evolving

Federico Rossi

@fedrossi.bsky.social

21 followers 30 following 0 posts

Principal investigator, Istituto Italiano di Tecnologia rossilab.iit.it

Posts Replies Media

Reposted by Federico Rossi

Matteo Carandini @carandinilab.net · 31/07/2026

The apical dendrite looks great, and does wonders in a slice. What does it do in the living cortex? It depends on the cell. A causal spatial role for apical dendrites in the cortex www.biorxiv.org/content/10.6... by @anyiliu.bsky.social with @kenneth-harris.bsky.social and @fedrossi.bsky.social

A cartoon providing a graphical summary of the paper. It is divided in 3 rows.

The top row shows a pyramidal cell and its apical tuft, and shows the two experiments that we ran: optical dendritic pruning (chopping off the apical tuft), and synaptic imaging done in the same neurons where we do somatic imaging.

The middle row shows the results pertaining to neurons that prefer large stimuli (this is visual cortex): pruning reduced their responses, and the receptive fields of apical synapses are far away from the that of the soma.

The bottom row shows the results pertaining to neurons that prefer small stimuli: pruning seemed to do nothing to the responses, and the receptive field of apical synapses are right around that of the soma.

17427

Reposted by Federico Rossi

Anyi Liu @anyiliu.bsky.social · 29/07/2026

Pyramidal cells in the cortex send a long apical dendrite to layer 1. What is its role? What happens when it's gone? ✂️ A causal spatial role for apical dendrites in the cortex Out today with @kenneth-harris.bsky.social, @carandinilab.net and @fedrossi.bsky.social www.biorxiv.org/content/10.6...

biorxiv.org

A causal spatial role for apical dendrites in the cortex

Cortical pyramidal neurons project a long apical dendrite to layer 1 (L1), to receive synaptic inputs that are thought to provide contextual and possibly suppressive modulation. In visual cortex, thes...

03215