Caspase-2 is a key genome-surveillance protease that functions to kill or arrest cells with abnormal chromosome content, via PIDDosome-dependent and -independent mechanisms. However, this surveillance...

The E3-ome defines the human repertoire of ubiquitin E3 ligases, creating a unified resource that maps their diversity across the ubiquitin and ubiquitin-like systems. By consolidating fragmented know...

Introduction Diabetic nephropathy (DN) is a leading cause of chronic kidney disease. Current diagnosis requires the persistent presence of albuminuria and/or reduction in estimated glomerular filtra...

The E3-ome defines the human repertoire of ubiquitin E3 ligases, creating a unified resource that maps their diversity across the ubiquitin and ubiquitin-like systems. By consolidating fragmented know...

Introduction Diabetic nephropathy (DN) is a leading cause of chronic kidney disease. Current diagnosis requires the persistent presence of albuminuria and/or reduction in estimated glomerular filtra...

Scientists have discovered that blocking a key cellular enzyme thought to protect against fatty liver disease may instead increase the risk of chronic liver damage and cancer as we age.

Caspase-2 inactivation promotes pathogenic hepatocyte polyploidy and age-related liver cancer.

Caspase-2 inactivation promotes pathogenic hepatocyte polyploidy and age-related liver cancer.

Caspase-2 inactivation promotes pathogenic hepatocyte polyploidy and age-related liver cancer.

The Trump administration is targeting a visa widely used by tech companies and other employers to hire foreign workers.

Lysosomal vacuolation is commonly found in many pathophysiological conditions, but its molecular mechanisms and functions remain largely unknown. Here, we show that the endoplasmic reticulum (ER)–anch...

Cell Death Discovery - Phospholipid scramblase 1 (PLSCR1) is a novel substrate of NEDD4-2 (NEDD4L) mediated ubiquitination

Cell Death & Disease - Nedd4-2 ablation in kidney improves glycaemic control in diabetic mice

An analysis shows that large fractions of future generations will be exposed to extreme climate events that would occur only once every 10,000 years in the absence of global warming.

Nature - Tiger numbers in India are starting to rebound after decades of being perilously low. This recovery offers lessons for conserving other rare animals.

Explosive growth is attributed to the BCR::ABL1 gene 3–14 years before diagnosis of chronic myeloid leukaemia, highlighting the oncogenic potency of gene fusion and the slow and sequential trajectories of most other cancers.

Communities of researchers worldwide are taking on the toxic research cultures that drive poor psychological health among academics.

DNA sequences for the chimpanzee, orangutans and more will help scientists to determine what sets humans apart from other apes.

3D reconstruction is the first to overlay neuronal activity on a large-scale map of brain cells.

But many U.S.-based scientists seeking to leave may struggle to find positions in countries grappling with funding issues of their own

Nature - In the wake of the Trump administration’s funding freezes and job cuts, some researchers are planning their next move.

Senolytics drugs can reduce back pain by removing senescent cells from the intervertebral discs and spinal cord.

National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.

Multisystem inflammatory syndrome following SARS-CoV-2 infection results from increased serum levels of TGFβ, which impairs the reactivation of virus-specific T cells.

In a model of pancreatic ductal adenocarcinoma, extrachromosomal DNAs are shown to be a source of high-level focal amplification driving MYC heterogeneity and phenotypic adaptation.

Chair explains why Australian Research Council is rejecting defined splits between basic and applied funding

Abrupt cuts by the Trump administration to the US National Institutes of Health threaten progress in medical research globally.

Wang et al. identified that the mechanoreceptor PIEZO2 is abundantly expressed in fat-innervating sensory neurons and plays a crucial role in mediating the adipose afferent pathway.

The immune regulatory mechanism for metabolic dysfunction-associated steatohepatitis (MASH) remains elusive. Here, the authors identify a c-kit+ cDC1 subset, which can be depleted by Desulfovibrio_sp....

NINJ1-mediated plasma membrane rupture enables the selective release of an intracellular viral protein.

Phagocytosed bacteria can serve as an alternative nutrient source for macrophages, influencing their metabolic and immune responses through the recycling of microbial components, with the process regulated by nutrient-sensing mechanisms and bacterial viability.

As proof of principle, an analysis using a suite of human-aligned immunocompetent mouse models of hepatocellular carcinoma identifies a promising therapeutic candidate, cladribine, which acts in a highly effective subtype-specific manner in combination with standard-of-care therapy.

Kennedy has expressed support for some fields, but has also declared he’d like a ‘break’ in infectious-disease research.

We show that gain-of-function cancer mutations in the KBTBD4 E3 ligase promote neodegradation of substrates via a shape-complementarity-based mechanism, which converges with the mechanism of action of the UM171 molecular glue degrader and can be blocked by HDAC1/2 inhibitors.

Most of the measles cases are still among school-aged children in Gaines County, Texas health officials said Friday.