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Jens Hjerling Leffler

@hjerling-leffler.bsky.social
448 followers 363 following 28 posts

Molecular Psychiatry, Neuroscience, Genetics, Professor at Karolinska Insitutet

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Reposted by Jens Hjerling Leffler
Taro Kitazawa @kitazawa-taro.bsky.social · 18/06/2026
Please RP! Excited to share our new preprint: “Single-cell chromatin tracing reveals multimodal molecular programs during memory formation” We built a single-cell multiomic atlas of aversive learning and used it to trace memory-linked molecular programs. doi.org/10.64898/202...
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Elena Dvoretskova @elena-dvoretskova.bsky.social · 14/06/2026
New preprint from our lab on bioRxiv: “Stoichiometric transcription factor partnerships control GABAergic neuron fate allocation” www.biorxiv.org/content/10.6... A great collaboration with @annrosebright.bsky.social, Connor Lynch, @chr-mayer.bsky.social, and many others.
biorxiv.org
Stoichiometric transcription factor partnerships control GABAergic neuron fate allocation
Combinatorial transcription factor (TF) codes specify neuronal fates, yet how quantitative differences in interacting TFs shape these decisions remains unresolved. We address this in the developing ba...
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Sjors Scheres @sjorsscheres.bsky.social · 10/05/2026
Scientists should be very careful with the term "reproducibility crisis". It is a (highly effective) tool to sow doubts by those who want to undermine science. There is no crisis; non-reproducible results are not ideal, they have always been part of the scientific process. Don't feed the beast.
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Oded Rechavi @odedrechavi.bsky.social · 07/05/2026
It’s still unclear whether Hantavirus is scary enough to guarantee 1,000 publications in Nature
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Richard Sever @richardsever.bsky.social · 12/03/2026
arXiv to spin out as an independent non-profit. They are seeking a CEO jobs.chronicle.com/job/37961678...
jobs.chronicle.com
Chief Executive Officer - New York City, New York (US) job with arXiv | 37961678
arXiv seeks its first CEO to champion open, free scientific discovery and guide the platform’s next chapter as an independent nonprofit.
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Jens Hjerling Leffler @hjerling-leffler.bsky.social · 11/03/2026
What's My JND? 0.0029 Can you beat it? www.keithcirkel.co.uk/whats-my-jnd...
keithcirkel.co.uk
What's My JND?
Find your Just Noticeable Difference in colour perception. How small a colour difference can you actually see?
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Ted Price @tedpricethepainguy.bsky.social · 10/03/2026
BOOM! Fantastic new paper from Patrik Ernfors and his team: www.nature.com/articles/s41... Persistent interferon signaling causes sensory neuron plasticity and pain before and during arthritis
nature.com
Persistent interferon signaling causes sensory neuron plasticity and pain before and during arthritis - Nature Neuroscience
Su et al. show that inflammatory arthritis pain stems from sustained interferon-driven MNK1/MNK2–elF4E signaling that sensitizes joint-innervating neurons. Blocking this pathway reverses pain, suggest...
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Jens Hjerling Leffler @hjerling-leffler.bsky.social · 05/03/2026
I am so happy for the recognition that my PhD supervisor and friend has received. Congratulations Patrik!
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Björn Högberg @bjornhogberg.bsky.social · 28/01/2026
Post-doc positions in my lab. Come join us in Stockholm! ki.varbi.com/en/what:job/... ki.varbi.com/en/what:job/...
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Gonçalo Castelo-Branco @gocastelobranco.bsky.social · 17/01/2026
A super intense and fantastic sunny week in Alicante discussing single cell and spatial omics in the CNS! Thanks all the students for lots of discussions, great flash talks and lots of fun in the social activities, the local organizers, aka @silviadesantis.bsky.social and my co-chair Ana Falcão.
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Jens Hjerling Leffler @hjerling-leffler.bsky.social · 21/12/2025
media.tenor.com
a back to the future car is driving down a dark street at night .
ALT: a back to the future car is driving down a dark street at night .
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 09/12/2025
🥁🎇✨ ... first up is KIRA HÖFFLER @kirahoeffler.bsky.social from the #UniversityofBergen in Norway and #McLeanHospital in Boston ! So tell us, Kira, what do you do in #functionalgenomics and @pgc_fg ?🤔 Any #funfacts #genetics 🐝❓ 🧵3/3
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 11/12/2025
🌟Today @fg-pgc.bsky.social and @pgcgenetics.bsky.social are in Bengaluru, India, where we love to highlight Dr KALYANI BINDU's work and the dynamic #functionalgenomics scene 🧬🧠 She shows that many of the same biological mechanisms play a role in different #mentalhealth disorders ! One drug for all?
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 14/12/2025
🌟for our last portrait, @fg-pgc.bsky.social is back in Germany @unibonn.bsky.social, where Dr EVA BEINS @evabeins.bsky.social studies #genetics and #microglia in #depression & #bipolardisorder. Think #brain #immune cells and #mentalhealth 🧠🧬👨‍🎓
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 08/12/2025
Our last, but by NO means least, group is the ✨Single Cell Transcriptomics✨group! Our two awesome chairs lead this group, with @hjerling-leffler.bsky.social focusing on brain🧠, and @maryellenlynall.bsky.social on immune🦠 🧵1/2
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Enric Llorens @ellorens.bsky.social · 02/12/2025
First paper from the lab is now online @natneuro.nature.com ! We mapped injury induced enhancers in the mouse CNS and decoded their sequence architecture. Little 🧵 rdcu.be/eSQi1
rdcu.be
The regulatory code of injury-responsive enhancers enables precision cell-state targeting in the CNS
Nature Neuroscience - Zamboni et al. reveal how enhancers encode cell-type-specific responses to CNS injury. By combining multiomic profiling, deep learning and in vivo screening, they uncover...
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Amy Johnston, PhD CPH @amydjohn.bsky.social · 16/11/2025
Pet peeve: when someone invites you to a meeting but instead of sending a calendar invitation, they just send a zoom link in an email. If you want profs to actually show up for meetings-- send a calendar invitation! #AcademicSky #ScienceSky #MedSky #EpiSky
media.tenor.com
a netflix ad shows a woman in a blue dress
ALT: a netflix ad shows a woman in a blue dress
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Olav Smeland @olavsmeland.bsky.social · 12/11/2025
Excited to share our cross-disorder GWAS analysis of neurological and psychiatric disorders (~1 M cases), now out in @natneuro.nature.com! We show more extensive genetic pleiotropy than previously recognized, supporting a more unified view of these disorders rdcu.be/ePmwD
rdcu.be
A genome-wide analysis of the shared genetic risk architecture of complex neurological and psychiatric disorders
Nature Neuroscience - Smeland et al. demonstrate greater genetic overlap between neurological and psychiatric disorders than previously recognized, along with diverse neurobiological associations....
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Gord Fishell @gordfishell.bsky.social · 03/11/2025
Well when it rains it pours. My son Will @fishell_will , just published a paper on biorxiv, much closer to my heart with my lab member Suraj Honnuraiah on spiking neural networks and understanding why they struggle as LLMs. www.biorxiv.org/content/10.1...
biorxiv.org
SNNs Are Not Transformers (Yet): The Architectural Problems for SNNs in Modeling Long-Range Dependencies
Spiking Neural Networks (SNNs) have gained increasing attention for their ability to operate on low-power neuromorphic hardware, offering a pathway toward energy-efficient large language models (LLMs)...
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PGC Functional Genomics @fg-pgc.bsky.social · 01/11/2025
✨Hello folks!✨ We're back in your feed with an amazing paper spotlight by @kirahoeffler.bsky.social & colleagues📰🔦 "Optimizing genetic ancestry adjustment in DNA methylation studies: a comparative analysis of approaches" 🔗http://bit.ly/49syndi Read our overview below! 🧵1/6
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Claire Foldi @foldi.bsky.social · 16/10/2025
Hey bsky-ers! New preprint from the lab on #psilocybin & social behaviour in #female mice in contexts relevant to eating disorders (food restriction, exercise & combo of) by PhD student Sheida 💙🦋
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Jens Hjerling Leffler @hjerling-leffler.bsky.social · 08/10/2025
Final speaker in the first session of (news.ki.se/calendar/dev...) with Michael Ziller (Muenster) talking about functional genomics of scizophrenia
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Jens Hjerling Leffler @hjerling-leffler.bsky.social · 08/10/2025
Next up in our great line up at Developing Brains (news.ki.se/calendar/dev...) is Beatriz Rico (King’s College)
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Jens Hjerling Leffler @hjerling-leffler.bsky.social · 08/10/2025
Kicking off the 12th edition of the Developing Brain Conference (news.ki.se/calendar/dev...) with Cecile Charrier (ENS).
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Butt Lab - Oxford @interneuron.bsky.social · 18/09/2025
A rather 'unique' paper from our lab is online in @cp-cellreports.bsky.social now. Unique in the sense that I don't think anyone else will be rushing to optotag cortical interneurons in the early postnatal brain... because it is nigh on impossible! www.sciencedirect.com/science/arti...
sciencedirect.com
GABAergic circuits reflect different requirements for sensory integration in postnatal mouse neocortex
Information transfer in mammalian cerebral cortex is dependent on GABAergic interneuron circuits that are widely assumed to be uniform across the neoc…
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Jens Hjerling Leffler @hjerling-leffler.bsky.social · 11/09/2025
Having a great time at the HiiLIFE Science Days at @Helsinki.fi Gracious hosts, beautiful venue, fantastic science and plenty of real coffee.
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Claire Foldi @foldi.bsky.social · 07/09/2025
Incredibly proud of @kxhuang.bsky.social for persisting with such a challenging dataset from her PhD! We found some intriguing genetic targets in a corticostriatal circuit that may be involved in the development of #anorexia nervosa 🤔 onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Toward a Genetic Signature of Resistance to Activity‐Based Anorexia in Striatal Projecting Cortical Neurons
Objective Converging evidence from neuroimaging studies and genome-wide association study (GWAS) suggests the involvement of prefrontal cortex (PFC) and striatum dysfunction in the pathophysiology o...
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Mary-Ellen Lynall @maryellenlynall.bsky.social · 01/09/2025
How do neutrophils contribute to mental health? Delighted to share research led by @staceykigar.bsky.social: meningeal neutrophils shape how the brain responds to stress. Out today @natcomms.nature.com. More in the thread⬇️ @psychiatry-ucam.bsky.social @medcambridge.bsky.social @camneuro.bsky.social
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Cambridge Psychiatry @psychiatry-ucam.bsky.social · 04/09/2025
Understanding why antidepressants don't always work 🧠🛡️ New research by @maryellenlynall.bsky.social reveals the key role played by the immune system in symptoms of depression. 📖https://bit.ly/469cXyI
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Gord Fishell @gordfishell.bsky.social · 25/08/2025
New updated on how pyramidal neurons impact interneuron subtypes. Turns out spontaneous activity, Wnt signaling in PV Interneurons and integrin-signaling in SST neurons are the culprits! Also see how optimal transport tracks identity.https://www.biorxiv.org/content/10.1101/2024.07.20.604399v2
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Sten Linnarsson @sten.linnarsson.org · 25/06/2025
A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)
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Madhu Pai, MD, PhD @madhupai.bsky.social · 25/07/2025
Wow Karolinska Institutet is recruiting 20 outstanding early-career researchers for assistant professor positions ki.se/en/about-ki/...
ki.se
Call for 20 Assistant Professor positions
Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...
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Olov Andersson @o-andersson-lab.bsky.social · 24/06/2025
Join us as a professor by taking this great opportunity in pharmacology (in any system/area) www.uu.se/en/about-uu/...
uu.se
Professor of Pharmacology - Uppsala University
Professor of Pharmacology, Department of Medical Cell Biology, Uppsala University
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Jens Hjerling Leffler @hjerling-leffler.bsky.social · 19/06/2025
I definitely never regretted the decision to leave New York for Stockholm and Karolinska - now you can join us: big call for assistant professors across medical disciplines coming up. news.ki.se/ki-to-recrui...
news.ki.se
KI to recruit junior researchers with a focus on excellence
On 25 June, Karolinska Institutet will be starting a major recruitment drive for 20 junior researchers with a focus on excellence and mobility. As one of Europe’s leading medical universities, KI offe...
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Matthijs Dorst @mattneuro.dorst-lab.org · 13/06/2025
#neuroskyence folks: as my postdoc grant is running out soon, I am looking for new opportunities in systems neuroscience! Keywords: patch clamp ephys, opto, mouse behavior, (in vivo) voltage imaging. Would love to return to the Basal Ganglia. Sharing appreciated, and happy #FluorescenceFriday !
Brightly labelled pyramidal cells in the mouse retrosplenial cortex. Blood vessels are visible of various thicknesses in darker colours.
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Butt Lab - Oxford @interneuron.bsky.social · 06/06/2025
Our study on the impact of altered serotonin (5-HT) signalling on the developing sensory cortex is now live at Nature Comms. We use longitudinal in vivo imaging of 5-HT and neural activity to show that this neuromodulator is buffered in early life to promote bottom-up instruction of sensory areas.
Image of a coronal section through postnatal mouse somatosensory cortex (S1BF with transient expression of the serotonin transporter in thalamic afferents shown in red.
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Keri Martinowich @martinowk.bsky.social · 05/06/2025
While commercialization and decreasing costs has democratized access to genomics and transcriptomics techniques for many, including in the neurosciences (good thing), there's been, IMO, some issues in adoption without corresponding best case analysis practices from the genomics field (bad thing)
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Jens Hjerling Leffler @hjerling-leffler.bsky.social · 02/06/2025
Postdoc positions available in my lab @ki.se Sweden - exciting science, fantastic environment and great quality of life. I take mentoring seriously - 7/7 postdocs that left my lab has faculty positions today. Existing datasets and funds to build new ones available. ki.varbi.com/en/what:job/...
ki.varbi.com
Postdoc in Single Cell Genomics, Jens Hjerling-Leffler group, Karolinska Institutet
Do you want to contribute to top quality medical research? The position is located within The Division of Molecular Neurobiology in the lab of Professor Jens Hjerling-Leffler at the Department of Medi
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Karl Carlström @carlstrom.bsky.social · 28/05/2025
Happy to share that I will kickstart my research group at @ki.se this autumn!🎉🎉 Are you interested in glial biology, using high-end tools for gene and cell programming to study metabolic and epigenetic interactions? Stay tuned! Will be 🔭 for RA, PhD-students & postdocs! Let the journey begin! 🧬🧫🔬
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Berna Devezer @devezer.bsky.social · 28/05/2025
Lastly to round up the 🧵: Science works doesn't mean every scientific study produces a fact ready for public consumption. Scientific work is incremental, iterative, nonlinear, slow, imperfect, relentless. Continuous improvement upon what was. Science works not despite but because of many failures.
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parafilm is cool dot com @parafilmm.bsky.social · 26/05/2025
At times like these it's important to remember the 3 branches of science
The side of a box of Parafilm that features the flask, dish, and beaker. Text has been added under them. The flask is labelled chemistry, the dish biology, and the beaker jam making. Jam making is written in a different handwritten font
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Jens Hjerling Leffler @hjerling-leffler.bsky.social · 24/05/2025
A recent preprint from the lab. Turns out biology trumps technical measures for benchmarking of transcriptomics.
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Debby Silver @debbysilver.bsky.social · 14/05/2025
Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...
nature.com
A human-specific enhancer fine-tunes radial glia potency and corticogenesis - Nature
HARE5, a human accelerated region enhancer, modulates cortical development by influencing neural progenitor cell behaviour, leading to an enlarged neocortex with increased functional independence betw...
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Paul T. Levin @paultlevin.bsky.social · 12/05/2025
Detta är ett allvarligt underbetyg för 🇸🇪. Det är många aspekter som spelar in här: den stramare migrationspolitiken, informella värderingar som gör det svårt att komma in i det svenska universitetsväsendet utifrån & en slutenhet som tex illustreras av att Etikprövning bara kan göras på svenska.+
universitetslararen.se
International PhD students advise against doctoral studies in Sweden - Universitetsläraren
Sweden is no longer an attractive country for international early-career researchers, says the SULF Doctoral Candidate Association in a new report.
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Luke Sjulson @lukesjulson.bsky.social · 18/04/2025
Check out this cool work from my superstar student Elie developing a new dimensionality reduction algorithm that compares two conditions! It works on many types of data
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Eliezyer de Oliveira @eliezyer.bsky.social · 18/04/2025
Does your research involve comparing experimental conditions? Then our latest publication is for you: We developed generalized contrastive PCA (gcPCA), a tool for comparing high-dimensional datasets. 🧠📊 doi.org/10.1371/journal.pcbi.1012747 This tool was born out of necessity, here is the story. 🧵 1/
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Marcus Stensmyr @marcusstensmyr.bsky.social · 07/04/2025
We are looking for a PhD student! If you are interested in Drosophilids, systematics, bioinformatics, fiddling with museum specimens of old/weird flies, and chemosensation, then maybe this is for you! Please rebutterfly(?)! Apply below. lu.varbi.com/en/what:job/...
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Christian Broberger @broberger.bsky.social · 09/04/2025
👇🏻Looking for a postdoc position? Want to do some truly innovative research on schizophrenia and the adolescent 🧠? How about a great boss? Jens has it all! Check it out.
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Jens Hjerling Leffler @hjerling-leffler.bsky.social · 08/04/2025
Alert! Postdoc positions available - at least two. Interested in coming to Karolinska and work on adolescent development/schizophrenia? Have a background in neuroscience, functional genomics, computational analysis or spatial transcriptomics? Large data sets available for analysis. Get in touch!
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Elin Bjarnegård @elinbja.bsky.social · 08/04/2025
Are you a researcher active outside of Europe who might consider coming to Sweden? Check out this @vetenskapsradet.bsky.social grant for recruitment of international visiting researchers! www.vr.se/english/appl...
vr.se
Grant for recruiting international visiting researchers to Sweden
The purpose of the grant is to provide higher education institutions and other research organisations the opportunity to develop and strengthen a research field by recruiting a distinguished researche...
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