Karolinska Institutet continues to grow a global community of excellence. In summer 2026, KI is inviting applications for 21 Assistant Professor positions in medicine and health. We are once again loo...

A transient grey matter microgliosis is required for remyelination, the failure of which results in a chronic neuroinflammatory state seen in neurodegenerative disorders.

A new study from Karolinska Institutet and SciLifeLab presents a detailed map of how gene activity is regulated in individual cells of the adult human brain and spinal cord. Published in Nature Neuros...

Researchers at Karolinska Institutet have created the first detailed map showing how genetic activity is controlled in individual cells of the adult human brain and spinal cord. The study, published i...

Single-nucleus epigenomic maps of the adult human brain and spinal cord reveal that adult oligodendroglia retain developmental chromatin patterns, suggesting a molecular memory that may shape repair p...

Researchers identified anoctamin-2 (ANO2) as a frequent autoimmune target in multiple sclerosis, with T cell responses against ANO2 occurring in over half of patients. These ANO2-specific T cells share cross-reactivity and pathogenic features with T cell responses to EBNA1 from Epstein-Barr virus, and their activation worsens MS-like disease in mice.

Nature Neuroscience - Zamboni et al. reveal how enhancers encode cell-type-specific responses to CNS injury. By combining multiomic profiling, deep learning and in vivo screening, they uncover...

A new study from Karolinska Institutet, published in Nature Neuroscience, explores how oligodendrocytes, the cells that produce myelin in the brain and spinal cord, respond during the development of m...

Single-cell ATAC/RNA multiomic profiling was used to investigate how oligodendrocyte lineage cells respond across multiple disease stages within a mouse MS model, revealing early activation of immune ...

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Welcome to The Ernest Arenas Memorial Lecture with Professor Roger Barker, Professor of Clinical Neuroscience at the University of Cambridge and Consultant Neurologist at Addenbrooke's Hospital.

Researchers at Karolinska Institutet and Yale University have created a multidimensional, molecular map of how the mouse brain develops after birth and how it reacts to inflammation. The study, which ...

Researchers at Karolinska Institutet and Yale University have created a multidimensional, molecular map of how the mouse brain develops after birth and how it reacts to inflammation. The study, which ...

A tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination.

Healthy brain development and function highly depend on the choroid plexus. Temporal alterations in the cellular landscape and gene expression of choroid plexus cells can alter immune cell trafficking...

Wallenberg Scholar Gonçalo Castelo-Branco is seeking to discover what happens in the brain during the progression of multiple sclerosis (MS). His findings may lead to new ways of diagnosing and treati...

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